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Compile Data Set for Download or QSAR

Found 129 hits from Domainex Limited   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148071
PNG
(US8962609, DMX-5)
Show SMILES COc1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C22H21N5O/c1-28-19-6-4-5-18(14-19)25-22-24-10-9-20(26-22)16-7-8-21(17(13-16)15-23)27-11-2-3-12-27/h4-10,13-14H,2-3,11-12H2,1H3,(H,24,25,26)
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n/an/a<30n/an/an/an/an/an/a



Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148072
PNG
(US8962609, DMX-6)
Show SMILES COc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cc1
Show InChI InChI=1S/C22H21N5O/c1-28-19-7-5-18(6-8-19)25-22-24-11-10-20(26-22)16-4-9-21(17(14-16)15-23)27-12-2-3-13-27/h4-11,14H,2-3,12-13H2,1H3,(H,24,25,26)
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n/an/a<30n/an/an/an/an/an/a



Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148073
PNG
(US8962609, DMX-7)
Show SMILES CC(=O)Nc1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C23H22N6O/c1-16(30)26-19-5-4-6-20(14-19)27-23-25-10-9-21(28-23)17-7-8-22(18(13-17)15-24)29-11-2-3-12-29/h4-10,13-14H,2-3,11-12H2,1H3,(H,26,30)(H,25,27,28)
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n/an/a<30n/an/an/an/an/an/a



Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148074
PNG
(US8962609, DMX-8)
Show SMILES NC(=O)c1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cc1
Show InChI InChI=1S/C22H20N6O/c23-14-17-13-16(5-8-20(17)28-11-1-2-12-28)19-9-10-25-22(27-19)26-18-6-3-15(4-7-18)21(24)29/h3-10,13H,1-2,11-12H2,(H2,24,29)(H,25,26,27)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148075
PNG
(US8962609, DMX-9)
Show SMILES CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cc1
Show InChI InChI=1S/C23H22N6O/c1-16(30)26-19-5-7-20(8-6-19)27-23-25-11-10-21(28-23)17-4-9-22(18(14-17)15-24)29-12-2-3-13-29/h4-11,14H,2-3,12-13H2,1H3,(H,26,30)(H,25,27,28)
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n/an/a<30n/an/an/an/an/an/a



Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148076
PNG
(US8962609, DMX-10)
Show SMILES CS(=O)(=O)c1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C22H21N5O2S/c1-30(28,29)19-6-4-5-18(14-19)25-22-24-10-9-20(26-22)16-7-8-21(17(13-16)15-23)27-11-2-3-12-27/h4-10,13-14H,2-3,11-12H2,1H3,(H,24,25,26)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148080
PNG
(US8962609, DMX-14)
Show SMILES O=C1Cc2cc(Nc3nccc(n3)-c3ccc(N4CCCC4)c(c3)C#N)ccc2N1
Show InChI InChI=1S/C23H20N6O/c24-14-17-11-15(3-6-21(17)29-9-1-2-10-29)20-7-8-25-23(28-20)26-18-4-5-19-16(12-18)13-22(30)27-19/h3-8,11-12H,1-2,9-10,13H2,(H,27,30)(H,25,26,28)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148081
PNG
(US8962609, DMX-15)
Show SMILES CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C22H21N7O/c1-15(30)26-21-7-5-18(14-25-21)27-22-24-9-8-19(28-22)16-4-6-20(17(12-16)13-23)29-10-2-3-11-29/h4-9,12,14H,2-3,10-11H2,1H3,(H,24,27,28)(H,25,26,30)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148082
PNG
(US8962609, DMX-16)
Show SMILES N#Cc1cc(ccc1N1CCCC1)-c1ccnc(Nc2ccc(nc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H25N7O/c25-16-19-15-18(3-5-22(19)30-9-1-2-10-30)21-7-8-26-24(29-21)28-20-4-6-23(27-17-20)31-11-13-32-14-12-31/h3-8,15,17H,1-2,9-14H2,(H,26,28,29)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148083
PNG
(US8962609, DMX-17)
Show SMILES O=C1CCc2ccc(Nc3nccc(n3)-c3ccc(N4CCCC4)c(c3)C#N)cc2N1
