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Compile Data Set for Download or QSAR

Found 23 hits from Dainippon Sumitomo Pharma Co Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298278
PNG
(CHEMBL574392 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ncccc1OCCCO
Show InChI InChI=1S/C34H47N5O4/c1-23(2)28-20-26(35)21-29(24(3)4)31(28)38-33(41)37-22-34(25-9-6-10-27(19-25)42-5)12-15-39(16-13-34)32-30(11-7-14-36-32)43-18-8-17-40/h6-7,9-11,14,19-21,23-24,40H,8,12-13,15-18,22,35H2,1-5H3,(H2,37,38,41)
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n/an/a 4n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298281
PNG
(CHEMBL1091036 | N-(4-Amino-2,6-diisopropylphenyl)-...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OCCCO
Show InChI InChI=1S/C35H48N4O4/c1-24(2)29-21-27(36)22-30(25(3)4)33(29)38-34(41)37-23-35(26-10-8-11-28(20-26)42-5)14-16-39(17-15-35)31-12-6-7-13-32(31)43-19-9-18-40/h6-8,10-13,20-22,24-25,40H,9,14-19,23,36H2,1-5H3,(H2,37,38,41)
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n/an/a 18n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50175765
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Show SMILES CCCCn1c2ncccc2c(-c2cccc(OCCCO)c2)c(NC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)c1=O
Show InChI InChI=1S/C34H43N5O4/c1-6-7-15-39-32-26(13-9-14-36-32)29(23-11-8-12-25(18-23)43-17-10-16-40)31(33(39)41)38-34(42)37-30-27(21(2)3)19-24(35)20-28(30)22(4)5/h8-9,11-14,18-22,40H,6-7,10,15-17,35H2,1-5H3,(H2,37,38,42)
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n/an/a 31n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276562
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-butoxyp...)
Show SMILES CCCCOc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C36H50N4O3/c1-7-8-20-43-33-15-10-9-14-32(33)40-18-16-36(17-19-40,27-12-11-13-29(21-27)42-6)24-38-35(41)39-34-30(25(2)3)22-28(37)23-31(34)26(4)5/h9-15,21-23,25-26H,7-8,16-20,24,37H2,1-6H3,(H2,38,39,41)
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n/an/a 32n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276483
PNG
(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(CC1)c1ccccc1
Show InChI InChI=1S/C32H41N3O2/c1-23(2)28-15-10-16-29(24(3)4)30(28)34-31(36)33-22-32(25-11-9-14-27(21-25)37-5)17-19-35(20-18-32)26-12-7-6-8-13-26/h6-16,21,23-24H,17-20,22H2,1-5H3,(H2,33,34,36)
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n/an/a 35n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276487
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-10-9-11-26(18-24)39-5)14-16-37(17-15-33)29-12-7-8-13-30(29)40-6/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 37n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298286
PNG
(CHEMBL574471 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC(C)C
Show InChI InChI=1S/C35H48N4O3/c1-23(2)29-20-27(36)21-30(24(3)4)33(29)38-34(40)37-22-35(26-11-10-12-28(19-26)41-7)15-17-39(18-16-35)31-13-8-9-14-32(31)42-25(5)6/h8-14,19-21,23-25H,15-18,22,36H2,1-7H3,(H2,37,38,40)
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n/an/a 37n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276485
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1
Show InChI InChI=1S/C32H42N4O2/c1-22(2)28-19-25(33)20-29(23(3)4)30(28)35-31(37)34-21-32(24-10-9-13-27(18-24)38-5)14-16-36(17-15-32)26-11-7-6-8-12-26/h6-13,18-20,22-23H,14-17,21,33H2,1-5H3,(H2,34,35,37)
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n/an/a 40n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276488
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(3-me...)
