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Compile Data Set for Download or QSAR

Found 64 hits from Daiichi Asubio Pharma Co., Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (human))
BDBM50210107
PNG
(7-chloro-3-(4-chlorophenylsulfonyl)quinazoline-2,4...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)n1c(=O)[nH]c2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C14H8Cl2N2O4S/c15-8-1-4-10(5-2-8)23(21,22)18-13(19)11-6-3-9(16)7-12(11)17-14(18)20/h1-7H,(H,17,20)
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n/an/a 18n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210098
PNG
(6-(4,5-dichloro-2-methoxybenzyl)-4-(4-chlorophenyl...)
Show SMILES COc1cc(Cl)c(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17Cl3N2O5S/c1-29-17-8-16(22)15(21)7-11(17)6-12-9-23-18(25)10-24(19(12)26)30(27,28)14-4-2-13(20)3-5-14/h2-5,7-8,12H,6,9-10H2,1H3,(H,23,25)
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n/an/a 23n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210116
PNG
(6-(5-fluoro-2-methoxybenzyl)-4-(4-chlorophenylsulf...)
Show SMILES COc1ccc(F)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClFN2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)
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n/an/a 26n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210120
PNG
((S)-6-(5-chloro-2-methoxybenzyl)-4-(4-chlorophenyl...)
Show SMILES COc1ccc(Cl)cc1C[C@H]1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)/t13-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210094
PNG
(3-((1-(4-chlorophenylsulfonyl)-3,7-dioxo-1,4-diaze...)
Show SMILES COc1ccc(cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1)C#N
Show InChI InChI=1S/C20H18ClN3O5S/c1-29-18-7-2-13(10-22)8-14(18)9-15-11-23-19(25)12-24(20(15)26)30(27,28)17-5-3-16(21)4-6-17/h2-8,15H,9,11-12H2,1H3,(H,23,25)
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n/an/a 27n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM100740
PNG
(CHEMBL391608 | US8507714, 29)
Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)
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n/an/a 34n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210743
PNG
(6-(4-chloro-2-methoxybenzyl)-4-(4-chlorophenylsulf...)
Show SMILES COc1cc(Cl)ccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-9-15(21)3-2-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-6-4-14(20)5-7-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)
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n/an/a 34n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210099
PNG
(CHEMBL246964 | rac-2q)
Show SMILES OC(=O)COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N2O7S/c21-14-1-4-16(5-2-14)32(29,30)24-10-18(25)23-9-13(20(24)28)7-12-8-15(22)3-6-17(12)31-11-19(26)27/h1-6,8,13H,7,9-11H2,(H,23,25)(H,26,27)
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n/an/a 39n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210096
PNG
(2-(4-chloro-2-((1-(4-chlorophenylsulfonyl)-3,7-dio...)
Show SMILES CNC(=O)COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21Cl2N3O6S/c1-24-20(28)12-32-18-7-4-16(23)9-13(18)8-14-10-25-19(27)11-26(21(14)29)33(30,31)17-5-2-15(22)3-6-17/h2-7,9,14H,8,10-12H2,1H3,(H,24,28)(H,25,27)
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n/an/a 42n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM87059
PNG
(CHEMBL247767 | Chymostatin)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C1CCNC(N)=N1)C(=O)N[C@@H](Cc1ccccc1)C=O
Show InChI InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210113
PNG
(6-(5-chloro-2-ethoxybenzyl)-4-(4-chlorophenylsulfo...)
Show SMILES CCOc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H20Cl2N2O5S/c1-2-29-18-8-5-16(22)10-13(18)9-14-11-23-19(25)12-24(20(14)26)30(27,28)17-6-3-15(21)4-7-17/h3-8,10,14H,2,9,11-12H2,1H3,(H,23,25)
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n/an/a 83n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210097
PNG
(6-(2-chlorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2ccccc2Cl)C1=O
Show InChI InChI=1S/C18H16Cl2N2O4S/c19-14-5-7-15(8-6-14)27(25,26)22-11-17(23)21-10-13(18(22)24)9-12-3-1-2-4-16(12)20/h1-8,13H,9-11H2,(H,21,23)
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n/an/a 110n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210115
PNG
(6-(2-methoxybenzyl)-4-(4-chlorophenylsulfonyl)-1,4...)