Show InChI InChI=1S/C24H22N6O/c25-15-18-13-17(4-7-22(18)30-11-1-2-12-30)20-9-10-26-24(29-20)27-19-6-3-16-5-8-23(31)28-21(16)14-19/h3-4,6-7,9-10,13-14H,1-2,5,8,11-12H2,(H,28,31)(H,26,27,29)
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n/an/a<30n/an/an/an/an/an/a



Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148084
PNG
(US8962609, DMX-18)
Show SMILES N#Cc1cc(ccc1N1CCCC1)-c1ccnc(Nc2cccnc2)n1
Show InChI InChI=1S/C20H18N6/c21-13-16-12-15(5-6-19(16)26-10-1-2-11-26)18-7-9-23-20(25-18)24-17-4-3-8-22-14-17/h3-9,12,14H,1-2,10-11H2,(H,23,24,25)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148085
PNG
(US8962609, DMX-19)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C25H28N8/c1-31-12-14-33(15-13-31)24-7-5-21(18-28-24)29-25-27-9-8-22(30-25)19-4-6-23(20(16-19)17-26)32-10-2-3-11-32/h4-9,16,18H,2-3,10-15H2,1H3,(H,27,29,30)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148086
PNG
(US8962609, DMX-20)
Show SMILES CN(C)c1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C22H23N7/c1-28(2)21-8-6-18(15-25-21)26-22-24-10-9-19(27-22)16-5-7-20(17(13-16)14-23)29-11-3-4-12-29/h5-10,13,15H,3-4,11-12H2,1-2H3,(H,24,26,27)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148088
PNG
(US8962609, DMX-56)
Show SMILES Cn1cc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C19H19N7/c1-25-13-16(12-22-25)23-19-21-7-6-17(24-19)14-4-5-18(15(10-14)11-20)26-8-2-3-9-26/h4-7,10,12-13H,2-3,8-9H2,1H3,(H,21,23,24)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148090
PNG
(US8962609, DMX-58)
Show SMILES COc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C21H20N6O/c1-28-20-7-5-17(14-24-20)25-21-23-9-8-18(26-21)15-4-6-19(16(12-15)13-22)27-10-2-3-11-27/h4-9,12,14H,2-3,10-11H2,1H3,(H,23,25,26)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148100
PNG
(US8962609, DMX-33)
Show SMILES CN(C)CCNc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C24H28N8/c1-31(2)14-11-26-23-8-6-20(17-28-23)29-24-27-10-9-21(30-24)18-5-7-22(19(15-18)16-25)32-12-3-4-13-32/h5-10,15,17H,3-4,11-14H2,1-2H3,(H,26,28)(H,27,29,30)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148101
PNG
(US8962609, DMX-34)
Show SMILES CN(C)CCN(C)c1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C25H30N8/c1-31(2)14-15-32(3)24-9-7-21(18-28-24)29-25-27-11-10-22(30-25)19-6-8-23(20(16-19)17-26)33-12-4-5-13-33/h6-11,16,18H,4-5,12-15H2,1-3H3,(H,27,29,30)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148102
PNG
(US8962609, DMX-37)
Show SMILES CN(C(C)=O)c1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cc1
Show InChI InChI=1S/C24H24N6O/c1-17(31)29(2)21-8-6-20(7-9-21)27-24-26-12-11-22(28-24)18-5-10-23(19(15-18)16-25)30-13-3-4-14-30/h5-12,15H,3-4,13-14H2,1-2H3,(H,26,27,28)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148103
PNG
(US8962609, DMX-61)
Show SMILES CN(C)CCOc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C24H27N7O/c1-30(2)13-14-32-23-8-6-20(17-27-23)28-24-26-10-9-21(29-24)18-5-7-22(19(15-18)16-25)31-11-3-4-12-31/h5-10,15,17H,3-4,11-14H2,1-2H3,(H,26,28,29)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148108
PNG
(US8962609, DMX-42)
Show SMILES OC(=O)c1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C22H19N5O2/c23-14-17-12-15(6-7-20(17)27-10-1-2-11-27)19-8-9-24-22(26-19)25-18-5-3-4-16(13-18)21(28)29/h3-9,12-13H,1-2,10-11H2,(H,28,29)(H,24,25,26)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148109
PNG
(US8962609, DMX-43)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C27H29N7O/c1-32-13-15-34(16-14-32)26(35)21-5-4-6-23(18-21)30-27-29-10-9-24(31-27)20-7-8-25(22(17-20)19-28)33-11-2-3-12-33/h4-10,17-18H,2-3,11-16H2,1H3,(H,29,30,31)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148110
