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Found 585 hits from Eisai R&D Management Co., Ltd.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119448
PNG
(US8686018, 107)
Show SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)(F)F)C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30(2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32,33)/t11-/m0/s1
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8n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119450
PNG
(US8686018, 109)
Show SMILES Cn1nc(C(F)F)c(C(=O)NC2(CC2)c2ccc(cc2)C(O)=O)c1Oc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H18F5N3O4/c1-31-20(35-15-4-2-3-14(11-15)23(26,27)28)16(17(30-31)18(24)25)19(32)29-22(9-10-22)13-7-5-12(6-8-13)21(33)34/h2-8,11,18H,9-10H2,1H3,(H,29,32)(H,33,34)
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8n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119451
PNG
(US8686018, 110)
Show SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(OC(F)F)c1)C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H19F4N3O5/c1-11(12-6-8-13(9-7-12)21(31)32)27-19(30)16-17(18(23)24)28-29(2)20(16)33-14-4-3-5-15(10-14)34-22(25)26/h3-11,18,22H,1-2H3,(H,27,30)(H,31,32)/t11-/m0/s1
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10n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119449
PNG
(US8686018, 108)
Show SMILES C[C@H](NC(=O)c1c(Oc2ccc(Cl)c(Cl)c2)n(C)nc1C(F)(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H16Cl2F3N3O4/c1-10(11-3-5-12(6-4-11)20(31)32)27-18(30)16-17(21(24,25)26)28-29(2)19(16)33-13-7-8-14(22)15(23)9-13/h3-10H,1-2H3,(H,27,30)(H,31,32)/t10-/m0/s1
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13n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119444
PNG
(US8686018, 103)
Show SMILES C[C@H](NC(=O)c1c(C)nn(C)c1Oc1cccc(c1)C(F)(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H20F3N3O4/c1-12(14-7-9-15(10-8-14)21(30)31)26-19(29)18-13(2)27-28(3)20(18)32-17-6-4-5-16(11-17)22(23,24)25/h4-12H,1-3H3,(H,26,29)(H,30,31)/t12-/m0/s1
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14n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119446
PNG
(US8686018, 105)
Show SMILES Cn1nc(c(C(=O)NC2(CC2)c2ccc(cc2)C(O)=O)c1Oc1cccc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H17F6N3O4/c1-32-19(36-15-4-2-3-14(11-15)22(24,25)26)16(17(31-32)23(27,28)29)18(33)30-21(9-10-21)13-7-5-12(6-8-13)20(34)35/h2-8,11H,9-10H2,1H3,(H,30,33)(H,34,35)
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16n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119452
PNG
(US8686018, 111)
Show SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)F)C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H19F4N3O4/c1-11(12-6-8-13(9-7-12)22(31)32)27-20(30)16-17(19(25)26)28-29(2)21(16)33-15-5-3-4-14(10-15)18(23)24/h3-11,18-19H,1-2H3,(H,27,30)(H,31,32)/t11-/m0/s1
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26n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119445
PNG
(US8686018, 104)
Show SMILES Cc1nn(C)c(Oc2cccc(c2)C(F)(F)F)c1C(=O)NC1(CC1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H20F3N3O4/c1-13-18(19(30)27-22(10-11-22)15-8-6-14(7-9-15)21(31)32)20(29(2)28-13)33-17-5-3-4-16(12-17)23(24,25)26/h3-9,12H,10-11H2,1-2H3,(H,27,30)(H,31,32)
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43n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119447
PNG
(US8686018, 106)
