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Compile Data Set for Download or QSAR

Found 105 hits from DePaul University   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Caspase-4


(Homo sapiens (human))
BDBM50200547
PNG
(CHEMBL3949842)
Show SMILES C(Cc1ccccc1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C24H34N6/c1-2-8-21(9-3-1)10-15-27-16-18-29(19-17-27)23-20-22(28-11-4-5-12-28)25-24(26-23)30-13-6-7-14-30/h1-3,8-9,20H,4-7,10-19H2
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8n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200547
PNG
(CHEMBL3949842)
Show SMILES C(Cc1ccccc1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C24H34N6/c1-2-8-21(9-3-1)10-15-27-16-18-29(19-17-27)23-20-22(28-11-4-5-12-28)25-24(26-23)30-13-6-7-14-30/h1-3,8-9,20H,4-7,10-19H2
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16n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200547
PNG
(CHEMBL3949842)
Show SMILES C(Cc1ccccc1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C24H34N6/c1-2-8-21(9-3-1)10-15-27-16-18-29(19-17-27)23-20-22(28-11-4-5-12-28)25-24(26-23)30-13-6-7-14-30/h1-3,8-9,20H,4-7,10-19H2
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16n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200556
PNG
(CHEMBL3904435)
Show SMILES [O-][N+](=O)c1ccccc1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H31N7O2/c31-30(32)20-8-2-1-7-19(20)18-26-13-15-28(16-14-26)22-17-21(27-9-3-4-10-27)24-23(25-22)29-11-5-6-12-29/h1-2,7-8,17H,3-6,9-16,18H2
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24n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200551
PNG
(CHEMBL3978901)
Show SMILES C(C1CCCCC1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H38N6/c1-2-8-20(9-3-1)19-26-14-16-28(17-15-26)22-18-21(27-10-4-5-11-27)24-23(25-22)29-12-6-7-13-29/h18,20H,1-17,19H2
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27n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200544
PNG
(CHEMBL3970645)
Show SMILES O=C(c1ccccc1)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C30H36N6O/c37-29(25-8-2-1-3-9-25)26-12-10-24(11-13-26)23-33-18-20-35(21-19-33)28-22-27(34-14-4-5-15-34)31-30(32-28)36-16-6-7-17-36/h1-3,8-13,22H,4-7,14-21,23H2
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28n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200545
PNG
(CHEMBL3965572)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1ccncc1
Show InChI InChI=1S/C22H31N7/c1-2-10-27(9-1)20-17-21(25-22(24-20)29-11-3-4-12-29)28-15-13-26(14-16-28)18-19-5-7-23-8-6-19/h5-8,17H,1-4,9-16,18H2
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34n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200543
PNG
(CHEMBL3941088)
Show SMILES COc1cc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc(OC)c1
Show InChI InChI=1S/C25H36N6O2/c1-32-21-15-20(16-22(17-21)33-2)19-28-11-13-30(14-12-28)24-18-23(29-7-3-4-8-29)26-25(27-24)31-9-5-6-10-31/h15-18H,3-14,19H2,1-2H3
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34n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200549
PNG
(CHEMBL3932441)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C23H32N6/c1-2-8-20(9-3-1)19-26-14-16-28(17-15-26)22-18-21(27-10-4-5-11-27)24-23(25-22)29-12-6-7-13-29/h1-3,8-9,18H,4-7,10-17,19H2
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41n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200550
PNG
(CHEMBL3905486)
Show SMILES C1CCN(C1)c1cc(nc(n1)N1CCCC1)N1CCNCC1
Show InChI InChI=1S/C16H26N6/c1-2-8-20(7-1)14-13-15(21-11-5-17-6-12-21)19-16(18-14)22-9-3-4-10-22/h13,17H,1-12H2
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47n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200553
PNG
(CHEMBL3898379)
Show SMILES CC1Oc2c(C)c(C)c(O)c(C)c2CC1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C30H44N6O2/c1-20-21(2)29-25(22(3)28(20)37)17-24(23(4)38-29)19-33-13-15-35(16-14-33)27-18-26(34-9-5-6-10-34)31-30(32-27)36-11-7-8-12-36/h18,23-24,37H,5-17,19H2,1-4H3
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48n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200552
PNG
(CHEMBL3898411)
Show SMILES FC(F)(F)c1cc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H30F6N6/c26-24(27,28)19-13-18(14-20(15-19)25(29,30)31)17-34-9-11-36(12-10-34)22-16-21(35-5-1-2-6-35)32-23(33-22)37-7-3-4-8-37/h13-16H,1-12,17H2
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48n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200543
PNG
(CHEMBL3941088)
Show SMILES COc1cc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc(OC)c1
Show InChI InChI=1S/C25H36N6O2/c1-32-21-15-20(16-22(17-21)33-2)19-28-11-13-30(14-12-28)24-18-23(29-7-3-4-8-29)26-25(27-24)31-9-5-6-10-31/h15-18H,3-14,19H2,1-2H3
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49n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM166683
PNG
(U74389G (B9))
Show SMILES C[C@]12CC=C3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C37H50N6O2/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-40)34-24-33(41-15-3-4-16-41)38-35(39-34)43-17-5-6-18-43/h11-13,23-24,28-29,31H,3-10,14-22,25H2,1-2H3/t28-,29-,31+,36-,37-/m0/s1
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50n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-1 expressed in Escherichia coli using WEHD-AMC as substrate after 30 mins by fluorescence assay


