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Compile Data Set for Download or QSAR

Found 53 hits from Eisai Co. Ltd.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoid receptor


(Homo sapiens)
BDBM31883
PNG
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
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Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor gamma


Bioorg Med Chem Lett 10: 619-22 (2000)


Article DOI: 10.1016/s0960-894x(00)00066-4
BindingDB Entry DOI: 10.7270/Q23T9GFV
More data for this
Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha


(Homo sapiens)
BDBM31883
PNG
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
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n/an/a 0.780n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor alpha


Bioorg Med Chem Lett 10: 619-22 (2000)


Article DOI: 10.1016/s0960-894x(00)00066-4
BindingDB Entry DOI: 10.7270/Q23T9GFV
More data for this
Ligand-Target Pair
Retinoid receptor


(Homo sapiens)
BDBM31883
PNG
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
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n/an/a 0.900n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor beta


Bioorg Med Chem Lett 10: 619-22 (2000)


Article DOI: 10.1016/s0960-894x(00)00066-4
BindingDB Entry DOI: 10.7270/Q23T9GFV
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 360n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a 450n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM23620
PNG
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
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n/an/a 520n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038986
PNG
(3-Benzo[1,3]dioxol-5-ylmethyl-6,7,8-trimethoxy-3H-...)
Show SMILES COc1cc2c(ncn(Cc3ccc4OCOc4c3)c2=O)c(OC)c1OC
Show InChI InChI=1S/C19H18N2O6/c1-23-15-7-12-16(18(25-3)17(15)24-2)20-9-21(19(12)22)8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3
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n/an/a 530n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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n/an/a 620n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042783
PNG
(7-(Benzo[1,3]dioxol-5-ylmethoxy)-4-oxo-8-propyl-4H...)
Show SMILES CCCc1c(OCc2ccc3OCOc3c2)ccc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C21H18O7/c1-2-3-14-16(25-10-12-4-6-17-18(8-12)27-11-26-17)7-5-13-15(22)9-19(21(23)24)28-20(13)14/h4-9H,2-3,10-11H2,1H3,(H,23,24)
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n/an/a 650n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042790
PNG
((2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-(6,7,8-t...)
Show SMILES COc1cc2c(NCc3ccc4OCCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C20H21N3O5/c1-24-16-9-13-17(19(26-3)18(16)25-2)22-11-23-20(13)21-10-12-4-5-14-15(8-12)28-7-6-27-14/h4-5,8-9,11H,6-7,10H2,1-3H3,(H,21,22,23)
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n/an/a 780n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038996
PNG
(4-(Benzo[1,3]dioxol-5-ylmethoxy)-6,7,8-trimethoxy-...)
Show SMILES COc1cc2c(OCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H18N2O6/c1-22-15-7-12-16(18(24-3)17(15)23-2)20-9-21-19(12)25-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042780
PNG
((4-Methoxy-benzyl)-(6,7,8-trimethoxy-quinazolin-4-...)
Show SMILES COc1ccc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H21N3O4/c1-23-13-7-5-12(6-8-13)10-20-19-14-9-15(24-2)17(25-3)18(26-4)16(14)21-11-22-19/h5-9,11H,10H2,1-4H3,(H,20,21,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042793
PNG
((3-Chloro-benzyl)-(6,7,8-trimethoxy-quinazolin-4-y...)
Show SMILES COc1cc2c(NCc3cccc(Cl)c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C18H18ClN3O3/c1-23-14-8-13-15(17(25-3)16(14)24-2)21-10-22-18(13)20-9-11-5-4-6-12(19)7-11/h4-8,10H,9H2,1-3H3,(H,20,21,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042792
PNG
((4-Chloro-benzyl)-(6,7,8-trimethoxy-quinazolin-4-y...)
Show SMILES COc1cc2c(NCc3ccc(Cl)cc3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C18H18ClN3O3/c1-23-14-8-13-15(17(25-3)16(14)24-2)21-10-22-18(13)20-9-11-4-6-12(19)7-5-11/h4-8,10H,9H2,1-3H3,(H,20,21,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50368744
PNG
(CHEMBL1794860)
Show SMILES COc1cc2c(NCCCCCO[N+]([O-])=O)ncnc2c(OC)c1OC
Show InChI InChI=1S/C16H22N4O6/c1-23-12-9-11-13(15(25-3)14(12)24-2)18-10-19-16(11)17-7-5-4-6-8-26-20(21)22/h9-10H,4-8H2,1-3H3,(H,17,18,19)
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n/an/a 1.47E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042784
PNG
(7-[2-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-ethoxy]...)
Show SMILES CCCc1c(OCCOc2ccc3c(oc(cc3=O)C(O)=O)c2CCC)ccc(C(C)=O)c1O
Show InChI InChI=1S/C26H28O8/c1-4-6-18-21(10-8-16(15(3)27)24(18)29)32-12-13-33-22-11-9-17-20(28)14-23(26(30)31)34-25(17)19(22)7-5-2/h8-11,14,29H,4-7,12-13H2,1-3H3,(H,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042771
PNG
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy...)
Show SMILES CCCc1c(OCCCOc2ccc3c(oc(cc3=O)C(O)=O)c2CCC)ccc(C(C)=O)c1O
Show InChI InChI=1S/C27H30O8/c1-4-7-19-22(11-9-17(16(3)28)25(19)30)33-13-6-14-34-23-12-10-18-21(29)15-24(27(31)32)35-26(18)20(23)8-5-2/h9-12,15,30H,4-8,13-14H2,1-3H3,(H,31,32)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50006812
PNG
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Show SMILES CCCc1c(OCC(O)COc2ccc3c(oc(cc3=O)C(O)=O)c2CCC)ccc(C(C)=O)c1O
Show InChI InChI=1S/C27H30O9/c1-4-6-19-22(10-8-17(15(3)28)25(19)31)34-13-16(29)14-35-23-11-9-18-21(30)12-24(27(32)33)36-26(18)20(23)7-5-2/h8-12,16,29,31H,4-7,13-14H2,1-3H3,(H,32,33)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042775
PNG
((3-Methoxy-benzyl)-(6,7,8-trimethoxy-quinazolin-4-...)
Show SMILES COc1cccc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)c1
Show InChI InChI=1S/C19H21N3O4/c1-23-13-7-5-6-12(8-13)10-20-19-14-9-15(24-2)17(25-3)18(26-4)16(14)21-11-22-19/h5-9,11H,10H2,1-4H3,(H,20,21,22)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50020874
PNG
((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042786
PNG
(CHEMBL125992 | Indan-5-ylmethyl-(6,7,8-trimethoxy-...)
Show SMILES COc1cc2c(NCc3ccc4CCCc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C21H23N3O3/c1-25-17-10-16-18(20(27-3)19(17)26-2)23-12-24-21(16)22-11-13-7-8-14-5-4-6-15(14)9-13/h7-10,12H,4-6,11H2,1-3H3,(H,22,23,24)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042777
PNG
(Benzyl-(6,7,8-trimethoxy-quinazolin-4-yl)-amine | ...)
Show SMILES COc1cc2c(NCc3ccccc3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C18H19N3O3/c1-22-14-9-13-15(17(24-3)16(14)23-2)20-11-21-18(13)19-10-12-7-5-4-6-8-12/h4-9,11H,10H2,1-3H3,(H,19,20,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042795
PNG
((2-Propoxy-benzyl)-(6,7,8-trimethoxy-quinazolin-4-...)
Show SMILES CCCOc1ccccc1CNc1ncnc2c(OC)c(OC)c(OC)cc12
Show InChI InChI=1S/C21H25N3O4/c1-5-10-28-16-9-7-6-8-14(16)12-22-21-15-11-17(25-2)19(26-3)20(27-4)18(15)23-13-24-21/h6-9,11,13H,5,10,12H2,1-4H3,(H,22,23,24)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042797
PNG
((2-Benzo[1,3]dioxol-5-yl-ethyl)-(6,7,8-trimethoxy-...)
Show SMILES COc1cc2c(NCCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C20H21N3O5/c1-24-16-9-13-17(19(26-3)18(16)25-2)22-10-23-20(13)21-7-6-12-4-5-14-15(8-12)28-11-27-14/h4-5,8-10H,6-7,11H2,1-3H3,(H,21,22,23)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042791
PNG
((3-Nitro-benzyl)-(6,7,8-trimethoxy-quinazolin-4-yl...)
Show SMILES COc1cc2c(NCc3cccc(c3)[N+]([O-])=O)ncnc2c(OC)c1OC
Show InChI InChI=1S/C18H18N4O5/c1-25-14-8-13-15(17(27-3)16(14)26-2)20-10-21-18(13)19-9-11-5-4-6-12(7-11)22(23)24/h4-8,10H,9H2,1-3H3,(H,19,20,21)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM23620
PNG
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
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n/an/a 3.60E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042787
PNG
(CHEMBL122093 | Furan-2-ylmethyl-(6,7,8-trimethoxy-...)
Show SMILES COc1cc2c(NCc3ccco3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C16H17N3O4/c1-20-12-7-11-13(15(22-3)14(12)21-2)18-9-19-16(11)17-8-10-5-4-6-23-10/h4-7,9H,8H2,1-3H3,(H,17,18,19)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042794
PNG
((3,4-Dimethoxy-benzyl)-(6,7,8-trimethoxy-quinazoli...)
Show SMILES COc1ccc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H23N3O5/c1-24-14-7-6-12(8-15(14)25-2)10-21-20-13-9-16(26-3)18(27-4)19(28-5)17(13)22-11-23-20/h6-9,11H,10H2,1-5H3,(H,21,22,23)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042796
PNG
(5-(6,7,8-Trimethoxy-quinazolin-4-ylamino)-pentan-1...)
Show SMILES COc1cc2c(NCCCCCO)ncnc2c(OC)c1OC
Show InChI InChI=1S/C16H23N3O4/c1-21-12-9-11-13(15(23-3)14(12)22-2)18-10-19-16(11)17-7-5-4-6-8-20/h9-10,20H,4-8H2,1-3H3,(H,17,18,19)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM23620
PNG
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
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n/an/a 6.40E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 8.70E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042776
PNG
((3,4,5-Trimethoxy-benzyl)-(6,7,8-trimethoxy-quinaz...)
Show SMILES COc1cc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)cc(OC)c1OC
Show InChI InChI=1S/C21H25N3O6/c1-25-14-7-12(8-15(26-2)18(14)28-4)10-22-21-13-9-16(27-3)19(29-5)20(30-6)17(13)23-11-24-21/h7-9,11H,10H2,1-6H3,(H,22,23,24)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042785
PNG
(6,7,8-Trimethoxy-quinazolin-4-ylamine;Ethanol | CH...)
Show SMILES COc1cc2c(N)ncnc2c(OC)c1OC
Show InChI InChI=1S/C11H13N3O3/c1-15-7-4-6-8(13-5-14-11(6)12)10(17-3)9(7)16-2/h4-5H,1-3H3,(H2,12,13,14)
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n/an/a 9.60E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042779
PNG
(Benzo[1,3]dioxol-5-yl-(6,7,8-trimethoxy-quinazolin...)
Show SMILES COc1cc2c(Nc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C18H17N3O5/c1-22-14-7-11-15(17(24-3)16(14)23-2)19-8-20-18(11)21-10-4-5-12-13(6-10)26-9-25-12/h4-8H,9H2,1-3H3,(H,19,20,21)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042773
PNG
(6,7,8-Trimethoxy-3-(2-propoxy-benzyl)-3H-quinazoli...)
Show SMILES CCCOc1ccccc1Cn1cnc2c(OC)c(OC)c(OC)cc2c1=O
Show InChI InChI=1S/C21H24N2O5/c1-5-10-28-16-9-7-6-8-14(16)12-23-13-22-18-15(21(23)24)11-17(25-2)19(26-3)20(18)27-4/h6-9,11,13H,5,10,12H2,1-4H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042789
PNG
(CHEMBL125714 | [2-(4-Nitro-phenyl)-ethyl]-(6,7,8-t...)
Show SMILES COc1cc2c(NCCc3ccc(cc3)[N+]([O-])=O)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H20N4O5/c1-26-15-10-14-16(18(28-3)17(15)27-2)21-11-22-19(14)20-9-8-12-4-6-13(7-5-12)23(24)25/h4-7,10-11H,8-9H2,1-3H3,(H,20,21,22)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042782
PNG
((4-Ethyl-benzyl)-(6,7,8-trimethoxy-quinazolin-4-yl...)
Show SMILES CCc1ccc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C20H23N3O3/c1-5-13-6-8-14(9-7-13)11-21-20-15-10-16(24-2)18(25-3)19(26-4)17(15)22-12-23-20/h6-10,12H,5,11H2,1-4H3,(H,21,22,23)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042781
PNG
(3-(2-Benzo[1,3]dioxol-5-yl-ethyl)-6,7,8-trimethoxy...)
Show SMILES COc1cc2c(ncn(CCc3ccc4OCOc4c3)c2=O)c(OC)c1OC
Show InChI InChI=1S/C20H20N2O6/c1-24-16-9-13-17(19(26-3)18(16)25-2)21-10-22(20(13)23)7-6-12-4-5-14-15(8-12)28-11-27-14/h4-5,8-10H,6-7,11H2,1-3H3
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n/an/a 3.20E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50042774
PNG
(CHEMBL341475 | Pyridin-4-ylmethyl-(6,7,8-trimethox...)
Show SMILES COc1cc2c(NCc3ccncc3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C17H18N4O3/c1-22-13-8-12-14(16(24-3)15(13)23-2)20-10-21-17(12)19-9-11-4-6-18-7-5-11/h4-8,10H,9H2,1-3H3,(H,19,20,21)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50020874
PNG
((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)
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n/an/a 3.72E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a 4.68E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a 7.96E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific phosphodiesterase from porcine aorta


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM23620
PNG
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50020874
PNG
((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
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