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Compile Data Set for Download or QSAR

Found 146 hits from Eli Lilly and Co   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195711
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccccc1
Show InChI InChI=1S/C27H26N4O6/c1-18-23(31-26(36-18)20-5-3-2-4-6-20)11-14-35-22-9-7-19(8-10-25(32)33)21(15-22)16-30-27(34)37-24-17-28-12-13-29-24/h2-7,9,12-13,15,17H,8,10-11,14,16H2,1H3,(H,30,34)(H,32,33)
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n/an/a 17n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195708
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(sc2C)N2CCOCC2)ccc1CCC(O)=O
Show InChI InChI=1S/C24H33N3O6S/c1-16(2)33-24(30)25-15-19-14-20(6-4-18(19)5-7-22(28)29)32-11-8-21-17(3)34-23(26-21)27-9-12-31-13-10-27/h4,6,14,16H,5,7-13,15H2,1-3H3,(H,25,30)(H,28,29)
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n/an/a 22n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195714
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C26H30N2O6/c1-17(2)33-26(31)27-16-21-15-22(11-9-19(21)10-12-24(29)30)32-14-13-23-18(3)34-25(28-23)20-7-5-4-6-8-20/h4-9,11,15,17H,10,12-14,16H2,1-3H3,(H,27,31)(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195716
PNG
(3-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C33H30N4O6/c1-22-29(37-32(42-22)26-9-7-24(8-10-26)23-5-3-2-4-6-23)15-18-41-28-13-11-25(12-14-31(38)39)27(19-28)20-36-33(40)43-30-21-34-16-17-35-30/h2-11,13,16-17,19,21H,12,14-15,18,20H2,1H3,(H,36,40)(H,38,39)
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n/an/a 26n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195702
PNG
(3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O6/c1-21(2)39-32(37)33-20-27-19-28(15-13-25(27)14-16-30(35)36)38-18-17-29-22(3)40-31(34-29)26-11-9-24(10-12-26)23-7-5-4-6-8-23/h4-13,15,19,21H,14,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/a 47n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195715
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(Oc3ccccc3)cc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O7/c1-21(2)39-32(37)33-20-25-19-28(15-9-23(25)12-16-30(35)36)38-18-17-29-22(3)40-31(34-29)24-10-13-27(14-11-24)41-26-7-5-4-6-8-26/h4-11,13-15,19,21H,12,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/a 50n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195713
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ncccn2)ccc1CCC(O)=O
Show InChI InChI=1S/C30H32N4O6/c1-19(2)39-30(37)33-18-24-17-25(11-9-21(24)10-12-27(35)36)38-16-13-26-20(3)40-29(34-26)23-7-5-22(6-8-23)28-31-14-4-15-32-28/h4-9,11,14-15,17,19H,10,12-13,16,18H2,1-3H3,(H,33,37)(H,35,36)
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n/an/a 50n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195711
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccccc1
Show InChI InChI=1S/C27H26N4O6/c1-18-23(31-26(36-18)20-5-3-2-4-6-20)11-14-35-22-9-7-19(8-10-25(32)33)21(15-22)16-30-27(34)37-24-17-28-12-13-29-24/h2-7,9,12-13,15,17H,8,10-11,14,16H2,1H3,(H,30,34)(H,32,33)
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n/an/a 53n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM28681
PNG
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Show SMILES CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1
Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23)
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n/an/a 67n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195707
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNS(=O)(=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O6S/c1-21-27(31-29(37-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(32)33)25(18-26)19-30-38(34,35)20-22-8-4-2-5-9-22/h2-12,14,18,30H,13,15-17,19-20H2,1H3,(H,32,33)
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n/an/a 72n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195710
PNG
(3-(2-((benzyloxycarbonyl)methyl)-4-(2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)OCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H30N2O6/c1-21-27(32-29(38-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(33)34)25(18-26)19-31-30(35)37-20-22-8-4-2-5-9-22/h2-12,14,18H,13,15-17,19-20H2,1H3,(H,31,35)(H,33,34)
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n/an/a 91n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195714
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C26H30N2O6/c1-17(2)33-26(31)27-16-21-15-22(11-9-19(21)10-12-24(29)30)32-14-13-23-18(3)34-25(28-23)20-7-5-4-6-8-20/h4-9,11,15,17H,10,12-14,16H2,1-3H3,(H,27,31)(H,29,30)
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n/an/a 146n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195712
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)CCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C31H32N2O5/c1-22-28(33-31(38-22)25-10-6-3-7-11-25)18-19-37-27-15-13-24(14-17-30(35)36)26(20-27)21-32-29(34)16-12-23-8-4-2-5-9-23/h2-11,13,15,20H,12,14,16-19,21H2,1H3,(H,32,34)(H,35,36)