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200553
PNG
(CHEMBL3898379)
Show SMILES CC1Oc2c(C)c(C)c(O)c(C)c2CC1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C30H44N6O2/c1-20-21(2)29-25(22(3)28(20)37)17-24(23(4)38-29)19-33-13-15-35(16-14-33)27-18-26(34-9-5-6-10-34)31-30(32-27)36-11-7-8-12-36/h18,23-24,37H,5-17,19H2,1-4H3
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50n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-1 expressed in Escherichia coli using WEHD-AMC as substrate after 30 mins by fluorescence assay


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM166683
PNG
(U74389G (B9))
Show SMILES C[C@]12CC=C3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C37H50N6O2/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-40)34-24-33(41-15-3-4-16-41)38-35(39-34)43-17-5-6-18-43/h11-13,23-24,28-29,31H,3-10,14-22,25H2,1-2H3/t28-,29-,31+,36-,37-/m0/s1
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50n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200544
PNG
(CHEMBL3970645)
Show SMILES O=C(c1ccccc1)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C30H36N6O/c37-29(25-8-2-1-3-9-25)26-12-10-24(11-13-26)23-33-18-20-35(21-19-33)28-22-27(34-14-4-5-15-34)31-30(32-28)36-16-6-7-17-36/h1-3,8-13,22H,4-7,14-21,23H2
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59n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200551
PNG
(CHEMBL3978901)
Show SMILES C(C1CCCCC1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H38N6/c1-2-8-20(9-3-1)19-26-14-16-28(17-15-26)22-18-21(27-10-4-5-11-27)24-23(25-22)29-12-6-7-13-29/h18,20H,1-17,19H2
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59n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200548
PNG
(CHEMBL3895496)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1cccnc1
Show InChI InChI=1S/C22H31N7/c1-2-9-27(8-1)20-16-21(25-22(24-20)29-10-3-4-11-29)28-14-12-26(13-15-28)18-19-6-5-7-23-17-19/h5-7,16-17H,1-4,8-15,18H2
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59n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200546
PNG
(CHEMBL3939229)
Show SMILES COc1cccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)c1
Show InChI InChI=1S/C24H34N6O/c1-31-21-8-6-7-20(17-21)19-27-13-15-29(16-14-27)23-18-22(28-9-2-3-10-28)25-24(26-23)30-11-4-5-12-30/h6-8,17-18H,2-5,9-16,19H2,1H3
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75n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200553
PNG
(CHEMBL3898379)
Show SMILES CC1Oc2c(C)c(C)c(O)c(C)c2CC1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C30H44N6O2/c1-20-21(2)29-25(22(3)28(20)37)17-24(23(4)38-29)19-33-13-15-35(16-14-33)27-18-26(34-9-5-6-10-34)31-30(32-27)36-11-7-8-12-36/h18,23-24,37H,5-17,19H2,1-4H3
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81n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200555
PNG
(CHEMBL3984293)
Show SMILES [O-][N+](=O)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C23H31N7O2/c31-30(32)20-7-5-19(6-8-20)18-26-13-15-28(16-14-26)22-17-21(27-9-1-2-10-27)24-23(25-22)29-11-3-4-12-29/h5-8,17H,1-4,9-16,18H2
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99n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200546
PNG
(CHEMBL3939229)
Show SMILES COc1cccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)c1
Show InChI InChI=1S/C24H34N6O/c1-31-21-8-6-7-20(17-21)19-27-13-15-29(16-14-27)23-18-22(28-9-2-3-10-28)25-24(26-23)30-11-4-5-12-30/h6-8,17-18H,2-5,9-16,19H2,1H3
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111n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200544
PNG
(CHEMBL3970645)
Show SMILES O=C(c1ccccc1)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C30H36N6O/c37-29(25-8-2-1-3-9-25)26-12-10-24(11-13-26)23-33-18-20-35(21-19-33)28-22-27(34-14-4-5-15-34)31-30(32-28)36-16-6-7-17-36/h1-3,8-13,22H,4-7,14-21,23H2