Show SMILES COc1ccccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClN2O5S/c1-27-17-5-3-2-4-13(17)10-14-11-21-18(23)12-22(19(14)24)28(25,26)16-8-6-15(20)7-9-16/h2-9,14H,10-12H2,1H3,(H,21,23)
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n/an/a 140n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210121
PNG
(6-(2-fluorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)
Show SMILES Fc1ccccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H16ClFN2O4S/c19-14-5-7-15(8-6-14)27(25,26)22-11-17(23)21-10-13(18(22)24)9-12-3-1-2-4-16(12)20/h1-8,13H,9-11H2,(H,21,23)
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n/an/a 150n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM100748
PNG
(CHEMBL246560 | US8507714, 277)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)/t15-,19+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210109
PNG
(6-(2-ethoxybenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)
Show SMILES CCOc1ccccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClN2O5S/c1-2-28-18-6-4-3-5-14(18)11-15-12-22-19(24)13-23(20(15)25)29(26,27)17-9-7-16(21)8-10-17/h3-10,15H,2,11-13H2,1H3,(H,22,24)
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n/an/a 180n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210110
PNG
(6-(5-chloro-2-propoxybenzyl)-4-(4-chlorophenylsulf...)
Show SMILES CCCOc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22Cl2N2O5S/c1-2-9-30-19-8-5-17(23)11-14(19)10-15-12-24-20(26)13-25(21(15)27)31(28,29)18-6-3-16(22)4-7-18/h3-8,11,15H,2,9-10,12-13H2,1H3,(H,24,26)
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n/an/a 220n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210729
PNG
(3-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O6/c1-3-19(14-5-4-6-15(9-14)23(31)32)27-24(33)28-13-21(29)26-12-17(22(28)30)10-16-11-18(25)7-8-20(16)34-2/h4-9,11,17,19H,3,10,12-13H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)/t17-,19-/m1/s1
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n/an/a 240n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210114
PNG
(6-(2-butoxy-5-chlorobenzyl)-4-(4-chlorophenylsulfo...)
Show SMILES CCCCOc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N2O5S/c1-2-3-10-31-20-9-6-18(24)12-15(20)11-16-13-25-21(27)14-26(22(16)28)32(29,30)19-7-4-17(23)5-8-19/h4-9,12,16H,2-3,10-11,13-14H2,1H3,(H,25,27)
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n/an/a 280n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210730
PNG
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)/t15-,19-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210118
PNG
(6-(3-chlorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C18H16Cl2N2O4S/c19-14-4-6-16(7-5-14)27(25,26)22-11-17(23)21-10-13(18(22)24)8-12-2-1-3-15(20)9-12/h1-7,9,13H,8,10-11H2,(H,21,23)
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n/an/a 310n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210740
PNG
(4-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)
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n/an/a 340n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210725
PNG
(5-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(O)c(c1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O7/c1-3-18(13-4-6-19(29)17(10-13)23(32)33)27-24(34)28-12-21(30)26-11-15(22(28)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,18,29H,3,8,11-12H2,1-2H3,(H,26,30)(H,27,34)(H,32,33)
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n/an/a 410n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210117
PNG
(6-benzyl-4-(4-chlorophenylsulfonyl)-1,4-diazepane-...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2ccccc2)C1=O
Show InChI InChI=1S/C18H17ClN2O4S/c19-15-6-8-16(9-7-15)26(24,25)21-12-17(22)20-11-14(18(21)23)10-13-4-2-1-3-5-13/h1-9,14H,10-12H2,(H,20,22)
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n/an/a 420n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210733
PNG
(4-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C24H26ClN3O7/c1-3-18(13-4-6-17(23(32)33)19(29)10-13)27-24(34)28-12-21(30)26-11-15(22(28)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,18,29H,3,8,11-12H2,1-2H3,(H,26,30)(H,27,34)(H,32,33)
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n/an/a 460n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210106
PNG
(6-(4-chlorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)
Show SMILES Clc1ccc(CC2CNC(=O)CN(C2=O)S(=O)(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H16Cl2N2O4S/c19-14-3-1-12(2-4-14)9-13-10-21-17(23)11-22(18(13)24)27(25,26)16-7-5-15(20)6-8-16/h1-8,13H,9-11H2,(H,21,23)
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n/an/a 460n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210741
PNG
(4-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O6/c1-3-19(14-4-6-15(7-5-14)23(31)32)27-24(33)28-13-21(29)26-12-17(22(28)30)10-16-11-18(25)8-9-20(16)34-2/h4-9,11,17,19H,3,10,12-13H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)
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n/an/a 470n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210740
PNG
(4-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)
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n/an/a 500n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210724
PNG
(3-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O6/c1-3-19(14-5-4-6-15(9-14)23(31)32)27-24(33)28-13-21(29)26-12-17(22(28)30)10-16-11-18(25)7-8-20(16)34-2/h4-9,11,17,19H,3,10,12-13H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)
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n/an/a 540n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210735
PNG
(5-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(N)c(c1)C(O)=O
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-18(26)17(10-13)23(32)33)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)
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n/an/a 630n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210108
PNG
(6-(5-hydroxy-2-methoxybenzyl)-4-(4-chlorophenylsul...)
