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Compile Data Set for Download or QSAR

Found 87 hits from Eberhard Karls University of Tuebingen   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM13336
PNG
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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n/an/a 45n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376645
PNG
(CHEMBL263648)
Show SMILES CC(=O)n1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H11FN2O3/c1-10(20)19-15(12-6-8-18-9-7-12)14(16(21)22-19)11-2-4-13(17)5-3-11/h2-9H,1H3
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n/an/a 120n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376644
PNG
(CHEMBL411094)
Show SMILES CCNC(=O)n1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H14FN3O3/c1-2-20-17(23)21-15(12-7-9-19-10-8-12)14(16(22)24-21)11-3-5-13(18)6-4-11/h3-10H,2H2,1H3,(H,20,23)
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n/an/a 230n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376643
PNG
(CHEMBL260837)
Show SMILES Fc1ccc(NC(=O)n2oc(=O)c(c2-c2ccncc2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H13F2N3O3/c22-15-3-1-13(2-4-15)18-19(14-9-11-24-12-10-14)26(29-20(18)27)21(28)25-17-7-5-16(23)6-8-17/h1-12H,(H,25,28)
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n/an/a 320n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376642
PNG
(CHEMBL411093)
Show SMILES Fc1ccc(NC(=S)n2oc(=O)c(c2-c2ccncc2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H13F2N3O2S/c22-15-3-1-13(2-4-15)18-19(14-9-11-24-12-10-14)26(28-20(18)27)21(29)25-17-7-5-16(23)6-8-17/h1-12H,(H,25,29)
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n/an/a 350n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376639
PNG
(CHEMBL260137)
Show SMILES Fc1ccc(cc1)-c1c([nH]oc1=O)-c1ccncc1
Show InChI InChI=1S/C14H9FN2O2/c15-11-3-1-9(2-4-11)12-13(17-19-14(12)18)10-5-7-16-8-6-10/h1-8,17H
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n/an/a 390n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376646
PNG
(CHEMBL408196)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H15FN2O4S/c1-14-2-8-18(9-3-14)29(26,27)24-20(16-10-12-23-13-11-16)19(21(25)28-24)15-4-6-17(22)7-5-15/h2-13H,1H3
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n/an/a 480n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376655
PNG
(CHEMBL263647)
Show SMILES CSc1nc(c(-c2ccncc2)n1CCCO)-c1ccc(F)cc1
Show InChI InChI=1S/C18H18FN3OS/c1-24-18-21-16(13-3-5-15(19)6-4-13)17(22(18)11-2-12-23)14-7-9-20-10-8-14/h3-10,23H,2,11-12H2,1H3
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n/an/a 813n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376641
PNG
(CHEMBL261287)
Show SMILES CCOC(=O)CCNC(=O)n1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN3O5/c1-2-28-16(25)9-12-23-20(27)24-18(14-7-10-22-11-8-14)17(19(26)29-24)13-3-5-15(21)6-4-13/h3-8,10-11H,2,9,12H2,1H3,(H,23,27)
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n/an/a 970n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376648
PNG
(CHEMBL407001)
Show SMILES OCCCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O3/c18-14-4-2-12(3-5-14)15-16(13-6-8-19-9-7-13)20(10-1-11-21)23-17(15)22/h2-9,21H,1,10-11H2
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n/an/a 1.15E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376648
PNG
(CHEMBL407001)
Show SMILES OCCCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O3/c18-14-4-2-12(3-5-14)15-16(13-6-8-19-9-7-13)20(10-1-11-21)23-17(15)22/h2-9,21H,1,10-11H2
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n/an/a 1.15E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376651
PNG
(CHEMBL259637)
Show SMILES CCOCCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H17FN2O3/c1-2-23-12-11-21-17(14-7-9-20-10-8-14)16(18(22)24-21)13-3-5-15(19)6-4-13/h3-10H,2,11-12H2,1H3
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n/an/a 1.32E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376640
PNG
(CHEMBL261080)
Show SMILES Fc1ccc(cc1)-c1[nH]oc(=O)c1-c1ccncc1
Show InChI InChI=1S/C14H9FN2O2/c15-11-3-1-10(2-4-11)13-12(14(18)19-17-13)9-5-7-16-8-6-9/h1-8,17H