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119n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200555
PNG
(CHEMBL3984293)
Show SMILES [O-][N+](=O)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C23H31N7O2/c31-30(32)20-7-5-19(6-8-20)18-26-13-15-28(16-14-26)22-17-21(27-9-1-2-10-27)24-23(25-22)29-11-3-4-12-29/h5-8,17H,1-4,9-16,18H2
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129n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200550
PNG
(CHEMBL3905486)
Show SMILES C1CCN(C1)c1cc(nc(n1)N1CCCC1)N1CCNCC1
Show InChI InChI=1S/C16H26N6/c1-2-8-20(7-1)14-13-15(21-11-5-17-6-12-21)19-16(18-14)22-9-3-4-10-22/h13,17H,1-12H2
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130n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200554
PNG
(CHEMBL3968765)
Show SMILES FC(F)(F)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C24H31F3N6/c25-24(26,27)20-7-5-19(6-8-20)18-30-13-15-32(16-14-30)22-17-21(31-9-1-2-10-31)28-23(29-22)33-11-3-4-12-33/h5-8,17H,1-4,9-16,18H2
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135n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200543
PNG
(CHEMBL3941088)
Show SMILES COc1cc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc(OC)c1
Show InChI InChI=1S/C25H36N6O2/c1-32-21-15-20(16-22(17-21)33-2)19-28-11-13-30(14-12-28)24-18-23(29-7-3-4-8-29)26-25(27-24)31-9-5-6-10-31/h15-18H,3-14,19H2,1-2H3
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148n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200554
PNG
(CHEMBL3968765)
Show SMILES FC(F)(F)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C24H31F3N6/c25-24(26,27)20-7-5-19(6-8-20)18-30-13-15-32(16-14-30)22-17-21(31-9-1-2-10-31)28-23(29-22)33-11-3-4-12-33/h5-8,17H,1-4,9-16,18H2
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183n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200549
PNG
(CHEMBL3932441)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C23H32N6/c1-2-8-20(9-3-1)19-26-14-16-28(17-15-26)22-18-21(27-10-4-5-11-27)24-23(25-22)29-12-6-7-13-29/h1-3,8-9,18H,4-7,10-17,19H2
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200n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200552
PNG
(CHEMBL3898411)
Show SMILES FC(F)(F)c1cc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H30F6N6/c26-24(27,28)19-13-18(14-20(15-19)25(29,30)31)17-34-9-11-36(12-10-34)22-16-21(35-5-1-2-6-35)32-23(33-22)37-7-3-4-8-37/h13-16H,1-12,17H2
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202n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200550
PNG
(CHEMBL3905486)
Show SMILES C1CCN(C1)c1cc(nc(n1)N1CCCC1)N1CCNCC1
Show InChI InChI=1S/C16H26N6/c1-2-8-20(7-1)14-13-15(21-11-5-17-6-12-21)19-16(18-14)22-9-3-4-10-22/h13,17H,1-12H2
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207n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM166683
PNG
(U74389G (B9))
Show SMILES C[C@]12CC=C3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C37H50N6O2/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-40)34-24-33(41-15-3-4-16-41)38-35(39-34)43-17-5-6-18-43/h11-13,23-24,28-29,31H,3-10,14-22,25H2,1-2H3/t28-,29-,31+,36-,37-/m0/s1
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210n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200555
PNG
(CHEMBL3984293)
Show SMILES [O-][N+](=O)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C23H31N7O2/c31-30(32)20-7-5-19(6-8-20)18-26-13-15-28(16-14-26)22-17-21(27-9-1-2-10-27)24-23(25-22)29-11-3-4-12-29/h5-8,17H,1-4,9-16,18H2
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215n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200556
PNG
(CHEMBL3904435)
Show SMILES [O-][N+](=O)c1ccccc1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H31N7O2/c31-30(32)20-8-2-1-7-19(20)18-26-13-15-28(16-14-26)22-17-21(27-9-3-4-10-27)24-23(25-22)29-11-5-6-12-29/h1-2,7-8,17H,3-6,9-16,18H2
