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Compile Data Set for Download or QSAR

Found 266 hits with Last Name = 'abbineni' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325971
PNG
(CHEMBL1224229 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H33FN4O/c1-22(36)32-26-8-6-7-24(21-26)23-16-19-34(20-17-23)18-5-4-11-30-33-28-9-2-3-10-29(28)35(30)27-14-12-25(31)13-15-27/h2-3,6-10,12-15,21,23H,4-5,11,16-20H2,1H3,(H,32,36)
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n/an/a 0.600n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325950
PNG
(CHEMBL1223770 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H32FN5O/c1-21(36)32-25-7-4-6-23(20-25)22-14-18-34(19-15-22)17-5-16-31-29-33-27-8-2-3-9-28(27)35(29)26-12-10-24(30)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,33)(H,32,36)
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n/an/a 2n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325971
PNG
(CHEMBL1224229 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H33FN4O/c1-22(36)32-26-8-6-7-24(21-26)23-16-19-34(20-17-23)18-5-4-11-30-33-28-9-2-3-10-29(28)35(30)27-14-12-25(31)13-15-27/h2-3,6-10,12-15,21,23H,4-5,11,16-20H2,1H3,(H,32,36)
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n/an/a 3n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381517
PNG
(CHEMBL2017748)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCCS1(=O)=O
Show InChI InChI=1S/C27H28F3N5O4S/c1-18-23-17-20(32-25(36)10-5-19-3-7-22(8-4-19)39-27(28,29)30)6-9-24(23)33-26(31-18)34-14-11-21(12-15-34)35-13-2-16-40(35,37)38/h3-10,17,21H,2,11-16H2,1H3,(H,32,36)/b10-5+
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n/an/a 4n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325976
PNG
(CHEMBL1224306 | N-(3-(1-(4,4-difluoro-4-(1-(4-fluo...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCC(F)(F)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31F3N4O/c1-21(38)34-25-7-4-6-23(20-25)22-14-18-36(19-15-22)17-5-16-30(32,33)29-35-27-8-2-3-9-28(27)37(29)26-12-10-24(31)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,34,38)
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n/an/a 4n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381530
PNG
(CHEMBL2017761)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)NC(=O)CO
Show InChI InChI=1S/C26H26F3N5O4/c1-16-21-14-19(32-23(36)9-4-17-2-6-20(7-3-17)38-26(27,28)29)5-8-22(21)33-25(30-16)34-12-10-18(11-13-34)31-24(37)15-35/h2-9,14,18,35H,10-13,15H2,1H3,(H,31,37)(H,32,36)/b9-4+
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n/an/a 6n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325952
PNG
(CHEMBL1223829 | N-(3-(1-(3-(1-(4-chlorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C30H34ClN5O/c1-22(37)33-27-7-4-6-25(20-27)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)21-23-10-12-26(31)13-11-23/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 8n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325979
PNG
(6-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-...)
Show SMILES Fc1ccc(cc1)-n1c(CCCCN2CCC(CC2)c2ccc3CC(=O)Nc3c2)nc2ccccc12
Show InChI InChI=1S/C30H31FN4O/c31-24-10-12-25(13-11-24)35-28-6-2-1-5-26(28)32-29(35)7-3-4-16-34-17-14-21(15-18-34)22-8-9-23-20-30(36)33-27(23)19-22/h1-2,5-6,8-13,19,21H,3-4,7,14-18,20H2,(H,33,36)
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n/an/a 9n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325979
PNG
(6-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-...)
