BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 27 hits from Deciphera Pharmaceuticals, LLC   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cFMS


(Homo sapiens (human))
BDBM181020
PNG
(US9133183, Example 29)
Show SMILES Cc1nc(NC(=O)N2CCN(C3CCCC3)C2=O)ccc1Oc1ccnc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H27N7O3/c1-16-21(34-19-9-10-25-20(13-19)17-14-26-29(2)15-17)7-8-22(27-16)28-23(32)31-12-11-30(24(31)33)18-5-3-4-6-18/h7-10,13-15,18H,3-6,11-12H2,1-2H3,(H,27,28,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 2n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181019
PNG
(US9133183, Example 15)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCCCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C24H27N7O3/c1-29-16-17(14-27-29)21-13-19(9-10-25-21)34-20-7-8-22(26-15-20)28-23(32)31-12-11-30(24(31)33)18-5-3-2-4-6-18/h7-10,13-16,18H,2-6,11-12H2,1H3,(H,26,28,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181027
PNG
(US9133183, Example 90)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1
Show InChI InChI=1S/C20H24N6O4/c1-20(2,3)26-10-9-25(19(26)29)18(28)24-16-6-5-14(12-23-16)30-13-7-8-22-15(11-13)17(27)21-4/h5-8,11-12H,9-10H2,1-4H3,(H,21,27)(H,23,24,28)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 5n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181018
PNG
(US9133183, Example 1)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCOCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C23H25N7O4/c1-28-15-16(13-26-28)20-12-18(4-7-24-20)34-19-2-3-21(25-14-19)27-22(31)30-9-8-29(23(30)32)17-5-10-33-11-6-17/h2-4,7,12-15,17H,5-6,8-11H2,1H3,(H,25,27,31)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 6n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 7n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181037
PNG
(US9133183, Example 42)
Show SMILES CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C21H23N7O3/c1-4-27-9-10-28(21(27)30)20(29)25-19-6-5-18(14(2)24-19)31-16-7-8-22-17(11-16)15-12-23-26(3)13-15/h5-8,11-13H,4,9-10H2,1-3H3,(H,24,25,29)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 8n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181035
PNG
(US9133183, Example 101)
Show SMILES CN(C)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2Cl)ccn1
Show InChI InChI=1S/C23H26ClFN6O5/c1-29(2)21(32)28-20-11-15(3-6-26-20)36-19-13-17(25)18(12-16(19)24)27-22(33)31-8-7-30(23(31)34)14-4-9-35-10-5-14/h3,6,11-14H,4-5,7-10H2,1-2H3,(H,27,33)(H,26,28,32)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 8n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181023
PNG
(US9133183, Compound A)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)nc2)ccn1
Show InChI InChI=1S/C24H20FN7O3/c1-30-15-16(13-28-30)21-12-19(8-9-26-21)35-20-6-7-22(27-14-20)29-23(33)32-11-10-31(24(32)34)18-4-2-17(25)3-5-18/h2-9,12-15H,10-11H2,1H3,(H,27,29,33)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 13n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
cFMS


(Homo sapiens (human))
BDBM181026
PNG
(US9133183, Example 18)
Show SMILES COCCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C22H25N7O4/c1-15-19(33-17-6-7-23-18(12-17)16-13-24-27(2)14-16)4-5-20(25-15)26-21(30)29-9-8-28(22(29)31)10-11-32-3/h4-7,12-14H,8-11H2,1-3H3,(H,25,26,30)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 20n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181023
PNG
(US9133183, Compound A)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)nc2)ccn1
Show InChI InChI=1S/C24H20FN7O3/c1-30-15-16(13-28-30)21-12-19(8-9-26-21)35-20-6-7-22(27-14-20)29-23(33)32-11-10-31(24(32)34)18-4-2-17(25)3-5-18/h2-9,12-15H,10-11H2,1H3,(H,27,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 196n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181019
PNG
(US9133183, Example 15)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCCCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C24H27N7O3/c1-29-16-17(14-27-29)21-13-19(9-10-25-21)34-20-7-8-22(26-15-20)28-23(32)31-12-11-30(24(31)33)18-5-3-2-4-6-18/h7-10,13-16,18H,2-6,11-12H2,1H3,(H,26,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 370n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181019
PNG
(US9133183, Example 15)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCCCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C24H27N7O3/c1-29-16-17(14-27-29)21-13-19(9-10-25-21)34-20-7-8-22(26-15-20)28-23(32)31-12-11-30(24(31)33)18-5-3-2-4-6-18/h7-10,13-16,18H,2-6,11-12H2,1H3,(H,26,28,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 670n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181020
PNG
(US9133183, Example 29)
Show SMILES Cc1nc(NC(=O)N2CCN(C3CCCC3)C2=O)ccc1Oc1ccnc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H27N7O3/c1-16-21(34-19-9-10-25-20(13-19)17-14-26-29(2)15-17)7-8-22(27-16)28-23(32)31-12-11-30(24(31)33)18-5-3-4-6-18/h7-10,13-15,18H,3-6,11-12H2,1-2H3,(H,27,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 898n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181023
PNG
(US9133183, Compound A)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)nc2)ccn1
Show InChI InChI=1S/C24H20FN7O3/c1-30-15-16(13-28-30)21-12-19(8-9-26-21)35-20-6-7-22(27-14-20)29-23(33)32-11-10-31(24(32)34)18-4-2-17(25)3-5-18/h2-9,12-15H,10-11H2,1H3,(H,27,29,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 990n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181035
PNG
(US9133183, Example 101)
Show SMILES CN(C)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2Cl)ccn1
Show InChI InChI=1S/C23H26ClFN6O5/c1-29(2)21(32)28-20-11-15(3-6-26-20)36-19-13-17(25)18(12-16(19)24)27-22(33)31-8-7-30(23(31)34)14-4-9-35-10-5-14/h3,6,11-14H,4-5,7-10H2,1-2H3,(H,27,33)(H,26,28,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a>3.30E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181027
PNG
(US9133183, Example 90)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1
Show InChI InChI=1S/C20H24N6O4/c1-20(2,3)26-10-9-25(19(26)29)18(28)24-16-6-5-14(12-23-16)30-13-7-8-22-15(11-13)17(27)21-4/h5-8,11-12H,9-10H2,1-4H3,(H,21,27)(H,23,24,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 3.30E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181020
PNG
(US9133183, Example 29)
Show SMILES Cc1nc(NC(=O)N2CCN(C3CCCC3)C2=O)ccc1Oc1ccnc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H27N7O3/c1-16-21(34-19-9-10-25-20(13-19)17-14-26-29(2)15-17)7-8-22(27-16)28-23(32)31-12-11-30(24(31)33)18-5-3-4-6-18/h7-10,13-15,18H,3-6,11-12H2,1-2H3,(H,27,28,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a>3.30E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181026
PNG
(US9133183, Example 18)
Show SMILES COCCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C22H25N7O4/c1-15-19(33-17-6-7-23-18(12-17)16-13-24-27(2)14-16)4-5-20(25-15)26-21(30)29-9-8-28(22(29)31)10-11-32-3/h4-7,12-14H,8-11H2,1-3H3,(H,25,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a>3.30E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a>3.30E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181018
PNG
(US9133183, Example 1)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCOCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C23H25N7O4/c1-28-15-16(13-26-28)20-12-18(4-7-24-20)34-19-2-3-21(25-14-19)27-22(31)30-9-8-29(23(30)32)17-5-10-33-11-6-17/h2-4,7,12-15,17H,5-6,8-11H2,1H3,(H,25,27,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a>3.30E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181035
PNG
(US9133183, Example 101)
Show SMILES CN(C)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2Cl)ccn1
Show InChI InChI=1S/C23H26ClFN6O5/c1-29(2)21(32)28-20-11-15(3-6-26-20)36-19-13-17(25)18(12-16(19)24)27-22(33)31-8-7-30(23(31)34)14-4-9-35-10-5-14/h3,6,11-14H,4-5,7-10H2,1-2H3,(H,27,33)(H,26,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 4.00E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181018
PNG
(US9133183, Example 1)
Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCOCC4)C3=O)nc2)ccn1
Show InChI InChI=1S/C23H25N7O4/c1-28-15-16(13-26-28)20-12-18(4-7-24-20)34-19-2-3-21(25-14-19)27-22(31)30-9-8-29(23(30)32)17-5-10-33-11-6-17/h2-4,7,12-15,17H,5-6,8-11H2,1H3,(H,25,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a>5.00E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181027
PNG
(US9133183, Example 90)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1
Show InChI InChI=1S/C20H24N6O4/c1-20(2,3)26-10-9-25(19(26)29)18(28)24-16-6-5-14(12-23-16)30-13-7-8-22-15(11-13)17(27)21-4/h5-8,11-12H,9-10H2,1-4H3,(H,21,27)(H,23,24,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181037
PNG
(US9133183, Example 42)
Show SMILES CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C21H23N7O3/c1-4-27-9-10-28(21(27)30)20(29)25-19-6-5-18(14(2)24-19)31-16-7-8-22-17(11-16)15-12-23-26(3)13-15/h5-8,11-13H,4,9-10H2,1-3H3,(H,24,25,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a>5.00E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181026
PNG
(US9133183, Example 18)
Show SMILES COCCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C22H25N7O4/c1-15-19(33-17-6-7-23-18(12-17)16-13-24-27(2)14-16)4-5-20(25-15)26-21(30)29-9-8-28(22(29)31)10-11-32-3/h4-7,12-14H,8-11H2,1-3H3,(H,25,26,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a>5.00E+3n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM181037
PNG
(US9133183, Example 42)
Show SMILES CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Show InChI InChI=1S/C21H23N7O3/c1-4-27-9-10-28(21(27)30)20(29)25-19-6-5-18(14(2)24-19)31-16-7-8-22-17(11-16)15-12-23-26(3)13-15/h5-8,11-13H,4,9-10H2,1-3H3,(H,24,25,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a>1.00E+4n/an/an/an/an/an/a



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair