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Compile Data Set for Download or QSAR

Found 116 hits from Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219087
PNG
(CHEMBL97637)
Show SMILES O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O2S/c30-32(31,22-9-6-20(7-10-22)19-4-2-1-3-5-19)28-21-8-11-24-23(18-21)25(12-13-27-24)29-16-14-26-15-17-29/h1-13,18,26,28H,14-17H2
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0.501n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219087
PNG
(CHEMBL97637)
Show SMILES O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O2S/c30-32(31,22-9-6-20(7-10-22)19-4-2-1-3-5-19)28-21-8-11-24-23(18-21)25(12-13-27-24)29-16-14-26-15-17-29/h1-13,18,26,28H,14-17H2
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0.501n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219081
PNG
(CHEMBL261917)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H28N4O2S/c1-23(2,3)17-4-7-19(8-5-17)30(28,29)26-18-6-9-21-20(16-18)22(10-11-25-21)27-14-12-24-13-15-27/h4-11,16,24,26H,12-15H2,1-3H3
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0.631n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219081
PNG
(CHEMBL261917)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H28N4O2S/c1-23(2,3)17-4-7-19(8-5-17)30(28,29)26-18-6-9-21-20(16-18)22(10-11-25-21)27-14-12-24-13-15-27/h4-11,16,24,26H,12-15H2,1-3H3
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0.631n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219089
PNG
(CHEMBL318018)
Show SMILES Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-22(18-12-15(23)2-5-21(18)30-14)31(28,29)26-16-3-4-19-17(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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1n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219084
PNG
(CHEMBL97596)
Show SMILES Clc1cccc2cc(ccc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H21ClN4O2S/c24-21-3-1-2-16-14-18(5-6-19(16)21)31(29,30)27-17-4-7-22-20(15-17)23(8-9-26-22)28-12-10-25-11-13-28/h1-9,14-15,25,27H,10-13H2
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1n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219089
PNG
(CHEMBL318018)
Show SMILES Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-22(18-12-15(23)2-5-21(18)30-14)31(28,29)26-16-3-4-19-17(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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1n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219084
PNG
(CHEMBL97596)
Show SMILES Clc1cccc2cc(ccc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H21ClN4O2S/c24-21-3-1-2-16-14-18(5-6-19(16)21)31(29,30)27-17-4-7-22-20(15-17)23(8-9-26-22)28-12-10-25-11-13-28/h1-9,14-15,25,27H,10-13H2
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1n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219083
PNG
(CHEMBL316081)
Show SMILES CN1CCN(CC1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-15-18-13-16(24)3-6-22(18)31-23(15)32(29,30)26-17-4-5-20-19(14-17)21(7-8-25-20)28-11-9-27(2)10-12-28/h3-8,13-14,26H,9-12H2,1-2H3
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1n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219083
PNG
(CHEMBL316081)
Show SMILES CN1CCN(CC1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-15-18-13-16(24)3-6-22(18)31-23(15)32(29,30)26-17-4-5-20-19(14-17)21(7-8-25-20)28-11-9-27(2)10-12-28/h3-8,13-14,26H,9-12H2,1-2H3
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1n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219085
PNG
(CHEMBL97211)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nc(C)cc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-11-21(28-9-7-25-8-10-28)19-13-17(4-5-20(19)26-14)27-32(29,30)23-15(2)18-12-16(24)3-6-22(18)31-23/h3-6,11-13,25,27H,7-10H2,1-2H3
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1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219086
PNG
(CHEMBL98965)
Show SMILES CCc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H23ClN4O2S2/c1-2-17-18-13-15(24)3-6-22(18)31-23(17)32(29,30)27-16-4-5-20-19(14-16)21(7-8-26-20)28-11-9-25-10-12-28/h3-8,13-14,25,27H,2,9-12H2,1H3
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1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM28583
PNG
(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1
Show InChI InChI=1S/C20H22ClN3O3S2/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24/h3-6,11-12,22-23H,7-10H2,1-2H3
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PubMed
1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219090
PNG
(CHEMBL95388)