Show SMILES COc1ccc(O)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClN2O6S/c1-28-17-7-4-15(23)9-12(17)8-13-10-21-18(24)11-22(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13,23H,8,10-11H2,1H3,(H,21,24)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210105
PNG
((E)-6-benzylidene-4-(4-chlorophenylsulfonyl)-1,4-d...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NC\C(=C/c2ccccc2)C1=O
Show InChI InChI=1S/C18H15ClN2O4S/c19-15-6-8-16(9-7-15)26(24,25)21-12-17(22)20-11-14(18(21)23)10-13-4-2-1-3-5-13/h1-10H,11-12H2,(H,20,22)/b14-10+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210733
PNG
(4-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C24H26ClN3O7/c1-3-18(13-4-6-17(23(32)33)19(29)10-13)27-24(34)28-12-21(30)26-11-15(22(28)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,18,29H,3,8,11-12H2,1-2H3,(H,26,30)(H,27,34)(H,32,33)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210727
PNG
(CHEMBL396302 | methyl 4-(1-(6-(5-chloro-2-methoxyb...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(cc1)C(=O)OC
Show InChI InChI=1S/C25H28ClN3O6/c1-4-20(15-5-7-16(8-6-15)24(32)35-3)28-25(33)29-14-22(30)27-13-18(23(29)31)11-17-12-19(26)9-10-21(17)34-2/h5-10,12,18,20H,4,11,13-14H2,1-3H3,(H,27,30)(H,28,33)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210737
PNG
(CHEMBL248181 | methyl 3-(1-(6-(5-chloro-2-methoxyb...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1cccc(c1)C(=O)OC
Show InChI InChI=1S/C25H28ClN3O6/c1-4-20(15-6-5-7-16(10-15)24(32)35-3)28-25(33)29-14-22(30)27-13-18(23(29)31)11-17-12-19(26)8-9-21(17)34-2/h5-10,12,18,20H,4,11,13-14H2,1-3H3,(H,27,30)(H,28,33)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210728
PNG
(6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenyl...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O4/c1-3-19(15-7-5-4-6-8-15)26-23(30)27-14-21(28)25-13-17(22(27)29)11-16-12-18(24)9-10-20(16)31-2/h4-10,12,17,19H,3,11,13-14H2,1-2H3,(H,25,28)(H,26,30)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM100740
PNG
(CHEMBL391608 | US8507714, 29)
Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil cathepsin G


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210736
PNG
(6-(5-chloro-2-methoxybenzyl)-N-(2-methyl-1-phenylp...)
Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C(=O)NC(C(C)C)c2ccccc2)C1=O
Show InChI InChI=1S/C24H28ClN3O4/c1-15(2)22(16-7-5-4-6-8-16)27-24(31)28-14-21(29)26-13-18(23(28)30)11-17-12-19(25)9-10-20(17)32-3/h4-10,12,15,18,22H,11,13-14H2,1-3H3,(H,26,29)(H,27,31)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210725
PNG
(5-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(O)c(c1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O7/c1-3-18(13-4-6-19(29)17(10-13)23(32)33)27-24(34)28-12-21(30)26-11-15(22(28)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,18,29H,3,8,11-12H2,1-2H3,(H,26,30)(H,27,34)(H,32,33)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210101
PNG
(6-(3-chloro-5-fluoro-2-methoxybenzyl)-4-(4-chlorop...)
Show SMILES COc1c(Cl)cc(F)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17Cl2FN2O5S/c1-29-18-11(7-14(22)8-16(18)21)6-12-9-23-17(25)10-24(19(12)26)30(27,28)15-4-2-13(20)3-5-15/h2-5,7-8,12H,6,9-10H2,1H3,(H,23,25)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210724
PNG
(3-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O6/c1-3-19(14-5-4-6-15(9-14)23(31)32)27-24(33)28-13-21(29)26-12-17(22(28)30)10-16-11-18(25)7-8-20(16)34-2/h4-9,11,17,19H,3,10,12-13H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210742
PNG
(6-(5-chloro-2-methoxybenzyl)-N-benzyl-3,7-dioxo-1,...)
Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C(=O)NCc2ccccc2)C1=O
Show InChI InChI=1S/C21H22ClN3O4/c1-29-18-8-7-17(22)10-15(18)9-16-12-23-19(26)13-25(20(16)27)21(28)24-11-14-5-3-2-4-6-14/h2-8,10,16H,9,11-13H2,1H3,(H,23,26)(H,24,28)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210741
PNG
(4-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O6/c1-3-19(14-4-6-15(7-5-14)23(31)32)27-24(33)28-13-21(29)26-12-17(22(28)30)10-16-11-18(25)8-9-20(16)34-2/h4-9,11,17,19H,3,10,12-13H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210738
PNG
(6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenyl...)
Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C(=O)NC(C)c2ccccc2)C1=O
Show InChI InChI=1S/C22H24ClN3O4/c1-14(15-6-4-3-5-7-15)25-22(29)26-13-20(27)24-12-17(21(26)28)10-16-11-18(23)8-9-19(16)30-2/h3-9,11,14,17H,10,12-13H2,1-2H3,(H,24,27)(H,25,29)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210735
PNG
(5-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-d...)
Show SMILES CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(N)c(c1)C(O)=O
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-18(26)17(10-13)23(32)33)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)
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n/an/a 6.10E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210103
PNG
(6-(2,5-dimethoxybenzyl)-4-(4-chlorophenylsulfonyl)...)
Show SMILES COc1ccc(OC)c(CC2CNC(=O)CN(C2=O)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H21ClN2O6S/c1-28-16-5-8-18(29-2)13(10-16)9-14-11-22-19(24)12-23(20(14)25)30(26,27)17-6-3-15(21)4-7-17/h3-8,10,14H,9,11-12H2,1-2H3,(H,22,24)
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n/an/a 7.40E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens)
BDBM50210729
PNG
(3-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C24H26ClN3O6/c1-3-19(14-5-4-6-15(9-14)23(31)32)27-24(33)28-13-21(29)26-12-17(22(28)30)10-16-11-18(25)7-8-20(16)34-2/h4-9,11,17,19H,3,10,12-13H2,1-2H3,(H,26,29)(H,27,33)(H,31,32)/t17-,19-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210734
PNG
(4-((S)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@H](NC(=O)N1CC(=O)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)/t15-,19+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210739
PNG
(4-((S)-1-((S)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Show SMILES CC[C@H](NC(=O)N1CC(=O)NC[C@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C24H27ClN4O6/c1-3-19(13-4-6-17(23(32)33)18(26)10-13)28-24(34)29-12-21(30)27-11-15(22(29)31)8-14-9-16(25)5-7-20(14)35-2/h4-7,9-10,15,19H,3,8,11-12,26H2,1-2H3,(H,27,30)(H,28,34)(H,32,33)/t15-,19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3435-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.085
BindingDB Entry DOI: 10.7270/Q2MK6CKH
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (human))
BDBM50210095
PNG
(4-(4-chlorophenylsulfonyl)-6-(pyridin-4-ylmethyl)-...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2ccncc2)C1=O
Show InChI InChI=1S/C17H16ClN3O4S/c18-14-1-3-15(4-2-14)26(24,25)21-11-16(22)20-10-13(17(21)23)9-12-5-7-19-8-6-12/h1-8,13H,9-11H2,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daiichi Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant chymase


Bioorg Med Chem Lett 17: 3431-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9
More data for this
Ligand-Target Pair
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