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Compile Data Set for Download or QSAR

Found 313 hits from eFFECTOR THERAPEUTICS, INC.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164267
PNG
(US9669031, 6 6′-(pyrimidin-4-ylamino)-1̸...)
Show SMILES O=C1NC2(CCCC2)n2c1ccc(Nc1ccncn1)c2=O
Show InChI InChI=1S/C15H15N5O2/c21-13-11-4-3-10(18-12-5-8-16-9-17-12)14(22)20(11)15(19-13)6-1-2-7-15/h3-5,8-9H,1-2,6-7H2,(H,19,21)(H,16,17,18)
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n/an/a<10n/an/an/an/an/an/a



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164268
PNG
(US9669031, 7 3-methyl-6-(pyrimidin-4-ylamino)-3-(2...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C14H12F3N5O2/c1-13(6-14(15,16)17)21-11(23)9-3-2-8(12(24)22(9)13)20-10-4-5-18-7-19-10/h2-5,7H,6H2,1H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164271
PNG
(US9669031, 10 N-(6-((3,3-dimethyl-1,5-dioxo-1,2,3,...)
Show SMILES CC1(C)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H18N6O3/c1-17(2)22-15(25)11-6-5-10(16(26)23(11)17)20-12-7-13(19-8-18-12)21-14(24)9-3-4-9/h5-9H,3-4H2,1-2H3,(H,22,25)(H2,18,19,20,21,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164271
PNG
(US9669031, 10 N-(6-((3,3-dimethyl-1,5-dioxo-1,2,3,...)
Show SMILES CC1(C)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H18N6O3/c1-17(2)22-15(25)11-6-5-10(16(26)23(11)17)20-12-7-13(19-8-18-12)21-14(24)9-3-4-9/h5-9H,3-4H2,1-2H3,(H,22,25)(H2,18,19,20,21,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164278
PNG
(US9669031, 14 3-methyl-6-(pyrimidin-4-ylamino)-3-(...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O2/c1-12(13(14,15)16)20-10(22)8-3-2-7(11(23)21(8)12)19-9-4-5-17-6-18-9/h2-6H,1H3,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164280
PNG
(US9669031, 16 3-methyl-6-(pyrimidin-4-ylamino)-3-(...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccsc1
Show InChI InChI=1S/C16H13N5O2S/c1-16(10-5-7-24-8-10)20-14(22)12-3-2-11(15(23)21(12)16)19-13-4-6-17-9-18-13/h2-9H,1H3,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164590
PNG
(US9669031, 18 3-(3-chlorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C18H14ClN5O2/c1-18(11-3-2-4-12(19)9-11)23-16(25)14-6-5-13(17(26)24(14)18)22-15-7-8-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164599
PNG
(US9669031, 20 6-(pyrimidin-4-ylamino)-1H-spiro[imi...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1ccc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C20H24N6O4/c1-19(2,3)30-18(29)25-10-4-8-20(11-25)24-16(27)14-6-5-13(17(28)26(14)20)23-15-7-9-21-12-22-15/h5-7,9,12H,4,8,10-11H2,1-3H3,(H,24,27)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164600
PNG
(US9669031, 21 N-[6-[(1,5-dioxospiro[2H-imidazo[1,5...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NC4(CCCC4)n3c2=O)ncn1)C1CC1
Show InChI InChI=1S/C19H20N6O3/c26-16(11-3-4-11)23-15-9-14(20-10-21-15)22-12-5-6-13-17(27)24-19(7-1-2-8-19)25(13)18(12)28/h5-6,9-11H,1-4,7-8H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164600
PNG
(US9669031, 21 N-[6-[(1,5-dioxospiro[2H-imidazo[1,5...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NC4(CCCC4)n3c2=O)ncn1)C1CC1
Show InChI InChI=1S/C19H20N6O3/c26-16(11-3-4-11)23-15-9-14(20-10-21-15)22-12-5-6-13-17(27)24-19(7-1-2-8-19)25(13)18(12)28/h5-6,9-11H,1-4,7-8H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164607
PNG
(US9669031, 22 N-(6-((3-methyl-1,5-dioxo-3-(2,2,2-t...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H17F3N6O3/c1-17(7-18(19,20)21)26-15(29)11-5-4-10(16(30)27(11)17)24-12-6-13(23-8-22-12)25-14(28)9-2-3-9/h4-6,8-9H,2-3,7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164607
PNG
(US9669031, 22 N-(6-((3-methyl-1,5-dioxo-3-(2,2,2-t...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H17F3N6O3/c1-17(7-18(19,20)21)26-15(29)11-5-4-10(16(30)27(11)17)24-12-6-13(23-8-22-12)25-14(28)9-2-3-9/h4-6,8-9H,2-3,7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164608
PNG
(US9669031, 118 6-[(6-aminopyrimidin-4-yl)amino]-3-...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C21H24N6O3/c1-21(13-4-2-3-5-13)26-19(29)15-9-8-14(20(30)27(15)21)24-16-10-17(23-11-22-16)25-18(28)12-6-7-12/h8-13H,2-7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164608
PNG
(US9669031, 118 6-[(6-aminopyrimidin-4-yl)amino]-3-...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C21H24N6O3/c1-21(13-4-2-3-5-13)26-19(29)15-9-8-14(20(30)27(15)21)24-16-10-17(23-11-22-16)25-18(28)12-6-7-12/h8-13H,2-7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM164609
PNG
(US9669031, 24 N-[6-[[3-methyl-1,5-dioxo-3-(trifluo...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H15F3N6O3/c1-16(17(18,19)20)25-14(28)10-5-4-9(15(29)26(10)16)23-11-6-12(22-7-21-11)24-13(27)8-2-3-8/h4-8H,2-3H2,1H3,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM164609
PNG
(US9669031, 24 N-[6-[[3-methyl-1,5-dioxo-3-(trifluo...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H15F3N6O3/c1-16(17(18,19)20)25-14(28)10-5-4-9(15(29)26(10)16)23-11-6-12(22-7-21-11)24-13(27)8-2-3-8/h4-8H,2-3H2,1H3,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168131
PNG
(US9669031, 29 N-[6-[(3-isopropyl-3-methyl-1,5-diox...)
Show SMILES CC(C)C1(C)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C19H22N6O3/c1-10(2)19(3)24-17(27)13-7-6-12(18(28)25(13)19)22-14-8-15(21-9-20-14)23-16(26)11-4-5-11/h6-11H,4-5H2,1-3H3,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168131
PNG
(US9669031, 29 N-[6-[(3-isopropyl-3-methyl-1,5-diox...)
Show SMILES CC(C)C1(C)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C19H22N6O3/c1-10(2)19(3)24-17(27)13-7-6-12(18(28)25(13)19)22-14-8-15(21-9-20-14)23-16(26)11-4-5-11/h6-11H,4-5H2,1-3H3,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168140
PNG
(US9669031, 30 N-[6-[[3-(3-fluorophenyl)-3-methyl-1...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H19FN6O3/c1-22(13-3-2-4-14(23)9-13)28-20(31)16-8-7-15(21(32)29(16)22)26-17-10-18(25-11-24-17)27-19(30)12-5-6-12/h2-4,7-12H,5-6H2,1H3,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168140
PNG
(US9669031, 30 N-[6-[[3-(3-fluorophenyl)-3-methyl-1...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H19FN6O3/c1-22(13-3-2-4-14(23)9-13)28-20(31)16-8-7-15(21(32)29(16)22)26-17-10-18(25-11-24-17)27-19(30)12-5-6-12/h2-4,7-12H,5-6H2,1H3,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168204
PNG
(US9669031, 35 8-chloro-3-methyl-6-(pyrimidin-4-yla...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H9ClF3N5O2/c1-12(13(15,16)17)21-10(23)9-6(14)4-7(11(24)22(9)12)20-8-2-3-18-5-19-8/h2-5H,1H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168204
PNG
(US9669031, 35 8-chloro-3-methyl-6-(pyrimidin-4-yla...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H9ClF3N5O2/c1-12(13(15,16)17)21-10(23)9-6(14)4-7(11(24)22(9)12)20-8-2-3-18-5-19-8/h2-5H,1H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168205
PNG
(US9669031, 36 2′,2′-dimethyl-6-(pyrimi...)
Show SMILES CC1(C)CCCC11NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C17H19N5O2/c1-16(2)7-3-8-17(16)21-14(23)12-5-4-11(15(24)22(12)17)20-13-6-9-18-10-19-13/h4-6,9-10H,3,7-8H2,1-2H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168205
PNG
(US9669031, 36 2′,2′-dimethyl-6-(pyrimi...)
Show SMILES CC1(C)CCCC11NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C17H19N5O2/c1-16(2)7-3-8-17(16)21-14(23)12-5-4-11(15(24)22(12)17)20-13-6-9-18-10-19-13/h4-6,9-10H,3,7-8H2,1-2H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168207
PNG
(US9669031, 38 N-[6-[(8-chloro-1,5-dioxo-spiro[2H-i...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C19H19ClN6O3/c20-11-7-12(18(29)26-15(11)17(28)25-19(26)5-1-2-6-19)23-13-8-14(22-9-21-13)24-16(27)10-3-4-10/h7-10H,1-6H2,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168207
PNG
(US9669031, 38 N-[6-[(8-chloro-1,5-dioxo-spiro[2H-i...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C19H19ClN6O3/c20-11-7-12(18(29)26-15(11)17(28)25-19(26)5-1-2-6-19)23-13-8-14(22-9-21-13)24-16(27)10-3-4-10/h7-10H,1-6H2,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168208
PNG
(US9669031, 39 8′-chloro-6′-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C15H14ClN5O2/c16-9-7-10(19-11-3-6-17-8-18-11)14(23)21-12(9)13(22)20-15(21)4-1-2-5-15/h3,6-8H,1-2,4-5H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168208
PNG
(US9669031, 39 8′-chloro-6′-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C15H14ClN5O2/c16-9-7-10(19-11-3-6-17-8-18-11)14(23)21-12(9)13(22)20-15(21)4-1-2-5-15/h3,6-8H,1-2,4-5H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168211
PNG
(US9669031, 42 N-[6-[(8-chloro-3-cyclopentyl-3-meth...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C21H23ClN6O3/c1-21(12-4-2-3-5-12)27-19(30)17-13(22)8-14(20(31)28(17)21)25-15-9-16(24-10-23-15)26-18(29)11-6-7-11/h8-12H,2-7H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168211
PNG
(US9669031, 42 N-[6-[(8-chloro-3-cyclopentyl-3-meth...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C21H23ClN6O3/c1-21(12-4-2-3-5-12)27-19(30)17-13(22)8-14(20(31)28(17)21)25-15-9-16(24-10-23-15)26-18(29)11-6-7-11/h8-12H,2-7H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168212
PNG
(US9669031, 43 N-[6-[(8-chloro-3,3-dimethyl-1,5-dio...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H17ClN6O3/c1-17(2)23-15(26)13-9(18)5-10(16(27)24(13)17)21-11-6-12(20-7-19-11)22-14(25)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,23,26)(H2,19,20,21,22,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168212
PNG
(US9669031, 43 N-[6-[(8-chloro-3,3-dimethyl-1,5-dio...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H17ClN6O3/c1-17(2)23-15(26)13-9(18)5-10(16(27)24(13)17)21-11-6-12(20-7-19-11)22-14(25)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,23,26)(H2,19,20,21,22,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168213
PNG
(US9669031, 44 N-(6-((8′-chloro-1′,5...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCC1
Show InChI InChI=1S/C18H17ClN6O3/c19-10-6-11(17(28)25-14(10)16(27)24-18(25)4-1-5-18)22-12-7-13(21-8-20-12)23-15(26)9-2-3-9/h6-9H,1-5H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168213
PNG
(US9669031, 44 N-(6-((8′-chloro-1′,5...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCC1
Show InChI InChI=1S/C18H17ClN6O3/c19-10-6-11(17(28)25-14(10)16(27)24-18(25)4-1-5-18)22-12-7-13(21-8-20-12)23-15(26)9-2-3-9/h6-9H,1-5H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168214
PNG
(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H21ClN6O3/c21-12-8-13(24-14-9-15(23-10-22-14)25-17(28)11-4-5-11)19(30)27-16(12)18(29)26-20(27)6-2-1-3-7-20/h8-11H,1-7H2,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168214
PNG
(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H21ClN6O3/c21-12-8-13(24-14-9-15(23-10-22-14)25-17(28)11-4-5-11)19(30)27-16(12)18(29)26-20(27)6-2-1-3-7-20/h8-11H,1-7H2,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168215
PNG
(US9669031, 46 N-[6-[[8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H16ClF3N6O3/c1-17(6-18(20,21)22)27-15(30)13-9(19)4-10(16(31)28(13)17)25-11-5-12(24-7-23-11)26-14(29)8-2-3-8/h4-5,7-8H,2-3,6H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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US Patent
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168215
PNG
(US9669031, 46 N-[6-[[8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H16ClF3N6O3/c1-17(6-18(20,21)22)27-15(30)13-9(19)4-10(16(31)28(13)17)25-11-5-12(24-7-23-11)26-14(29)8-2-3-8/h4-5,7-8H,2-3,6H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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n/an/a<10n/an/an/an/an/an/a



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168216
PNG
(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12ClN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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n/an/a<10n/an/an/an/an/an/a



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168216
PNG
(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12ClN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168217
PNG
(US9669031, 48 8-chloro-3-cyclopentyl-3-methyl-6-(p...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C17H18ClN5O2/c1-17(10-4-2-3-5-10)22-15(24)14-11(18)8-12(16(25)23(14)17)21-13-6-7-19-9-20-13/h6-10H,2-5H2,1H3,(H,22,24)(H,19,20,21)
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n/an/a<10n/an/an/an/an/an/a



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168217
PNG
(US9669031, 48 8-chloro-3-cyclopentyl-3-methyl-6-(p...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C17H18ClN5O2/c1-17(10-4-2-3-5-10)22-15(24)14-11(18)8-12(16(25)23(14)17)21-13-6-7-19-9-20-13/h6-10H,2-5H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168220
PNG
(US9669031, 49 N-(6-((8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N6O3/c1-16(17(19,20)21)26-14(29)12-8(18)4-9(15(30)27(12)16)24-10-5-11(23-6-22-10)25-13(28)7-2-3-7/h4-7H,2-3H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168220
PNG
(US9669031, 49 N-(6-((8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N6O3/c1-16(17(19,20)21)26-14(29)12-8(18)4-9(15(30)27(12)16)24-10-5-11(23-6-22-10)25-13(28)7-2-3-7/h4-7H,2-3H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168221
PNG
(US9669031, 50 N-[6-[(8-chloro-4′,4′-di...)
Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168221
PNG
(US9669031, 50 N-[6-[(8-chloro-4′,4′-di...)
Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168223
PNG
(US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H18ClFN6O3/c1-22(12-3-2-4-13(24)7-12)29-20(32)18-14(23)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM168223
PNG
(US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H18ClFN6O3/c1-22(12-3-2-4-13(24)7-12)29-20(32)18-14(23)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
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