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227n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200553
PNG
(CHEMBL3898379)
Show SMILES CC1Oc2c(C)c(C)c(O)c(C)c2CC1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C30H44N6O2/c1-20-21(2)29-25(22(3)28(20)37)17-24(23(4)38-29)19-33-13-15-35(16-14-33)27-18-26(34-9-5-6-10-34)31-30(32-27)36-11-7-8-12-36/h18,23-24,37H,5-17,19H2,1-4H3
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248n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200556
PNG
(CHEMBL3904435)
Show SMILES [O-][N+](=O)c1ccccc1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H31N7O2/c31-30(32)20-8-2-1-7-19(20)18-26-13-15-28(16-14-26)22-17-21(27-9-3-4-10-27)24-23(25-22)29-11-5-6-12-29/h1-2,7-8,17H,3-6,9-16,18H2
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267n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200546
PNG
(CHEMBL3939229)
Show SMILES COc1cccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)c1
Show InChI InChI=1S/C24H34N6O/c1-31-21-8-6-7-20(17-21)19-27-13-15-29(16-14-27)23-18-22(28-9-2-3-10-28)25-24(26-23)30-11-4-5-12-30/h6-8,17-18H,2-5,9-16,19H2,1H3
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276n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200545
PNG
(CHEMBL3965572)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1ccncc1
Show InChI InChI=1S/C22H31N7/c1-2-10-27(9-1)20-17-21(25-22(24-20)29-11-3-4-12-29)28-15-13-26(14-16-28)18-19-5-7-23-8-6-19/h5-8,17H,1-4,9-16,18H2
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303n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200551
PNG
(CHEMBL3978901)
Show SMILES C(C1CCCCC1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H38N6/c1-2-8-20(9-3-1)19-26-14-16-28(17-15-26)22-18-21(27-10-4-5-11-27)24-23(25-22)29-12-6-7-13-29/h18,20H,1-17,19H2
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306n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM166683
PNG
(U74389G (B9))
Show SMILES C[C@]12CC=C3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C37H50N6O2/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-40)34-24-33(41-15-3-4-16-41)38-35(39-34)43-17-5-6-18-43/h11-13,23-24,28-29,31H,3-10,14-22,25H2,1-2H3/t28-,29-,31+,36-,37-/m0/s1
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337n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200545
PNG
(CHEMBL3965572)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1ccncc1
Show InChI InChI=1S/C22H31N7/c1-2-10-27(9-1)20-17-21(25-22(24-20)29-11-3-4-12-29)28-15-13-26(14-16-28)18-19-5-7-23-8-6-19/h5-8,17H,1-4,9-16,18H2
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393n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200548
PNG
(CHEMBL3895496)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1cccnc1
Show InChI InChI=1S/C22H31N7/c1-2-9-27(8-1)20-16-21(25-22(24-20)29-10-3-4-11-29)28-14-12-26(13-15-28)18-19-6-5-7-23-17-19/h5-7,16-17H,1-4,8-15,18H2
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534n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200554
PNG
(CHEMBL3968765)
Show SMILES FC(F)(F)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1
Show InChI InChI=1S/C24H31F3N6/c25-24(26,27)20-7-5-19(6-8-20)18-30-13-15-32(16-14-30)22-17-21(31-9-1-2-10-31)28-23(29-22)33-11-3-4-12-33/h5-8,17H,1-4,9-16,18H2
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563n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200548
PNG
(CHEMBL3895496)
Show SMILES C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1cccnc1
Show InChI InChI=1S/C22H31N7/c1-2-9-27(8-1)20-16-21(25-22(24-20)29-10-3-4-11-29)28-14-12-26(13-15-28)18-19-6-5-7-23-17-19/h5-7,16-17H,1-4,8-15,18H2
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870n/an/an/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-4