PNG
(US8962609, DMX-44)
Show SMILES CN1CCC(CC1)NC(=O)c1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C28H31N7O/c1-34-15-10-23(11-16-34)31-27(36)21-5-4-6-24(18-21)32-28-30-12-9-25(33-28)20-7-8-26(22(17-20)19-29)35-13-2-3-14-35/h4-9,12,17-18,23H,2-3,10-11,13-16H2,1H3,(H,31,36)(H,30,32,33)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148111
PNG
(US8962609, DMX-45)
Show SMILES CN(C)CCNC(=O)c1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C26H29N7O/c1-32(2)15-12-28-25(34)20-6-5-7-22(17-20)30-26-29-11-10-23(31-26)19-8-9-24(21(16-19)18-27)33-13-3-4-14-33/h5-11,16-17H,3-4,12-15H2,1-2H3,(H,28,34)(H,29,30,31)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148114
PNG
(US8962609, DMX-48)
Show SMILES CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@H](O)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C22H21N7O2/c1-14(30)26-21-5-3-17(12-25-21)27-22-24-8-6-19(28-22)15-2-4-20(16(10-15)11-23)29-9-7-18(31)13-29/h2-6,8,10,12,18,31H,7,9,13H2,1H3,(H,24,27,28)(H,25,26,30)/t18-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148115
PNG
(US8962609, DMX-49)
Show SMILES CN(C)CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C24H26N8O/c1-31(2)16-23(33)30-22-8-6-19(15-27-22)28-24-26-10-9-20(29-24)17-5-7-21(18(13-17)14-25)32-11-3-4-12-32/h5-10,13,15H,3-4,11-12,16H2,1-2H3,(H,26,28,29)(H,27,30,33)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148119
PNG
(US8962609, DMX-54)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@H](O)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C25H28N8O/c1-31-10-12-32(13-11-31)24-5-3-20(16-28-24)29-25-27-8-6-22(30-25)18-2-4-23(19(14-18)15-26)33-9-7-21(34)17-33/h2-6,8,14,16,21,34H,7,9-13,17H2,1H3,(H,27,29,30)/t21-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148120
PNG
(US8962609, DMX-55)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(N3CCC[C@@H]3C(N)=O)c(c2)C#N)cn1
Show InChI InChI=1S/C26H29N9O/c1-33-11-13-34(14-12-33)24-7-5-20(17-30-24)31-26-29-9-8-21(32-26)18-4-6-22(19(15-18)16-27)35-10-2-3-23(35)25(28)36/h4-9,15,17,23H,2-3,10-14H2,1H3,(H2,28,36)(H,29,31,32)/t23-/m1/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148121
PNG
(US8962609, DMX-62)
Show SMILES CN(C)CCNc1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@H](O)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C24H28N8O/c1-31(2)12-10-26-23-6-4-19(15-28-23)29-24-27-9-7-21(30-24)17-3-5-22(18(13-17)14-25)32-11-8-20(33)16-32/h3-7,9,13,15,20,33H,8,10-12,16H2,1-2H3,(H,26,28)(H,27,29,30)/t20-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148122
PNG
(US8962609, DMX-63)
Show SMILES C[C@H]1CCCN1c1ccc(cc1C#N)-c1ccnc(Nc2ccc(NCCN(C)C)nc2)n1
Show InChI InChI=1S/C25H30N8/c1-18-5-4-13-33(18)23-8-6-19(15-20(23)16-26)22-10-11-28-25(31-22)30-21-7-9-24(29-17-21)27-12-14-32(2)3/h6-11,15,17-18H,4-5,12-14H2,1-3H3,(H,27,29)(H,28,30,31)/t18-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148123
PNG
(US8962609, DMX-64)
Show SMILES CN(C)CCNc1ccc(Nc2nccc(n2)-c2ccc(N3CCC(CC3)C(N)=O)c(c2)C#N)cn1
Show InChI InChI=1S/C26H31N9O/c1-34(2)14-11-29-24-6-4-21(17-31-24)32-26-30-10-7-22(33-26)19-3-5-23(20(15-19)16-27)35-12-8-18(9-13-35)25(28)36/h3-7,10,15,17-18H,8-9,11-14H2,1-2H3,(H2,28,36)(H,29,31)(H,30,32,33)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148125
PNG
(US8962609, DMX-66)
Show SMILES CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CC(O)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C21H19N7O2/c1-13(29)25-20-5-3-16(10-24-20)26-21-23-7-6-18(27-21)14-2-4-19(15(8-14)9-22)28-11-17(30)12-28/h2-8,10,17,30H,11-12H2,1H3,(H,23,26,27)(H,24,25,29)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148128