Show SMILES Cc1cc(c(C)cc1Cl)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C21H23ClN4O2S/c1-14-12-21(15(2)11-18(14)22)29(27,28)25-16-3-4-19-17(13-16)20(5-6-24-19)26-9-7-23-8-10-26/h3-6,11-13,23,25H,7-10H2,1-2H3
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1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219082
PNG
(CHEMBL95823)
Show SMILES C[C@H]1CN(CCN1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-13-28(10-9-25-14)21-7-8-26-20-5-4-17(12-19(20)21)27-32(29,30)23-15(2)18-11-16(24)3-6-22(18)31-23/h3-8,11-12,14,25,27H,9-10,13H2,1-2H3/t14-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219086
PNG
(CHEMBL98965)
Show SMILES CCc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H23ClN4O2S2/c1-2-17-18-13-15(24)3-6-22(18)31-23(17)32(29,30)27-16-4-5-20-19(14-16)21(7-8-26-20)28-11-9-25-10-12-28/h3-8,13-14,25,27H,2,9-12H2,1H3
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1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219085
PNG
(CHEMBL97211)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nc(C)cc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-11-21(28-9-7-25-8-10-28)19-13-17(4-5-20(19)26-14)27-32(29,30)23-15(2)18-12-16(24)3-6-22(18)31-23/h3-6,11-13,25,27H,7-10H2,1-2H3
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1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219082
PNG
(CHEMBL95823)
Show SMILES C[C@H]1CN(CCN1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-13-28(10-9-25-14)21-7-8-26-20-5-4-17(12-19(20)21)27-32(29,30)23-15(2)18-11-16(24)3-6-22(18)31-23/h3-8,11-12,14,25,27H,9-10,13H2,1-2H3/t14-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219096
PNG
(CHEMBL99982)
Show SMILES CC(C)c1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C24H25ClN4O2S2/c1-15(2)23-19-13-16(25)3-6-22(19)32-24(23)33(30,31)28-17-4-5-20-18(14-17)21(7-8-27-20)29-11-9-26-10-12-29/h3-8,13-15,26,28H,9-12H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219100
PNG
(CHEMBL95878)
Show SMILES Ic1ccc(cc1)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C19H19IN4O2S/c20-14-1-4-16(5-2-14)27(25,26)23-15-3-6-18-17(13-15)19(7-8-22-18)24-11-9-21-10-12-24/h1-8,13,21,23H,9-12H2
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1.60n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219095
PNG
(CHEMBL94988)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCN4CCC[C@H]4C3)c2c1
Show InChI InChI=1S/C25H25ClN4O2S2/c1-16-20-13-17(26)4-7-24(20)33-25(16)34(31,32)28-18-5-6-22-21(14-18)23(8-9-27-22)30-12-11-29-10-2-3-19(29)15-30/h4-9,13-14,19,28H,2-3,10-12,15H2,1H3/t19-/m0/s1
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2n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50001825
PNG
(CHEMBL97158 | SB-331711)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-17-12-15(23)2-5-21(17)30-22(14)31(28,29)26-16-3-4-19-18(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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2n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219099
PNG
(CHEMBL98353)
Show SMILES Cc1sc2c(Cl)cccc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-22(16-3-2-4-18(23)21(16)30-14)31(28,29)26-15-5-6-19-17(13-15)20(7-8-25-19)27-11-9-24-10-12-27/h2-8,13,24,26H,9-12H2,1H3
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2n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50001825
PNG
(CHEMBL97158 | SB-331711)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-17-12-15(23)2-5-21(17)30-22(14)31(28,29)26-16-3-4-19-18(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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2n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219127
PNG
(CHEMBL316643)
Show SMILES C[C@@H]1CN(CCN1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-13-28(10-9-25-14)21-7-8-26-20-5-4-17(12-19(20)21)27-32(29,30)23-15(2)18-11-16(24)3-6-22(18)31-23/h3-8,11-12,14,25,27H,9-10,13H2,1-2H3/t14-/m1/s1
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2n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219128
PNG
(CHEMBL95568)
Show SMILES Cc1sc2c(Cl)cc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H20Cl2N4O2S2/c1-13-22(17-10-14(23)11-18(24)21(17)31-13)32(29,30)27-15-2-3-19-16(12-15)20(4-5-26-19)28-8-6-25-7-9-28/h2-5,10-12,25,27H,6-9H2,1H3
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2n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219098
PNG
(CHEMBL97899)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2ncc(C)c(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-13-26-20-5-4-17(12-19(20)22(14)28-9-7-25-8-10-28)27-32(29,30)23-15(2)18-11-16(24)3-6-21(18)31-23/h3-6,11-13,25,27H,7-10H2,1-2H3