Show SMILES Fc1ccc(cc1)-n1c(CCCCN2CCC(CC2)c2ccc3CC(=O)Nc3c2)nc2ccccc12
Show InChI InChI=1S/C30H31FN4O/c31-24-10-12-25(13-11-24)35-28-6-2-1-5-26(28)32-29(35)7-3-4-16-34-17-14-21(15-18-34)22-8-9-23-20-30(36)33-27(23)19-22/h1-2,5-6,8-13,19,21H,3-4,7,14-18,20H2,(H,33,36)
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n/an/a 9n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381510
PNG
(CHEMBL2017741)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C28H30F3N5O3/c1-19-24-18-21(33-26(37)9-4-20-2-6-23(7-3-20)39-28(29,30)31)5-8-25(24)34-27(32-19)36-12-10-22(11-13-36)35-14-16-38-17-15-35/h2-9,18,22H,10-17H2,1H3,(H,33,37)/b9-4+
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n/an/a 10n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325967
PNG
(CHEMBL1224152 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES Fc1ccc(cc1)-n1c(NCCCN2CCC(CC2)c2cccc(NC(=O)C3CC3)c2)nc2ccccc12
Show InChI InChI=1S/C31H34FN5O/c32-25-11-13-27(14-12-25)37-29-8-2-1-7-28(29)35-31(37)33-17-4-18-36-19-15-22(16-20-36)24-5-3-6-26(21-24)34-30(38)23-9-10-23/h1-3,5-8,11-14,21-23H,4,9-10,15-20H2,(H,33,35)(H,34,38)
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n/an/a 10n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325944
PNG
(CHEMBL1223708 | N-(3-(1-(3-(1-(4-chlorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H32ClN5O/c1-21(36)32-25-7-4-6-23(20-25)22-14-18-34(19-15-22)17-5-16-31-29-33-27-8-2-3-9-28(27)35(29)26-12-10-24(30)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,33)(H,32,36)
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n/an/a 11n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381513
PNG
(CHEMBL2017744)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCCC1=O
Show InChI InChI=1S/C28H28F3N5O3/c1-18-23-17-20(33-25(37)11-6-19-4-8-22(9-5-19)39-28(29,30)31)7-10-24(23)34-27(32-18)35-15-12-21(13-16-35)36-14-2-3-26(36)38/h4-11,17,21H,2-3,12-16H2,1H3,(H,33,37)/b11-6+
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n/an/a 11n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381513
PNG
(CHEMBL2017744)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCCC1=O
Show InChI InChI=1S/C28H28F3N5O3/c1-18-23-17-20(33-25(37)11-6-19-4-8-22(9-5-19)39-28(29,30)31)7-10-24(23)34-27(32-18)35-15-12-21(13-16-35)36-14-2-3-26(36)38/h4-11,17,21H,2-3,12-16H2,1H3,(H,33,37)/b11-6+
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n/an/a 12n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325975
PNG
(CHEMBL1224305 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCC(=O)c2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31FN4O2/c1-21(36)32-25-7-4-6-23(20-25)22-15-18-34(19-16-22)17-5-10-29(37)30-33-27-8-2-3-9-28(27)35(30)26-13-11-24(31)12-14-26/h2-4,6-9,11-14,20,22H,5,10,15-19H2,1H3,(H,32,36)
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n/an/a 13n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381511
PNG
(CHEMBL2017742)
Show SMILES Cc1nc(nc2ccc(NC(=O)C=Cc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCOCC1=O
Show InChI InChI=1S/C28H28F3N5O4/c1-18-23-16-20(33-25(37)9-4-19-2-6-22(7-3-19)40-28(29,30)31)5-8-24(23)34-27(32-18)35-12-10-21(11-13-35)36-14-15-39-17-26(36)38/h2-9,16,21H,10-15,17H2,1H3,(H,33,37)
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Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381510
PNG
(CHEMBL2017741)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C28H30F3N5O3/c1-19-24-18-21(33-26(37)9-4-20-2-6-23(7-3-20)39-28(29,30)31)5-8-25(24)34-27(32-19)36-12-10-22(11-13-36)35-14-16-38-17-15-35/h2-9,18,22H,10-17H2,1H3,(H,33,37)/b9-4+
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Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381527
PNG
(CHEMBL2017757)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N1CCC(CC1)NS(C)(=O)=O
Show InChI InChI=1S/C24H26ClN5O3S/c1-16-21-15-20(27-23(31)10-5-17-3-6-18(25)7-4-17)8-9-22(21)28-24(26-16)30-13-11-19(12-14-30)29-34(2,32)33/h3-10,15,19,29H,11-14H2,1-2H3,(H,27,31)/b10-5+
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n/an/a 14n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381531
PNG
(CHEMBL2017762)
Show SMILES COCC(=O)NC1CCN(CC1)c1nc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C27H28F3N5O4/c1-17-22-15-20(33-24(36)10-5-18-3-7-21(8-4-18)39-27(28,29)30)6-9-23(22)34-26(31-17)35-13-11-19(12-14-35)32-25(37)16-38-2/h3-10,15,19H,11-14,16H2,1-2H3,(H,32,37)(H,33,36)/b10-5+
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n/an/a 14n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381512
PNG
(CHEMBL2017743)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCCCC1=O
Show InChI InChI=1S/C29H30F3N5O3/c1-19-24-18-21(34-26(38)12-7-20-5-9-23(10-6-20)40-29(30,31)32)8-11-25(24)35-28(33-19)36-16-13-22(14-17-36)37-15-3-2-4-27(37)39/h5-12,18,22H,2-4,13-17H2,1H3,(H,34,38)/b12-7+
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n/an/a 15n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325968
PNG
(CHEMBL1224153 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(C)C(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C31H36FN5O/c1-22(2)30(38)34-26-8-5-7-24(21-26)23-15-19-36(20-16-23)18-6-17-33-31-35-28-9-3-4-10-29(28)37(31)27-13-11-25(32)12-14-27/h3-5,7-14,21-23H,6,15-20H2,1-2H3,(H,33,35)(H,34,38)
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n/an/a 15n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381517
PNG
(CHEMBL2017748)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCCS1(=O)=O
Show InChI InChI=1S/C27H28F3N5O4S/c1-18-23-17-20(32-25(36)10-5-19-3-7-22(8-4-19)39-27(28,29)30)6-9-24(23)33-26(31-18)34-14-11-21(12-15-34)35-13-2-16-40(35,37)38/h3-10,17,21H,2,11-16H2,1H3,(H,32,36)/b10-5+
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n/an/a 16n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381509
PNG
(CHEMBL2017740)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C27H30ClN5O2/c1-19-24-18-22(30-26(34)9-4-20-2-5-21(28)6-3-20)7-8-25(24)31-27(29-19)33-12-10-23(11-13-33)32-14-16-35-17-15-32/h2-9,18,23H,10-17H2,1H3,(H,30,34)/b9-4+
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n/an/a 16n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381485
PNG
(CHEMBL2017593)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N1CCC(O)(CC1)C1CC1
Show InChI InChI=1S/C26H27ClN4O2/c1-17-22-16-21(29-24(32)11-4-18-2-7-20(27)8-3-18)9-10-23(22)30-25(28-17)31-14-12-26(33,13-15-31)19-5-6-19/h2-4,7-11,16,19,33H,5-6,12-15H2,1H3,(H,29,32)/b11-4+
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n/an/a 16n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381509
PNG
(CHEMBL2017740)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C27H30ClN5O2/c1-19-24-18-22(30-26(34)9-4-20-2-5-21(28)6-3-20)7-8-25(24)31-27(29-19)33-12-10-23(11-13-33)32-14-16-35-17-15-32/h2-9,18,23H,10-17H2,1H3,(H,30,34)/b9-4+
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n/an/a 17n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325950
PNG
(CHEMBL1223770 | N-(3-(1-(3-(1-(4-fluorophenyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H32FN5O/c1-21(36)32-25-7-4-6-23(20-25)22-14-18-34(19-15-22)17-5-16-31-29-33-27-8-2-3-9-28(27)35(29)26-12-10-24(30)11-13-26/h2-4,6-13,20,22H,5,14-19H2,1H3,(H,31,33)(H,32,36)
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n/an/a 18n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proxi...


