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Compile Data Set for Download or QSAR

Found 100 hits from Cytopia Research Pty Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311010
PNG
(CHEMBL1078889 | N-(4-{2-[4-(1,1-Dioxo-1lambda*6*-t...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCS(=O)(=O)CC3)cc2)n1
Show InChI InChI=1S/C22H25N5O4S2/c1-32(28,29)26-20-8-4-18(5-9-20)21-10-11-23-22(25-21)24-19-6-2-17(3-7-19)16-27-12-14-33(30,31)15-13-27/h2-11,26H,12-16H2,1H3,(H,23,24,25)
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n/an/a 2n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27634
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cc(C)ccc2F)c1
Show InChI InChI=1S/C20H18ClFN4O/c1-12-6-7-17(22)16(8-12)20(27)25-15-5-3-4-14(9-15)13(2)24-19-11-23-10-18(21)26-19/h3-11,13H,1-2H3,(H,24,26)(H,25,27)/t13-/m0/s1
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n/an/a 2n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27633
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C20H19ClN4O/c1-13-5-3-7-16(9-13)20(26)24-17-8-4-6-15(10-17)14(2)23-19-12-22-11-18(21)25-19/h3-12,14H,1-2H3,(H,23,25)(H,24,26)/t14-/m0/s1
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n/an/a 2n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311001
PNG
(2-methoxy-4-(2-(4-morpholinophenylamino)pyrimidin-...)
Show SMILES COc1cc(ccc1O)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H22N4O3/c1-27-20-14-15(2-7-19(20)26)18-8-9-22-21(24-18)23-16-3-5-17(6-4-16)25-10-12-28-13-11-25/h2-9,14,26H,10-13H2,1H3,(H,22,23,24)
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n/an/a 3n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311011
PNG
(CHEMBL1079077 | N-(4-(2-(4-morpholinophenylamino)p...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H23N5O3S/c1-30(27,28)25-18-4-2-16(3-5-18)20-10-11-22-21(24-20)23-17-6-8-19(9-7-17)26-12-14-29-15-13-26/h2-11,25H,12-15H2,1H3,(H,22,23,24)
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n/an/a 4n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27628
PNG
(5-bromo-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cncc(Br)c2)c1
Show InChI InChI=1S/C18H15BrClN5O/c1-11(23-17-10-22-9-16(20)25-17)12-3-2-4-15(6-12)24-18(26)13-5-14(19)8-21-7-13/h2-11H,1H3,(H,23,25)(H,24,26)/t11-/m0/s1
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n/an/a 4n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27627
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cncc(C)c2)c1
Show InChI InChI=1S/C19H18ClN5O/c1-12-6-15(9-21-8-12)19(26)24-16-5-3-4-14(7-16)13(2)23-18-11-22-10-17(20)25-18/h3-11,13H,1-2H3,(H,23,25)(H,24,26)/t13-/m0/s1
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n/an/a 5n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50193995
PNG
(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27637
PNG
(N-{3-[(1S)-1-[(5-bromopyridin-3-yl)amino]ethyl]phe...)
Show SMILES C[C@H](Nc1cncc(Br)c1)c1cccc(NC(=O)c2cncc(C)c2)c1
Show InChI InChI=1S/C20H19BrN4O/c1-13-6-16(10-22-9-13)20(26)25-18-5-3-4-15(7-18)14(2)24-19-8-17(21)11-23-12-19/h3-12,14,24H,1-2H3,(H,25,26)/t14-/m0/s1
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n/an/a 5n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311012
PNG
(CHEMBL1079078 | N-(4-(2-(4-(4-hydroxypiperidin-1-y...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCC(O)CC2)n1
Show InChI InChI=1S/C22H25N5O3S/c1-31(29,30)26-18-4-2-16(3-5-18)21-10-13-23-22(25-21)24-17-6-8-19(9-7-17)27-14-11-20(28)12-15-27/h2-10,13,20,26,28H,11-12,14-15H2,1H3,(H,23,24,25)
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n/an/a 6n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311002
PNG
(CHEMBL1078275 | N-(4-(2-(3-(pyrrolidin-1-ylmethyl)...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(CN3CCCC3)c2)n1
Show InChI InChI=1S/C22H25N5O2S/c1-30(28,29)26-19-9-7-18(8-10-19)21-11-12-23-22(25-21)24-20-6-4-5-17(15-20)16-27-13-2-3-14-27/h4-12,15,26H,2-3,13-14,16H2,1H3,(H,23,24,25)
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n/an/a 6n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311022
PNG
(CHEMBL1078005 | N-(cyanomethyl)-4-(5-methyl-2-(4-m...)
Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(cc1)C(=O)NCC#N
Show InChI InChI=1S/C24H24N6O2/c1-17-16-27-24(28-20-6-8-21(9-7-20)30-12-14-32-15-13-30)29-22(17)18-2-4-19(5-3-18)23(31)26-11-10-25/h2-9,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 8n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311004
PNG
(CHEMBL1078277 | N-(4-(2-(3-(morpholinomethyl)pheny...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(CN3CCOCC3)c2)n1
Show InChI InChI=1S/C22H25N5O3S/c1-31(28,29)26-19-7-5-18(6-8-19)21-9-10-23-22(25-21)24-20-4-2-3-17(15-20)16-27-11-13-30-14-12-27/h2-10,15,26H,11-14,16H2,1H3,(H,23,24,25)
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n/an/a 8n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311006
PNG
(CHEMBL1078689 | N-(4-(2-(4-(morpholinomethyl)pheny...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCOCC3)cc2)n1
Show InChI InChI=1S/C22H25N5O3S/c1-31(28,29)26-20-8-4-18(5-9-20)21-10-11-23-22(25-21)24-19-6-2-17(3-7-19)16-27-12-14-30-15-13-27/h2-11,26H,12-16H2,1H3,(H,23,24,25)
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n/an/a 9n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27631
PNG
(3-chloro-N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C19H15Cl2FN4O/c1-11(24-18-10-23-9-17(21)26-18)12-3-2-4-14(7-12)25-19(27)13-5-6-16(22)15(20)8-13/h2-11H,1H3,(H,24,26)(H,25,27)/t11-/m0/s1
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n/an/a 9n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27632
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccc(C)cc2)c1
Show InChI InChI=1S/C20H19ClN4O/c1-13-6-8-15(9-7-13)20(26)24-17-5-3-4-16(10-17)14(2)23-19-12-22-11-18(21)25-19/h3-12,14H,1-2H3,(H,23,25)(H,24,26)/t14-/m0/s1
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n/an/a 9n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311019
PNG
(CHEMBL1078364 | N-(cyanomethyl)-2-methoxy-4-(2-(4-...)
Show SMILES COc1cc(ccc1C(=O)NCC#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H24N6O3/c1-32-22-16-17(2-7-20(22)23(31)26-11-9-25)21-8-10-27-24(29-21)28-18-3-5-19(6-4-18)30-12-14-33-15-13-30/h2-8,10,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 9n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27630
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H16ClF3N4O/c1-12(26-18-11-25-10-17(21)28-18)13-4-3-7-16(9-13)27-19(29)14-5-2-6-15(8-14)20(22,23)24/h2-12H,1H3,(H,26,28)(H,27,29)/t12-/m0/s1
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n/an/a 10n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311016
PNG
(2-cyano-N-(4-(2-(4-morpholinophenylamino)pyrimidin...)
Show SMILES O=C(CC#N)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-11-9-22(30)26-18-3-1-17(2-4-18)21-10-12-25-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-8,10,12H,9,13-16H2,(H,26,30)(H,25,27,28)
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n/an/a 10n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27639
PNG
(N-{3-[(1S)-1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazi...)
Show SMILES COc1cc(ccc1O)-c1cncc(N[C@@H](C)c2cccc(NC(=O)c3cccnc3)c2)n1
Show InChI InChI=1S/C25H23N5O3/c1-16(17-5-3-7-20(11-17)29-25(32)19-6-4-10-26-13-19)28-24-15-27-14-21(30-24)18-8-9-22(31)23(12-18)33-2/h3-16,31H,1-2H3,(H,28,30)(H,29,32)/t16-/m0/s1
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n/an/a 11n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50311017
PNG
(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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n/an/a 11n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311003
PNG
(CHEMBL1078276 | N-(4-(2-(4-(piperidin-1-ylmethyl)p...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCCCC3)cc2)n1
Show InChI InChI=1S/C23H27N5O2S/c1-31(29,30)27-21-11-7-19(8-12-21)22-13-14-24-23(26-22)25-20-9-5-18(6-10-20)17-28-15-3-2-4-16-28/h5-14,27H,2-4,15-17H2,1H3,(H,24,25,26)
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n/an/a 11n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311005
PNG
(CHEMBL1078688 | N-(4-(2-(3-((4-hydroxypiperidin-1-...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(CN3CCC(O)CC3)c2)n1
Show InChI InChI=1S/C23H27N5O3S/c1-32(30,31)27-19-7-5-18(6-8-19)22-9-12-24-23(26-22)25-20-4-2-3-17(15-20)16-28-13-10-21(29)11-14-28/h2-9,12,15,21,27,29H,10-11,13-14,16H2,1H3,(H,24,25,26)
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n/an/a 12n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311008
PNG
(CHEMBL1078866 | N-(4-(2-(3-((4-methylpiperazin-1-y...)