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2.5n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219092
PNG
(CHEMBL329482)
Show SMILES Clc1cccc2c(cccc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H21ClN4O2S/c24-20-5-1-4-18-17(20)3-2-6-23(18)31(29,30)27-16-7-8-21-19(15-16)22(9-10-26-21)28-13-11-25-12-14-28/h1-10,15,25,27H,11-14H2
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3.20n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219091
PNG
(CHEMBL318262)
Show SMILES Cc1c(oc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O3S/c1-14-17-12-15(23)2-5-21(17)30-22(14)31(28,29)26-16-3-4-19-18(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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4n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219097
PNG
(CHEMBL95511)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C24H25ClN4O2S2/c1-14-12-29(13-15(2)27-14)22-8-9-26-21-6-5-18(11-20(21)22)28-33(30,31)24-16(3)19-10-17(25)4-7-23(19)32-24/h4-11,14-15,27-28H,12-13H2,1-3H3/t14-,15+
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5n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219088
PNG
(CHEMBL94930)
Show SMILES Cc1c(sc2c(Cl)cc(Cl)cc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H20Cl2N4O2S2/c1-13-16-10-14(23)11-18(24)21(16)31-22(13)32(29,30)27-15-2-3-19-17(12-15)20(4-5-26-19)28-8-6-25-7-9-28/h2-5,10-12,25,27H,6-9H2,1H3
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6.30n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219094
PNG
(CHEMBL369071)
Show SMILES Cc1sc2cc(Cl)cc(Cl)c2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H20Cl2N4O2S2/c1-13-22(21-17(24)10-14(23)11-20(21)31-13)32(29,30)27-15-2-3-18-16(12-15)19(4-5-26-18)28-8-6-25-7-9-28/h2-5,10-12,25,27H,6-9H2,1H3
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7.90n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219126
PNG
(CHEMBL95504)
Show SMILES CC(C)[C@@H]1CN(CCN1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C25H27ClN4O2S2/c1-15(2)22-14-30(11-10-28-22)23-8-9-27-21-6-5-18(13-20(21)23)29-34(31,32)25-16(3)19-12-17(26)4-7-24(19)33-25/h4-9,12-13,15,22,28-29H,10-11,14H2,1-3H3/t22-/m0/s1
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20n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219125
PNG
(CHEMBL95628)
Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C19H18Cl2N4O2S/c20-13-9-14(21)11-16(10-13)28(26,27)24-15-1-2-18-17(12-15)19(3-4-23-18)25-7-5-22-6-8-25/h1-4,9-12,22,24H,5-8H2
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25n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219093
PNG
(CHEMBL95285)
Show SMILES C[C@@H]1CN([C@@H](C)CN1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C24H25ClN4O2S2/c1-14-13-29(15(2)12-27-14)22-8-9-26-21-6-5-18(11-20(21)22)28-33(30,31)24-16(3)19-10-17(25)4-7-23(19)32-24/h4-11,14-15,27-28H,12-13H2,1-3H3/t14-,15+/m1/s1
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32n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219119
PNG
(CHEMBL95517)
Show SMILES CN1CCN(CC1)c1cnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc2c1
Show InChI InChI=1S/C23H23ClN4O2S2/c1-15-20-13-17(24)3-6-22(20)31-23(15)32(29,30)26-18-4-5-21-16(11-18)12-19(14-25-21)28-9-7-27(2)8-10-28/h3-6,11-14,26H,7-10H2,1-2H3
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79n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity against human 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219087
PNG
(CHEMBL97637)
Show SMILES O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O2S/c30-32(31,22-9-6-20(7-10-22)19-4-2-1-3-5-19)28-21-8-11-24-23(18-21)25(12-13-27-24)29-16-14-26-15-17-29/h1-13,18,26,28H,14-17H2
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158n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50219084
PNG
(CHEMBL97596)
Show SMILES Clc1cccc2cc(ccc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H21ClN4O2S/c24-21-3-1-2-16-14-18(5-6-19(16)21)31(29,30)27-17-4-7-22-20(15-17)23(8-9-26-22)28-12-10-25-11-13-28/h1-9,14-15,25,27H,10-13H2
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158n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1A receptor in HEK 293 cells using [3H]-8-OH- DPAT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219084
PNG
(CHEMBL97596)
Show SMILES Clc1cccc2cc(ccc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H21ClN4O2S/c24-21-3-1-2-16-14-18(5-6-19(16)21)31(29,30)27-17-4-7-22-20(15-17)23(8-9-26-22)28-12-10-25-11-13-28/h1-9,14-15,25,27H,10-13H2
