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Found 98 from Molecumetics
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126528(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  0.0230nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076227((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.0270nMAssay Description:Inhibitory concentration of the compound against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071565(2-(2,2-Diphenyl-ethyl)-7-methyl-1,3-dioxo-2,3,5,8-...)
Affinity DataKi:  0.0350nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126525(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  0.0570nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076227((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.0710nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076224((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.0730nMAssay Description:Inhibitory concentration of the compound against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076224((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.0730nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126521(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  0.0870nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071575(2,2-Dibutyl-7-methyl-1,3-dioxo-2,3,5,8-tetrahydro-...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076219((3S,6R)-6-Amino-6-benzyl-octahydro-indolizine-3-ca...)
Affinity DataKi:  0.230nMAssay Description:Inhibitory concentration of the compound against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126508(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  0.240nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126520(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071570(8-Isobutyl-2-(4-methoxy-phenyl)-1,3-dioxo-2,3,5,8-...)
Affinity DataKi:  0.280nMAssay Description:Compound was evaluated for its binding affinity to the trypsin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071573(2-(2,2-Diphenyl-ethyl)-1,3-dioxo-2,3,5,8-tetrahydr...)
Affinity DataKi:  0.300nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076223((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126526(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  0.320nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071571(8-Isobutyl-2-(3-methyl-butyl)-1,3-dioxo-2,3,5,8-te...)
Affinity DataKi:  0.430nMAssay Description:Compound was evaluated for its binding affinity to the trypsin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076225((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.450nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.640nMAssay Description:Inhibitory concentration of the compound against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076222((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.650nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126500(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  0.75nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076219((3S,6R)-6-Amino-6-benzyl-octahydro-indolizine-3-ca...)
Affinity DataKi:  0.850nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076219((3S,6R)-6-Amino-6-benzyl-octahydro-indolizine-3-ca...)
Affinity DataKi:  0.850nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126523(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126514(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071568(2-Amino-2-benzyl-7-methyl-1,3-dioxo-2,3,5,8-tetrah...)
Affinity DataKi:  1.60nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071567(2,2-Dibenzyl-7-methyl-1,3-dioxo-2,3,5,8-tetrahydro...)
Affinity DataKi:  1.90nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50076228((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory concentration of the compound against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126529(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126532(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071566(2-Amino-8-benzyl-2-ethyl-1,3-dioxo-2,3,5,8-tetrahy...)
Affinity DataKi:  4.30nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126534(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  4.70nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071574(2,2-Diisobutyl-7-methyl-1,3-dioxo-2,3,5,8-tetrahyd...)
Affinity DataKi:  5.10nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126505(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  5.70nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50216213(CHEMBL306744)
Affinity DataKi:  5.90nMAssay Description:Compound was evaluated for its binding affinity to the tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126519(2-[1-(4-Chloro-phenylsulfanylmethyl)-2-morpholin-4...)
Affinity DataKi:  7.70nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126513(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126506(2-{5-[(4-Amino-cyclohexylmethyl)-carbamoyl]-1,3-di...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126510(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126501(2-[1-(3,4-Dichloro-phenylsulfanylmethyl)-2-oxo-2-p...)
Affinity DataKi:  18nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071564(2,2-Diallyl-7-methyl-1,3-dioxo-2,3,5,8-tetrahydro-...)
Affinity DataKi:  18nMAssay Description:Compound was evaluated for its binding affinity to the thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071572(8-{5-Amino-1-[2-(4-carbamoyl-phenyl)-ethylaminooxa...)
Affinity DataKi:  21nMAssay Description:Compound was evaluated for its inhibitory activity against KallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126503(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126516(2-[1-(4-Chloro-phenylsulfanylmethyl)-2-oxo-2-pyrro...)
Affinity DataKi:  24nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126511(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126522(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126512(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  29nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126517(2-[1-(4-Bromo-phenylsulfanylmethyl)-2-oxo-2-pyrrol...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50071563(4-(2-{6-amino-2-[7-(3,4-dichlorobenzyl)-13,13-dime...)
Affinity DataKi:  31nMAssay Description:Compound was evaluated for its inhibitory activity against KallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Molecumetics

Curated by ChEMBL
LigandPNGBDBM50126535(2-{5-[(6-Amino-2-methyl-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  32nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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