Show SMILES C[C@H](NC(=O)c1c(Oc2cccc(Cl)c2)n(C)nc1C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H18ClF2N3O4/c1-11(12-6-8-13(9-7-12)21(29)30)25-19(28)16-17(18(23)24)26-27(2)20(16)31-15-5-3-4-14(22)10-15/h3-11,18H,1-2H3,(H,25,28)(H,29,30)/t11-/m0/s1
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50n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252685
PNG
(US9458176, 82)
Show SMILES CCOc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C24H26F3N3O2/c1-5-31-21-12-17(6-7-19(21)24(25,26)27)23-29-22(18-10-14(2)28-15(3)11-18)20-8-9-32-16(4)13-30(20)23/h6-7,10-12,16H,5,8-9,13H2,1-4H3/t16-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252846
PNG
(US9458176, 243)
Show SMILES CCOc1ccc(cc1C)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C24H28FN3O2/c1-5-29-22-7-6-18(10-15(22)2)24-27-23(19-11-16(3)26-17(4)12-19)21-8-9-30-20(13-25)14-28(21)24/h6-7,10-12,20H,5,8-9,13-14H2,1-4H3/t20-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252686
PNG
(US9458176, 83)
Show SMILES CCOc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1ccnc(C)c1
Show InChI InChI=1S/C23H24F3N3O2/c1-4-30-20-12-17(5-6-18(20)23(24,25)26)22-28-21(16-7-9-27-14(2)11-16)19-8-10-31-15(3)13-29(19)22/h5-7,9,11-12,15H,4,8,10,13H2,1-3H3/t15-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252847
PNG
(US9458176, 244)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C25H30FN3O2/c1-15(2)31-23-7-6-19(10-16(23)3)25-28-24(20-11-17(4)27-18(5)12-20)22-8-9-30-21(13-26)14-29(22)25/h6-7,10-12,15,21H,8-9,13-14H2,1-5H3/t21-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252770
PNG
(US9458176, 167)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC3CC3)c(Cl)c2)n2C[C@@H](CF)OCCc12
Show InChI InChI=1S/C24H25ClFN3O2/c1-14-9-17(10-15(2)27-14)23-21-7-8-30-19(12-26)13-29(21)24(28-23)16-3-6-22(20(25)11-16)31-18-4-5-18/h3,6,9-11,18-19H,4-5,7-8,12-13H2,1-2H3/t19-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252837
PNG
(US9458176, 234)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(CF)c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H24F3N3O2/c1-13-8-17(9-14(2)27-13)21-19-6-7-30-15(3)12-29(19)22(28-21)16-4-5-20(31-23(25)26)18(10-16)11-24/h4-5,8-10,15,23H,6-7,11-12H2,1-3H3/t15-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252612
PNG
(US9458176, 9)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(C)c1)-c1ccnc(C)c1
Show InChI InChI=1S/C22H22F3N3O2/c1-13-10-17(4-5-19(13)30-22(23,24)25)21-27-20(16-6-8-26-14(2)11-16)18-7-9-29-15(3)12-28(18)21/h4-6,8,10-11,15H,7,9,12H2,1-3H3/t15-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252836
PNG
(US9458176, 233)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)F)c(Cl)c2)n2C[C@@H](CF)OCCc12
Show InChI InChI=1S/C22H21ClF3N3O2/c1-12-7-15(8-13(2)27-12)20-18-5-6-30-16(10-24)11-29(18)21(28-20)14-3-4-19(17(23)9-14)31-22(25)26/h3-4,7-9,16,22H,5-6,10-11H2,1-2H3/t16-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252834
PNG
(US9458176, 231)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(CF)c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H23F4N3O2/c1-13-8-17(9-14(2)28-13)21-19-6-7-31-15(3)12-30(19)22(29-21)16-4-5-20(18(10-16)11-24)32-23(25,26)27/h4-5,8-10,15H,6-7,11-12H2,1-3H3/t15-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252804
PNG
(US9458176, 201)
Show SMILES COc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(CF)c1
Show InChI InChI=1S/C23H22F5N3O2/c1-13-7-15(8-16(10-24)29-13)21-19-5-6-33-17(11-25)12-31(19)22(30-21)14-3-4-18(23(26,27)28)20(9-14)32-2/h3-4,7-9,17H,5-6,10-12H2,1-2H3/t17-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252845
PNG
(US9458176, 242)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C25H31N3O2/c1-15(2)30-23-8-7-20(11-16(23)3)25-27-24(21-12-17(4)26-18(5)13-21)22-9-10-29-19(6)14-28(22)25/h7-8,11-13,15,19H,9-10,14H2,1-6H3/t19-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252642
PNG
(US9458176, 39)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(CF)c1)-c1ccnc(C)c1
Show InChI InChI=1S/C22H21F4N3O2/c1-13-9-15(5-7-27-13)20-18-6-8-30-14(2)12-29(18)21(28-20)16-3-4-19(17(10-16)11-23)31-22(24,25)26/h3-5,7,9-10,14H,6,8,11-12H2,1-2H3/t14-/m1/s1
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US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252619
PNG
(US9458176, 16)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H23F4N3O3/c1-13-8-16(9-14(2)28-13)21-18-6-7-32-17(11-24)12-30(18)22(29-21)15-4-5-19(20(10-15)31-3)33-23(25,26)27/h4-5,8-10,17H,6-7,11-12H2,1-3H3/t17-/m1/s1
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US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252638
PNG
(US9458176, 35)
Show SMILES CC(C)Oc1ccc(cc1Cl)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C24H28ClN3O2/c1-14(2)30-22-7-6-18(12-20(22)25)24-27-23(19-10-15(3)26-16(4)11-19)21-8-9-29-17(5)13-28(21)24/h6-7,10-12,14,17H,8-9,13H2,1-5H3/t17-/m1/s1
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US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252635
PNG
(US9458176, 32)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(Cl)c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C22H22ClF2N3O2/c1-12-8-16(9-13(2)26-12)20-18-6-7-29-14(3)11-28(18)21(27-20)15-4-5-19(17(23)10-15)30-22(24)25/h4-5,8-10,14,22H,6-7,11H2,1-3H3/t14-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252637
PNG
(US9458176, 34)
Show SMILES CCOc1ccc(cc1Cl)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H26ClN3O2/c1-5-28-21-7-6-17(12-19(21)24)23-26-22(18-10-14(2)25-15(3)11-18)20-8-9-29-16(4)13-27(20)23/h6-7,10-12,16H,5,8-9,13H2,1-4H3/t16-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252844
PNG
(US9458176, 241)
Show SMILES CCOc1ccc(cc1C)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C24H29N3O2/c1-6-28-22-8-7-19(11-15(22)2)24-26-23(20-12-16(3)25-17(4)13-20)21-9-10-29-18(5)14-27(21)24/h7-8,11-13,18H,6,9-10,14H2,1-5H3/t18-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252839
PNG
(US9458176, 236)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(CF)c1)-c1ccnc(C)c1
Show InChI InChI=1S/C22H22F3N3O2/c1-13-9-15(5-7-26-13)20-18-6-8-29-14(2)12-28(18)21(27-20)16-3-4-19(30-22(24)25)17(10-16)11-23/h3-5,7,9-10,14,22H,6,8,11-12H2,1-2H3/t14-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252756
PNG
(US9458176, 153)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(Cl)c1)-c1ccnc(C)c1
Show InChI InChI=1S/C21H19ClF3N3O2/c1-12-9-14(5-7-26-12)19-17-6-8-29-13(2)11-28(17)20(27-19)15-3-4-18(16(22)10-15)30-21(23,24)25/h3-5,7,9-10,13H,6,8,11H2,1-2H3/t13-/m1/s1
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US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252622
PNG
(US9458176, 19)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC2CC2)c(Cl)c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C24H26ClN3O2/c1-14-10-18(11-15(2)26-14)23-21-8-9-29-16(3)13-28(21)24(27-23)17-4-7-22(20(25)12-17)30-19-5-6-19/h4,7,10-12,16,19H,5-6,8-9,13H2,1-3H3/t16-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252701
PNG