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200n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219083
PNG
(CHEMBL316081)
Show SMILES CN1CCN(CC1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-15-18-13-16(24)3-6-22(18)31-23(15)32(29,30)26-17-4-5-20-19(14-17)21(7-8-25-20)28-11-9-27(2)10-12-28/h3-8,13-14,26H,9-12H2,1-2H3
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251n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50219089
PNG
(CHEMBL318018)
Show SMILES Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-22(18-12-15(23)2-5-21(18)30-14)31(28,29)26-16-3-4-19-17(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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251n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1A receptor in HEK 293 cells using [3H]-8-OH- DPAT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219085
PNG
(CHEMBL97211)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1ccc2nc(C)cc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-11-21(28-9-7-25-8-10-28)19-13-17(4-5-20(19)26-14)27-32(29,30)23-15(2)18-12-16(24)3-6-22(18)31-23/h3-6,11-13,25,27H,7-10H2,1-2H3
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316n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219087
PNG
(CHEMBL97637)
Show SMILES O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O2S/c30-32(31,22-9-6-20(7-10-22)19-4-2-1-3-5-19)28-21-8-11-24-23(18-21)25(12-13-27-24)29-16-14-26-15-17-29/h1-13,18,26,28H,14-17H2
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316n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219082
PNG
(CHEMBL95823)
Show SMILES C[C@H]1CN(CCN1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-14-13-28(10-9-25-14)21-7-8-26-20-5-4-17(12-19(20)21)27-32(29,30)23-15(2)18-11-16(24)3-6-22(18)31-23/h3-8,11-12,14,25,27H,9-10,13H2,1-2H3/t14-/m0/s1
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398n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219089
PNG
(CHEMBL318018)
Show SMILES Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-22(18-12-15(23)2-5-21(18)30-14)31(28,29)26-16-3-4-19-17(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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398n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219083
PNG
(CHEMBL316081)
Show SMILES CN1CCN(CC1)c1ccnc2ccc(NS(=O)(=O)c3sc4ccc(Cl)cc4c3C)cc12
Show InChI InChI=1S/C23H23ClN4O2S2/c1-15-18-13-16(24)3-6-22(18)31-23(15)32(29,30)26-17-4-5-20-19(14-17)21(7-8-25-20)28-11-9-27(2)10-12-28/h3-8,13-14,26H,9-12H2,1-2H3
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501n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50219087
PNG
(CHEMBL97637)
Show SMILES O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O2S/c30-32(31,22-9-6-20(7-10-22)19-4-2-1-3-5-19)28-21-8-11-24-23(18-21)25(12-13-27-24)29-16-14-26-15-17-29/h1-13,18,26,28H,14-17H2
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501n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 2A receptor in HEK 293 cells using [3H]- ketanserin as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219089
PNG
(CHEMBL318018)
Show SMILES Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H21ClN4O2S2/c1-14-22(18-12-15(23)2-5-21(18)30-14)31(28,29)26-16-3-4-19-17(13-16)20(6-7-25-19)27-10-8-24-9-11-27/h2-7,12-13,24,26H,8-11H2,1H3
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501n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50219087
PNG
(CHEMBL97637)
Show SMILES O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O2S/c30-32(31,22-9-6-20(7-10-22)19-4-2-1-3-5-19)28-21-8-11-24-23(18-21)25(12-13-27-24)29-16-14-26-15-17-29/h1-13,18,26,28H,14-17H2
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631n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1A receptor in HEK 293 cells using [3H]-8-OH- DPAT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM50219084
PNG
(CHEMBL97596)
Show SMILES Clc1cccc2cc(ccc12)S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H21ClN4O2S/c24-21-3-1-2-16-14-18(5-6-19(16)21)31(29,30)27-17-4-7-22-20(15-17)23(8-9-26-22)28-12-10-25-11-13-28/h1-9,14-15,25,27H,10-13H2
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631n/an/an/an/an/an/an/an/a



Discovery Chemistry Europe, GlaxoSmithKline, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells using [3H]5-HT as radioligand


Bioorg Med Chem Lett 11: 2843-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00558-3
More data for this
Ligand-Target Pair
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