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n/an/a 1.40E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376638
PNG
(CHEMBL411134)
Show SMILES CCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H13FN2O2/c1-2-19-15(12-7-9-18-10-8-12)14(16(20)21-19)11-3-5-13(17)6-4-11/h3-10H,2H2,1H3
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n/an/a 1.63E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 1.64E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376652
PNG
(CHEMBL414666)
Show SMILES COCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H13FN2O3/c1-21-10-19-15(12-6-8-18-9-7-12)14(16(20)22-19)11-2-4-13(17)5-3-11/h2-9H,10H2,1H3
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n/an/a 2.13E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376654
PNG
(CHEMBL264178)
Show SMILES Fc1ccc(cc1)-c1c(-c2ccncc2)n(CC2CC2)oc1=O
Show InChI InChI=1S/C18H15FN2O2/c19-15-5-3-13(4-6-15)16-17(14-7-9-20-10-8-14)21(23-18(16)22)11-12-1-2-12/h3-10,12H,1-2,11H2
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n/an/a 2.13E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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n/an/a 2.20E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM84980
PNG
((-) EPIGALLOCATECHIN GALLATE)
Show SMILES Oc1cc(O)c2CC(OC(=O)c3ccc(O)c(O)c3O)C(Oc2c1)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C22H18O11/c23-9-5-13(25)11-7-17(33-22(31)10-1-2-12(24)20(30)18(10)28)21(32-16(11)6-9)8-3-14(26)19(29)15(27)4-8/h1-6,17,21,23-30H,7H2
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n/an/a 2.21E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 2.24E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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n/an/a 2.30E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 2.31E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM84980
PNG
((-) EPIGALLOCATECHIN GALLATE)
Show SMILES Oc1cc(O)c2CC(OC(=O)c3ccc(O)c(O)c3O)C(Oc2c1)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C22H18O11/c23-9-5-13(25)11-7-17(33-22(31)10-1-2-12(24)20(30)18(10)28)21(32-16(11)6-9)8-3-14(26)19(29)15(27)4-8/h1-6,17,21,23-30H,7H2
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n/an/a 2.35E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50241242
PNG
(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/a 2.45E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376649
PNG
(CHEMBL411727)
Show SMILES OCCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H13FN2O3/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)19(9-10-20)22-16(14)21/h1-8,20H,9-10H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM7457
PNG
(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
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n/an/a 2.60E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM7457
PNG
(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
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n/an/a 2.70E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 3.45E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50135165
PNG
((+)-gallocatechin | (2R,3S)-2-(3,4,5-Trihydroxy-ph...)
Show SMILES O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15+/m0/s1
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n/an/a 3.53E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376653
PNG
(CHEMBL428259)
Show SMILES Fc1ccc(cc1)-c1c(-c2ccncc2)n(CC2CO2)oc1=O
Show InChI InChI=1S/C17H13FN2O3/c18-13-3-1-11(2-4-13)15-16(12-5-7-19-8-6-12)20(23-17(15)21)9-14-10-22-14/h1-8,14H,9-10H2
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n/an/a 3.83E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376647
PNG
(CHEMBL195518)
Show SMILES COCCOCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H17FN2O4/c1-23-10-11-24-12-21-17(14-6-8-20-9-7-14)16(18(22)25-21)13-2-4-15(19)5-3-13/h2-9H,10-12H2,1H3
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n/an/a 3.83E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50376650
PNG
(CHEMBL410506)
Show SMILES CSCCn1oc(=O)c(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O2S/c1-23-11-10-20-16(13-6-8-19-9-7-13)15(17(21)22-20)12-2-4-14(18)5-3-12/h2-9H,10-11H2,1H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



