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Compile Data Set for Download or QSAR

Found 67 hits from EMD Serono Research Institute   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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0.330n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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0.790n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213980
PNG
(4-(2-((R)-2-((S)-3-hydroxyhept-1-enyl)-5-oxopyrrol...)
Show SMILES CCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H27NO4/c1-2-3-4-18(22)11-9-17-10-12-19(23)21(17)14-13-15-5-7-16(8-6-15)20(24)25/h5-9,11,17-18,22H,2-4,10,12-14H2,1H3,(H,24,25)/b11-9+/t17-,18-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213978
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7-/t20-/m0/s1
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4n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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4.90n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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9.10n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213977
PNG
(4-(2-((R)-2-(4-methylhexa-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CC\C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H25NO3/c1-3-15(2)5-4-6-18-11-12-19(22)21(18)14-13-16-7-9-17(10-8-16)20(23)24/h4-10,18H,3,11-14H2,1-2H3,(H,23,24)/b6-4+,15-5-/t18-/m0/s1
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24n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213981
PNG
(4-(2-((R)-2-(octa-1,3-dienyl)-5-oxopyrrolidin-1-yl...)
Show SMILES CCCC\C=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H27NO3/c1-2-3-4-5-6-7-8-19-13-14-20(23)22(19)16-15-17-9-11-18(12-10-17)21(24)25/h5-12,19H,2-4,13-16H2,1H3,(H,24,25)/b6-5-,8-7+/t19-/m0/s1
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25n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213974
PNG
(4-(2-((R)-2-oxo-5-(4-phenylpenta-1,3-dienyl)pyrrol...)
Show SMILES C\C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-18(20-7-3-2-4-8-20)6-5-9-22-14-15-23(26)25(22)17-16-19-10-12-21(13-11-19)24(27)28/h2-13,22H,14-17H2,1H3,(H,27,28)/b9-5+,18-6+/t22-/m0/s1
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29n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213979
PNG
(4-(2-((R)-2-(3-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C=C(/C)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-5-6-17(2)7-12-20-13-14-21(24)23(20)16-15-18-8-10-19(11-9-18)22(25)26/h6-12,20H,3-5,13-16H2,1-2H3,(H,25,26)/b12-7+,17-6+/t20-/m0/s1
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29n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213976
PNG
((R)-4-(2-(2-(4-methylpenta-1,3-dienyl)-5-oxopyrrol...)
Show SMILES CC(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C19H23NO3/c1-14(2)4-3-5-17-10-11-18(21)20(17)13-12-15-6-8-16(9-7-15)19(22)23/h3-9,17H,10-13H2,1-2H3,(H,22,23)/b5-3+/t17-/m0/s1
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45n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213983
PNG
(4-(2-((R)-2-(4-(cyclopentylmethyl)penta-1,3-dienyl...)
Show SMILES C\C(CC1CCCC1)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H31NO3/c1-18(17-20-6-2-3-7-20)5-4-8-22-13-14-23(26)25(22)16-15-19-9-11-21(12-10-19)24(27)28/h4-5,8-12,20,22H,2-3,6-7,13-17H2,1H3,(H,27,28)/b8-4+,18-5-/t22-/m0/s1
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60n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213978
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7-/t20-/m0/s1
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60n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213981
PNG
(4-(2-((R)-2-(octa-1,3-dienyl)-5-oxopyrrolidin-1-yl...)
Show SMILES CCCC\C=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H27NO3/c1-2-3-4-5-6-7-8-19-13-14-20(23)22(19)16-15-17-9-11-18(12-10-17)21(24)25/h5-12,19H,2-4,13-16H2,1H3,(H,24,25)/b6-5-,8-7+/t19-/m0/s1
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88n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213983
PNG
(4-(2-((R)-2-(4-(cyclopentylmethyl)penta-1,3-dienyl...)
Show SMILES C\C(CC1CCCC1)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H31NO3/c1-18(17-20-6-2-3-7-20)5-4-8-22-13-14-23(26)25(22)16-15-19-9-11-21(12-10-19)24(27)28/h4-5,8-12,20,22H,2-3,6-7,13-17H2,1H3,(H,27,28)/b8-4+,18-5-/t22-/m0/s1
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117n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213980
PNG
(4-(2-((R)-2-((S)-3-hydroxyhept-1-enyl)-5-oxopyrrol...)
