BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 28 hits from EGIS Pharmaceuticals Ltd.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119864
PNG
(2-{2-[4-(2-Chloro-benzyl)-piperazin-1-yl]-ethylsul...)
Show SMILES COc1cc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4Cl)CC3)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C27H35ClN6O3S/c1-35-22-15-18(16-23(36-2)24(22)37-3)14-20-25(29)31-27(32-26(20)30)38-13-12-33-8-10-34(11-9-33)17-19-6-4-5-7-21(19)28/h4-7,15-16H,8-14,17H2,1-3H3,(H4,29,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.30n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119871
PNG
(5-(3-Methoxy-benzyl)-2-{2-[4-(3-trifluoromethyl-be...)
Show SMILES COc1cccc(Cc2c(N)nc(SCCN3CCN(Cc4cccc(c4)C(F)(F)F)CC3)nc2N)c1
Show InChI InChI=1S/C26H31F3N6OS/c1-36-21-7-3-4-18(15-21)16-22-23(30)32-25(33-24(22)31)37-13-12-34-8-10-35(11-9-34)17-19-5-2-6-20(14-19)26(27,28)29/h2-7,14-15H,8-13,16-17H2,1H3,(H4,30,31,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.90n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119867
PNG
(5-(2-Methoxy-benzyl)-2-{2-[4-(3-trifluoromethyl-be...)
Show SMILES COc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C26H31F3N6OS/c1-36-22-8-3-2-6-19(22)16-21-23(30)32-25(33-24(21)31)37-14-13-34-9-11-35(12-10-34)17-18-5-4-7-20(15-18)26(27,28)29/h2-8,15H,9-14,16-17H2,1H3,(H4,30,31,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.5n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119875
PNG
(2-(4,6-Diamino-2-{2-[4-(2-chloro-benzyl)-piperazin...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1O
Show InChI InChI=1S/C24H29ClN6OS/c25-20-7-3-1-6-18(20)16-31-11-9-30(10-12-31)13-14-33-24-28-22(26)19(23(27)29-24)15-17-5-2-4-8-21(17)32/h1-8,32H,9-16H2,(H4,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.5n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119870
PNG
(2-{2-[4-(2-Chloro-benzyl)-piperazin-1-yl]-ethylsul...)
Show SMILES COc1ccc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4Cl)CC3)nc2N)cc1
Show InChI InChI=1S/C25H31ClN6OS/c1-33-20-8-6-18(7-9-20)16-21-23(27)29-25(30-24(21)28)34-15-14-31-10-12-32(13-11-31)17-19-4-2-3-5-22(19)26/h2-9H,10-17H2,1H3,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.70n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119873
PNG
(2-(4,6-Diamino-2-{2-[4-(3-trifluoromethyl-benzyl)-...)
Show SMILES Nc1nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc(N)c1Cc1ccccc1O
Show InChI InChI=1S/C25H29F3N6OS/c26-25(27,28)19-6-3-4-17(14-19)16-34-10-8-33(9-11-34)12-13-36-24-31-22(29)20(23(30)32-24)15-18-5-1-2-7-21(18)35/h1-7,14,35H,8-13,15-16H2,(H4,29,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.20n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119874
PNG
(5-(2-Methoxy-benzyl)-2-{2-[4-(2-trifluoromethyl-be...)
Show SMILES COc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3ccccc3C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C26H31F3N6OS/c1-36-22-9-5-3-6-18(22)16-20-23(30)32-25(33-24(20)31)37-15-14-34-10-12-35(13-11-34)17-19-7-2-4-8-21(19)26(27,28)29/h2-9H,10-17H2,1H3,(H4,30,31,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.70n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119866
PNG
(5-(2-Isopropoxy-benzyl)-2-{2-[4-(3-trifluoromethyl...)
Show SMILES CC(C)Oc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C28H35F3N6OS/c1-19(2)38-24-9-4-3-7-21(24)17-23-25(32)34-27(35-26(23)33)39-15-14-36-10-12-37(13-11-36)18-20-6-5-8-22(16-20)28(29,30)31/h3-9,16,19H,10-15,17-18H2,1-2H3,(H4,32,33,34,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
8.60n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119863
PNG
(5-(2-Chloro-benzyl)-2-{2-[4-(2-chloro-benzyl)-pipe...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1Cl
Show InChI InChI=1S/C24H28Cl2N6S/c25-20-7-3-1-5-17(20)15-19-22(27)29-24(30-23(19)28)33-14-13-31-9-11-32(12-10-31)16-18-6-2-4-8-21(18)26/h1-8H,9-16H2,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
8.70n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119865
PNG
(5-(2-Ethoxy-benzyl)-2-{2-[4-(3-trifluoromethyl-ben...)