(US9458176, 98)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(F)c(OCC2CCC2)c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C26H30FN3O2/c1-16-11-21(12-17(2)28-16)25-23-9-10-31-18(3)14-30(23)26(29-25)20-7-8-22(27)24(13-20)32-15-19-5-4-6-19/h7-8,11-13,18-19H,4-6,9-10,14-15H2,1-3H3/t18-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252628
PNG
(US9458176, 25)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H24F3N3O3/c1-13-9-17(10-14(2)27-13)21-18-7-8-31-15(3)12-29(18)22(28-21)16-5-6-19(20(11-16)30-4)32-23(24,25)26/h5-6,9-11,15H,7-8,12H2,1-4H3/t15-/m1/s1
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US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM142338
PNG
(US8933099, 112)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@H](C)O)CC2)c1)C(=O)NC
Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m0/s1
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Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252623
PNG
(US9458176, 20)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC2CC2)c(C)c1)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C25H29N3O2/c1-15-11-19(5-8-23(15)30-21-6-7-21)25-27-24(20-12-16(2)26-17(3)13-20)22-9-10-29-18(4)14-28(22)25/h5,8,11-13,18,21H,6-7,9-10,14H2,1-4H3/t18-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252630
PNG
(US9458176, 27)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)F)c(C)c2)n2C[C@@H](CF)OCCc12
Show InChI InChI=1S/C23H24F3N3O2/c1-13-8-16(4-5-20(13)31-23(25)26)22-28-21(17-9-14(2)27-15(3)10-17)19-6-7-30-18(11-24)12-29(19)22/h4-5,8-10,18,23H,6-7,11-12H2,1-3H3/t18-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252798
PNG
(US9458176, 195)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)(F)F)c(c2)C#N)n2C[C@@H](CF)OCCc12
Show InChI InChI=1S/C23H20F4N4O2/c1-13-7-16(8-14(2)29-13)21-19-5-6-32-18(10-24)12-31(19)22(30-21)15-3-4-20(17(9-15)11-28)33-23(25,26)27/h3-4,7-9,18H,5-6,10,12H2,1-2H3/t18-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM142348
PNG
(US8933099, 114)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C)CC2)c1)C(=O)NC
Show InChI InChI=1S/C32H37N5O5/c1-4-40-17-18-41-28-21-27-25(12-16-37(27)32(39)33-2)19-29(28)42-26-9-13-34-30(20-26)35-31(38)24-7-5-22(6-8-24)23-10-14-36(3)15-11-23/h5-9,12-13,16,19-21,23H,4,10-11,14-15,17-18H2,1-3H3,(H,33,39)(H,34,35,38)
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Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252799
PNG
(US9458176, 196)
Show SMILES Cc1cc(ccn1)-c1nc(-c2ccc(OC(F)(F)F)c(c2)C#N)n2C[C@@H](CF)OCCc12
Show InChI InChI=1S/C22H18F4N4O2/c1-13-8-14(4-6-28-13)20-18-5-7-31-17(10-23)12-30(18)21(29-20)15-2-3-19(16(9-15)11-27)32-22(24,25)26/h2-4,6,8-9,17H,5,7,10,12H2,1H3/t17-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252620
PNG
(US9458176, 17)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1ccnc(C)c1
Show InChI InChI=1S/C22H21F4N3O3/c1-13-9-14(5-7-27-13)20-17-6-8-31-16(11-23)12-29(17)21(28-20)15-3-4-18(19(10-15)30-2)32-22(24,25)26/h3-5,7,9-10,16H,6,8,11-12H2,1-2H3/t16-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252632
PNG
(US9458176, 29)
Show SMILES COc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H23F4N3O2/c1-13-8-16(9-14(2)28-13)21-19-6-7-32-17(11-24)12-30(19)22(29-21)15-4-5-18(23(25,26)27)20(10-15)31-3/h4-5,8-10,17H,6-7,11-12H2,1-3H3/t17-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252681
PNG
(US9458176, 78)
Show SMILES CC[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(Cl)c(OC)c1)-c1ccnc(C)c1
Show InChI InChI=1S/C22H24ClN3O2/c1-4-17-13-26-19(8-10-28-17)21(15-7-9-24-14(2)11-15)25-22(26)16-5-6-18(23)20(12-16)27-3/h5-7,9,11-12,17H,4,8,10,13H2,1-3H3/t17-/m1/s1