Show SMILES CCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H27NO4/c1-2-3-4-18(22)11-9-17-10-12-19(23)21(17)14-13-15-5-7-16(8-6-15)20(24)25/h5-9,11,17-18,22H,2-4,10,12-14H2,1H3,(H,24,25)/b11-9+/t17-,18-/m0/s1
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126n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213975
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7+/t20-/m0/s1
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134n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213979
PNG
(4-(2-((R)-2-(3-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C=C(/C)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-5-6-17(2)7-12-20-13-14-21(24)23(20)16-15-18-8-10-19(11-9-18)22(25)26/h6-12,20H,3-5,13-16H2,1-2H3,(H,25,26)/b12-7+,17-6+/t20-/m0/s1
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145n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213977
PNG
(4-(2-((R)-2-(4-methylhexa-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CC\C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H25NO3/c1-3-15(2)5-4-6-18-11-12-19(22)21(18)14-13-16-7-9-17(10-8-16)20(23)24/h4-10,18H,3,11-14H2,1-2H3,(H,23,24)/b6-4+,15-5-/t18-/m0/s1
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173n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50213975
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7+/t20-/m0/s1
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181n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50411582
PNG
(CHEMBL2096894)
Show SMILES CCCC\C=C(/C)\C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-5-6-17(2)7-12-20-13-14-21(24)23(20)16-15-18-8-10-19(11-9-18)22(25)26/h6-12,20H,3-5,13-16H2,1-2H3,(H,25,26)/b12-7-,17-6+/t20-/m0/s1
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443n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213974
PNG
(4-(2-((R)-2-oxo-5-(4-phenylpenta-1,3-dienyl)pyrrol...)
Show SMILES C\C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-18(20-7-3-2-4-8-20)6-5-9-22-14-15-23(26)25(22)17-16-19-10-12-21(13-11-19)24(27)28/h2-13,22H,14-17H2,1H3,(H,27,28)/b9-5+,18-6+/t22-/m0/s1
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749n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50411582
PNG
(CHEMBL2096894)
Show SMILES CCCC\C=C(/C)\C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-5-6-17(2)7-12-20-13-14-21(24)23(20)16-15-18-8-10-19(11-9-18)22(25)26/h6-12,20H,3-5,13-16H2,1-2H3,(H,25,26)/b12-7-,17-6+/t20-/m0/s1
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802n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50213976
PNG
((R)-4-(2-(2-(4-methylpenta-1,3-dienyl)-5-oxopyrrol...)
Show SMILES CC(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C19H23NO3/c1-14(2)4-3-5-17-10-11-18(21)20(17)13-12-15-6-8-16(9-7-15)19(22)23/h3-9,17H,10-13H2,1-2H3,(H,22,23)/b5-3+/t17-/m0/s1
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PubMed
1.85E+3n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50213980
PNG
(4-(2-((R)-2-((S)-3-hydroxyhept-1-enyl)-5-oxopyrrol...)
Show SMILES CCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H27NO4/c1-2-3-4-18(22)11-9-17-10-12-19(23)21(17)14-13-15-5-7-16(8-6-15)20(24)25/h5-9,11,17-18,22H,2-4,10,12-14H2,1H3,(H,24,25)/b11-9+/t17-,18-/m0/s1
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9.00E+3n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50213980
PNG
(4-(2-((R)-2-((S)-3-hydroxyhept-1-enyl)-5-oxopyrrol...)
Show SMILES CCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H27NO4/c1-2-3-4-18(22)11-9-17-10-12-19(23)21(17)14-13-15-5-7-16(8-6-15)20(24)25/h5-9,11,17-18,22H,2-4,10,12-14H2,1H3,(H,24,25)/b11-9+/t17-,18-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50213978
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7-/t20-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50213978
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7-/t20-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50213975
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7+/t20-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1)


(Homo sapiens (Human))
BDBM50213975
PNG
(4-(2-((R)-2-(4-methylocta-1,3-dienyl)-5-oxopyrroli...)