Show SMILES CCOc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C27H33F3N6OS/c1-2-37-23-9-4-3-7-20(23)17-22-24(31)33-26(34-25(22)32)38-15-14-35-10-12-36(13-11-35)18-19-6-5-8-21(16-19)27(28,29)30/h3-9,16H,2,10-15,17-18H2,1H3,(H4,31,32,33,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.10n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119870
PNG
(2-{2-[4-(2-Chloro-benzyl)-piperazin-1-yl]-ethylsul...)
Show SMILES COc1ccc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4Cl)CC3)nc2N)cc1
Show InChI InChI=1S/C25H31ClN6OS/c1-33-20-8-6-18(7-9-20)16-21-23(27)29-25(30-24(21)28)34-15-14-31-10-12-32(13-11-31)17-19-4-2-3-5-22(19)26/h2-9H,10-17H2,1H3,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119869
PNG
(5-Benzyl-2-{2-[4-(2-chloro-benzyl)-piperazin-1-yl]...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1
Show InChI InChI=1S/C24H29ClN6S/c25-21-9-5-4-8-19(21)17-31-12-10-30(11-13-31)14-15-32-24-28-22(26)20(23(27)29-24)16-18-6-2-1-3-7-18/h1-9H,10-17H2,(H4,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119868
PNG
(5-(4-Methoxy-benzyl)-2-{2-[4-(2-methyl-benzyl)-pip...)
Show SMILES COc1ccc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4C)CC3)nc2N)cc1
Show InChI InChI=1S/C26H34N6OS/c1-19-5-3-4-6-21(19)18-32-13-11-31(12-14-32)15-16-34-26-29-24(27)23(25(28)30-26)17-20-7-9-22(33-2)10-8-20/h3-10H,11-18H2,1-2H3,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119863
PNG
(5-(2-Chloro-benzyl)-2-{2-[4-(2-chloro-benzyl)-pipe...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1Cl
Show InChI InChI=1S/C24H28Cl2N6S/c25-20-7-3-1-5-17(20)15-19-22(27)29-24(30-23(19)28)33-14-13-31-9-11-32(12-10-31)16-18-6-2-4-8-21(18)26/h1-8H,9-16H2,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119862
PNG
(5-(4-Methoxy-benzyl)-2-{2-[4-(4-methyl-benzyl)-pip...)
Show SMILES COc1ccc(Cc2c(N)nc(SCCN3CCN(Cc4ccc(C)cc4)CC3)nc2N)cc1
Show InChI InChI=1S/C26H34N6OS/c1-19-3-5-21(6-4-19)18-32-13-11-31(12-14-32)15-16-34-26-29-24(27)23(25(28)30-26)17-20-7-9-22(33-2)10-8-20/h3-10H,11-18H2,1-2H3,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
13n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119868
PNG
(5-(4-Methoxy-benzyl)-2-{2-[4-(2-methyl-benzyl)-pip...)
Show SMILES COc1ccc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4C)CC3)nc2N)cc1
Show InChI InChI=1S/C26H34N6OS/c1-19-5-3-4-6-21(19)18-32-13-11-31(12-14-32)15-16-34-26-29-24(27)23(25(28)30-26)17-20-7-9-22(33-2)10-8-20/h3-10H,11-18H2,1-2H3,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
16n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119864
PNG
(2-{2-[4-(2-Chloro-benzyl)-piperazin-1-yl]-ethylsul...)
Show SMILES COc1cc(Cc2c(N)nc(SCCN3CCN(Cc4ccccc4Cl)CC3)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C27H35ClN6O3S/c1-35-22-15-18(16-23(36-2)24(22)37-3)14-20-25(29)31-27(32-26(20)30)38-13-12-33-8-10-34(11-9-33)17-19-6-4-5-7-21(19)28/h4-7,15-16H,8-14,17H2,1-3H3,(H4,29,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
18n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119869
PNG
(5-Benzyl-2-{2-[4-(2-chloro-benzyl)-piperazin-1-yl]...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1
Show InChI InChI=1S/C24H29ClN6S/c25-21-9-5-4-8-19(21)17-31-12-10-30(11-13-31)14-15-32-24-28-22(26)20(23(27)29-24)16-18-6-2-1-3-7-18/h1-9H,10-17H2,(H4,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
18n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119872
PNG
(5-Benzyl-2-{2-[4-(2-trifluoromethyl-benzyl)-pipera...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3C(F)(F)F)CC2)nc(N)c1Cc1ccccc1
Show InChI InChI=1S/C25H29F3N6S/c26-25(27,28)21-9-5-4-8-19(21)17-34-12-10-33(11-13-34)14-15-35-24-31-22(29)20(23(30)32-24)16-18-6-2-1-3-7-18/h1-9H,10-17H2,(H4,29,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
21n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119875
PNG
(2-(4,6-Diamino-2-{2-[4-(2-chloro-benzyl)-piperazin...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3Cl)CC2)nc(N)c1Cc1ccccc1O
Show InChI InChI=1S/C24H29ClN6OS/c25-20-7-3-1-6-18(20)16-31-11-9-30(10-12-31)13-14-33-24-28-22(26)19(23(27)29-24)15-17-5-2-4-8-21(17)32/h1-8,32H,9-16H2,(H4,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119871
PNG
(5-(3-Methoxy-benzyl)-2-{2-[4-(3-trifluoromethyl-be...)