Show SMILES COc1cccc(c1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-18-25(34)19-30(23(3)4)31(29)36-32(38)35-21-33(24-9-7-11-27(17-24)39-5)13-15-37(16-14-33)26-10-8-12-28(20-26)40-6/h7-12,17-20,22-23H,13-16,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 48n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276565
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C34H43F3N4O3/c1-22(2)27-18-25(38)19-28(23(3)4)31(27)40-32(42)39-20-33(24-9-8-10-26(17-24)43-5)13-15-41(16-14-33)29-11-6-7-12-30(29)44-21-34(35,36)37/h6-12,17-19,22-23H,13-16,20-21,38H2,1-5H3,(H2,39,40,42)
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n/an/a 48n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298279
PNG
(CHEMBL574388 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OCCCO)c1
Show InChI InChI=1S/C35H48N4O4/c1-24(2)29-21-27(36)22-30(25(3)4)33(29)38-34(41)37-23-35(26-10-8-11-28(20-26)43-19-9-18-40)14-16-39(17-15-35)31-12-6-7-13-32(31)42-5/h6-8,10-13,20-22,24-25,40H,9,14-19,23,36H2,1-5H3,(H2,37,38,41)
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n/an/a 62n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276564
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C33H41F3N4O3/c1-21(2)26-18-24(37)19-27(22(3)4)30(26)39-31(41)38-20-32(23-9-8-10-25(17-23)42-5)13-15-40(16-14-32)28-11-6-7-12-29(28)43-33(34,35)36/h6-12,17-19,21-22H,13-16,20,37H2,1-5H3,(H2,38,39,41)
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n/an/a 68n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276491
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1ccccc1
Show InChI InChI=1S/C32H42N4O2/c1-22(2)26-19-25(33)20-27(23(3)4)30(26)35-31(37)34-21-32(24-11-7-6-8-12-24)15-17-36(18-16-32)28-13-9-10-14-29(28)38-5/h6-14,19-20,22-23H,15-18,21,33H2,1-5H3,(H2,34,35,37)
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n/an/a 82n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298282
PNG
(CHEMBL573802 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OCCO
Show InChI InChI=1S/C34H46N4O4/c1-23(2)28-20-26(35)21-29(24(3)4)32(28)37-33(40)36-22-34(25-9-8-10-27(19-25)41-5)13-15-38(16-14-34)30-11-6-7-12-31(30)42-18-17-39/h6-12,19-21,23-24,39H,13-18,22,35H2,1-5H3,(H2,36,37,40)
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n/an/a 96n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276489
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1ccc(cc1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-19-25(34)20-30(23(3)4)31(29)36-32(38)35-21-33(24-8-7-9-28(18-24)40-6)14-16-37(17-15-33)26-10-12-27(39-5)13-11-26/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 142n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298284
PNG
(CHEMBL574472 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OCCCN
Show InChI InChI=1S/C35H49N5O3/c1-24(2)29-21-27(37)22-30(25(3)4)33(29)39-34(41)38-23-35(26-10-8-11-28(20-26)42-5)14-17-40(18-15-35)31-12-6-7-13-32(31)43-19-9-16-36/h6-8,10-13,20-22,24-25H,9,14-19,23,36-37H2,1-5H3,(H2,38,39,41)
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n/an/a 195n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298283
PNG
(CHEMBL574453 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OCCCN(C)C
Show InChI InChI=1S/C37H53N5O3/c1-26(2)31-23-29(38)24-32(27(3)4)35(31)40-36(43)39-25-37(28-12-10-13-30(22-28)44-7)16-19-42(20-17-37)33-14-8-9-15-34(33)45-21-11-18-41(5)6/h8-10,12-15,22-24,26-27H,11,16-21,25,38H2,1-7H3,(H2,39,40,43)
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n/an/a 239n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50069900
PNG
(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Show SMILES CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(cccc2C(C)C)C(C)C)c(c1)C(C)C
Show InChI InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)
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n/an/a 479n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298280
PNG
(CHEMBL574266 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(O)c1
Show InChI InChI=1S/C32H42N4O3/c1-21(2)26-18-24(33)19-27(22(3)4)30(26)35-31(38)34-20-32(23-9-8-10-25(37)17-23)13-15-36(16-14-32)28-11-6-7-12-29(28)39-5/h6-12,17-19,21-22,37H,13-16,20,33H2,1-5H3,(H2,34,35,38)
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n/an/a 797n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298296
PNG
(CHEMBL574194 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ncccc1OC
Show InChI InChI=1S/C32H43N5O3/c1-21(2)26-18-24(33)19-27(22(3)4)29(26)36-31(38)35-20-32(23-9-7-10-25(17-23)39-5)12-15-37(16-13-32)30-28(40-6)11-8-14-34-30/h7-11,14,17-19,21-22H,12-13,15-16,20,33H2,1-6H3,(H2,35,36,38)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298295
PNG
(CHEMBL573093 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccn1
Show InChI InChI=1S/C31H41N5O2/c1-21(2)26-18-24(32)19-27(22(3)4)29(26)35-30(37)34-20-31(23-9-8-10-25(17-23)38-5)12-15-36(16-13-31)28-11-6-7-14-33-28/h6-11,14,17-19,21-22H,12-13,15-16,20,32H2,1-5H3,(H2,34,35,37)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298298
PNG
(CHEMBL577185 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1cccnc1
Show InChI InChI=1S/C31H41N5O2/c1-21(2)27-17-24(32)18-28(22(3)4)29(27)35-30(37)34-20-31(23-8-6-10-26(16-23)38-5)11-14-36(15-12-31)25-9-7-13-33-19-25/h6-10,13,16-19,21-22H,11-12,14-15,20,32H2,1-5H3,(H2,34,35,37)
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n/an/a 4.66E+5n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50298297
PNG
(CHEMBL578441 | N-(4-Amino-2,6-diisopropylphenyl)-N...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccncc1
Show InChI InChI=1S/C31H41N5O2/c1-21(2)27-18-24(32)19-28(22(3)4)29(27)35-30(37)34-20-31(23-7-6-8-26(17-23)38-5)11-15-36(16-12-31)25-9-13-33-14-10-25/h6-10,13-14,17-19,21-22H,11-12,15-16,20,32H2,1-5H3,(H2,34,35,37)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair