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Compile Data Set for Download or QSAR

Found 38 hits from Duphar Research Laboratories   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020174
PNG
(1-Benzofuran-7-yl-4-[5-(4-fluoro-phenyl)-1H-pyrrol...)
Show SMILES Fc1ccc(cc1)-c1ccc(CN2CCN(CC2)c2cccc3ccoc23)[nH]1
Show InChI InChI=1S/C23H22FN3O/c24-19-6-4-17(5-7-19)21-9-8-20(25-21)16-26-11-13-27(14-12-26)22-3-1-2-18-10-15-28-23(18)22/h1-10,15,25H,11-14,16H2
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0.450n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020177
PNG
(1-(3,4-Dihydro-2H-benzo[b][1,4]dioxepin-6-yl)-4-(5...)
Show SMILES C(N1CCN(CC1)c1cccc2OCCCOc12)c1ccc([nH]1)-c1ccccc1
Show InChI InChI=1S/C24H27N3O2/c1-2-6-19(7-3-1)21-11-10-20(25-21)18-26-12-14-27(15-13-26)22-8-4-9-23-24(22)29-17-5-16-28-23/h1-4,6-11,25H,5,12-18H2
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0.680n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020182
PNG
(1-(2-Methoxy-phenyl)-4-(5-phenyl-1H-pyrrol-2-ylmet...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2ccccc2)CC1
Show InChI InChI=1S/C22H25N3O/c1-26-22-10-6-5-9-21(22)25-15-13-24(14-16-25)17-19-11-12-20(23-19)18-7-3-2-4-8-18/h2-12,23H,13-17H2,1H3
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0.760n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019961
PNG
(1-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-ylmethyl]-4-(2-...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H24FN3O/c1-27-22-5-3-2-4-21(22)26-14-12-25(13-15-26)16-19-10-11-20(24-19)17-6-8-18(23)9-7-17/h2-11,24H,12-16H2,1H3
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0.910n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019961
PNG
(1-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-ylmethyl]-4-(2-...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H24FN3O/c1-27-22-5-3-2-4-21(22)26-14-12-25(13-15-26)16-19-10-11-20(24-19)17-6-8-18(23)9-7-17/h2-11,24H,12-16H2,1H3
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0.960n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020185
PNG
(4-(2-Methoxy-phenyl)-1-(5-phenyl-1H-pyrrol-2-ylmet...)
Show SMILES COc1ccccc1C1CCN(Cc2ccc([nH]2)-c2ccccc2)CC1
Show InChI InChI=1S/C23H26N2O/c1-26-23-10-6-5-9-21(23)18-13-15-25(16-14-18)17-20-11-12-22(24-20)19-7-3-2-4-8-19/h2-12,18,24H,13-17H2,1H3
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1n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020173
PNG
(1-[5-(2,6-Difluoro-phenyl)-1H-pyrrol-2-ylmethyl]-4...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2c(F)cccc2F)CC1
Show InChI InChI=1S/C22H23F2N3O/c1-28-21-8-3-2-7-20(21)27-13-11-26(12-14-27)15-16-9-10-19(25-16)22-17(23)5-4-6-18(22)24/h2-10,25H,11-15H2,1H3
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1.10n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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1.40n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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1.40n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019959
PNG
(1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...)
Show SMILES COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H25FN2O2/c1-26-21-7-3-2-5-19(21)24-15-13-23(14-16-24)12-4-6-20(25)17-8-10-18(22)11-9-17/h2-3,5,7-11H,4,6,12-16H2,1H3
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2.40n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019959
PNG
(1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...)