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n/an/a 161n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195710
PNG
(3-(2-((benzyloxycarbonyl)methyl)-4-(2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)OCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H30N2O6/c1-21-27(32-29(38-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(33)34)25(18-26)19-31-30(35)37-20-22-8-4-2-5-9-22/h2-12,14,18H,13,15-17,19-20H2,1H3,(H,31,35)(H,33,34)
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n/an/a 441n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195716
PNG
(3-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C33H30N4O6/c1-22-29(37-32(42-22)26-9-7-24(8-10-26)23-5-3-2-4-6-23)15-18-41-28-13-11-25(12-14-31(38)39)27(19-28)20-36-33(40)43-30-21-34-16-17-35-30/h2-11,13,16-17,19,21H,12,14-15,18,20H2,1H3,(H,36,40)(H,38,39)
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n/an/a 449n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195715
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(Oc3ccccc3)cc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O7/c1-21(2)39-32(37)33-20-25-19-28(15-9-23(25)12-16-30(35)36)38-18-17-29-22(3)40-31(34-29)24-10-13-27(14-11-24)41-26-7-5-4-6-8-26/h4-11,13-15,19,21H,12,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/a 516n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195709
PNG
(3-(2-((3-benzylureido)methyl)-4-(2-(5-methyl-2-phe...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)NCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O5/c1-21-27(33-29(38-21)24-10-6-3-7-11-24)16-17-37-26-14-12-23(13-15-28(34)35)25(18-26)20-32-30(36)31-19-22-8-4-2-5-9-22/h2-12,14,18H,13,15-17,19-20H2,1H3,(H,34,35)(H2,31,32,36)
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n/an/a 706n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195708
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(sc2C)N2CCOCC2)ccc1CCC(O)=O
Show InChI InChI=1S/C24H33N3O6S/c1-16(2)33-24(30)25-15-19-14-20(6-4-18(19)5-7-22(28)29)32-11-8-21-17(3)34-23(26-21)27-9-12-31-13-10-27/h4,6,14,16H,5,7-13,15H2,1-3H3,(H,25,30)(H,28,29)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195707
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNS(=O)(=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O6S/c1-21-27(31-29(37-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(32)33)25(18-26)19-30-38(34,35)20-22-8-4-2-5-9-22/h2-12,14,18,30H,13,15-17,19-20H2,1H3,(H,32,33)
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n/an/a 3.39E+3n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195702
PNG
(3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O6/c1-21(2)39-32(37)33-20-27-19-28(15-13-25(27)14-16-30(35)36)38-18-17-29-22(3)40-31(34-29)26-11-9-24(10-12-26)23-7-5-4-6-8-23/h4-13,15,19,21H,14,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/a 3.49E+3n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195712
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)CCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C31H32N2O5/c1-22-28(33-31(38-22)25-10-6-3-7-11-25)18-19-37-27-15-13-24(14-17-30(35)36)26(20-27)21-32-29(34)16-12-23-8-4-2-5-9-23/h2-11,13,15,20H,12,14,16-19,21H2,1H3,(H,32,34)(H,35,36)
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n/an/a 4.96E+3n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195713
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ncccn2)ccc1CCC(O)=O
Show InChI InChI=1S/C30H32N4O6/c1-19(2)39-30(37)33-18-24-17-25(11-9-21(24)10-12-27(35)36)38-16-13-26-20(3)40-29(34-26)23-7-5-22(6-8-23)28-31-14-4-15-32-28/h4-9,11,14-15,17,19H,10,12-13,16,18H2,1-3H3,(H,33,37)(H,35,36)
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n/an/a 9.94E+3n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM28700
PNG
(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)
Show SMILES CC(C)(Oc1ccc(cc1)C(=O)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28681
PNG
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Show SMILES CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1
Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28700
PNG
(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)
Show SMILES CC(C)(Oc1ccc(cc1)C(=O)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195709
PNG
(3-(2-((3-benzylureido)methyl)-4-(2-(5-methyl-2-phe...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)NCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O5/c1-21-27(33-29(38-21)24-10-6-3-7-11-24)16-17-37-26-14-12-23(13-15-28(34)35)25(18-26)20-32-30(36)31-19-22-8-4-2-5-9-22/h2-12,14,18H,13,15-17,19-20H2,1H3,(H,34,35)(H2,31,32,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195707
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNS(=O)(=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O6S/c1-21-27(31-29(37-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(32)33)25(18-26)19-30-38(34,35)20-22-8-4-2-5-9-22/h2-12,14,18,30H,13,15-17,19-20H2,1H3,(H,32,33)
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n/an/an/an/a 2.94E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195710
PNG
(3-(2-((benzyloxycarbonyl)methyl)-4-(2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)OCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H30N2O6/c1-21-27(32-29(38-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(33)34)25(18-26)19-31-30(35)37-20-22-8-4-2-5-9-22/h2-12,14,18H,13,15-17,19-20H2,1H3,(H,31,35)(H,33,34)
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n/an/an/an/a 515n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195709
PNG
(3-(2-((3-benzylureido)methyl)-4-(2-(5-methyl-2-phe...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)NCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O5/c1-21-27(33-29(38-21)24-10-6-3-7-11-24)16-17-37-26-14-12-23(13-15-28(34)35)25(18-26)20-32-30(36)31-19-22-8-4-2-5-9-22/h2-12,14,18H,13,15-17,19-20H2,1H3,(H,34,35)(H2,31,32,36)
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n/an/an/an/a 2.68E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195708
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(sc2C)N2CCOCC2)ccc1CCC(O)=O
Show InChI InChI=1S/C24H33N3O6S/c1-16(2)33-24(30)25-15-19-14-20(6-4-18(19)5-7-22(28)29)32-11-8-21-17(3)34-23(26-21)27-9-12-31-13-10-27/h4,6,14,16H,5,7-13,15H2,1-3H3,(H,25,30)(H,28,29)
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n/an/an/an/a 986n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM28681
PNG
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Show SMILES CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1
Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23)
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n/an/an/an/a 308n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195712
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)CCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C31H32N2O5/c1-22-28(33-31(38-22)25-10-6-3-7-11-25)18-19-37-27-15-13-24(14-17-30(35)36)26(20-27)21-32-29(34)16-12-23-8-4-2-5-9-23/h2-11,13,15,20H,12,14,16-19,21H2,1H3,(H,32,34)(H,35,36)
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n/an/an/an/a 1.02E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195713
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ncccn2)ccc1CCC(O)=O
Show InChI InChI=1S/C30H32N4O6/c1-19(2)39-30(37)33-18-24-17-25(11-9-21(24)10-12-27(35)36)38-16-13-26-20(3)40-29(34-26)23-7-5-22(6-8-23)28-31-14-4-15-32-28/h4-9,11,14-15,17,19H,10,12-13,16,18H2,1-3H3,(H,33,37)(H,35,36)
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n/an/an/an/a 4n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195702
PNG
(3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O6/c1-21(2)39-32(37)33-20-27-19-28(15-13-25(27)14-16-30(35)36)38-18-17-29-22(3)40-31(34-29)26-11-9-24(10-12-26)23-7-5-4-6-8-23/h4-13,15,19,21H,14,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/an/an/a 19n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195714
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C26H30N2O6/c1-17(2)33-26(31)27-16-21-15-22(11-9-19(21)10-12-24(29)30)32-14-13-23-18(3)34-25(28-23)20-7-5-4-6-8-20/h4-9,11,15,17H,10,12-14,16H2,1-3H3,(H,27,31)(H,29,30)
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n/an/an/an/a 8n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28700
PNG
(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)
Show SMILES CC(C)(Oc1ccc(cc1)C(=O)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
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n/an/an/an/a 2.65E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195711
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccccc1
Show InChI InChI=1S/C27H26N4O6/c1-18-23(31-26(36-18)20-5-3-2-4-6-20)11-14-35-22-9-7-19(8-10-25(32)33)21(15-22)16-30-27(34)37-24-17-28-12-13-29-24/h2-7,9,12-13,15,17H,8,10-11,14,16H2,1H3,(H,30,34)(H,32,33)
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n/an/an/an/a 35n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195708
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(sc2C)N2CCOCC2)ccc1CCC(O)=O
Show InChI InChI=1S/C24H33N3O6S/c1-16(2)33-24(30)25-15-19-14-20(6-4-18(19)5-7-22(28)29)32-11-8-21-17(3)34-23(26-21)27-9-12-31-13-10-27/h4,6,14,16H,5,7-13,15H2,1-3H3,(H,25,30)(H,28,29)
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n/an/an/an/a 28n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195715
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(Oc3ccccc3)cc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O7/c1-21(2)39-32(37)33-20-25-19-28(15-9-23(25)12-16-30(35)36)38-18-17-29-22(3)40-31(34-29)24-10-13-27(14-11-24)41-26-7-5-4-6-8-26/h4-11,13-15,19,21H,12,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/an/an/a 2n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195715
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(Oc3ccccc3)cc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O7/c1-21(2)39-32(37)33-20-25-19-28(15-9-23(25)12-16-30(35)36)38-18-17-29-22(3)40-31(34-29)24-10-13-27(14-11-24)41-26-7-5-4-6-8-26/h4-11,13-15,19,21H,12,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/an/an/a 78n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195711
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccccc1
Show InChI InChI=1S/C27H26N4O6/c1-18-23(31-26(36-18)20-5-3-2-4-6-20)11-14-35-22-9-7-19(8-10-25(32)33)21(15-22)16-30-27(34)37-24-17-28-12-13-29-24/h2-7,9,12-13,15,17H,8,10-11,14,16H2,1H3,(H,30,34)(H,32,33)
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n/an/an/an/a 7n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195713
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ncccn2)ccc1CCC(O)=O
Show InChI InChI=1S/C30H32N4O6/c1-19(2)39-30(37)33-18-24-17-25(11-9-21(24)10-12-27(35)36)38-16-13-26-20(3)40-29(34-26)23-7-5-22(6-8-23)28-31-14-4-15-32-28/h4-9,11,14-15,17,19H,10,12-13,16,18H2,1-3H3,(H,33,37)(H,35,36)
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n/an/an/an/a 900n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195710
PNG
(3-(2-((benzyloxycarbonyl)methyl)-4-(2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)OCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H30N2O6/c1-21-27(32-29(38-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(33)34)25(18-26)19-31-30(35)37-20-22-8-4-2-5-9-22/h2-12,14,18H,13,15-17,19-20H2,1H3,(H,31,35)(H,33,34)
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n/an/an/an/a 115n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195714
PNG
(3-(2-((isopropoxycarbonyl)methyl)-4-(2-(5-methyl-2...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C26H30N2O6/c1-17(2)33-26(31)27-16-21-15-22(11-9-19(21)10-12-24(29)30)32-14-13-23-18(3)34-25(28-23)20-7-5-4-6-8-20/h4-9,11,15,17H,10,12-14,16H2,1-3H3,(H,27,31)(H,29,30)
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n/an/an/an/a 70n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195712
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)CCc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C31H32N2O5/c1-22-28(33-31(38-22)25-10-6-3-7-11-25)18-19-37-27-15-13-24(14-17-30(35)36)26(20-27)21-32-29(34)16-12-23-8-4-2-5-9-23/h2-11,13,15,20H,12,14,16-19,21H2,1H3,(H,32,34)(H,35,36)
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n/an/an/an/a 2.80E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195716
PNG
(3-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C33H30N4O6/c1-22-29(37-32(42-22)26-9-7-24(8-10-26)23-5-3-2-4-6-23)15-18-41-28-13-11-25(12-14-31(38)39)27(19-28)20-36-33(40)43-30-21-34-16-17-35-30/h2-11,13,16-17,19,21H,12,14-15,18,20H2,1H3,(H,36,40)(H,38,39)
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n/an/an/an/a 2n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195702
PNG
(3-[4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES CC(C)OC(=O)NCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)-c2ccccc2)ccc1CCC(O)=O
Show InChI InChI=1S/C32H34N2O6/c1-21(2)39-32(37)33-20-27-19-28(15-13-25(27)14-16-30(35)36)38-18-17-29-22(3)40-31(34-29)26-11-9-24(10-12-26)23-7-5-4-6-8-23/h4-13,15,19,21H,14,16-18,20H2,1-3H3,(H,33,37)(H,35,36)
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n/an/an/an/a 845n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50195716
PNG
(3-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNC(=O)Oc2cnccn2)c1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C33H30N4O6/c1-22-29(37-32(42-22)26-9-7-24(8-10-26)23-5-3-2-4-6-23)15-18-41-28-13-11-25(12-14-31(38)39)27(19-28)20-36-33(40)43-30-21-34-16-17-35-30/h2-11,13,16-17,19,21H,12,14-15,18,20H2,1H3,(H,36,40)(H,38,39)
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n/an/an/an/a 198n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARalpha in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50195707
PNG
(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-((...)
Show SMILES Cc1oc(nc1CCOc1ccc(CCC(O)=O)c(CNS(=O)(=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O6S/c1-21-27(31-29(37-21)24-10-6-3-7-11-24)16-17-36-26-14-12-23(13-15-28(32)33)25(18-26)19-30-38(34,35)20-22-8-4-2-5-9-22/h2-12,14,18,30H,13,15-17,19-20H2,1H3,(H,32,33)
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n/an/an/an/a 527n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human PPARgamma in CV1 cells


Bioorg Med Chem Lett 16: 6328-33 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.011
BindingDB Entry DOI: 10.7270/Q2PK0FSC
More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50191947
PNG
(4-cyano-5-ethyl-1-methyl-3-(4'-methyl-biphenyl-4-y...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C22H20N2O2/c1-4-19-18(13-23)20(21(22(25)26)24(19)3)17-11-9-16(10-12-17)15-7-5-14(2)6-8-15/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 412n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
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