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Compile Data Set for Download or QSAR

Found 73 hits from Curis, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279664
PNG
(US10035797, Compound 3)
Show SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCOc4cc3I)nc12
Show InChI InChI=1S/C18H15IN4O2S/c1-2-3-4-7-23-12-5-6-21-17(20)16(12)22-18(23)26-15-9-14-13(8-11(15)19)24-10-25-14/h1,5-6,8-9H,3-4,7,10H2,(H2,20,21)
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n/an/a<100n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM50439622
PNG
(CHEMBL2419346 | US10035797, Compound 111)
Show SMILES CN(C)c1cc2OCOc2cc1Sc1nc2c(N)nccc2n1CCNCC(C)(C)C
Show InChI InChI=1S/C22H30N6O2S/c1-22(2,3)12-24-8-9-28-14-6-7-25-20(23)19(14)26-21(28)31-18-11-17-16(29-13-30-17)10-15(18)27(4)5/h6-7,10-11,24H,8-9,12-13H2,1-5H3,(H2,23,25)
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US Patent
n/an/a<100n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279695
PNG
(US10035797, Compound 34 | US10035797, Compound 37)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C20H24IN5O2S/c1-20(2,3)10-23-6-7-26-13-4-5-24-18(22)17(13)25-19(26)29-16-9-15-14(8-12(16)21)27-11-28-15/h4-5,8-9,23H,6-7,10-11H2,1-3H3,(H2,22,24)
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n/an/a<100n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279695
PNG
(US10035797, Compound 34 | US10035797, Compound 37)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C20H24IN5O2S/c1-20(2,3)10-23-6-7-26-13-4-5-24-18(22)17(13)25-19(26)29-16-9-15-14(8-12(16)21)27-11-28-15/h4-5,8-9,23H,6-7,10-11H2,1-3H3,(H2,22,24)
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n/an/a<100n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279657
PNG
(US10035797, Compound 1)
Show SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCOc4cc3Br)nc12
Show InChI InChI=1S/C18H15BrN4O2S/c1-2-3-4-7-23-12-5-6-21-17(20)16(12)22-18(23)26-15-9-14-13(8-11(15)19)24-10-25-14/h1,5-6,8-9H,3-4,7,10H2,(H2,20,21)
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n/an/a 550n/an/an/an/an/a25



Curis, Inc.

US Patent


Assay Description
The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279657
PNG
(US10035797, Compound 1)
Show SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCOc4cc3Br)nc12
Show InChI InChI=1S/C18H15BrN4O2S/c1-2-3-4-7-23-12-5-6-21-17(20)16(12)22-18(23)26-15-9-14-13(8-11(15)19)24-10-25-14/h1,5-6,8-9H,3-4,7,10H2,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279658
PNG
(US10035797, Compound 2)
Show SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCOc4cc3Cl)nc12
Show InChI InChI=1S/C18H15ClN4O2S/c1-2-3-4-7-23-12-5-6-21-17(20)16(12)22-18(23)26-15-9-14-13(8-11(15)19)24-10-25-14/h1,5-6,8-9H,3-4,7,10H2,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279658
PNG
(US10035797, Compound 2)
Show SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCOc4cc3Cl)nc12
Show InChI InChI=1S/C18H15ClN4O2S/c1-2-3-4-7-23-12-5-6-21-17(20)16(12)22-18(23)26-15-9-14-13(8-11(15)19)24-10-25-14/h1,5-6,8-9H,3-4,7,10H2,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279664
PNG
(US10035797, Compound 3)
Show SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCOc4cc3I)nc12
Show InChI InChI=1S/C18H15IN4O2S/c1-2-3-4-7-23-12-5-6-21-17(20)16(12)22-18(23)26-15-9-14-13(8-11(15)19)24-10-25-14/h1,5-6,8-9H,3-4,7,10H2,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279666
PNG
(US10035797, Compound 4)
Show SMILES CCCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C18H19IN4O2S/c1-2-3-4-7-23-12-5-6-21-17(20)16(12)22-18(23)26-15-9-14-13(8-11(15)19)24-10-25-14/h5-6,8-9H,2-4,7,10H2,1H3,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279667
PNG
(US10035797, Compound 7)
Show SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCCOc4cc3I)nc12
Show InChI InChI=1S/C19H17IN4O2S/c1-2-3-4-7-24-13-5-6-22-18(21)17(13)23-19(24)27-16-11-15-14(10-12(16)20)25-8-9-26-15/h1,5-6,10-11H,3-4,7-9H2,(H2,21,22)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279673
PNG
(US10035797, Compound 12)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)nccc3n2CCCC#C)c1
Show InChI InChI=1S/C18H17IN4OS/c1-3-4-5-10-23-14-8-9-21-17(20)16(14)22-18(23)25-15-11-12(24-2)6-7-13(15)19/h1,6-9,11H,4-5,10H2,2H3,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279685
PNG
(US10035797, Compound 23)
Show SMILES Nc1nccc2n(CCC#C)c(Sc3cc4OCOc4cc3I)nc12
Show InChI InChI=1S/C17H13IN4O2S/c1-2-3-6-22-11-4-5-20-16(19)15(11)21-17(22)25-14-8-13-12(7-10(14)18)23-9-24-13/h1,4-5,7-8H,3,6,9H2,(H2,19,20)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279687
PNG
(US10035797, Compound 25)
Show SMILES Nc1nccc2n(CCCCC#C)c(Sc3cc4OCOc4cc3I)nc12
Show InChI InChI=1S/C19H17IN4O2S/c1-2-3-4-5-8-24-13-6-7-22-18(21)17(13)23-19(24)27-16-10-15-14(9-12(16)20)25-11-26-15/h1,6-7,9-10H,3-5,8,11H2,(H2,21,22)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279690
PNG
(US10035797, Compound 28)
Show SMILES Nc1nccc2n(CCCC#N)c(Sc3cc4OCOc4cc3I)nc12
Show InChI InChI=1S/C17H14IN5O2S/c18-10-7-12-13(25-9-24-12)8-14(10)26-17-22-15-11(3-5-21-16(15)20)23(17)6-2-1-4-19/h3,5,7-8H,1-2,6,9H2,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279692
PNG
(US10035797, Compound 30)
Show SMILES Nc1nccc2n(CCCCC#N)c(Sc3cc4OCOc4cc3I)nc12
Show InChI InChI=1S/C18H16IN5O2S/c19-11-8-13-14(26-10-25-13)9-15(11)27-18-23-16-12(4-6-22-17(16)21)24(18)7-3-1-2-5-20/h4,6,8-9H,1-3,7,10H2,(H2,21,22)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279693
PNG
(US10035797, Compound 32)
Show SMILES NCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C15H14IN5O2S/c16-8-5-10-11(23-7-22-10)6-12(8)24-15-20-13-9(21(15)4-2-17)1-3-19-14(13)18/h1,3,5-6H,2,4,7,17H2,(H2,18,19)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279694
PNG
(US10035797, Compound 33)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2Br)nc2c(N)nccc12
Show InChI InChI=1S/C20H24BrN5O2S/c1-20(2,3)10-23-6-7-26-13-4-5-24-18(22)17(13)25-19(26)29-16-9-15-14(8-12(16)21)27-11-28-15/h4-5,8-9,23H,6-7,10-11H2,1-3H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279695
PNG
(US10035797, Compound 34 | US10035797, Compound 37)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C20H24IN5O2S/c1-20(2,3)10-23-6-7-26-13-4-5-24-18(22)17(13)25-19(26)29-16-9-15-14(8-12(16)21)27-11-28-15/h4-5,8-9,23H,6-7,10-11H2,1-3H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279697
PNG
(US10035797, Compound 40)
Show SMILES CC(C)(C)NCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C19H22IN5O2S/c1-19(2,3)23-6-7-25-12-4-5-22-17(21)16(12)24-18(25)28-15-9-14-13(8-11(15)20)26-10-27-14/h4-5,8-9,23H,6-7,10H2,1-3H3,(H2,21,22)
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n/an/a 550n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279698
PNG
(US10035797, Compound 42)
Show SMILES CC(C)NCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C18H20IN5O2S/c1-10(2)21-5-6-24-12-3-4-22-17(20)16(12)23-18(24)27-15-8-14-13(7-11(15)19)25-9-26-14/h3-4,7-8,10,21H,5-6,9H2,1-2H3,(H2,20,22)
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n/an/a 550n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279699
PNG
(US10035797, Compound 44)
Show SMILES CCC(CC)NCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C20H24IN5O2S/c1-3-12(4-2)23-7-8-26-14-5-6-24-19(22)18(14)25-20(26)29-17-10-16-15(9-13(17)21)27-11-28-16/h5-6,9-10,12,23H,3-4,7-8,11H2,1-2H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279700
PNG
(US10035797, Compound 46)
Show SMILES CN(C)CCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C17H18IN5O2S/c1-22(2)5-6-23-11-3-4-20-16(19)15(11)21-17(23)26-14-8-13-12(7-10(14)18)24-9-25-13/h3-4,7-8H,5-6,9H2,1-2H3,(H2,19,20)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279702
PNG
(US10035797, Compound 50)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)nccc3n2CCNCC(C)(C)C)c1
Show InChI InChI=1S/C20H26IN5OS/c1-20(2,3)12-23-9-10-26-15-7-8-24-18(22)17(15)25-19(26)28-16-11-13(27-4)5-6-14(16)21/h5-8,11,23H,9-10,12H2,1-4H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279703
PNG
(US10035797, Compound 51 | US10035797, Compound 52)
Show SMILES CC(C)NCCCn1c(Sc2cc3OCOc3cc2Br)nc2c(N)nccc12
Show InChI InChI=1S/C19H22BrN5O2S/c1-11(2)22-5-3-7-25-13-4-6-23-18(21)17(13)24-19(25)28-16-9-15-14(8-12(16)20)26-10-27-15/h4,6,8-9,11,22H,3,5,7,10H2,1-2H3,(H2,21,23)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279707
PNG
(US10035797, Compound 56)
Show SMILES CC(C)(C)CNCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C21H26IN5O2S/c1-21(2,3)11-24-6-4-8-27-14-5-7-25-19(23)18(14)26-20(27)30-17-10-16-15(9-13(17)22)28-12-29-16/h5,7,9-10,24H,4,6,8,11-12H2,1-3H3,(H2,23,25)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279708
PNG
(US10035797, Compound 58)
Show SMILES CC(C)(C)NCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C20H24IN5O2S/c1-20(2,3)24-6-4-8-26-13-5-7-23-18(22)17(13)25-19(26)29-16-10-15-14(9-12(16)21)27-11-28-15/h5,7,9-10,24H,4,6,8,11H2,1-3H3,(H2,22,23)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279709
PNG
(US10035797, Compound 60)
Show SMILES CCC(CC)NCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C21H26IN5O2S/c1-3-13(4-2)24-7-5-9-27-15-6-8-25-20(23)19(15)26-21(27)30-18-11-17-16(10-14(18)22)28-12-29-17/h6,8,10-11,13,24H,3-5,7,9,12H2,1-2H3,(H2,23,25)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279710
PNG
(US10035797, Compound 61)
Show SMILES CC(C)OCCn1c(Sc2cc3OCOc3cc2Br)nc2c(N)nccc12
Show InChI InChI=1S/C18H19BrN4O3S/c1-10(2)24-6-5-23-12-3-4-21-17(20)16(12)22-18(23)27-15-8-14-13(7-11(15)19)25-9-26-14/h3-4,7-8,10H,5-6,9H2,1-2H3,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279711
PNG
(US10035797, Compound 62)
Show SMILES CC(C)OCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C18H19IN4O3S/c1-10(2)24-6-5-23-12-3-4-21-17(20)16(12)22-18(23)27-15-8-14-13(7-11(15)19)25-9-26-14/h3-4,7-8,10H,5-6,9H2,1-2H3,(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279713
PNG
(US10035797, Compound 66)
Show SMILES NC(=O)CCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C17H16IN5O3S/c18-9-6-11-12(26-8-25-11)7-13(9)27-17-22-15-10(3-4-21-16(15)20)23(17)5-1-2-14(19)24/h3-4,6-7H,1-2,5,8H2,(H2,19,24)(H2,20,21)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279714
PNG
(US10035797, Compound 68)
Show SMILES NC(=O)CCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C18H18IN5O3S/c19-10-7-12-13(27-9-26-12)8-14(10)28-18-23-16-11(4-5-22-17(16)21)24(18)6-2-1-3-15(20)25/h4-5,7-8H,1-3,6,9H2,(H2,20,25)(H2,21,22)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279715
PNG
(US10035797, Compound 70)
Show SMILES NC(=O)CCCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C19H20IN5O3S/c20-11-8-13-14(28-10-27-13)9-15(11)29-19-24-17-12(5-6-23-18(17)22)25(19)7-3-1-2-4-16(21)26/h5-6,8-9H,1-4,7,10H2,(H2,21,26)(H2,22,23)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279716
PNG
(US10035797, Compound 72)
Show SMILES CC(=O)NCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C17H16IN5O3S/c1-9(24)20-4-5-23-11-2-3-21-16(19)15(11)22-17(23)27-14-7-13-12(6-10(14)18)25-8-26-13/h2-3,6-7H,4-5,8H2,1H3,(H2,19,21)(H,20,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279717
PNG
(US10035797, Compound 74)
Show SMILES CC(=O)NCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C18H18IN5O3S/c1-10(25)21-4-2-6-24-12-3-5-22-17(20)16(12)23-18(24)28-15-8-14-13(7-11(15)19)26-9-27-14/h3,5,7-8H,2,4,6,9H2,1H3,(H2,20,22)(H,21,25)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279718
PNG
(US10035797, Compound 76)
Show SMILES CC(=O)NCCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Show InChI InChI=1S/C19H20IN5O3S/c1-11(26)22-5-2-3-7-25-13-4-6-23-18(21)17(13)24-19(25)29-16-9-15-14(8-12(16)20)27-10-28-15/h4,6,8-9H,2-3,5,7,10H2,1H3,(H2,21,23)(H,22,26)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279719
PNG
(US10035797, Compound 77)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2Cl)nc2c(N)nccc12
Show InChI InChI=1S/C20H24ClN5O2S/c1-20(2,3)10-23-6-7-26-13-4-5-24-18(22)17(13)25-19(26)29-16-9-15-14(8-12(16)21)27-11-28-15/h4-5,8-9,23H,6-7,10-11H2,1-3H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279721
PNG
(US10035797, Compound 79)
Show SMILES COc1cc2OCOc2cc1Sc1nc2c(N)nccc2n1CCNCC(C)(C)C
Show InChI InChI=1S/C21H27N5O3S/c1-21(2,3)11-23-7-8-26-13-5-6-24-19(22)18(13)25-20(26)30-17-10-15-14(28-12-29-15)9-16(17)27-4/h5-6,9-10,23H,7-8,11-12H2,1-4H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279722
PNG
(US10035797, Compound 84)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2C=C)nc2c(N)nccc12
Show InChI InChI=1S/C22H27N5O2S/c1-5-14-10-16-17(29-13-28-16)11-18(14)30-21-26-19-15(6-7-25-20(19)23)27(21)9-8-24-12-22(2,3)4/h5-7,10-11,24H,1,8-9,12-13H2,2-4H3,(H2,23,25)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279723
PNG
(US10035797, Compound 85)
Show SMILES CCc1cc2OCOc2cc1Sc1nc2c(N)nccc2n1CCNCC(C)(C)C
Show InChI InChI=1S/C22H29N5O2S/c1-5-14-10-16-17(29-13-28-16)11-18(14)30-21-26-19-15(6-7-25-20(19)23)27(21)9-8-24-12-22(2,3)4/h6-7,10-11,24H,5,8-9,12-13H2,1-4H3,(H2,23,25)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279725
PNG
(US10035797, Compound 87)
Show SMILES CSc1cc2OCOc2cc1Sc1nc2c(N)nccc2n1CCNCC(C)(C)C
Show InChI InChI=1S/C21H27N5O2S2/c1-21(2,3)11-23-7-8-26-13-5-6-24-19(22)18(13)25-20(26)30-17-10-15-14(27-12-28-15)9-16(17)29-4/h5-6,9-10,23H,7-8,11-12H2,1-4H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279726
PNG
(US10035797, Compound 89)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2[N+]#[C-])nc2c(N)nccc12
Show InChI InChI=1S/C21H24N6O2S/c1-21(2,3)11-24-7-8-27-14-5-6-25-19(22)18(14)26-20(27)30-17-10-16-15(28-12-29-16)9-13(17)23-4/h5-6,9-10,24H,7-8,11-12H2,1-3H3,(H2,22,25)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279729
PNG
(US10035797, Compound 113)
Show SMILES CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2[N+]([O-])=O)nc2c(N)nccc12
Show InChI InChI=1S/C20H24N6O4S/c1-20(2,3)10-22-6-7-25-12-4-5-23-18(21)17(12)24-19(25)31-16-9-15-14(29-11-30-15)8-13(16)26(27)28/h4-5,8-9,22H,6-7,10-11H2,1-3H3,(H2,21,23)
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US Patent
n/an/a 550n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279673
PNG
(US10035797, Compound 12)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)nccc3n2CCCC#C)c1
Show InChI InChI=1S/C18H17IN4OS/c1-3-4-5-10-23-14-8-9-21-17(20)16(14)22-18(23)25-15-11-12(24-2)6-7-13(15)19/h1,6-9,11H,4-5,10H2,2H3,(H2,20,21)
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n/an/a 5.50E+3n/an/an/an/an/a25



Curis, Inc.

US Patent


Assay Description
The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279689
PNG
(US10035797, Compound 27)
Show SMILES Nc1nccc2n(CCCC#N)c(Sc3cc4OCOc4cc3Br)nc12
Show InChI InChI=1S/C17H14BrN5O2S/c18-10-7-12-13(25-9-24-12)8-14(10)26-17-22-15-11(3-5-21-16(15)20)23(17)6-2-1-4-19/h3,5,7-8H,1-2,6,9H2,(H2,20,21)
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n/an/a 5.50E+3n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279720
PNG
(US10035797, Compound 78)
Show SMILES Cc1cc2OCOc2cc1Sc1nc2c(N)nccc2n1CCNCC(C)(C)C
Show InChI InChI=1S/C21H27N5O2S/c1-13-9-15-16(28-12-27-15)10-17(13)29-20-25-18-14(5-6-24-19(18)22)26(20)8-7-23-11-21(2,3)4/h5-6,9-10,23H,7-8,11-12H2,1-4H3,(H2,22,24)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279712
PNG
(US10035797, Compound 64)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)nccc3n2CCOC(C)C)c1
Show InChI InChI=1S/C18H21IN4O2S/c1-11(2)25-9-8-23-14-6-7-21-17(20)16(14)22-18(23)26-15-10-12(24-3)4-5-13(15)19/h4-7,10-11H,8-9H2,1-3H3,(H2,20,21)
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n/an/a 5.50E+3n/an/an/an/a7.3n/a



Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279706
PNG
(US10035797, Compound 54)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)nccc3n2CCCNC(C)C)c1
Show InChI InChI=1S/C19H24IN5OS/c1-12(2)22-8-4-10-25-15-7-9-23-18(21)17(15)24-19(25)27-16-11-13(26-3)5-6-14(16)20/h5-7,9,11-12,22H,4,8,10H2,1-3H3,(H2,21,23)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279705
PNG
(US10035797, Compound 53)
Show SMILES COc1ccc(Br)c(Sc2nc3c(N)nccc3n2CCCNC(C)C)c1
Show InChI InChI=1S/C19H24BrN5OS/c1-12(2)22-8-4-10-25-15-7-9-23-18(21)17(15)24-19(25)27-16-11-13(26-3)5-6-14(16)20/h5-7,9,11-12,22H,4,8,10H2,1-3H3,(H2,21,23)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (human))
BDBM279703
PNG
(US10035797, Compound 51 | US10035797, Compound 52)
Show SMILES CC(C)NCCCn1c(Sc2cc3OCOc3cc2Br)nc2c(N)nccc12
Show InChI InChI=1S/C19H22BrN5O2S/c1-11(2)22-5-3-7-25-13-4-6-23-18(21)17(13)24-19(25)28-16-9-15-14(8-12(16)20)26-10-27-15/h4,6,8-9,11,22H,3,5,7,10H2,1-2H3,(H2,21,23)
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Curis, Inc.

US Patent


Assay Description
A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...


US Patent US10035797 (2018)

More data for this
Ligand-Target Pair
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