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Found 1 hit from Department of Pharmaceutical Technology (Biotechnology), Department of Pharmacoinformatics, and Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER)   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Topoisomerase II alpha (HuTopoIIα)


(Homo sapiens (Human))
BDBM50089640
PNG
(CHEMBL3578326)
Show SMILES CC(C)(C)Nc1c(nc2ccc(cn12)-c1ccccc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClN3/c1-23(2,3)26-22-21(17-9-12-19(24)13-10-17)25-20-14-11-18(15-27(20)22)16-7-5-4-6-8-16/h4-15,26H,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.54E+4n/an/an/an/an/an/a



Department of Pharmaceutical Technology (Biotechnology), Department of Pharmacoinformatics, and Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 2alpha assessed as reduction in enzyme-mediated kinetoplast DNA decatenation incubated for 30 mins by agarose gel e...


ACS Med Chem Lett 6: 481-5 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00040
BindingDB Entry DOI: 10.7270/Q2S1848C
More data for this
Ligand-Target Pair