Show SMILES COc1cccc(Cc2c(N)nc(SCCN3CCN(Cc4cccc(c4)C(F)(F)F)CC3)nc2N)c1
Show InChI InChI=1S/C26H31F3N6OS/c1-36-21-7-3-4-18(15-21)16-22-23(30)32-25(33-24(22)31)37-13-12-34-8-10-35(11-9-34)17-19-5-2-6-20(14-19)26(27,28)29/h2-7,14-15H,8-13,16-17H2,1H3,(H4,30,31,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
45n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119874
PNG
(5-(2-Methoxy-benzyl)-2-{2-[4-(2-trifluoromethyl-be...)
Show SMILES COc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3ccccc3C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C26H31F3N6OS/c1-36-22-9-5-3-6-18(22)16-20-23(30)32-25(33-24(20)31)37-15-14-34-10-12-35(13-11-34)17-19-7-2-4-8-21(19)26(27,28)29/h2-9H,10-17H2,1H3,(H4,30,31,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
48n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119867
PNG
(5-(2-Methoxy-benzyl)-2-{2-[4-(3-trifluoromethyl-be...)
Show SMILES COc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C26H31F3N6OS/c1-36-22-8-3-2-6-19(22)16-21-23(30)32-25(33-24(21)31)37-14-13-34-9-11-35(12-10-34)17-18-5-4-7-20(15-18)26(27,28)29/h2-8,15H,9-14,16-17H2,1H3,(H4,30,31,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
60n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119872
PNG
(5-Benzyl-2-{2-[4-(2-trifluoromethyl-benzyl)-pipera...)
Show SMILES Nc1nc(SCCN2CCN(Cc3ccccc3C(F)(F)F)CC2)nc(N)c1Cc1ccccc1
Show InChI InChI=1S/C25H29F3N6S/c26-25(27,28)21-9-5-4-8-19(21)17-34-12-10-33(11-13-34)14-15-35-24-31-22(29)20(23(30)32-24)16-18-6-2-1-3-7-18/h1-9H,10-17H2,(H4,29,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
61n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119865
PNG
(5-(2-Ethoxy-benzyl)-2-{2-[4-(3-trifluoromethyl-ben...)
Show SMILES CCOc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C27H33F3N6OS/c1-2-37-23-9-4-3-7-20(23)17-22-24(31)33-26(34-25(22)32)38-15-14-35-10-12-36(13-11-35)18-19-6-5-8-21(16-19)27(28,29)30/h3-9,16H,2,10-15,17-18H2,1H3,(H4,31,32,33,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
70n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119873
PNG
(2-(4,6-Diamino-2-{2-[4-(3-trifluoromethyl-benzyl)-...)
Show SMILES Nc1nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc(N)c1Cc1ccccc1O
Show InChI InChI=1S/C25H29F3N6OS/c26-25(27,28)19-6-3-4-17(14-19)16-34-10-8-33(9-11-34)12-13-36-24-31-22(29)20(23(30)32-24)15-18-5-1-2-7-21(18)35/h1-7,14,35H,8-13,15-16H2,(H4,29,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
93n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50119866
PNG
(5-(2-Isopropoxy-benzyl)-2-{2-[4-(3-trifluoromethyl...)
Show SMILES CC(C)Oc1ccccc1Cc1c(N)nc(SCCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)nc1N
Show InChI InChI=1S/C28H35F3N6OS/c1-19(2)38-24-9-4-3-7-21(24)17-23-25(32)34-27(35-26(23)33)39-15-14-36-10-12-37(13-11-36)18-20-6-5-8-22(16-20)28(29,30)31/h3-9,16,19H,10-15,17-18H2,1-2H3,(H4,32,33,34,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
121n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50119862
PNG
(5-(4-Methoxy-benzyl)-2-{2-[4-(4-methyl-benzyl)-pip...)
Show SMILES COc1ccc(Cc2c(N)nc(SCCN3CCN(Cc4ccc(C)cc4)CC3)nc2N)cc1
Show InChI InChI=1S/C26H34N6OS/c1-19-3-5-21(6-4-19)18-32-13-11-31(12-14-32)15-16-34-26-29-24(27)23(25(28)30-26)17-20-7-9-22(33-2)10-8-20/h3-10H,11-18H2,1-2H3,(H4,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
300n/an/an/an/an/an/an/an/a



EGIS Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Affinity for 5-hydroxytryptamine 2C receptor


Bioorg Med Chem Lett 12: 3097-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00660-1
BindingDB Entry DOI: 10.7270/Q2PC31QK
More data for this
Ligand-Target Pair