PNG
(US8962609, DMX-69)
Show SMILES CN(C)CCNc1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@H](F)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C24H27FN8/c1-32(2)12-10-27-23-6-4-20(15-29-23)30-24-28-9-7-21(31-24)17-3-5-22(18(13-17)14-26)33-11-8-19(25)16-33/h3-7,9,13,15,19H,8,10-12,16H2,1-2H3,(H,27,29)(H,28,30,31)/t19-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148130
PNG
(US8962609, DMX-71)
Show SMILES COC[C@H]1CCCN1c1ccc(cc1C#N)-c1ccnc(Nc2ccc(NC(C)=O)nc2)n1
Show InChI InChI=1S/C24H25N7O2/c1-16(32)28-23-8-6-19(14-27-23)29-24-26-10-9-21(30-24)17-5-7-22(18(12-17)13-25)31-11-3-4-20(31)15-33-2/h5-10,12,14,20H,3-4,11,15H2,1-2H3,(H,26,29,30)(H,27,28,32)/t20-/m1/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148132
PNG
(US8962609, DMX-73)
Show SMILES CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@@H](O)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C22H21N7O2/c1-14(30)26-21-5-3-17(12-25-21)27-22-24-8-6-19(28-22)15-2-4-20(16(10-15)11-23)29-9-7-18(31)13-29/h2-6,8,10,12,18,31H,7,9,13H2,1H3,(H,24,27,28)(H,25,26,30)/t18-/m1/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148133
PNG
(US8962609, DMX-74)
Show SMILES Cn1cc(Nc2nccc(n2)-c2ccc(N3CC[C@H](O)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C19H19N7O/c1-25-11-15(10-22-25)23-19-21-6-4-17(24-19)13-2-3-18(14(8-13)9-20)26-7-5-16(27)12-26/h2-4,6,8,10-11,16,27H,5,7,12H2,1H3,(H,21,23,24)/t16-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148134
PNG
(US8962609, DMX-75)
Show SMILES Cn1cc(Nc2nccc(n2)-c2ccc(N3CCC(CC3)C(N)=O)c(c2)C#N)cn1
Show InChI InChI=1S/C21H22N8O/c1-28-13-17(12-25-28)26-21-24-7-4-18(27-21)15-2-3-19(16(10-15)11-22)29-8-5-14(6-9-29)20(23)30/h2-4,7,10,12-14H,5-6,8-9H2,1H3,(H2,23,30)(H,24,26,27)
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148135
PNG
(US8962609, DMX-76)
Show SMILES CO[C@H]1CCN(C1)c1ccc(cc1C#N)-c1ccnc(Nc2ccc(NC(C)=O)nc2)n1
Show InChI InChI=1S/C23H23N7O2/c1-15(31)27-22-6-4-18(13-26-22)28-23-25-9-7-20(29-23)16-3-5-21(17(11-16)12-24)30-10-8-19(14-30)32-2/h3-7,9,11,13,19H,8,10,14H2,1-2H3,(H,25,28,29)(H,26,27,31)/t19-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148136
PNG
(US8962609, DMX-77)
Show SMILES CN1CCC(CC1)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@@H](F)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C26H29FN8/c1-34-11-8-21(9-12-34)31-25-5-3-22(16-30-25)32-26-29-10-6-23(33-26)18-2-4-24(19(14-18)15-28)35-13-7-20(27)17-35/h2-6,10,14,16,20-21H,7-9,11-13,17H2,1H3,(H,30,31)(H,29,32,33)/t20-/m1/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148137
PNG
(US8962609, DMX-78)
Show SMILES CN1CCC(CC1)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@H](F)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C26H29FN8/c1-34-11-8-21(9-12-34)31-25-5-3-22(16-30-25)32-26-29-10-6-23(33-26)18-2-4-24(19(14-18)15-28)35-13-7-20(27)17-35/h2-6,10,14,16,20-21H,7-9,11-13,17H2,1H3,(H,30,31)(H,29,32,33)/t20-/m0/s1
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Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148138
PNG
(US8962609, DMX-79)
Show SMILES CN1CCC(CC1)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CC[C@H](O)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C26H30N8O/c1-33-11-7-20(8-12-33)30-25-5-3-21(16-29-25)31-26-28-10-6-23(32-26)18-2-4-24(19(14-18)15-27)34-13-9-22(35)17-34/h2-6,10,14,16,20,22,35H,7-9,11-13,17H2,1H3,(H,29,30)(H,28,31,32)/t22-/m0/s1