(Homo sapiens (human))
BDBM50200547
PNG
(CHEMBL3949842)
Show SMILES C(Cc1ccccc1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C24H34N6/c1-2-8-21(9-3-1)10-15-27-16-18-29(19-17-27)23-20-22(28-11-4-5-12-28)25-24(26-23)30-13-6-7-14-30/h1-3,8-9,20H,4-7,10-19H2
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n/an/a 21n/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200547
PNG
(CHEMBL3949842)
Show SMILES C(Cc1ccccc1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C24H34N6/c1-2-8-21(9-3-1)10-15-27-16-18-29(19-17-27)23-20-22(28-11-4-5-12-28)25-24(26-23)30-13-6-7-14-30/h1-3,8-9,20H,4-7,10-19H2
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n/an/a 56n/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200547
PNG
(CHEMBL3949842)
Show SMILES C(Cc1ccccc1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C24H34N6/c1-2-8-21(9-3-1)10-15-27-16-18-29(19-17-27)23-20-22(28-11-4-5-12-28)25-24(26-23)30-13-6-7-14-30/h1-3,8-9,20H,4-7,10-19H2
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n/an/a 71n/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-1


(Homo sapiens (human))
BDBM50200551
PNG
(CHEMBL3978901)
Show SMILES C(C1CCCCC1)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H38N6/c1-2-8-20(9-3-1)19-26-14-16-28(17-15-26)22-18-21(27-10-4-5-11-27)24-23(25-22)29-12-6-7-13-29/h18,20H,1-17,19H2
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n/an/a 95n/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
Caspase-5


(Homo sapiens (human))
BDBM50200556
PNG
(CHEMBL3904435)
Show SMILES [O-][N+](=O)c1ccccc1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C23H31N7O2/c31-30(32)20-8-2-1-7-19(20)18-26-13-15-28(16-14-26)22-17-21(27-9-3-4-10-27)24-23(25-22)29-11-5-6-12-29/h1-2,7-8,17H,3-6,9-16,18H2
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n/an/a 105n/an/an/an/an/an/a



DePaul University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...


Bioorg Med Chem Lett 26: 5476-5480 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.025
BindingDB Entry DOI: 10.7270/Q2NZ89M0
More data for this
Ligand-Target Pair
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