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Compile Data Set for Download or QSAR

Found 84 hits from Elanco Tiergesundheit AG   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270876
PNG
(US10059709, 22)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H21N5O2S/c1-17-24(22,23)9-11-2-4-12(5-3-11)21-10-20-14-8-19-16-13(15(14)21)6-7-18-16/h6-8,10-12,17H,2-5,9H2,1H3,(H,18,19)/t11-,12-
PDB

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n/an/a 10n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270872
PNG
(US10059709, 18)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)[N+]([O-])=O
Show InChI InChI=1S/C16H23N5O4S/c1-17-26(24,25)10-11-3-5-12(6-4-11)20(2)15-13-7-8-18-16(13)19-9-14(15)21(22)23/h7-9,11-12,17H,3-6,10H2,1-2H3,(H,18,19)/t11-,12-
PDB

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n/an/a 21n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270880
PNG
(US10059709, 26)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)11-12-3-5-14(6-4-12)22(2)16-13(9-18)10-21-17-15(16)7-8-20-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3,(H,20,21)/t12-,14-
PDB

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n/an/a 34n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270879
PNG
(US10059709, 25)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O
Show InChI InChI=1S/C15H20N4O5S/c1-16-25(22,23)9-10-2-4-11(5-3-10)24-14-12-6-7-17-15(12)18-8-13(14)19(20)21/h6-8,10-11,16H,2-5,9H2,1H3,(H,17,18)/t10-,11-
PDB

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n/an/a 71n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270876
PNG
(US10059709, 22)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H21N5O2S/c1-17-24(22,23)9-11-2-4-12(5-3-11)21-10-20-14-8-19-16-13(15(14)21)6-7-18-16/h6-8,10-12,17H,2-5,9H2,1H3,(H,18,19)/t11-,12-
PDB

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n/an/a 130n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270876
PNG
(US10059709, 22)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H21N5O2S/c1-17-24(22,23)9-11-2-4-12(5-3-11)21-10-20-14-8-19-16-13(15(14)21)6-7-18-16/h6-8,10-12,17H,2-5,9H2,1H3,(H,18,19)/t11-,12-
PDB

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n/an/a 260n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270872
PNG
(US10059709, 18)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)[N+]([O-])=O
Show InChI InChI=1S/C16H23N5O4S/c1-17-26(24,25)10-11-3-5-12(6-4-11)20(2)15-13-7-8-18-16(13)19-9-14(15)21(22)23/h7-9,11-12,17H,3-6,10H2,1-2H3,(H,18,19)/t11-,12-
PDB

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n/an/a 390n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270882
PNG
(US10059709, 28)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnn2cccc12
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13-
PDB

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n/an/a 550n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270856
PNG
(US10059709, 2)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]cnc12
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)7-10-3-5-11(6-4-10)20(2)14-12-13(17-8-16-12)18-9-19-14/h8-11,15H,3-7H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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n/an/a 582n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270855
PNG
(US10059709, 1)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(C)nc12
Show InChI InChI=1S/C15H24N6O2S/c1-10-19-13-14(20-10)17-9-18-15(13)21(3)12-6-4-11(5-7-12)8-24(22,23)16-2/h9,11-12,16H,4-8H2,1-3H3,(H,17,18,19,20)/t11-,12-
PDB

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n/an/a 838n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270880
PNG
(US10059709, 26)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)11-12-3-5-14(6-4-12)22(2)16-13(9-18)10-21-17-15(16)7-8-20-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3,(H,20,21)/t12-,14-
PDB

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n/an/a 840n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270878
PNG
(US10059709, 24)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnn2cccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15-
PDB

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n/an/a 930n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270879
PNG
(US10059709, 25)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O
Show InChI InChI=1S/C15H20N4O5S/c1-16-25(22,23)9-10-2-4-11(5-3-10)24-14-12-6-7-17-15(12)18-8-13(14)19(20)21/h6-8,10-11,16H,2-5,9H2,1H3,(H,17,18)/t10-,11-
PDB

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n/an/a 1.10E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270872
PNG
(US10059709, 18)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)[N+]([O-])=O
Show InChI InChI=1S/C16H23N5O4S/c1-17-26(24,25)10-11-3-5-12(6-4-11)20(2)15-13-7-8-18-16(13)19-9-14(15)21(22)23/h7-9,11-12,17H,3-6,10H2,1-2H3,(H,18,19)/t11-,12-
PDB

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n/an/a 1.20E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270881
PNG
(US10059709, 27)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnn2cccc12)C#N
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14-
PDB

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n/an/a 1.80E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270856
PNG
(US10059709, 2)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]cnc12
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)7-10-3-5-11(6-4-10)20(2)14-12-13(17-8-16-12)18-9-19-14/h8-11,15H,3-7H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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n/an/a 1.89E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270867
PNG
(US10059709, 13)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1Br
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9-
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270880
PNG
(US10059709, 26)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)11-12-3-5-14(6-4-12)22(2)16-13(9-18)10-21-17-15(16)7-8-20-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3,(H,20,21)/t12-,14-
PDB

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n/an/a 3.00E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270882
PNG
(US10059709, 28)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnn2cccc12
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13-
PDB

