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Compile Data Set for Download or QSAR

Found 129 hits from DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222632
PNG
(US9315491, MTR-0391)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1)N1CCOCC1
Show InChI InChI=1S/C31H31N7O4S/c1-43-28-27(21-10-12-32-13-11-21)35-29(36-30(28)37-14-17-41-18-15-37)22-2-4-23(5-3-22)33-31(40)34-24-6-8-25(9-7-24)38-16-19-42-20-26(38)39/h2-13H,14-20H2,1H3,(H2,33,34,40)
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n/an/a 5.40n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222657
PNG
(US9315491, MTR-0457)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1)N1CCOCC1
Show InChI InChI=1S/C31H31N7O4S/c1-43-28-27(22-3-2-12-32-19-22)35-29(36-30(28)37-13-16-41-17-14-37)21-4-6-23(7-5-21)33-31(40)34-24-8-10-25(11-9-24)38-15-18-42-20-26(38)39/h2-12,19H,13-18,20H2,1H3,(H2,33,34,40)
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n/an/a 5.80n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222591
PNG
(US9315491, MTR-0262)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCSCC2)cc1
Show InChI InChI=1S/C26H30N6O3S/c1-34-23-18-27-24(30-25(23)32-10-14-35-15-11-32)19-2-4-20(5-3-19)28-26(33)29-21-6-8-22(9-7-21)31-12-16-36-17-13-31/h2-9,18H,10-17H2,1H3,(H2,28,29,33)
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n/an/a 8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222580
PNG
(US9315491, MTR-0241)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C26H28N6O5/c1-35-22-16-27-24(30-25(22)31-10-13-36-14-11-31)18-2-4-19(5-3-18)28-26(34)29-20-6-8-21(9-7-20)32-12-15-37-17-23(32)33/h2-9,16H,10-15,17H2,1H3,(H2,28,29,34)
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n/an/a 8.10n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222569
PNG
(US9315491, MTR-0222)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C30H34N6O7/c1-3-42-26-25(29(38)43-4-2)33-27(34-28(26)35-13-16-40-17-14-35)20-5-7-21(8-6-20)31-30(39)32-22-9-11-23(12-10-22)36-15-18-41-19-24(36)37/h5-12H,3-4,13-19H2,1-2H3,(H2,31,32,39)
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n/an/a 11.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222582
PNG
(US9315491, MTR-0244)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C27H30N6O6/c1-3-38-22-21(26(35)39-4-2)31-24(32-25(22)33-13-15-37-16-14-33)18-7-11-20(12-8-18)30-27(36)29-19-9-5-17(6-10-19)23(28)34/h5-12H,3-4,13-16H2,1-2H3,(H2,28,34)(H2,29,30,36)
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n/an/a 18n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222572
PNG
(US9315491, MTR-0227)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C26H28N6O4S/c1-37-22-16-27-24(30-25(22)31-10-13-35-14-11-31)18-2-4-19(5-3-18)28-26(34)29-20-6-8-21(9-7-20)32-12-15-36-17-23(32)33/h2-9,16H,10-15,17H2,1H3,(H2,28,29,34)
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n/an/a 18.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222633
PNG
(US9315491, MTR-0392)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1)N1CCOCC1
Show InChI InChI=1S/C28H27N7O3S/c1-39-24-23(18-10-12-30-13-11-18)33-26(34-27(24)35-14-16-38-17-15-35)20-4-8-22(9-5-20)32-28(37)31-21-6-2-19(3-7-21)25(29)36/h2-13H,14-17H2,1H3,(H2,29,36)(H2,31,32,37)
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n/an/a 19.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222667
PNG
(US9315491, MTR-0477)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c(SC)c(n1)-c1ccncc1
Show InChI InChI=1S/C23H26N6O2S/c1-3-25-23(30)26-18-6-4-17(5-7-18)21-27-19(16-8-10-24-11-9-16)20(32-2)22(28-21)29-12-14-31-15-13-29/h4-11H,3,12-15H2,1-2H3,(H2,25,26,30)
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n/an/a 23.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222612
PNG
(US9315491, MTR-0325)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C27H30N6O5/c1-2-38-23-17-28-25(31-26(23)32-11-14-36-15-12-32)19-3-5-20(6-4-19)29-27(35)30-21-7-9-22(10-8-21)33-13-16-37-18-24(33)34/h3-10,17H,2,11-16,18H2,1H3,(H2,29,30,35)
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n/an/a 24.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222668
PNG
(US9315491, MTR-0478)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c(SC)c(n1)-c1ccncc1
Show InChI InChI=1S/C22H24N6O2S/c1-23-22(29)25-17-5-3-16(4-6-17)20-26-18(15-7-9-24-10-8-15)19(31-2)21(27-20)28-11-13-30-14-12-28/h3-10H,11-14H2,1-2H3,(H2,23,25,29)
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n/an/a 25.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222618
PNG
(US9315491, MTR-0358)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C22H23ClN6O4S2/c1-34-18-19(23)27-20(28-21(18)29-10-12-33-13-11-29)14-2-4-15(5-3-14)25-22(30)26-16-6-8-17(9-7-16)35(24,31)32/h2-9H,10-13H2,1H3,(H2,24,31,32)(H2,25,26,30)
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n/an/a 26.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222643
PNG
(US9315491, MTR-0424)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C24H27N5O5S/c1-3-34-21-16-25-22(28-23(21)29-12-14-33-15-13-29)17-4-6-18(7-5-17)26-24(30)27-19-8-10-20(11-9-19)35(2,31)32/h4-11,16H,3,12-15H2,1-2H3,(H2,26,27,30)
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n/an/a 30.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222653
PNG
(US9315491, MTR-0453)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(=O)Nc2ccncc2)cc1)N1CCOCC1
Show InChI InChI=1S/C26H25N7O2S/c1-36-23-22(18-6-10-27-11-7-18)31-24(32-25(23)33-14-16-35-17-15-33)19-2-4-20(5-3-19)29-26(34)30-21-8-12-28-13-9-21/h2-13H,14-17H2,1H3,(H2,28,29,30,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222602
PNG
(US9315491, MTR-0283)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C22H24N6O5S/c1-32-19-14-24-20(27-21(19)28-10-12-33-13-11-28)15-2-4-16(5-3-15)25-22(29)26-17-6-8-18(9-7-17)34(23,30)31/h2-9,14H,10-13H2,1H3,(H2,23,30,31)(H2,25,26,29)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222648
PNG
(US9315491, MTR-0442)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)nc2)cc1
Show InChI InChI=1S/C24H27N7O4/c1-3-35-20-15-26-22(30-23(20)31-10-12-34-13-11-31)17-4-6-18(7-5-17)28-24(33)29-19-8-9-21(25-14-19)27-16(2)32/h4-9,14-15H,3,10-13H2,1-2H3,(H,25,27,32)(H2,28,29,33)
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n/an/a 39n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222613
PNG
(US9315491, MTR-0326)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C23H26N6O5S/c1-2-34-20-15-25-21(28-22(20)29-11-13-33-14-12-29)16-3-5-17(6-4-16)26-23(30)27-18-7-9-19(10-8-18)35(24,31)32/h3-10,15H,2,11-14H2,1H3,(H2,24,31,32)(H2,26,27,30)
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n/an/a 40.9n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222655
PNG
(US9315491, MTR-0455)
Show SMILES O=C(Nc1ccc(cc1)N1CCOCC1=O)Nc1ccc(cc1)-c1ncc(OCCN2CCOCC2)c(n1)N1CCOCC1
Show InChI InChI=1S/C31H37N7O6/c39-28-22-43-19-14-38(28)26-7-5-25(6-8-26)34-31(40)33-24-3-1-23(2-4-24)29-32-21-27(30(35-29)37-12-17-42-18-13-37)44-20-11-36-9-15-41-16-10-36/h1-8,21H,9-20,22H2,(H2,33,34,40)
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US Patent
n/an/a 42.3n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222601
PNG
(US9315491, MTR-0282)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C23H24N6O4/c1-32-19-14-25-21(28-22(19)29-10-12-33-13-11-29)16-4-8-18(9-5-16)27-23(31)26-17-6-2-15(3-7-17)20(24)30/h2-9,14H,10-13H2,1H3,(H2,24,30)(H2,26,27,31)
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US Patent
n/an/a 47.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222660
PNG
(US9315491, MTR-0463)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H29N7O4S2/c1-40-25-24(20-4-3-13-29-18-20)32-26(33-27(25)35-14-16-39-17-15-35)19-5-7-21(8-6-19)30-28(36)31-22-9-11-23(12-10-22)34-41(2,37)38/h3-13,18,34H,14-17H2,1-2H3,(H2,30,31,36)
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n/an/a 47.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222606
PNG
(US9315491, MTR-0308)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C27H29ClN6O4S/c1-39-22-23(28)31-24(32-25(22)33-10-14-37-15-11-33)18-2-6-20(7-3-18)29-27(36)30-21-8-4-19(5-9-21)26(35)34-12-16-38-17-13-34/h2-9H,10-17H2,1H3,(H2,29,30,36)
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n/an/a 48.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222637
PNG
(US9315491, MTR-0405)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)c(F)c1
Show InChI InChI=1S/C26H27FN6O5/c1-36-22-15-28-24(31-25(22)32-8-11-37-12-9-32)17-2-7-21(20(27)14-17)30-26(35)29-18-3-5-19(6-4-18)33-10-13-38-16-23(33)34/h2-7,14-15H,8-13,16H2,1H3,(H2,29,30,35)
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n/an/a 49.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222611
PNG
(US9315491, MTR-0323)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C24H26N6O4/c1-2-34-20-15-26-22(29-23(20)30-11-13-33-14-12-30)17-5-9-19(10-6-17)28-24(32)27-18-7-3-16(4-8-18)21(25)31/h3-10,15H,2,11-14H2,1H3,(H2,25,31)(H2,27,28,32)
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n/an/a 50.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222647
PNG
(US9315491, MTR-0438)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C27H26N6O2S/c1-36-24-23(20-6-5-13-28-18-20)31-25(32-26(24)33-14-16-35-17-15-33)19-9-11-22(12-10-19)30-27(34)29-21-7-3-2-4-8-21/h2-13,18H,14-17H2,1H3,(H2,29,30,34)
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n/an/a 51.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222565
PNG
(US9315491, MTR-0215)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C27H32ClN7O2S/c1-33-11-13-34(14-12-33)22-9-7-21(8-10-22)30-27(36)29-20-5-3-19(4-6-20)25-31-24(28)23(38-2)26(32-25)35-15-17-37-18-16-35/h3-10H,11-18H2,1-2H3,(H2,29,30,36)
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n/an/a 52.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222650
PNG
(US9315491, MTR-0446)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C22H24N6O3/c1-2-31-19-15-24-20(27-21(19)28-11-13-30-14-12-28)16-3-5-17(6-4-16)25-22(29)26-18-7-9-23-10-8-18/h3-10,15H,2,11-14H2,1H3,(H2,23,25,26,29)
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n/an/a 56.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222670
PNG
(US9315491, MTR-0484)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccon2)cc1
Show InChI InChI=1S/C19H19ClN6O3S/c1-30-15-16(20)23-17(24-18(15)26-7-10-28-11-8-26)12-2-4-13(5-3-12)21-19(27)22-14-6-9-29-25-14/h2-6,9H,7-8,10-11H2,1H3,(H2,21,22,25,27)
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n/an/a 58.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222642
PNG
(US9315491, MTR-0421)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C28H32N6O5/c1-2-39-24-19-29-25(32-26(24)33-11-15-37-16-12-33)20-3-7-22(8-4-20)30-28(36)31-23-9-5-21(6-10-23)27(35)34-13-17-38-18-14-34/h3-10,19H,2,11-18H2,1H3,(H2,30,31,36)
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n/an/a 58.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222588
PNG
(US9315491, MTR-0253)
Show SMILES CCOc1c(nc(nc1C(=O)N1CCOCC1)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C27H31N7O5/c1-2-39-23-22(26(35)34-12-16-38-17-13-34)31-24(32-25(23)33-10-14-37-15-11-33)19-5-7-20(8-6-19)29-27(36)30-21-4-3-9-28-18-21/h3-9,18H,2,10-17H2,1H3,(H2,29,30,36)
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n/an/a 62.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222635
PNG
(US9315491, MTR-0401)
Show SMILES CS(=O)c1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C26H28N6O5S/c1-38(35)22-16-27-24(30-25(22)31-10-13-36-14-11-31)18-2-4-19(5-3-18)28-26(34)29-20-6-8-21(9-7-20)32-12-15-37-17-23(32)33/h2-9,16H,10-15,17H2,1H3,(H2,28,29,34)
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n/an/a 64.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222641
PNG
(US9315491, MTR-0420)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(CC2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C28H35N7O5S/c1-3-40-25-20-29-26(32-27(25)34-16-18-39-19-17-34)21-4-6-22(7-5-21)30-28(36)31-23-8-10-24(11-9-23)33-12-14-35(15-13-33)41(2,37)38/h4-11,20H,3,12-19H2,1-2H3,(H2,30,31,36)
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n/an/a 65.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222616
PNG
(US9315491, MTR-0351)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C23H23N5O5/c1-32-19-14-24-20(27-21(19)28-10-12-33-13-11-28)15-2-6-17(7-3-15)25-23(31)26-18-8-4-16(5-9-18)22(29)30/h2-9,14H,10-13H2,1H3,(H,29,30)(H2,25,26,31)
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n/an/a 65.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222600
PNG
(US9315491, MTR-0278)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C31H36N6O7/c1-3-43-26-25(30(39)44-4-2)34-27(35-28(26)36-13-17-41-18-14-36)21-5-9-23(10-6-21)32-31(40)33-24-11-7-22(8-12-24)29(38)37-15-19-42-20-16-37/h5-12H,3-4,13-20H2,1-2H3,(H2,32,33,40)
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n/an/a 67n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222628
PNG
(US9315491, MTR-0382)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C27H30N6O5/c1-36-23-18-28-24(31-25(23)32-10-14-37-15-11-32)19-2-6-21(7-3-19)29-27(35)30-22-8-4-20(5-9-22)26(34)33-12-16-38-17-13-33/h2-9,18H,10-17H2,1H3,(H2,29,30,35)
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n/an/a 67.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222646
PNG
(US9315491, MTR-0436)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCC(CC2)N(C)C)cc1
Show InChI InChI=1S/C30H36ClN7O3S/c1-36(2)24-12-14-38(15-13-24)29(39)21-6-10-23(11-7-21)33-30(40)32-22-8-4-20(5-9-22)27-34-26(31)25(42-3)28(35-27)37-16-18-41-19-17-37/h4-11,24H,12-19H2,1-3H3,(H2,32,33,40)
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n/an/a 69.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222634
PNG
(US9315491, MTR-0394)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C24H28N6O5S/c1-3-35-21-16-25-22(28-23(21)30-12-14-34-15-13-30)17-4-6-18(7-5-17)26-24(31)27-19-8-10-20(11-9-19)29-36(2,32)33/h4-11,16,29H,3,12-15H2,1-2H3,(H2,26,27,31)
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n/an/a 70.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222619
PNG
(US9315491, MTR-0364)
Show SMILES CCOc1c(nc(nc1C(=O)N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1)N1CCOCC1
Show InChI InChI=1S/C29H33N7O6/c1-2-42-24-23(28(38)36-13-17-41-18-14-36)33-26(34-27(24)35-11-15-40-16-12-35)20-5-9-22(10-6-20)32-29(39)31-21-7-3-19(4-8-21)25(30)37/h3-10H,2,11-18H2,1H3,(H2,30,37)(H2,31,32,39)
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US Patent
n/an/a 70.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222567
PNG
(US9315491, MTR-0220)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2nccs2)cc1
Show InChI InChI=1S/C23H26N6O5S/c1-3-33-18-17(21(30)34-4-2)26-19(27-20(18)29-10-12-32-13-11-29)15-5-7-16(8-6-15)25-22(31)28-23-24-9-14-35-23/h5-9,14H,3-4,10-13H2,1-2H3,(H2,24,25,28,31)
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n/an/a 72.2n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222589
PNG
(US9315491, MTR-0257)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C23H23ClN6O3S/c1-34-18-19(24)28-21(29-22(18)30-10-12-33-13-11-30)15-4-8-17(9-5-15)27-23(32)26-16-6-2-14(3-7-16)20(25)31/h2-9H,10-13H2,1H3,(H2,25,31)(H2,26,27,32)
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n/an/a 74.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222661
PNG
(US9315491, MTR-0464)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C26H25N7O2S/c1-36-23-22(19-4-2-10-27-16-19)31-24(32-25(23)33-12-14-35-15-13-33)18-6-8-20(9-7-18)29-26(34)30-21-5-3-11-28-17-21/h2-11,16-17H,12-15H2,1H3,(H2,29,30,34)
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n/an/a 75.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222649
PNG
(US9315491, MTR-0443)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)nc2)cc1
Show InChI InChI=1S/C27H31N7O6/c1-4-39-23-22(26(36)40-5-2)32-24(33-25(23)34-12-14-38-15-13-34)18-6-8-19(9-7-18)30-27(37)31-20-10-11-21(28-16-20)29-17(3)35/h6-11,16H,4-5,12-15H2,1-3H3,(H,28,29,35)(H2,30,31,37)
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n/an/a 76.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222599
PNG
(US9315491, MTR-0277)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NCCN(C)C)cc1
Show InChI InChI=1S/C31H39N7O6/c1-5-43-26-25(30(40)44-6-2)35-27(36-28(26)38-17-19-42-20-18-38)21-7-11-23(12-8-21)33-31(41)34-24-13-9-22(10-14-24)29(39)32-15-16-37(3)4/h7-14H,5-6,15-20H2,1-4H3,(H,32,39)(H2,33,34,41)
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US Patent
n/an/a 78.3n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222603
PNG
(US9315491, MTR-0288)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C22H24N6O4S2/c1-33-19-14-24-20(27-21(19)28-10-12-32-13-11-28)15-2-4-16(5-3-15)25-22(29)26-17-6-8-18(9-7-17)34(23,30)31/h2-9,14H,10-13H2,1H3,(H2,23,30,31)(H2,25,26,29)
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n/an/a 78.9n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222651
PNG
(US9315491, MTR-0449)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C23H26N6O5S/c1-33-20-15-24-21(27-22(20)29-11-13-34-14-12-29)16-3-5-17(6-4-16)25-23(30)26-18-7-9-19(10-8-18)28-35(2,31)32/h3-10,15,28H,11-14H2,1-2H3,(H2,25,26,30)
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n/an/a 79.2n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222631
PNG
(US9315491, MTR-0388)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(N)=O)cc1)N1CCOCC1
Show InChI InChI=1S/C21H22N6O2S/c1-30-18-17(14-6-8-23-9-7-14)25-19(26-20(18)27-10-12-29-13-11-27)15-2-4-16(5-3-15)24-21(22)28/h2-9H,10-13H2,1H3,(H3,22,24,28)
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n/an/a 79.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222577
PNG
(US9315491, MTR-0233)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2)cc1
Show InChI InChI=1S/C30H36N6O6/c1-3-41-26-25(29(37)42-4-2)33-27(34-28(26)36-15-19-40-20-16-36)21-5-7-22(8-6-21)31-30(38)32-23-9-11-24(12-10-23)35-13-17-39-18-14-35/h5-12H,3-4,13-20H2,1-2H3,(H2,31,32,38)
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n/an/a 80.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222578
PNG
(US9315491, MTR-0236)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(nc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C26H31ClN8O2S/c1-33-9-11-34(12-10-33)21-8-7-20(17-28-21)30-26(36)29-19-5-3-18(4-6-19)24-31-23(27)22(38-2)25(32-24)35-13-15-37-16-14-35/h3-8,17H,9-16H2,1-2H3,(H2,29,30,36)
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n/an/a 80.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222597
PNG
(US9315491, MTR-0273)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C26H30N6O7S/c1-3-38-22-21(25(33)39-4-2)30-23(31-24(22)32-13-15-37-16-14-32)17-5-7-18(8-6-17)28-26(34)29-19-9-11-20(12-10-19)40(27,35)36/h5-12H,3-4,13-16H2,1-2H3,(H2,27,35,36)(H2,28,29,34)
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n/an/a 81.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222573
PNG
(US9315491, MTR-0228)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C21H22N6O3/c1-29-18-14-23-19(26-20(18)27-9-11-30-12-10-27)15-4-6-16(7-5-15)24-21(28)25-17-3-2-8-22-13-17/h2-8,13-14H,9-12H2,1H3,(H2,24,25,28)
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n/an/a 82.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222621
PNG
(US9315491, MTR-0368)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)cc2)cc1
Show InChI InChI=1S/C25H28N6O4/c1-3-35-22-16-26-23(30-24(22)31-12-14-34-15-13-31)18-4-6-20(7-5-18)28-25(33)29-21-10-8-19(9-11-21)27-17(2)32/h4-11,16H,3,12-15H2,1-2H3,(H,27,32)(H2,28,29,33)
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n/an/a 83.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


US Patent US9315491 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZH4
More data for this
Ligand-Target Pair
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