Show SMILES CCCC\C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H29NO3/c1-3-4-6-17(2)7-5-8-20-13-14-21(24)23(20)16-15-18-9-11-19(12-10-18)22(25)26/h5,7-12,20H,3-4,6,13-16H2,1-2H3,(H,25,26)/b8-5+,17-7+/t20-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 17: 4323-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.025
BindingDB Entry DOI: 10.7270/Q2RF5VVC
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012099
PNG
(CHEMBL3263660)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccoc1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C30H35N5O4/c1-22-6-2-3-7-26(22)33-15-17-34(18-16-33)27-10-9-23(20-25(27)32-30(38)24-11-19-39-21-24)29(37)31-12-5-14-35-13-4-8-28(35)36/h2-3,6-7,9-11,19-21H,4-5,8,12-18H2,1H3,(H,31,37)(H,32,38)
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n/an/an/an/a 4.94E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012100
PNG
(CHEMBL3263661)
Show SMILES CN(C(=O)c1ccco1)c1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H37N5O4/c1-23-8-3-4-9-25(23)34-17-19-35(20-18-34)26-13-12-24(22-27(26)33(2)31(39)28-10-6-21-40-28)30(38)32-14-7-16-36-15-5-11-29(36)37/h3-4,6,8-10,12-13,21-22H,5,7,11,14-20H2,1-2H3,(H,32,38)
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n/an/an/an/a 8.82E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012101
PNG
(CHEMBL3263663)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H37N5O4/c1-22-7-3-4-8-26(22)34-17-19-35(20-18-34)27-12-11-24(21-25(27)33-31(39)28-13-10-23(2)40-28)30(38)32-14-6-16-36-15-5-9-29(36)37/h3-4,7-8,10-13,21H,5-6,9,14-20H2,1-2H3,(H,32,38)(H,33,39)
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n/an/an/an/a 1.29E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012102
PNG
(CHEMBL3263664)
Show SMILES Cc1ccoc1C(=O)Nc1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H37N5O4/c1-22-7-3-4-8-26(22)34-16-18-35(19-17-34)27-11-10-24(21-25(27)33-31(39)29-23(2)12-20-40-29)30(38)32-13-6-15-36-14-5-9-28(36)37/h3-4,7-8,10-12,20-21H,5-6,9,13-19H2,1-2H3,(H,32,38)(H,33,39)
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n/an/an/an/a 5.08E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012103
PNG
(CHEMBL3263665)
Show SMILES CN(C(=O)c1ccc[nH]1)c1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H38N6O3/c1-23-8-3-4-10-26(23)35-18-20-36(21-19-35)27-13-12-24(22-28(27)34(2)31(40)25-9-5-14-32-25)30(39)33-15-7-17-37-16-6-11-29(37)38/h3-5,8-10,12-14,22,32H,6-7,11,15-21H2,1-2H3,(H,33,39)
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n/an/an/an/a 4.90E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012104
PNG
(CHEMBL3263666)
Show SMILES Cc1nc(co1)C(=O)Nc1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C30H36N6O4/c1-21-7-3-4-8-26(21)34-15-17-35(18-16-34)27-11-10-23(19-24(27)33-30(39)25-20-40-22(2)32-25)29(38)31-12-6-14-36-13-5-9-28(36)37/h3-4,7-8,10-11,19-20H,5-6,9,12-18H2,1-2H3,(H,31,38)(H,33,39)
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n/an/an/an/a 2.50E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012105
PNG
(CHEMBL3263667)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O4/c1-22-6-2-3-7-27(22)36-16-18-37(19-17-36)28-12-11-24(30(40)33-13-5-15-38-14-4-8-29(38)39)20-25(28)34-31(41)26-21-42-32(35-26)23-9-10-23/h2-3,6-7,11-12,20-21,23H,4-5,8-10,13-19H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a 9.90E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012106
PNG
(CHEMBL3263668)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1csc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O3S/c1-22-6-2-3-7-27(22)36-16-18-37(19-17-36)28-12-11-24(30(40)33-13-5-15-38-14-4-8-29(38)39)20-25(28)34-31(41)26-21-42-32(35-26)23-9-10-23/h2-3,6-7,11-12,20-21,23H,4-5,8-10,13-19H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a 1.84E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012107
PNG
(CHEMBL3263669)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C29H37N5O3/c1-21-6-2-3-7-25(21)32-16-18-33(19-17-32)26-12-11-23(20-24(26)31-29(37)22-9-10-22)28(36)30-13-5-15-34-14-4-8-27(34)35/h2-3,6-7,11-12,20,22H,4-5,8-10,13-19H2,1H3,(H,30,36)(H,31,37)
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n/an/an/an/a 1.99E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012108
PNG
(CHEMBL3263670)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccccc1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H37N5O3/c1-24-9-5-6-12-28(24)35-19-21-36(22-20-35)29-15-14-26(23-27(29)34-32(40)25-10-3-2-4-11-25)31(39)33-16-8-18-37-17-7-13-30(37)38/h2-6,9-12,14-15,23H,7-8,13,16-22H2,1H3,(H,33,39)(H,34,40)