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n/an/a 3.20E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270879
PNG
(US10059709, 25)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O
Show InChI InChI=1S/C15H20N4O5S/c1-16-25(22,23)9-10-2-4-11(5-3-10)24-14-12-6-7-17-15(12)18-8-13(14)19(20)21/h6-8,10-11,16H,2-5,9H2,1H3,(H,17,18)/t10-,11-
PDB

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n/an/a 3.60E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270856
PNG
(US10059709, 2)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]cnc12
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)7-10-3-5-11(6-4-10)20(2)14-12-13(17-8-16-12)18-9-19-14/h8-11,15H,3-7H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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n/an/a 4.59E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270855
PNG
(US10059709, 1)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(C)nc12
Show InChI InChI=1S/C15H24N6O2S/c1-10-19-13-14(20-10)17-9-18-15(13)21(3)12-6-4-11(5-7-12)8-24(22,23)16-2/h9,11-12,16H,4-8H2,1-3H3,(H,17,18,19,20)/t11-,12-
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n/an/a 5.51E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270867
PNG
(US10059709, 13)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1Br
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270881
PNG
(US10059709, 27)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnn2cccc12)C#N
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270855
PNG
(US10059709, 1)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(C)nc12
Show InChI InChI=1S/C15H24N6O2S/c1-10-19-13-14(20-10)17-9-18-15(13)21(3)12-6-4-11(5-7-12)8-24(22,23)16-2/h9,11-12,16H,4-8H2,1-3H3,(H,17,18,19,20)/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270878
PNG
(US10059709, 24)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnn2cccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270857
PNG
(US10059709, 3)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ncc12
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)8-10-3-5-11(6-4-10)20(2)14-12-7-18-19-13(12)16-9-17-14/h7,9-11,15H,3-6,8H2,1-2H3,(H,16,17,18,19)/t10-,11-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270882
PNG
(US10059709, 28)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnn2cccc12
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270857
PNG
(US10059709, 3)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ncc12
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)8-10-3-5-11(6-4-10)20(2)14-12-7-18-19-13(12)16-9-17-14/h7,9-11,15H,3-6,8H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270858
PNG
(US10059709, 4)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1
Show InChI InChI=1S/C20H26N6O2S/c1-21-29(27,28)12-14-8-10-16(11-9-14)26(2)20-17-19(22-13-23-20)25-18(24-17)15-6-4-3-5-7-15/h3-7,13-14,16,21H,8-12H2,1-2H3,(H,22,23,24,25)/t14-,16-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270858
PNG
(US10059709, 4)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1
Show InChI InChI=1S/C20H26N6O2S/c1-21-29(27,28)12-14-8-10-16(11-9-14)26(2)20-17-19(22-13-23-20)25-18(24-17)15-6-4-3-5-7-15/h3-7,13-14,16,21H,8-12H2,1-2H3,(H,22,23,24,25)/t14-,16-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270858
PNG
(US10059709, 4)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1
Show InChI InChI=1S/C20H26N6O2S/c1-21-29(27,28)12-14-8-10-16(11-9-14)26(2)20-17-19(22-13-23-20)25-18(24-17)15-6-4-3-5-7-15/h3-7,13-14,16,21H,8-12H2,1-2H3,(H,22,23,24,25)/t14-,16-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270859
PNG
(US10059709, 5)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12
Show InChI InChI=1S/C21H28N6O2S/c1-22-30(28,29)13-16-8-10-17(11-9-16)27(2)21-19-20(23-14-24-21)26-18(25-19)12-15-6-4-3-5-7-15/h3-7,14,16-17,22H,8-13H2,1-2H3,(H,23,24,25,26)/t16-,17-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270859
PNG
(US10059709, 5)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12
Show InChI InChI=1S/C21H28N6O2S/c1-22-30(28,29)13-16-8-10-17(11-9-16)27(2)21-19-20(23-14-24-21)26-18(25-19)12-15-6-4-3-5-7-15/h3-7,14,16-17,22H,8-13H2,1-2H3,(H,23,24,25,26)/t16-,17-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270859
PNG
(US10059709, 5)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12
Show InChI InChI=1S/C21H28N6O2S/c1-22-30(28,29)13-16-8-10-17(11-9-16)27(2)21-19-20(23-14-24-21)26-18(25-19)12-15-6-4-3-5-7-15/h3-7,14,16-17,22H,8-13H2,1-2H3,(H,23,24,25,26)/t16-,17-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270860
PNG
(US10059709, 6)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnn2cccc12
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270860
PNG
(US10059709, 6)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnn2cccc12
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270860
PNG
(US10059709, 6)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnn2cccc12
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270861
PNG
(US10059709, 7)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270861
PNG
(US10059709, 7)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270861
PNG
(US10059709, 7)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270862
PNG
(US10059709, 8)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnc2sccc12
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270862
PNG
(US10059709, 8)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnc2sccc12
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270862
PNG
(US10059709, 8)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnc2sccc12
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11-
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270863
PNG
(US10059709, 9)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2sccc12
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12-
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270863
PNG
(US10059709, 9)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2sccc12
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12-
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270863
PNG
(US10059709, 9)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2sccc12
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12-
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM270864
PNG
(US10059709, 10)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1cc(Cl)nc(N)n1
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM270864
PNG
(US10059709, 10)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1cc(Cl)nc(N)n1
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM270864
PNG
(US10059709, 10)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1cc(Cl)nc(N)n1
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10059709 (2018)

More data for this
Ligand-Target Pair
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