Show SMILES COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H25FN2O2/c1-26-21-7-3-2-5-19(21)24-15-13-23(14-16-24)12-4-6-20(25)17-8-10-18(22)11-9-17/h2-3,5,7-11H,4,6,12-16H2,1H3
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2.90n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019960
PNG
(4-Fluoro-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C20H24FN3O2/c1-26-19-5-3-2-4-18(19)24-14-12-23(13-15-24)11-10-22-20(25)16-6-8-17(21)9-7-16/h2-9H,10-15H2,1H3,(H,22,25)
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4.30n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020191
PNG
(1-[5-(3-Chloro-phenyl)-1H-pyrrol-2-ylmethyl]-4-(2-...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C22H24ClN3O/c1-27-22-8-3-2-7-21(22)26-13-11-25(12-14-26)16-19-9-10-20(24-19)17-5-4-6-18(23)15-17/h2-10,15,24H,11-14,16H2,1H3
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4.40n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019960
PNG
(4-Fluoro-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C20H24FN3O2/c1-26-19-5-3-2-4-18(19)24-14-12-23(13-15-24)11-10-22-20(25)16-6-8-17(21)9-7-16/h2-9H,10-15H2,1H3,(H,22,25)
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5n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020180
PNG
(4-(4-Benzofuran-7-yl-piperazin-1-yl)-1-(4-fluoro-p...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1cccc2ccoc12
Show InChI InChI=1S/C22H23FN2O2/c23-19-8-6-17(7-9-19)21(26)5-2-11-24-12-14-25(15-13-24)20-4-1-3-18-10-16-27-22(18)20/h1,3-4,6-10,16H,2,5,11-15H2
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5.10n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020181
PNG
(1-(2-Methoxy-phenyl)-4-[5-(2-methoxy-phenyl)-1H-py...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2ccccc2OC)CC1
Show InChI InChI=1S/C23H27N3O2/c1-27-22-9-5-3-7-19(22)20-12-11-18(24-20)17-25-13-15-26(16-14-25)21-8-4-6-10-23(21)28-2/h3-12,24H,13-17H2,1-2H3
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6.5n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019956
PNG
(1-[5-(5-Ethanesulfonyl-2-methoxy-phenyl)-1H-pyrrol...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(c1)-c1ccc(CN2CCN(CC2)c2ccccc2OC)[nH]1
Show InChI InChI=1S/C25H31N3O4S/c1-4-33(29,30)20-10-12-24(31-2)21(17-20)22-11-9-19(26-22)18-27-13-15-28(16-14-27)23-7-5-6-8-25(23)32-3/h5-12,17,26H,4,13-16,18H2,1-3H3
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7n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020178
PNG
(CHEMBL294633 | CHEMBL555633 | N-[2-(4-Benzofuran-7...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1cccc2ccoc12
Show InChI InChI=1S/C21H22FN3O2/c22-18-6-4-17(5-7-18)21(26)23-9-10-24-11-13-25(14-12-24)19-3-1-2-16-8-15-27-20(16)19/h1-8,15H,9-14H2,(H,23,26)
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7.10n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019956
PNG
(1-[5-(5-Ethanesulfonyl-2-methoxy-phenyl)-1H-pyrrol...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(c1)-c1ccc(CN2CCN(CC2)c2ccccc2OC)[nH]1
Show InChI InChI=1S/C25H31N3O4S/c1-4-33(29,30)20-10-12-24(31-2)21(17-20)22-11-9-19(26-22)18-27-13-15-28(16-14-27)23-7-5-6-8-25(23)32-3/h5-12,17,26H,4,13-16,18H2,1-3H3
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7.30n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019957
PNG
(5-Ethanesulfonyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)CC
Show InChI InChI=1S/C17H26N2O4S/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20)/t13-/m0/s1
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9.30n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020186
PNG
(1-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-ylmethyl]-4-phe...)
Show SMILES Fc1ccc(cc1)-c1ccc(CN2CCC(CC2)c2ccccc2)[nH]1
Show InChI InChI=1S/C22H23FN2/c23-20-8-6-19(7-9-20)22-11-10-21(24-22)16-25-14-12-18(13-15-25)17-4-2-1-3-5-17/h1-11,18,24H,12-16H2
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11n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020176
PNG
((4-Fluoro-phenyl)-{1-[5-(4-fluoro-phenyl)-1H-pyrro...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H22F2N2O/c24-19-5-1-16(2-6-19)22-10-9-21(26-22)15-27-13-11-18(12-14-27)23(28)17-3-7-20(25)8-4-17/h1-10,18,26H,11-15H2
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12n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020172
PNG
(1-(4-Fluoro-phenyl)-4-[5-(4-fluoro-phenyl)-1H-pyrr...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H21F2N3/c22-17-3-1-16(2-4-17)21-10-7-19(24-21)15-25-11-13-26(14-12-25)20-8-5-18(23)6-9-20/h1-10,24H,11-15H2
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16n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020188
PNG
(1-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-ylmethyl]-4-(3-...)
Show SMILES Fc1ccc(cc1)-c1ccc(CN2CCN(CC2)c2cccc(c2)C(F)(F)F)[nH]1
Show InChI InChI=1S/C22H21F4N3/c23-18-6-4-16(5-7-18)21-9-8-19(27-21)15-28-10-12-29(13-11-28)20-3-1-2-17(14-20)22(24,25)26/h1-9,14,27H,10-13,15H2
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19n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020189
PNG
(1-[5-(4-Fluoro-phenyl)-1-methyl-1H-pyrrol-2-ylmeth...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc(-c3ccc(F)cc3)n2C)CC1
Show InChI InChI=1S/C23H26FN3O/c1-25-20(11-12-21(25)18-7-9-19(24)10-8-18)17-26-13-15-27(16-14-26)22-5-3-4-6-23(22)28-2/h3-12H,13-17H2,1-2H3
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20n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020187
PNG
(1-(2-Methoxy-phenyl)-4-[5-(4-trifluoromethyl-pheny...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2ccc(cc2)C(F)(F)F)CC1
Show InChI InChI=1S/C23H24F3N3O/c1-30-22-5-3-2-4-21(22)29-14-12-28(13-15-29)16-19-10-11-20(27-19)17-6-8-18(9-7-17)23(24,25)26/h2-11,27H,12-16H2,1H3
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25n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50005117
PNG
((racemic)5'-(5-Ethanesulfonyl-2-methoxy-phenyl)-1-...)
Show SMILES CCN1CCCC1c1ccc([nH]1)-c1cc(ccc1OC)S(=O)(=O)CC
Show InChI InChI=1S/C19H26N2O3S/c1-4-21-12-6-7-18(21)17-10-9-16(20-17)15-13-14(25(22,23)5-2)8-11-19(15)24-3/h8-11,13,18,20H,4-7,12H2,1-3H3
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29n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM81774
PNG
(CAS_15676-16-1 | SULPIRIDE,(+) | Sulpiride-S | Sul...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Show InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
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39n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020184
PNG
(2-{2-(4-Fluoro-phenyl)-5-[4-(2-methoxy-phenyl)-pip...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc(-c3ccc(F)cc3)n2CCO)CC1
Show InChI InChI=1S/C24H28FN3O2/c1-30-24-5-3-2-4-23(24)27-14-12-26(13-15-27)18-21-10-11-22(28(21)16-17-29)19-6-8-20(25)9-7-19/h2-11,29H,12-18H2,1H3
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52n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020179
PNG
(1-[5-(4-Isopropyl-phenyl)-1H-pyrrol-2-ylmethyl]-4-...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc([nH]2)-c2ccc(cc2)C(C)C)CC1
Show InChI InChI=1S/C25H31N3O/c1-19(2)20-8-10-21(11-9-20)23-13-12-22(26-23)18-27-14-16-28(17-15-27)24-6-4-5-7-25(24)29-3/h4-13,19,26H,14-18H2,1-3H3
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59n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020183
PNG
(1-[5-(4-Fluoro-phenyl)-1-propyl-1H-pyrrol-2-ylmeth...)