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381518
PNG
(CHEMBL2017751)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CC(C)(C)OC1=O
Show InChI InChI=1S/C29H30F3N5O4/c1-18-23-16-20(34-25(38)11-6-19-4-8-22(9-5-19)40-29(30,31)32)7-10-24(23)35-26(33-18)36-14-12-21(13-15-36)37-17-28(2,3)41-27(37)39/h4-11,16,21H,12-15,17H2,1-3H3,(H,34,38)/b11-6+
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n/an/a 18n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381529
PNG
(CHEMBL2017760)
Show SMILES COCC(=O)NC1CCN(CC1)c1nc(C)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C26H28ClN5O3/c1-17-22-15-21(30-24(33)10-5-18-3-6-19(27)7-4-18)8-9-23(22)31-26(28-17)32-13-11-20(12-14-32)29-25(34)16-35-2/h3-10,15,20H,11-14,16H2,1-2H3,(H,29,34)(H,30,33)/b10-5+
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n/an/a 19n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381508
PNG
(CHEMBL2017618)
Show SMILES Cc1nc(NCCCC(=O)NC2CC2)nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C26H26F3N5O3/c1-16-21-15-19(33-24(36)13-6-17-4-10-20(11-5-17)37-26(27,28)29)9-12-22(21)34-25(31-16)30-14-2-3-23(35)32-18-7-8-18/h4-6,9-13,15,18H,2-3,7-8,14H2,1H3,(H,32,35)(H,33,36)(H,30,31,34)/b13-6+
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n/an/a 20n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381515
PNG
(CHEMBL2017746)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N1CCC(CC1)N1CCCC1=O
Show InChI InChI=1S/C27H28ClN5O2/c1-18-23-17-21(30-25(34)11-6-19-4-7-20(28)8-5-19)9-10-24(23)31-27(29-18)32-15-12-22(13-16-32)33-14-2-3-26(33)35/h4-11,17,22H,2-3,12-16H2,1H3,(H,30,34)/b11-6+
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n/an/a 20n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381520
PNG
(CHEMBL2017753)
Show SMILES CN1CCN(C2CCN(CC2)c2nc(C)c3cc(NC(=O)\C=C\c4ccc(OC(F)(F)F)cc4)ccc3n2)C1=O
Show InChI InChI=1S/C28H29F3N6O3/c1-18-23-17-20(33-25(38)10-5-19-3-7-22(8-4-19)40-28(29,30)31)6-9-24(23)34-26(32-18)36-13-11-21(12-14-36)37-16-15-35(2)27(37)39/h3-10,17,21H,11-16H2,1-2H3,(H,33,38)/b10-5+
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n/an/a 21n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381520
PNG
(CHEMBL2017753)
Show SMILES CN1CCN(C2CCN(CC2)c2nc(C)c3cc(NC(=O)\C=C\c4ccc(OC(F)(F)F)cc4)ccc3n2)C1=O
Show InChI InChI=1S/C28H29F3N6O3/c1-18-23-17-20(33-25(38)10-5-19-3-7-22(8-4-19)40-28(29,30)31)6-9-24(23)34-26(32-18)36-13-11-21(12-14-36)37-16-15-35(2)27(37)39/h3-10,17,21H,11-16H2,1-2H3,(H,33,38)/b10-5+
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n/an/a 21n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325946
PNG
(CHEMBL1223710 | N-(3-(1-(3-(1-phenyl-1H-benzo[d]im...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccccc2)CC1
Show InChI InChI=1S/C29H33N5O/c1-22(35)31-25-10-7-9-24(21-25)23-15-19-33(20-16-23)18-8-17-30-29-32-27-13-5-6-14-28(27)34(29)26-11-3-2-4-12-26/h2-7,9-14,21,23H,8,15-20H2,1H3,(H,30,32)(H,31,35)
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n/an/a 21n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325953
PNG