Show SMILES CN1CCN(Cc2cccc(Nc3nccc(n3)-c3ccc(NS(C)(=O)=O)cc3)c2)CC1
Show InChI InChI=1S/C23H28N6O2S/c1-28-12-14-29(15-13-28)17-18-4-3-5-21(16-18)25-23-24-11-10-22(26-23)19-6-8-20(9-7-19)27-32(2,30)31/h3-11,16,27H,12-15,17H2,1-2H3,(H,24,25,26)
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n/an/a 14n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27626
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccnc(C)c2)c1
Show InChI InChI=1S/C19H18ClN5O/c1-12-8-15(6-7-22-12)19(26)24-16-5-3-4-14(9-16)13(2)23-18-11-21-10-17(20)25-18/h3-11,13H,1-2H3,(H,23,25)(H,24,26)/t13-/m0/s1
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n/an/a 15n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311007
PNG
(CHEMBL1078767 | N-(4-(2-(4-((4-hydroxypiperidin-1-...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCC(O)CC3)cc2)n1
Show InChI InChI=1S/C23H27N5O3S/c1-32(30,31)27-20-8-4-18(5-9-20)22-10-13-24-23(26-22)25-19-6-2-17(3-7-19)16-28-14-11-21(29)12-15-28/h2-10,13,21,27,29H,11-12,14-16H2,1H3,(H,24,25,26)
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n/an/a 16n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311000
PNG
(4-(4-amino-3-methoxyphenyl)-N-(4-morpholinophenyl)...)
Show SMILES COc1cc(ccc1N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H23N5O2/c1-27-20-14-15(2-7-18(20)22)19-8-9-23-21(25-19)24-16-3-5-17(6-4-16)26-10-12-28-13-11-26/h2-9,14H,10-13,22H2,1H3,(H,23,24,25)
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n/an/a 16n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311017
PNG
(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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n/an/a 18n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311009
PNG
(CHEMBL1078971 | N-(4-(2-(4-((4-methylpiperazin-1-y...)
Show SMILES CN1CCN(Cc2ccc(Nc3nccc(n3)-c3ccc(NS(C)(=O)=O)cc3)cc2)CC1
Show InChI InChI=1S/C23H28N6O2S/c1-28-13-15-29(16-14-28)17-18-3-7-20(8-4-18)25-23-24-12-11-22(26-23)19-5-9-21(10-6-19)27-32(2,30)31/h3-12,27H,13-17H2,1-2H3,(H,24,25,26)
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n/an/a 18n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27619
PNG
(N-[3-(1-{[6-(4-hydroxy-3-methoxyphenyl)pyrazin-2-y...)
Show SMILES COc1cc(ccc1O)-c1cncc(NC(C)c2cccc(NC(=O)c3cccnc3)c2)n1
Show InChI InChI=1S/C25H23N5O3/c1-16(17-5-3-7-20(11-17)29-25(32)19-6-4-10-26-13-19)28-24-15-27-14-21(30-24)18-8-9-22(31)23(12-18)33-2/h3-16,31H,1-2H3,(H,28,30)(H,29,32)
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n/an/a 22n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311019
PNG
(CHEMBL1078364 | N-(cyanomethyl)-2-methoxy-4-(2-(4-...)
Show SMILES COc1cc(ccc1C(=O)NCC#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H24N6O3/c1-32-22-16-17(2-7-20(22)23(31)26-11-9-25)21-8-10-27-24(29-21)28-18-3-5-19(6-4-18)30-12-14-33-15-13-30/h2-8,10,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 30n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50310999
PNG
(4-(1H-indol-5-yl)-N-(4-morpholinophenyl)pyrimidin-...)
