BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 14 hits from deCODE Chemistry Inc   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232529
PNG
(5-(2-fluorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Show SMILES Nc1nc(N)c2c(OCc3ccccc3F)cccc2n1
Show InChI InChI=1S/C15H13FN4O/c16-10-5-2-1-4-9(10)8-21-12-7-3-6-11-13(12)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.390n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM18050
PNG
(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

DrugBank
PDB
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232565
PNG
((S)-5-(1-(3-chlorophenyl)ethoxy)quinazoline-2,4-di...)
Show SMILES C[C@H](Oc1cccc2nc(N)nc(N)c12)c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClN4O/c1-9(10-4-2-5-11(17)8-10)22-13-7-3-6-12-14(13)15(18)21-16(19)20-12/h2-9H,1H3,(H4,18,19,20,21)/t9-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232535
PNG
(5-(1-(3-chlorophenyl)ethoxy)quinazoline-2,4-diamin...)
Show SMILES CC(Oc1cccc2nc(N)nc(N)c12)c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClN4O/c1-9(10-4-2-5-11(17)8-10)22-13-7-3-6-12-14(13)15(18)21-16(19)20-12/h2-9H,1H3,(H4,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 34n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232534
PNG
(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Show SMILES Nc1nc(N)c2c(COc3ccccc3F)cccc2n1
Show InChI InChI=1S/C15H13FN4O/c16-10-5-1-2-7-12(10)21-8-9-4-3-6-11-13(9)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 39n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232589
PNG
(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Show SMILES Nc1nc(N)c2c(COc3cccc(Cl)c3)cccc2n1
Show InChI InChI=1S/C15H13ClN4O/c16-10-4-2-5-11(7-10)21-8-9-3-1-6-12-13(9)14(17)20-15(18)19-12/h1-7H,8H2,(H4,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.40E+3n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50232538
PNG
(5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quina...)
Show SMILES Nc1nc(N)c2c(OCC3CCN(Cc4ccccc4F)CC3)cccc2n1
Show InChI InChI=1S/C21H24FN5O/c22-16-5-2-1-4-15(16)12-27-10-8-14(9-11-27)13-28-18-7-3-6-17-19(18)20(23)26-21(24)25-17/h1-7,14H,8-13H2,(H4,23,24,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 9.38E+3n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human CYP2D6


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232526
PNG
(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Show SMILES Nc1nc(N)c2c(COc3ccc(F)cc3F)cccc2n1
Show InChI InChI=1S/C15H12F2N4O/c16-9-4-5-12(10(17)6-9)22-7-8-2-1-3-11-13(8)14(18)21-15(19)20-11/h1-6H,7H2,(H4,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.07E+4n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232527
PNG
(5-((1-(3-chlorobenzyl)piperidin-4-yl)methoxy)quina...)
Show SMILES Nc1nc(N)c2c(OCC3CCN(Cc4cccc(Cl)c4)CC3)cccc2n1
Show InChI InChI=1S/C21H24ClN5O/c22-16-4-1-3-15(11-16)12-27-9-7-14(8-10-27)13-28-18-6-2-5-17-19(18)20(23)26-21(24)25-17/h1-6,11,14H,7-10,12-13H2,(H4,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.52E+4n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232566
PNG
(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Show SMILES Nc1nc(N)c2c(OCc3cccc(Cl)c3)cccc2n1
Show InChI InChI=1S/C15H13ClN4O/c16-10-4-1-3-9(7-10)8-21-12-6-2-5-11-13(12)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.80E+4n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232538
PNG
(5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quina...)
Show SMILES Nc1nc(N)c2c(OCC3CCN(Cc4ccccc4F)CC3)cccc2n1
Show InChI InChI=1S/C21H24FN5O/c22-16-5-2-1-4-15(16)12-27-10-8-14(9-11-27)13-28-18-7-3-6-17-19(18)20(23)26-21(24)25-17/h1-7,14H,8-13H2,(H4,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>1.25E+5n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232571
PNG
((2-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Show SMILES Nc1nc(N)c2c(OCC3CCN(CC3)C(=O)c3ccccc3Cl)cccc2n1
Show InChI InChI=1S/C21H22ClN5O2/c22-15-5-2-1-4-14(15)20(28)27-10-8-13(9-11-27)12-29-17-7-3-6-16-18(17)19(23)26-21(24)25-16/h1-7,13H,8-12H2,(H4,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.25E+5n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232541
PNG
((3-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Show SMILES Nc1nc(N)c2c(OCC3CCN(CC3)C(=O)c3cccc(Cl)c3)cccc2n1
Show InChI InChI=1S/C21H22ClN5O2/c22-15-4-1-3-14(11-15)20(28)27-9-7-13(8-10-27)12-29-17-6-2-5-16-18(17)19(23)26-21(24)25-16/h1-6,11,13H,7-10,12H2,(H4,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.25E+5n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50232561
PNG
(5-((1-(2-fluorophenylsulfonyl)piperidin-4-yl)metho...)
Show SMILES Nc1nc(N)c2c(OCC3CCN(CC3)S(=O)(=O)c3ccccc3F)cccc2n1
Show InChI InChI=1S/C20H22FN5O3S/c21-14-4-1-2-7-17(14)30(27,28)26-10-8-13(9-11-26)12-29-16-6-3-5-15-18(16)19(22)25-20(23)24-15/h1-7,13H,8-12H2,(H4,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.25E+5n/an/an/an/an/an/a



deCODE Chemistry Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHFR


J Med Chem 51: 449-69 (2008)


Article DOI: 10.1021/jm061475p
BindingDB Entry DOI: 10.7270/Q27S7NJD
More data for this
Ligand-Target Pair