(CHEMBL1223830 | N-(3-(1-(3-(1-(4-fluorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H34FN5O/c1-22(37)33-27-7-4-6-25(20-27)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)21-23-10-12-26(31)13-11-23/h2-4,6-13,20,24H,5,14-19,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 22n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381506
PNG
(CHEMBL2017616)
Show SMILES Cc1nc(NCCNC(=O)C2CC2)nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C25H24F3N5O3/c1-15-20-14-18(32-22(34)11-4-16-2-8-19(9-3-16)36-25(26,27)28)7-10-21(20)33-24(31-15)30-13-12-29-23(35)17-5-6-17/h2-4,7-11,14,17H,5-6,12-13H2,1H3,(H,29,35)(H,32,34)(H,30,31,33)/b11-4+
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n/an/a 23n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325948
PNG
(CHEMBL1223768 | N-(3-(1-(3-(1-(4-cyanophenyl)-1H-b...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2-c2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C30H32N6O/c1-22(37)33-26-7-4-6-25(20-26)24-14-18-35(19-15-24)17-5-16-32-30-34-28-8-2-3-9-29(28)36(30)27-12-10-23(21-31)11-13-27/h2-4,6-13,20,24H,5,14-19H2,1H3,(H,32,34)(H,33,37)
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n/an/a 24n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381498
PNG
(CHEMBL2017606)
Show SMILES CC(=O)CC1(O)CCN(CC1)c1nc(C)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C26H27ClN4O3/c1-17(32)16-26(34)11-13-31(14-12-26)25-28-18(2)22-15-21(8-9-23(22)30-25)29-24(33)10-5-19-3-6-20(27)7-4-19/h3-10,15,34H,11-14,16H2,1-2H3,(H,29,33)/b10-5+
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n/an/a 24n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381507
PNG
(CHEMBL2017617)
Show SMILES Cc1nc(NCCCNC(=O)C2CC2)nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C26H26F3N5O3/c1-16-21-15-19(33-23(35)12-5-17-3-9-20(10-4-17)37-26(27,28)29)8-11-22(21)34-25(32-16)31-14-2-13-30-24(36)18-6-7-18/h3-5,8-12,15,18H,2,6-7,13-14H2,1H3,(H,30,36)(H,33,35)(H,31,32,34)/b12-5+
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n/an/a 26n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381530
PNG
(CHEMBL2017761)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)NC(=O)CO
Show InChI InChI=1S/C26H26F3N5O4/c1-16-21-14-19(32-23(36)9-4-17-2-6-20(7-3-17)38-26(27,28)29)5-8-22(21)33-25(30-16)34-12-10-18(11-13-34)31-24(37)15-35/h2-9,14,18,35H,10-13,15H2,1H3,(H,31,37)(H,32,36)/b9-4+
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n/an/a 26n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381521
PNG
(CHEMBL2017754)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCNS1(=O)=O
Show InChI InChI=1S/C26H27F3N6O4S/c1-17-22-16-19(32-24(36)9-4-18-2-6-21(7-3-18)39-26(27,28)29)5-8-23(22)33-25(31-17)34-13-10-20(11-14-34)35-15-12-30-40(35,37)38/h2-9,16,20,30H,10-15H2,1H3,(H,32,36)/b9-4+
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n/an/a 26n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381528
PNG
(CHEMBL2017759)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N1CCC(CC1)NC(=O)CO
Show InChI InChI=1S/C25H26ClN5O3/c1-16-21-14-20(29-23(33)9-4-17-2-5-18(26)6-3-17)7-8-22(21)30-25(27-16)31-12-10-19(11-13-31)28-24(34)15-32/h2-9,14,19,32H,10-13,15H2,1H3,(H,28,34)(H,29,33)/b9-4+
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n/an/a 27n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50325961
PNG
(CHEMBL1223968 | N-(3-(1-(3-(1-(3-chlorobenzyl)-1H-...)
Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCNc2nc3ccccc3n2Cc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C30H34ClN5O/c1-22(37)33-27-10-5-8-25(20-27)24-13-17-35(18-14-24)16-6-15-32-30-34-28-11-2-3-12-29(28)36(30)21-23-7-4-9-26(31)19-23/h2-5,7-12,19-20,24H,6,13-18,21H2,1H3,(H,32,34)(H,33,37)
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n/an/a 29n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay


Bioorg Med Chem Lett 20: 5443-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381511
PNG
(CHEMBL2017742)
Show SMILES Cc1nc(nc2ccc(NC(=O)C=Cc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCOCC1=O
Show InChI InChI=1S/C28H28F3N5O4/c1-18-23-16-20(33-25(37)9-4-19-2-6-22(7-3-19)40-28(29,30)31)5-8-24(23)34-27(32-18)35-12-10-21(11-13-35)36-14-15-39-17-26(36)38/h2-9,16,21H,10-15,17H2,1H3,(H,33,37)
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n/an/a 30n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381502
PNG
(CHEMBL2017612)
Show SMILES Cc1nc(NCCCO)nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C22H21F3N4O3/c1-14-18-13-16(6-9-19(18)29-21(27-14)26-11-2-12-30)28-20(31)10-5-15-3-7-17(8-4-15)32-22(23,24)25/h3-10,13,30H,2,11-12H2,1H3,(H,28,31)(H,26,27,29)/b10-5+
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n/an/a 30n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381519
PNG
(CHEMBL2017752)
Show SMILES Cc1nc(nc2ccc(NC(=O)C=Cc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCNC1=O
Show InChI InChI=1S/C27H27F3N6O3/c1-17-22-16-19(33-24(37)9-4-18-2-6-21(7-3-18)39-27(28,29)30)5-8-23(22)34-25(32-17)35-13-10-20(11-14-35)36-15-12-31-26(36)38/h2-9,16,20H,10-15H2,1H3,(H,31,38)(H,33,37)
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n/an/a 31n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381527
PNG
(CHEMBL2017757)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N1CCC(CC1)NS(C)(=O)=O
Show InChI InChI=1S/C24H26ClN5O3S/c1-16-21-15-20(27-23(31)10-5-17-3-6-18(25)7-4-17)8-9-22(21)28-24(26-16)30-13-11-19(12-14-30)29-34(2,32)33/h3-10,15,19,29H,11-14H2,1-2H3,(H,27,31)/b10-5+
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n/an/a 31n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381480
PNG
(CHEMBL2017750)
Show SMILES Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCOC1=O
Show InChI InChI=1S/C27H26F3N5O4/c1-17-22-16-19(32-24(36)9-4-18-2-6-21(7-3-18)39-27(28,29)30)5-8-23(22)33-25(31-17)34-12-10-20(11-13-34)35-14-15-38-26(35)37/h2-9,16,20H,10-15H2,1H3,(H,32,36)/b9-4+
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n/an/a 31n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381534
PNG
(CHEMBL2017765)
Show SMILES CN(C)S(=O)(=O)NC1CCN(CC1)c1nc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H29F3N6O4S/c1-17-22-16-20(31-24(36)11-6-18-4-8-21(9-5-18)39-26(27,28)29)7-10-23(22)32-25(30-17)35-14-12-19(13-15-35)33-40(37,38)34(2)3/h4-11,16,19,33H,12-15H2,1-3H3,(H,31,36)/b11-6+
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n/an/a 31n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381531
PNG
(CHEMBL2017762)
Show SMILES COCC(=O)NC1CCN(CC1)c1nc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C27H28F3N5O4/c1-17-22-15-20(33-24(36)10-5-18-3-7-21(8-4-18)39-27(28,29)30)6-9-23(22)34-26(31-17)35-13-11-19(12-14-35)32-25(37)16-38-2/h3-10,15,19H,11-14,16H2,1-2H3,(H,32,37)(H,33,36)/b10-5+
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n/an/a 32n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50381505
PNG
(CHEMBL2017615)
Show SMILES Cc1nc(NCCCNS(C)(=O)=O)nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C23H24F3N5O4S/c1-15-19-14-17(7-10-20(19)31-22(29-15)27-12-3-13-28-36(2,33)34)30-21(32)11-6-16-4-8-18(9-5-16)35-23(24,25)26/h4-11,14,28H,3,12-13H2,1-2H3,(H,30,32)(H,27,29,31)/b11-6+
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n/an/a 32n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...


Bioorg Med Chem Lett 22: 3163-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.049
BindingDB Entry DOI: 10.7270/Q20Z7485
More data for this
Ligand-Target Pair
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