Show SMILES CCCn1c(CN2CCN(CC2)c2ccccc2OC)ccc1-c1ccc(F)cc1
Show InChI InChI=1S/C25H30FN3O/c1-3-14-29-22(12-13-23(29)20-8-10-21(26)11-9-20)19-27-15-17-28(18-16-27)24-6-4-5-7-25(24)30-2/h4-13H,3,14-19H2,1-2H3
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110n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020190
PNG
((4-Fluoro-phenyl)-{4-[5-(4-fluoro-phenyl)-1H-pyrro...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H21F2N3O/c23-18-5-1-16(2-6-18)21-10-9-20(25-21)15-26-11-13-27(14-12-26)22(28)17-3-7-19(24)8-4-17/h1-10,25H,11-15H2
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120n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019963
PNG
(4-(4-Chloro-phenyl)-1-[5-(5-ethanesulfonyl-2-metho...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(c1)-c1ccc(CN2CCC(O)(CC2)c2ccc(Cl)cc2)[nH]1
Show InChI InChI=1S/C25H29ClN2O4S/c1-3-33(30,31)21-9-11-24(32-2)22(16-21)23-10-8-20(27-23)17-28-14-12-25(29,13-15-28)18-4-6-19(26)7-5-18/h4-11,16,27,29H,3,12-15,17H2,1-2H3
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150n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020175
PNG
(1-(1,5-Diphenyl-1H-pyrrol-2-ylmethyl)-4-(2-methoxy...)
Show SMILES COc1ccccc1N1CCN(Cc2ccc(-c3ccccc3)n2-c2ccccc2)CC1
Show InChI InChI=1S/C28H29N3O/c1-32-28-15-9-8-14-27(28)30-20-18-29(19-21-30)22-25-16-17-26(23-10-4-2-5-11-23)31(25)24-12-6-3-7-13-24/h2-17H,18-22H2,1H3
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160n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019962
PNG
(CHEMBL62499 | N-{2-[4-(4-Chloro-phenyl)-4-hydroxy-...)
Show SMILES OC1(CCN(CCNC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClFN2O2/c21-17-5-3-16(4-6-17)20(26)9-12-24(13-10-20)14-11-23-19(25)15-1-7-18(22)8-2-15/h1-8,26H,9-14H2,(H,23,25)
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480n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019958
PNG
(4-(4-Chloro-phenyl)-1-[5-(4-fluoro-phenyl)-1H-pyrr...)
Show SMILES OC1(CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClFN2O/c23-18-5-3-17(4-6-18)22(27)11-13-26(14-12-22)15-20-9-10-21(25-20)16-1-7-19(24)8-2-16/h1-10,25,27H,11-15H2
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1.10E+3n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019958
PNG
(4-(4-Chloro-phenyl)-1-[5-(4-fluoro-phenyl)-1H-pyrr...)
Show SMILES OC1(CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClFN2O/c23-18-5-3-17(4-6-18)22(27)11-13-26(14-12-22)15-20-9-10-21(25-20)16-1-7-19(24)8-2-16/h1-10,25,27H,11-15H2
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1.10E+3n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat


J Med Chem 30: 2099-104 (1987)


Article DOI: 10.1021/jm00394a028
BindingDB Entry DOI: 10.7270/Q2W959R8
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020171
PNG
(2-{4-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-ylmethyl]-pi...)
Show SMILES OCCN1CCN(Cc2ccc([nH]2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C17H22FN3O/c18-15-3-1-14(2-4-15)17-6-5-16(19-17)13-21-9-7-20(8-10-21)11-12-22/h1-6,19,22H,7-13H2
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3.10E+4n/an/an/an/an/an/an/an/a



Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum


J Med Chem 31: 1934-40 (1988)


Article DOI: 10.1021/jm00118a011
BindingDB Entry DOI: 10.7270/Q2SJ1JMB
More data for this
Ligand-Target Pair