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n/an/an/an/a 5.54E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012109
PNG
(CHEMBL3263671)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccccn1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H36N6O3/c1-23-8-2-3-10-27(23)35-18-20-36(21-19-35)28-13-12-24(22-26(28)34-31(40)25-9-4-5-14-32-25)30(39)33-15-7-17-37-16-6-11-29(37)38/h2-5,8-10,12-14,22H,6-7,11,15-21H2,1H3,(H,33,39)(H,34,40)
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n/an/an/an/a 1.85E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012110
PNG
(CHEMBL3263674)
Show SMILES FC(F)(F)c1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H35F3N6O4/c33-32(34,35)23-5-1-2-6-26(23)39-15-17-40(18-16-39)27-11-10-22(29(43)36-12-4-14-41-13-3-7-28(41)42)19-24(27)37-30(44)25-20-45-31(38-25)21-8-9-21/h1-2,5-6,10-11,19-21H,3-4,7-9,12-18H2,(H,36,43)(H,37,44)
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n/an/an/an/a 1.00E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012111
PNG
(CHEMBL3263676)
Show SMILES Cc1cccc(c1)N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O4/c1-22-5-2-6-25(19-22)36-15-17-37(18-16-36)28-11-10-24(30(40)33-12-4-14-38-13-3-7-29(38)39)20-26(28)34-31(41)27-21-42-32(35-27)23-8-9-23/h2,5-6,10-11,19-21,23H,3-4,7-9,12-18H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a 1.44E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012112
PNG
(CHEMBL3263683)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCN1CCCC1=O
Show InChI InChI=1S/C29H33N5O4/c1-21-6-2-3-7-24(21)32-15-17-33(18-16-32)25-11-10-22(20-23(25)31-29(37)26-8-5-19-38-26)28(36)30-12-14-34-13-4-9-27(34)35/h2-3,5-8,10-11,19-20H,4,9,12-18H2,1H3,(H,30,36)(H,31,37)
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n/an/an/an/a 3.00E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012113
PNG
(CHEMBL3263684)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCN
Show InChI InChI=1S/C25H29N5O3/c1-18-5-2-3-6-21(18)29-12-14-30(15-13-29)22-9-8-19(24(31)27-11-10-26)17-20(22)28-25(32)23-7-4-16-33-23/h2-9,16-17H,10-15,26H2,1H3,(H,27,31)(H,28,32)
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n/an/an/an/a 1.85E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012114
PNG
(CHEMBL3263685)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCc1cccc(c1)C(N)=O
Show InChI InChI=1S/C31H31N5O4/c1-21-6-2-3-9-26(21)35-13-15-36(16-14-35)27-12-11-24(19-25(27)34-31(39)28-10-5-17-40-28)30(38)33-20-22-7-4-8-23(18-22)29(32)37/h2-12,17-19H,13-16,20H2,1H3,(H2,32,37)(H,33,38)(H,34,39)
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n/an/an/an/a 4.60E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012115
PNG
(CHEMBL3263686)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCC1CCCC1
Show InChI InChI=1S/C30H36N4O3/c1-22-7-2-5-10-26(22)33-16-18-34(19-17-33)27-13-12-24(29(35)31-15-14-23-8-3-4-9-23)21-25(27)32-30(36)28-11-6-20-37-28/h2,5-7,10-13,20-21,23H,3-4,8-9,14-19H2,1H3,(H,31,35)(H,32,36)
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n/an/an/an/a 1.29E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012116
PNG
(CHEMBL3263687)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCC1CCOC1
Show InChI InChI=1S/C30H36N4O4/c1-22-6-2-3-8-26(22)33-14-16-34(17-15-33)27-11-10-24(20-25(27)32-30(36)28-9-5-18-38-28)29(35)31-13-4-7-23-12-19-37-21-23/h2-3,5-6,8-11,18,20,23H,4,7,12-17,19,21H2,1H3,(H,31,35)(H,32,36)
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n/an/an/an/a 8.80E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012117
PNG
(CHEMBL3263688)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCc1ccncc1
Show InChI InChI=1S/C33H36N6O3/c1-23-5-2-3-7-29(23)38-17-19-39(20-18-38)30-11-10-26(31(40)35-14-4-6-24-12-15-34-16-13-24)21-27(30)36-32(41)28-22-42-33(37-28)25-8-9-25/h2-3,5,7,10-13,15-16,21-22,25H,4,6,8-9,14,17-20H2,1H3,(H,35,40)(H,36,41)
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n/an/an/an/a 1.53E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012118
PNG
(CHEMBL3263689)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCN1CCOC1=O
Show InChI InChI=1S/C29H33N5O5/c1-21-6-2-3-7-24(21)32-13-15-33(16-14-32)25-10-9-22(20-23(25)31-28(36)26-8-4-18-38-26)27(35)30-11-5-12-34-17-19-39-29(34)37/h2-4,6-10,18,20H,5,11-17,19H2,1H3,(H,30,35)(H,31,36)
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n/an/an/an/a 2.80E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...


Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
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