Show SMILES C1CN(CCO1)c1ccc(Nc2nccc(n2)-c2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C22H21N5O/c1-6-20-17(7-9-23-20)15-16(1)21-8-10-24-22(26-21)25-18-2-4-19(5-3-18)27-11-13-28-14-12-27/h1-10,15,23H,11-14H2,(H,24,25,26)
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n/an/a 33n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50193995
PNG
(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27625
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccc(C)nc2)c1
Show InChI InChI=1S/C19H18ClN5O/c1-12-6-7-15(9-22-12)19(26)24-16-5-3-4-14(8-16)13(2)23-18-11-21-10-17(20)25-18/h3-11,13H,1-2H3,(H,23,25)(H,24,26)/t13-/m0/s1
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n/an/a 40n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM27629
PNG
(N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...)
Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C19H17ClN4O/c1-13(22-18-12-21-11-17(20)24-18)15-8-5-9-16(10-15)23-19(25)14-6-3-2-4-7-14/h2-13H,1H3,(H,22,24)(H,23,25)/t13-/m0/s1
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n/an/a 40n/an/an/an/a7.537



Cytopia Research Pty Ltd



Assay Description
Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...


Bioorg Med Chem Lett 19: 1206-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.073
BindingDB Entry DOI: 10.7270/Q2PZ5742
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311032
PNG
(CHEMBL1078934 | N-(cyanomethyl)-4-(2-(4-(4-methylp...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)cc1
Show InChI InChI=1S/C24H25N7O/c1-30-14-16-31(17-15-30)21-8-6-20(7-9-21)28-24-27-12-10-22(29-24)18-2-4-19(5-3-18)23(32)26-13-11-25/h2-10,12H,13-17H2,1H3,(H,26,32)(H,27,28,29)
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n/an/a 41n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311031
PNG
(CHEMBL1078933 | N-(cyanomethyl)-4-(2-(4-((4-ethylp...)
Show SMILES CCN1CCN(Cc2ccc(Nc3nccc(n3)-c3ccc(cc3)C(=O)NCC#N)cc2)CC1
Show InChI InChI=1S/C26H29N7O/c1-2-32-15-17-33(18-16-32)19-20-3-9-23(10-4-20)30-26-29-13-11-24(31-26)21-5-7-22(8-6-21)25(34)28-14-12-27/h3-11,13H,2,14-19H2,1H3,(H,28,34)(H,29,30,31)
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n/an/a 47n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311030
PNG
(CHEMBL1077842 | N-Cyanomethyl-4-{2-[4-(1,1-dioxo-1...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(CN3CCS(=O)(=O)CC3)cc2)n1
Show InChI InChI=1S/C24H24N6O3S/c25-10-12-26-23(31)20-5-3-19(4-6-20)22-9-11-27-24(29-22)28-21-7-1-18(2-8-21)17-30-13-15-34(32,33)16-14-30/h1-9,11H,12-17H2,(H,26,31)(H,27,28,29)
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PubMed
n/an/a 52n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311001
PNG
(2-methoxy-4-(2-(4-morpholinophenylamino)pyrimidin-...)
Show SMILES COc1cc(ccc1O)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H22N4O3/c1-27-20-14-15(2-7-19(20)26)18-8-9-22-21(24-18)23-16-3-5-17(6-4-16)25-10-12-28-13-11-25/h2-9,14,26H,10-13H2,1H3,(H,22,23,24)
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PubMed
n/an/a 62n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311018
PNG
(CHEMBL1078363 | N-(cyanomethyl)-2-methyl-4-(2-(4-m...)
Show SMILES Cc1cc(ccc1C(=O)NCC#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H24N6O2/c1-17-16-18(2-7-21(17)23(31)26-11-9-25)22-8-10-27-24(29-22)28-19-3-5-20(6-4-19)30-12-14-32-15-13-30/h2-8,10,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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PubMed
n/an/a 65n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311016
PNG
(2-cyano-N-(4-(2-(4-morpholinophenylamino)pyrimidin...)
Show SMILES O=C(CC#N)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-11-9-22(30)26-18-3-1-17(2-4-18)21-10-12-25-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-8,10,12H,9,13-16H2,(H,26,30)(H,25,27,28)
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n/an/a 66n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50310998
PNG
(CHEMBL1077458 | N-(4-(2-(4-morpholinophenylamino)p...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C22H23N5O2/c1-16(28)24-18-4-2-17(3-5-18)21-10-11-23-22(26-21)25-19-6-8-20(9-7-19)27-12-14-29-15-13-27/h2-11H,12-15H2,1H3,(H,24,28)(H,23,25,26)
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n/an/a 67n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311029
PNG
(CHEMBL1077841 | N-(cyanomethyl)-4-(2-(4-thiomorpho...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCSCC2)n1
Show InChI InChI=1S/C23H22N6OS/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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n/an/a 69n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50310997
PNG
(4-(4-((2-methyl-1H-imidazol-1-yl)methyl)phenyl)-N-...)
Show SMILES Cc1nccn1Cc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C25H26N6O/c1-19-26-12-13-31(19)18-20-2-4-21(5-3-20)24-10-11-27-25(29-24)28-22-6-8-23(9-7-22)30-14-16-32-17-15-30/h2-13H,14-18H2,1H3,(H,27,28,29)
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n/an/a 81n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50310996
PNG
(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benze...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C20H21N5O3S/c21-29(26,27)18-7-1-15(2-8-18)19-9-10-22-20(24-19)23-16-3-5-17(6-4-16)25-11-13-28-14-12-25/h1-10H,11-14H2,(H2,21,26,27)(H,22,23,24)
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n/an/a 83n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311022
PNG
(CHEMBL1078005 | N-(cyanomethyl)-4-(5-methyl-2-(4-m...)
Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1ccc(cc1)C(=O)NCC#N
Show InChI InChI=1S/C24H24N6O2/c1-17-16-27-24(28-20-6-8-21(9-7-20)30-12-14-32-15-13-30)29-22(17)18-2-4-19(5-3-18)23(31)26-11-10-25/h2-9,16H,11-15H2,1H3,(H,26,31)(H,27,28,29)
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n/an/a 85n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50310995
PNG
(2,6-dimethyl-4-(2-(4-morpholinophenylamino)pyrimid...)
Show SMILES Cc1cc(cc(C)c1O)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C22H24N4O2/c1-15-13-17(14-16(2)21(15)27)20-7-8-23-22(25-20)24-18-3-5-19(6-4-18)26-9-11-28-12-10-26/h3-8,13-14,27H,9-12H2,1-2H3,(H,23,24,25)
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n/an/a 88n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50311002
PNG
(CHEMBL1078275 | N-(4-(2-(3-(pyrrolidin-1-ylmethyl)...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(CN3CCCC3)c2)n1
Show InChI InChI=1S/C22H25N5O2S/c1-30(28,29)26-19-9-7-18(8-10-19)21-11-12-23-22(25-21)24-20-6-4-5-17(15-20)16-27-13-2-3-14-27/h4-12,15,26H,2-3,13-14,16H2,1H3,(H,23,24,25)
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n/an/a 110n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK3 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311028
PNG
(CHEMBL1078229 | N-(cyanomethyl)-4-(2-(3-morpholino...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2cccc(c2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-9-11-25-22(30)18-6-4-17(5-7-18)21-8-10-26-23(28-21)27-19-2-1-3-20(16-19)29-12-14-31-15-13-29/h1-8,10,16H,11-15H2,(H,25,30)(H,26,27,28)
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n/an/a 113n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50311027
PNG
(CHEMBL1078228 | N-(cyanomethyl)-4-(2-(3-fluoro-4-m...)
Show SMILES Fc1cc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)ccc1N1CCOCC1
Show InChI InChI=1S/C23H21FN6O2/c24-19-15-18(5-6-21(19)30-11-13-32-14-12-30)28-23-27-9-7-20(29-23)16-1-3-17(4-2-16)22(31)26-10-8-25/h1-7,9,15H,10-14H2,(H,26,31)(H,27,28,29)
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PubMed
n/an/a 116n/an/an/an/an/an/a



Cytopia Research Pty Ltd

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 kinase


Bioorg Med Chem Lett 19: 5887-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.071
BindingDB Entry DOI: 10.7270/Q2C24WKM
More data for this
Ligand-Target Pair
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