BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 85 hits from Cubist Pharmaceuticals Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140706
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140706
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
DNA gyrase


(Staphylococcus aureus)
BDBM50135115
PNG
(CHEMBL3741066)
Show SMILES CCCOc1nccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(CO)nc1
Show InChI InChI=1S/C18H17N5O2S/c1-2-7-25-17-16-13(5-6-19-17)15(22-23-16)14-9-21-18(26-14)11-3-4-12(10-24)20-8-11/h3-6,8-9,24H,2,7,10H2,1H3,(H,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<8n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
DNA gyrase


(Staphylococcus aureus)
BDBM50135116
PNG
(CHEMBL3740365)
Show SMILES CCCOc1nccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C18H15N5O3S/c1-2-7-26-16-15-11(5-6-19-16)14(22-23-15)13-9-21-17(27-13)10-3-4-12(18(24)25)20-8-10/h3-6,8-9H,2,7H2,1H3,(H,22,23)(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a<8n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
DNA Gyrase Subunit B


(Staphylococcus aureus)
BDBM50134212
PNG
(CHEMBL3741453)
Show SMILES CCCn1c2[nH]nc(-c3cnc(s3)-c3ccc(nc3)C(O)=O)c2ccc1=O
Show InChI InChI=1S/C18H15N5O3S/c1-2-7-23-14(24)6-4-11-15(21-22-16(11)23)13-9-20-17(27-13)10-3-5-12(18(25)26)19-8-10/h3-6,8-9H,2,7H2,1H3,(H,21,22)(H,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a<8n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
DNA gyrase


(Staphylococcus aureus)
BDBM50135114
PNG
(CHEMBL3742072)
Show SMILES [Na+].[Na+].CCCOc1nccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(COP([O-])([O-])=O)nc1
Show InChI InChI=1S/C18H18N5O5PS.2Na/c1-2-7-27-17-16-13(5-6-19-17)15(22-23-16)14-9-21-18(30-14)11-3-4-12(20-8-11)10-28-29(24,25)26;;/h3-6,8-9H,2,7,10H2,1H3,(H,22,23)(H2,24,25,26);;/q;2*+1/p-2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<8n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
DNA Gyrase Subunit B


(Staphylococcus aureus)
BDBM50134213
PNG
(CHEMBL3741270)
Show SMILES CCCc1cccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C19H16N4O2S/c1-2-4-11-5-3-6-13-16(11)22-23-17(13)15-10-21-18(26-15)12-7-8-14(19(24)25)20-9-12/h3,5-10H,2,4H2,1H3,(H,22,23)(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
DNA gyrase


(Staphylococcus aureus)
BDBM50135112
PNG
(CHEMBL3739453)
Show SMILES CCCc1cccc2c(n[nH]c12)-c1cnc(s1)-c1ccnc(c1)C(O)=O
Show InChI InChI=1S/C19H16N4O2S/c1-2-4-11-5-3-6-13-16(11)22-23-17(13)15-10-21-18(26-15)12-7-8-20-14(9-12)19(24)25/h3,5-10H,2,4H2,1H3,(H,22,23)(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
DNA gyrase


(Staphylococcus aureus)
BDBM50135111
PNG
(CHEMBL3739684)
Show SMILES CCCc1cccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(nc1)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C26H30N6OS/c1-2-7-18-8-6-9-20-23(18)30-31-24(20)22-17-29-26(34-22)19-10-11-21(28-16-19)25(33)27-12-15-32-13-4-3-5-14-32/h6,8-11,16-17H,2-5,7,12-15H2,1H3,(H,27,33)(H,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
DNA gyrase


(Staphylococcus aureus)
BDBM50135113
PNG
(CHEMBL3741416)
Show SMILES CCCc1cccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(CC(O)=O)nc1
Show InChI InChI=1S/C20H18N4O2S/c1-2-4-12-5-3-6-15-18(12)23-24-19(15)16-11-22-20(27-16)13-7-8-14(21-10-13)9-17(25)26/h3,5-8,10-11H,2,4,9H2,1H3,(H,23,24)(H,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis


ACS Med Chem Lett 6: 1080-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00266
BindingDB Entry DOI: 10.7270/Q2GB25VF
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140709
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Show SMILES Oc1c2C(NC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H16Cl2N2O4/c27-17-11-10-14(12-18(17)28)30-24(33)19-20(25(30)34)26(29-21(19)13-6-2-1-3-7-13)22(31)15-8-4-5-9-16(15)23(26)32/h1-12,21,29,33-34H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140709
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Show SMILES Oc1c2C(NC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H16Cl2N2O4/c27-17-11-10-14(12-18(17)28)30-24(33)19-20(25(30)34)26(29-21(19)13-6-2-1-3-7-13)22(31)15-8-4-5-9-16(15)23(26)32/h1-12,21,29,33-34H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140707
PNG
(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,22,32-33H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140728
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22+,23+,26+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140707
PNG
(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,22,32-33H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140728
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22+,23+,26+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140729
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22-,23+,26+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 470n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140729
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22-,23+,26+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 510n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140706
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 560n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140716
PNG
(5'-(3-chloro-4-methylphenyl)-3'-phenyl-(3'R,3a'S,6...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(NC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19ClN2O4/c1-14-11-12-16(13-19(14)28)30-25(33)20-21(26(30)34)27(29-22(20)15-7-3-2-4-8-15)23(31)17-9-5-6-10-18(17)24(27)32/h2-13,22,29,33-34H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 730n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140706
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140717
PNG
(5-benzo[d][1,3]dioxol-5-yl-3-phenylspiro[perhydrof...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C27H17NO7/c29-23-16-8-4-5-9-17(16)24(30)27(23)21-20(22(35-27)14-6-2-1-3-7-14)25(31)28(26(21)32)15-10-11-18-19(12-15)34-13-33-18/h1-12,22,31-32H,13H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 970n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140716
PNG
(5'-(3-chloro-4-methylphenyl)-3'-phenyl-(3'R,3a'S,6...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(NC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19ClN2O4/c1-14-11-12-16(13-19(14)28)30-25(33)20-21(26(30)34)27(29-22(20)15-7-3-2-4-8-15)23(31)17-9-5-6-10-18(17)24(27)32/h2-13,22,29,33-34H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 990n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140705
PNG
(5-(2-methoxyphenyl)-3-phenylspiro[perhydrofuro[3,4...)
Show SMILES COc1ccccc1-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19NO6/c1-33-19-14-8-7-13-18(19)28-25(31)20-21(26(28)32)27(34-22(20)15-9-3-2-4-10-15)23(29)16-11-5-6-12-17(16)24(27)30/h2-14,22,31-32H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140727
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2[C@@H](OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140725
PNG
(13N-(3,4-dichlorophenyl)-2,11-dioxo-14-phenyl-(1R,...)
Show SMILES Clc1ccc(NC(=O)[C@H]2[C@@H](O[C@@]34[C@@H](OC(=O)[C@@H]23)c2ccccc2C4=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C26H17Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-21,23H,(H,29,31)/t19-,20-,21+,23+,26+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140717
PNG
(5-benzo[d][1,3]dioxol-5-yl-3-phenylspiro[perhydrof...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C27H17NO7/c29-23-16-8-4-5-9-17(16)24(30)27(23)21-20(22(35-27)14-6-2-1-3-7-14)25(31)28(26(21)32)15-10-11-18-19(12-15)34-13-33-18/h1-12,22,31-32H,13H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140709
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Show SMILES Oc1c2C(NC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H16Cl2N2O4/c27-17-11-10-14(12-18(17)28)30-24(33)19-20(25(30)34)26(29-21(19)13-6-2-1-3-7-13)22(31)15-8-4-5-9-16(15)23(26)32/h1-12,21,29,33-34H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140725
PNG
(13N-(3,4-dichlorophenyl)-2,11-dioxo-14-phenyl-(1R,...)
Show SMILES Clc1ccc(NC(=O)[C@H]2[C@@H](O[C@@]34[C@@H](OC(=O)[C@@H]23)c2ccccc2C4=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C26H17Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-21,23H,(H,29,31)/t19-,20-,21+,23+,26+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140709
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Show SMILES Oc1c2C(NC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H16Cl2N2O4/c27-17-11-10-14(12-18(17)28)30-24(33)19-20(25(30)34)26(29-21(19)13-6-2-1-3-7-13)22(31)15-8-4-5-9-16(15)23(26)32/h1-12,21,29,33-34H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140726
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES OC1c2ccccc2C2OC(=O)[C@@H]3[C@@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21-,22?,23?,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.90E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140727
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2[C@@H](OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140716
PNG
(5'-(3-chloro-4-methylphenyl)-3'-phenyl-(3'R,3a'S,6...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(NC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19ClN2O4/c1-14-11-12-16(13-19(14)28)30-25(33)20-21(26(30)34)27(29-22(20)15-7-3-2-4-8-15)23(31)17-9-5-6-10-18(17)24(27)32/h2-13,22,29,33-34H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140705