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Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM142347
PNG
(US8933099, 109)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC(C)(C)O)CC2)c1)C(=O)NC
Show InChI InChI=1S/C35H43N5O6/c1-5-44-18-19-45-30-22-29-27(13-17-40(29)34(42)36-4)20-31(30)46-28-10-14-37-32(21-28)38-33(41)26-8-6-24(7-9-26)25-11-15-39(16-12-25)23-35(2,3)43/h6-10,13-14,17,20-22,25,43H,5,11-12,15-16,18-19,23H2,1-4H3,(H,36,42)(H,37,38,41)
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252828
PNG
(US9458176, 225)
Show SMILES CCOc1cc(ccc1C)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C24H29N3O2/c1-6-28-22-13-19(8-7-15(22)2)24-26-23(20-11-16(3)25-17(4)12-20)21-9-10-29-18(5)14-27(21)24/h7-8,11-13,18H,6,9-10,14H2,1-5H3/t18-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252807
PNG
(US9458176, 204)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(C)c1)-c1cc(C)nc(CF)c1
Show InChI InChI=1S/C23H23F4N3O2/c1-13-8-16(4-5-20(13)32-23(25,26)27)22-29-21(17-9-14(2)28-18(10-17)11-24)19-6-7-31-15(3)12-30(19)22/h4-5,8-10,15H,6-7,11-12H2,1-3H3/t15-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252764
PNG
(US9458176, 161)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)(F)F)c(C)c2)n2C[C@@H](CF)OCCc12
Show InChI InChI=1S/C23H23F4N3O2/c1-13-8-16(4-5-20(13)32-23(25,26)27)22-29-21(17-9-14(2)28-15(3)10-17)19-6-7-31-18(11-24)12-30(19)22/h4-5,8-10,18H,6-7,11-12H2,1-3H3/t18-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252644
PNG
(US9458176, 41)
Show SMILES COc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1ccnc(C)c1
Show InChI InChI=1S/C22H21F4N3O2/c1-13-9-14(5-7-27-13)20-18-6-8-31-16(11-23)12-29(18)21(28-20)15-3-4-17(22(24,25)26)19(10-15)30-2/h3-5,7,9-10,16H,6,8,11-12H2,1-2H3/t16-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252625
PNG
(US9458176, 22)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC3CC3)c(C)c2)n2C[C@@H](CF)OCCc12
Show InChI InChI=1S/C25H28FN3O2/c1-15-10-18(4-7-23(15)31-20-5-6-20)25-28-24(19-11-16(2)27-17(3)12-19)22-8-9-30-21(13-26)14-29(22)25/h4,7,10-12,20-21H,5-6,8-9,13-14H2,1-3H3/t21-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252771
PNG
(US9458176, 168)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(c1)C#N)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H21F3N4O2/c1-13-8-17(9-14(2)28-13)21-19-6-7-31-15(3)12-30(19)22(29-21)16-4-5-20(18(10-16)11-27)32-23(24,25)26/h4-5,8-10,15H,6-7,12H2,1-3H3/t15-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM142339
PNG
(US8933099, 113)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC)CC2)c1)C(=O)NC
Show InChI InChI=1S/C33H39N5O5/c1-4-37-15-11-24(12-16-37)23-6-8-25(9-7-23)32(39)36-31-21-27(10-14-35-31)43-30-20-26-13-17-38(33(40)34-3)28(26)22-29(30)42-19-18-41-5-2/h6-10,13-14,17,20-22,24H,4-5,11-12,15-16,18-19H2,1-3H3,(H,34,40)(H,35,36,39)
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM142337
PNG
(US8933099, 111)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@@H](C)O)CC2)c1)C(=O)NC
Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM252610
PNG
(US9458176, 7)
Show SMILES COc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C23H24F3N3O2/c1-13-9-17(10-14(2)27-13)21-19-7-8-31-15(3)12-29(19)22(28-21)16-5-6-18(23(24,25)26)20(11-16)30-4/h5-6,9-11,15H,7-8,12H2,1-4H3/t15-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...


US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
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