Eberhard Karls University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha MAPK


J Med Chem 51: 2580-4 (2008)


Article DOI: 10.1021/jm701343f
BindingDB Entry DOI: 10.7270/Q2ZS2XDJ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50240614
PNG
(3,5-Dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-met...)
Show SMILES COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-12(23-2)10(18)5-8/h3-7,18-19,21H,1-2H3
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n/an/a 3.98E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50135165
PNG
((+)-gallocatechin | (2R,3S)-2-(3,4,5-Trihydroxy-ph...)
Show SMILES O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15+/m0/s1
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n/an/a 5.30E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM23415
PNG
(5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one...)
Show SMILES COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3
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n/an/a 5.78E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM23409
PNG
(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Show SMILES COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
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n/an/a 6.30E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50240897
PNG
(2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H...)
Show SMILES COc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(OC)c2=O
Show InChI InChI=1S/C17H14O7/c1-22-9-6-12(20)14-13(7-9)24-16(17(23-2)15(14)21)8-3-4-10(18)11(19)5-8/h3-7,18-20H,1-2H3
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n/an/a 7.70E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM84983
PNG
(Velutin)
Show SMILES COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(OC)c1
Show InChI InChI=1S/C17H14O6/c1-21-10-6-12(19)17-13(20)8-14(23-16(17)7-10)9-3-4-11(18)15(5-9)22-2/h3-8,18-19H,1-2H3
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n/an/a 7.80E+3n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM26658
PNG
(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Show SMILES Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
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n/an/a 1.14E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM7461
PNG
(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
Show InChI InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 1.18E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50240897
PNG
(2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H...)
Show SMILES COc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(OC)c2=O
Show InChI InChI=1S/C17H14O7/c1-22-9-6-12(20)14-13(7-9)24-16(17(23-2)15(14)21)8-3-4-10(18)11(19)5-8/h3-7,18-20H,1-2H3
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PubMed
n/an/a 1.23E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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n/an/a 1.43E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM23412
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H...)
Show SMILES COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H12O7/c1-22-16-11(20)6-13-14(15(16)21)10(19)5-12(23-13)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3
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n/an/a 1.59E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM84976
PNG
(Patuletin)
Show SMILES COc1c(O)cc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c2c1O
Show InChI InChI=1S/C16H12O8/c1-23-16-9(19)5-10-11(13(16)21)12(20)14(22)15(24-10)6-2-3-7(17)8(18)4-6/h2-5,17-19,21-22H,1H3
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PubMed
n/an/a 1.63E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM84985
PNG
(Nevadensin)
Show SMILES COc1ccc(cc1)-c1cc(=O)c2c(O)c(OC)c(O)c(OC)c2o1
Show InChI InChI=1S/C18H16O7/c1-22-10-6-4-9(5-7-10)12-8-11(19)13-14(20)17(23-2)15(21)18(24-3)16(13)25-12/h4-8,20-21H,1-3H3
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PubMed
n/an/a 1.63E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM84977
PNG
(6-methoxy kaempferol)
Show SMILES COc1c(O)cc2oc(-c3ccc(O)cc3)c(O)c(=O)c2c1O
Show InChI InChI=1S/C16H12O7/c1-22-16-9(18)6-10-11(13(16)20)12(19)14(21)15(23-10)7-2-4-8(17)5-3-7/h2-6,17-18,20-21H,1H3
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PubMed
n/an/a 1.72E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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n/an/a 1.80E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM7462
PNG
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
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n/an/a 1.84E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50049395
PNG
(5,7,4'-Trihydroxy-6-methoxyflavone | 5,7-Dihydroxy...)
Show SMILES COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1
Show InChI InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
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n/an/a 1.86E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM84984
PNG
(Jaceosidin)
Show SMILES COc1cc(ccc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
Show InChI InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3
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PubMed
n/an/a 1.89E+4n/an/an/an/an/a37



Eberhard Karls University of Tuebingen



Assay Description
The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...


Chembiochem 11: 2579-88 (2010)


Article DOI: 10.1002/cbic.201000487
BindingDB Entry DOI: 10.7270/Q21C1VDT
More data for this
Ligand-Target Pair
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