PNG
(5-(2-methoxyphenyl)-3-phenylspiro[perhydrofuro[3,4...)
Show SMILES COc1ccccc1-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19NO6/c1-33-19-14-8-7-13-18(19)28-25(31)20-21(26(28)32)27(34-22(20)15-9-3-2-4-10-15)23(29)16-11-5-6-12-17(16)24(27)30/h2-14,22,31-32H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140713
PNG
(4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,...)
Show SMILES Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H18Cl2N2O3/c26-17-12-11-16(13-18(17)27)29-24(31)19-20(25(29)32)22(23(30)15-9-5-2-6-10-15)28-21(19)14-7-3-1-4-8-14/h1-13,21-22,28,31-32H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.70E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140707
PNG
(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,22,32-33H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140716
PNG
(5'-(3-chloro-4-methylphenyl)-3'-phenyl-(3'R,3a'S,6...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(NC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19ClN2O4/c1-14-11-12-16(13-19(14)28)30-25(33)20-21(26(30)34)27(29-22(20)15-7-3-2-4-8-15)23(31)17-9-5-6-10-18(17)24(27)32/h2-13,22,29,33-34H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.70E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140730
PNG
(4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phen...)
Show SMILES OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H17Cl2NO6/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(33)34)26(35-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,19-21H,(H,29,32)(H,33,34)/t19-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140708
PNG
(5-(2-methoxyphenyl)-3-(2-methylphenyl)-(3R,3aS,6aR...)
Show SMILES COc1ccccc1-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1C
Show InChI InChI=1S/C28H21NO6/c1-15-9-3-4-10-16(15)23-21-22(27(33)29(26(21)32)19-13-7-8-14-20(19)34-2)28(35-23)24(30)17-11-5-6-12-18(17)25(28)31/h3-14,23,32-33H,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140707
PNG
(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,22,32-33H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.37E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140726
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES OC1c2ccccc2C2OC(=O)[C@@H]3[C@@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21-,22?,23?,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140726
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES OC1c2ccccc2C2OC(=O)[C@@H]3[C@@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21-,22?,23?,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140713
PNG
(4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,...)
Show SMILES Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H18Cl2N2O3/c26-17-12-11-16(13-18(17)27)29-24(31)19-20(25(29)32)22(23(30)15-9-5-2-6-10-15)28-21(19)14-7-3-1-4-8-14/h1-13,21-22,28,31-32H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.57E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140713
PNG
(4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,...)
Show SMILES Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H18Cl2N2O3/c26-17-12-11-16(13-18(17)27)29-24(31)19-20(25(29)32)22(23(30)15-9-5-2-6-10-15)28-21(19)14-7-3-1-4-8-14/h1-13,21-22,28,31-32H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140704
PNG
(5-(4-chloro-3-trifluoromethylphenyl)-3-phenyl-(3R,...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(c1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C27H15ClF3NO5/c28-18-11-10-14(12-17(18)27(29,30)31)32-24(35)19-20(25(32)36)26(37-21(19)13-6-2-1-3-7-13)22(33)15-8-4-5-9-16(15)23(26)34/h1-12,21,35-36H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140730
PNG
(4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phen...)
Show SMILES OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H17Cl2NO6/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(33)34)26(35-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,19-21H,(H,29,32)(H,33,34)/t19-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Bioorg Med Chem Lett 14: 1343-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.082
BindingDB Entry DOI: 10.7270/Q2K073Q6
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140704
PNG
(5-(4-chloro-3-trifluoromethylphenyl)-3-phenyl-(3R,...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(c1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C27H15ClF3NO5/c28-18-11-10-14(12-17(18)27(29,30)31)32-24(35)19-20(25(32)36)26(37-21(19)13-6-2-1-3-7-13)22(33)15-8-4-5-9-16(15)23(26)34/h1-12,21,35-36H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140708
PNG
(5-(2-methoxyphenyl)-3-(2-methylphenyl)-(3R,3aS,6aR...)
Show SMILES COc1ccccc1-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1C
Show InChI InChI=1S/C28H21NO6/c1-15-9-3-4-10-16(15)23-21-22(27(33)29(26(21)32)19-13-7-8-14-20(19)34-2)28(35-23)24(30)17-11-5-6-12-18(17)25(28)31/h3-14,23,32-33H,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.70E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain


(Streptococcus pyogenes serotype M18)
BDBM50140713
PNG
(4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,...)
Show SMILES Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H18Cl2N2O3/c26-17-12-11-16(13-18(17)27)29-24(31)19-20(25(29)32)22(23(30)15-9-5-2-6-10-15)28-21(19)14-7-3-1-4-8-14/h1-13,21-22,28,31-32H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.90E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140713
PNG
(4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,...)
Show SMILES Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H18Cl2N2O3/c26-17-12-11-16(13-18(17)27)29-24(31)19-20(25(29)32)22(23(30)15-9-5-2-6-10-15)28-21(19)14-7-3-1-4-8-14/h1-13,21-22,28,31-32H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Bioorg Med Chem Lett 14: 1339-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.081
BindingDB Entry DOI: 10.7270/Q2PR7VDS
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 85 total )  |  Next  |  Last  >>
Jump to: