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Compile Data Set for Download or QSAR

Found 585 hits from Daiichi Sankyo Company, Limited   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252902
PNG
(US9464076, 54)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C23H21N3O3S/c1-12-20-14(11-29-3)8-9-15(13(2)27)22(20)30-21(12)23(28)26-19-10-17(24)16-6-4-5-7-18(16)25-19/h4-10H,11H2,1-3H3,(H3,24,25,26,28)
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n/an/a 0.0540n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252906
PNG
(US9464076, 58)
Show SMILES COCc1ccc(C(=O)C(C)(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C31H35N3O4S/c1-18-26-19(17-38-5)10-11-23(29(36)31(2,3)4)28(26)39-27(18)30(37)33-25-14-20(15-34-13-12-21(35)16-34)22-8-6-7-9-24(22)32-25/h6-11,14,21,35H,12-13,15-17H2,1-5H3,(H,32,33,37)/t21-/m1/s1
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n/an/a 0.0850n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252941
PNG
(US9464076, 93)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(O)=O)c(C)c12
Show InChI InChI=1S/C24H20N2O5S/c1-12-20-14(11-31-3)7-8-15(13(2)27)22(20)32-21(12)23(28)26-19-10-9-16-17(24(29)30)5-4-6-18(16)25-19/h4-10H,11H2,1-3H3,(H,29,30)(H,25,26,28)
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n/an/a 0.110n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252947
PNG
(US9464076, 99)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(F)C3)c(C)c12
Show InChI InChI=1S/C27H24FN3O4S/c1-14-23-16(13-35-3)7-8-18(15(2)32)25(23)36-24(14)26(33)30-22-10-9-19-20(5-4-6-21(19)29-22)27(34)31-11-17(28)12-31/h4-10,17H,11-13H2,1-3H3,(H,29,30,33)
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n/an/a 0.110n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252949
PNG
(US9464076, 101)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(O)C3)c(C)c12
Show InChI InChI=1S/C27H25N3O5S/c1-14-23-16(13-35-3)7-8-18(15(2)31)25(23)36-24(14)26(33)29-22-10-9-19-20(5-4-6-21(19)28-22)27(34)30-11-17(32)12-30/h4-10,17,32H,11-13H2,1-3H3,(H,28,29,33)
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n/an/a 0.110n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252961
PNG
(US9464076, 113)
Show SMILES COCc1cccc2nc(NC(=O)c3sc4c(ccc(CO)c4c3C)C(C)=O)ccc12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-15(11-27)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-16(12-30-3)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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n/an/a 0.120n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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n/an/a 0.150n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252946
PNG
(US9464076, 98)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCC3)c(C)c12
Show InChI InChI=1S/C27H25N3O4S/c1-15-23-17(14-34-3)8-9-18(16(2)31)25(23)35-24(15)26(32)29-22-11-10-19-20(6-4-7-21(19)28-22)27(33)30-12-5-13-30/h4,6-11H,5,12-14H2,1-3H3,(H,28,29,32)
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n/an/a 0.210n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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n/an/a 0.220n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252886
PNG
(US9464076, 38)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m0/s1
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n/an/a 0.230n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252957
PNG
(US9464076, 109 | US9464076, 110 | US9464076, 111 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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n/an/a 0.230n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252945
PNG
(US9464076, 97)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N(C)C)c(C)c12
Show InChI InChI=1S/C26H25N3O4S/c1-14-22-16(13-33-5)9-10-17(15(2)30)24(22)34-23(14)25(31)28-21-12-11-18-19(26(32)29(3)4)7-6-8-20(18)27-21/h6-12H,13H2,1-5H3,(H,27,28,31)
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n/an/a 0.260n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252883
PNG
(US9464076, 35)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)
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n/an/a 0.290n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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n/an/a 0.290n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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n/an/a 0.300n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM142001
PNG
(US8927536, 26)
Show SMILES CC1(CO)Cc2nnc(n2CCS1)C1(CC1)c1ccc(c(F)c1)-c1cccnc1
Show InChI InChI=1S/C22H23FN4OS/c1-21(14-28)12-19-25-26-20(27(19)9-10-29-21)22(6-7-22)16-4-5-17(18(23)11-16)15-3-2-8-24-13-15/h2-5,8,11,13,28H,6-7,9-10,12,14H2,1H3
PDB
MMDB

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n/an/a 0.300n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A reaction was performed on a 384-well plate (Greiner Bio One) using a reaction volume of 24 ÁL, and all the samples were diluted with an assay buffe...


US Patent US8927536 (2015)


BindingDB Entry DOI: 10.7270/Q2Q23XZP
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252944
PNG
(US9464076, 96)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C29H30N4O4S/c1-17-25-19(16-37-4)8-9-20(18(2)34)27(25)38-26(17)28(35)31-24-11-10-21-22(6-5-7-23(21)30-24)29(36)33-14-12-32(3)13-15-33/h5-11H,12-16H2,1-4H3,(H,30,31,35)
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n/an/a 0.310n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252907
PNG
(US9464076, 59)
Show SMILES COCc1ccc(C(=O)C(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C30H33N3O4S/c1-17(2)27(35)23-10-9-19(16-37-4)26-18(3)28(38-29(23)26)30(36)32-25-13-20(14-33-12-11-21(34)15-33)22-7-5-6-8-24(22)31-25/h5-10,13,17,21,34H,11-12,14-16H2,1-4H3,(H,31,32,36)/t21-/m1/s1
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n/an/a 0.310n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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n/an/a 0.310n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252884
PNG
(US9464076, 36)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)CC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C29H31N3O4S/c1-17-26-19(16-36-3)8-9-22(18(2)33)28(26)37-27(17)29(35)31-25-14-20(15-32-12-10-21(34)11-13-32)23-6-4-5-7-24(23)30-25/h4-9,14,21,34H,10-13,15-16H2,1-3H3,(H,30,31,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252937
PNG
(US9464076, 89)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)CCC(O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H26N2O7S/c1-15-25-18(13-36-3)7-8-19(16(2)31)27(25)38-26(15)28(35)30-22-10-9-20-17(5-4-6-21(20)29-22)14-37-24(34)12-11-23(32)33/h4-10H,11-14H2,1-3H3,(H,32,33)(H,29,30,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252913
PNG
(US9464076, 65)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC(O)C5)cccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O4S/c1-15-24-18(14-34-3)7-8-20(16(2)31)26(24)35-25(15)27(33)29-23-10-9-21-17(5-4-6-22(21)28-23)11-30-12-19(32)13-30/h4-10,19,32H,11-14H2,1-3H3,(H,28,29,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252886
PNG
(US9464076, 38)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m0/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252948
PNG
(US9464076, 100)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(F)(F)C3)c(C)c12
Show InChI InChI=1S/C27H23F2N3O4S/c1-14-22-16(11-36-3)7-8-17(15(2)33)24(22)37-23(14)25(34)31-21-10-9-18-19(5-4-6-20(18)30-21)26(35)32-12-27(28,29)13-32/h4-10H,11-13H2,1-3H3,(H,30,31,34)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252894
PNG
(US9464076, 46)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(F)CC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C29H30FN3O3S/c1-17-26-19(16-36-3)8-9-22(18(2)34)28(26)37-27(17)29(35)32-25-14-20(15-33-12-10-21(30)11-13-33)23-6-4-5-7-24(23)31-25/h4-9,14,21H,10-13,15-16H2,1-3H3,(H,31,32,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252903
PNG
(US9464076, 55)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N(C)C)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C25H25N3O3S/c1-14-22-16(13-31-5)10-11-17(15(2)29)24(22)32-23(14)25(30)27-21-12-20(28(3)4)18-8-6-7-9-19(18)26-21/h6-12H,13H2,1-5H3,(H,26,27,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252866
PNG
(US9464076, 18)
Show SMILES CC(C)C(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H26N2O3S/c1-14(2)22(29)18-11-8-10-16-15(3)23(32-24(16)18)25(30)28-21-13-19(26(4,5)31)17-9-6-7-12-20(17)27-21/h6-14,31H,1-5H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252943
PNG
(US9464076, 95)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCOCC3)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-16-24-18(15-35-3)7-8-19(17(2)32)26(24)37-25(16)27(33)30-23-10-9-20-21(5-4-6-22(20)29-23)28(34)31-11-13-36-14-12-31/h4-10H,11-15H2,1-3H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252895
PNG
(US9464076, 47)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC(O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O4S/c1-15-24-17(14-34-3)8-9-20(16(2)31)26(24)35-25(15)27(33)29-23-10-18(11-30-12-19(32)13-30)21-6-4-5-7-22(21)28-23/h4-10,19,32H,11-14H2,1-3H3,(H,28,29,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252893
PNG
(US9464076, 45)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](F)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H28FN3O3S/c1-16-25-18(15-35-3)8-9-21(17(2)33)27(25)36-26(16)28(34)31-24-12-19(13-32-11-10-20(29)14-32)22-6-4-5-7-23(22)30-24/h4-9,12,20H,10-11,13-15H2,1-3H3,(H,30,31,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252885
PNG
(US9464076, 37)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCCC(O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C29H31N3O4S/c1-17-26-19(16-36-3)10-11-22(18(2)33)28(26)37-27(17)29(35)31-25-13-20(14-32-12-6-7-21(34)15-32)23-8-4-5-9-24(23)30-25/h4-5,8-11,13,21,34H,6-7,12,14-16H2,1-3H3,(H,30,31,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252924
PNG
(US9464076, 76)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(C)O)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-13-22-16(12-31-4)8-9-18(15(3)29)24(22)32-23(13)25(30)27-21-11-10-19-17(14(2)28)6-5-7-20(19)26-21/h5-11,14,28H,12H2,1-4H3,(H,26,27,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252920
PNG
(US9464076, 72)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COCCO)cccc4n3)c(C)c12
Show InChI InChI=1S/C26H26N2O5S/c1-15-23-18(13-32-3)7-8-19(16(2)30)25(23)34-24(15)26(31)28-22-10-9-20-17(14-33-12-11-29)5-4-6-21(20)27-22/h4-10,29H,11-14H2,1-3H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
PDB

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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252935
PNG
(US9464076, 87)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COP(O)(O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H23N2O7PS/c1-13-21-16(11-32-3)7-8-17(14(2)27)23(21)35-22(13)24(28)26-20-10-9-18-15(12-33-34(29,30)31)5-4-6-19(18)25-20/h4-10H,11-12H2,1-3H3,(H,25,26,28)(H2,29,30,31)
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n/an/a 0.600n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252957
PNG
(US9464076, 109 | US9464076, 110 | US9464076, 111 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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n/an/a 0.610n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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n/an/a 0.610n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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n/an/a 0.640n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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n/an/a 0.650n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252869
PNG
(US9464076, 21)
Show SMILES Cc1c(sc2c(cccc12)C(=O)C1CCC1)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C27H26N2O3S/c1-15-17-11-7-12-19(23(30)16-8-6-9-16)25(17)33-24(15)26(31)29-22-14-20(27(2,3)32)18-10-4-5-13-21(18)28-22/h4-5,7,10-14,16,32H,6,8-9H2,1-3H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252939
PNG
(US9464076, 91)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@@H](N)CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O6S/c1-14-23-17(12-35-3)7-8-18(15(2)32)25(23)37-24(14)26(33)30-22-10-9-19-16(5-4-6-21(19)29-22)13-36-27(34)20(28)11-31/h4-10,20,31H,11-13,28H2,1-3H3,(H,29,30,33)/t20-/m0/s1
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n/an/a 0.740n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252919
PNG
(US9464076, 71)
Show SMILES COCCOCc1cccc2nc(NC(=O)c3sc4c(ccc(COC)c4c3C)C(C)=O)ccc12
Show InChI InChI=1S/C27H28N2O5S/c1-16-24-19(14-33-4)8-9-20(17(2)30)26(24)35-25(16)27(31)29-23-11-10-21-18(15-34-13-12-32-3)6-5-7-22(21)28-23/h5-11H,12-15H2,1-4H3,(H,28,29,31)
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n/an/a 0.75n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252912
PNG
(US9464076, 64)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC[C@@H](O)C5)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-19(15-35-3)7-8-21(17(2)32)27(25)36-26(16)28(34)30-24-10-9-22-18(5-4-6-23(22)29-24)13-31-12-11-20(33)14-31/h4-10,20,33H,11-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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n/an/a 0.760n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


US Patent US9464076 (2016)


BindingDB Entry DOI: 10.7270/Q2JS9PC4
More data for this
Ligand-Target Pair
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