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (human))
BDBM148139
PNG
(US8962609, DMX-80)
Show SMILES CN1CCC(CC1)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CCC(F)(F)C3)c(c2)C#N)cn1
Show InChI InChI=1S/C26H28F2N8/c1-35-11-7-20(8-12-35)32-24-5-3-21(16-31-24)33-25-30-10-6-22(34-25)18-2-4-23(19(14-18)15-29)36-13-9-26(27,28)17-36/h2-6,10,14,16,20H,7-9,11-13,17H2,1H3,(H,31,32)(H,30,33,34)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148073
PNG
(US8962609, DMX-7)
Show SMILES CC(=O)Nc1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C23H22N6O/c1-16(30)26-19-5-4-6-20(14-19)27-23-25-10-9-21(28-23)17-7-8-22(18(13-17)15-24)29-11-2-3-12-29/h4-10,13-14H,2-3,11-12H2,1H3,(H,26,30)(H,25,27,28)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148074
PNG
(US8962609, DMX-8)
Show SMILES NC(=O)c1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cc1
Show InChI InChI=1S/C22H20N6O/c23-14-17-13-16(5-8-20(17)28-11-1-2-12-28)19-9-10-25-22(27-19)26-18-6-3-15(4-7-18)21(24)29/h3-10,13H,1-2,11-12H2,(H2,24,29)(H,25,26,27)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148075
PNG
(US8962609, DMX-9)
Show SMILES CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cc1
Show InChI InChI=1S/C23H22N6O/c1-16(30)26-19-5-7-20(8-6-19)27-23-25-11-10-21(28-23)17-4-9-22(18(14-17)15-24)29-12-2-3-13-29/h4-11,14H,2-3,12-13H2,1H3,(H,26,30)(H,25,27,28)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148076
PNG
(US8962609, DMX-10)
Show SMILES CS(=O)(=O)c1cccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)c1
Show InChI InChI=1S/C22H21N5O2S/c1-30(28,29)19-6-4-5-18(14-19)25-22-24-10-9-20(26-22)16-7-8-21(17(13-16)15-23)27-11-2-3-12-27/h4-10,13-14H,2-3,11-12H2,1H3,(H,24,25,26)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148080
PNG
(US8962609, DMX-14)
Show SMILES O=C1Cc2cc(Nc3nccc(n3)-c3ccc(N4CCCC4)c(c3)C#N)ccc2N1
Show InChI InChI=1S/C23H20N6O/c24-14-17-11-15(3-6-21(17)29-9-1-2-10-29)20-7-8-25-23(28-20)26-18-4-5-19-16(12-18)13-22(30)27-19/h3-8,11-12H,1-2,9-10,13H2,(H,27,30)(H,25,26,28)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148081
PNG
(US8962609, DMX-15)
Show SMILES CC(=O)Nc1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C22H21N7O/c1-15(30)26-21-7-5-18(14-25-21)27-22-24-9-8-19(28-22)16-4-6-20(17(12-16)13-23)29-10-2-3-11-29/h4-9,12,14H,2-3,10-11H2,1H3,(H,24,27,28)(H,25,26,30)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148082
PNG
(US8962609, DMX-16)
Show SMILES N#Cc1cc(ccc1N1CCCC1)-c1ccnc(Nc2ccc(nc2)N2CCOCC2)n1
Show InChI InChI=1S/C24H25N7O/c25-16-19-15-18(3-5-22(19)30-9-1-2-10-30)21-7-8-26-24(29-21)28-20-4-6-23(27-17-20)31-11-13-32-14-12-31/h3-8,15,17H,1-2,9-14H2,(H,26,28,29)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148083
PNG
(US8962609, DMX-17)
Show SMILES O=C1CCc2ccc(Nc3nccc(n3)-c3ccc(N4CCCC4)c(c3)C#N)cc2N1
Show InChI InChI=1S/C24H22N6O/c25-15-18-13-17(4-7-22(18)30-11-1-2-12-30)20-9-10-26-24(29-20)27-19-6-3-16-5-8-23(31)28-21(16)14-19/h3-4,6-7,9-10,13-14H,1-2,5,8,11-12H2,(H,28,31)(H,26,27,29)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
IKK epsilon/TBK1


(Homo sapiens (Human))
BDBM148085
PNG
(US8962609, DMX-19)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(N3CCCC3)c(c2)C#N)cn1
Show InChI InChI=1S/C25H28N8/c1-31-12-14-33(15-13-31)24-7-5-21(18-28-24)29-25-27-9-8-22(30-25)19-4-6-23(20(16-19)17-26)32-10-2-3-11-32/h4-9,16,18H,2-3,10-15H2,1H3,(H,27,29,30)
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US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
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