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Compile Data Set for Download or QSAR

Found 50 hits with Last Name = 'abdel-latif' and Initial = 'ms'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222084
PNG
(6-(4-nitrophenyl)-2-oxo-4-(thiophen-2-yl)-1,2-dihy...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2cccs2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C16H9N3O3S/c17-9-13-12(15-2-1-7-23-15)8-14(18-16(13)20)10-3-5-11(6-4-10)19(21)22/h1-8H,(H,18,20)
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n/an/a 870n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222088
PNG
(4-(4-Fluorophenyl)-6-(4-isobutylphenyl)-2-oxo-1,2-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccc(F)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H19FN2O/c1-14(2)11-15-3-5-17(6-4-15)21-12-19(20(13-24)22(26)25-21)16-7-9-18(23)10-8-16/h3-10,12,14H,11H2,1-2H3,(H,25,26)
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n/an/a 930n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222089
PNG
(4-(2-Furyl)-6-(4-isobutylphenyl)-2-oxo-1,2-dihydro...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccco2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H18N2O2/c1-13(2)10-14-5-7-15(8-6-14)18-11-16(19-4-3-9-24-19)17(12-21)20(23)22-18/h3-9,11,13H,10H2,1-2H3,(H,22,23)
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n/an/a 1.11E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222083
PNG
(4-(2-Furyl)-6-(4-nitrophenyl)-2-oxo-1,2-dihydropyr...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccco2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C16H9N3O4/c17-9-13-12(15-2-1-7-23-15)8-14(18-16(13)20)10-3-5-11(6-4-10)19(21)22/h1-8H,(H,18,20)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222092
PNG
(6-(4-Methanesulfonylaminophenyl)-2-oxo-4-(4-tolyl)...)
Show SMILES Cc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C20H17N3O3S/c1-13-3-5-14(6-4-13)17-11-19(22-20(24)18(17)12-21)15-7-9-16(10-8-15)23-27(2,25)26/h3-11,23H,1-2H3,(H,22,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222097
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methanesulfonylamin...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H22N4O4S2/c1-31(27,28)25-18-9-7-16(8-10-18)21-15-22(17-5-3-2-4-6-17)26(24-21)19-11-13-20(14-12-19)32(23,29)30/h2-14,22,25H,15H2,1H3,(H2,23,29,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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PubMed
n/an/a 1.33E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222091
PNG
(6-(4-Methanesulfonylaminophenyl)-2-oxo-4-phenyl-1,...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H15N3O3S/c1-26(24,25)22-15-9-7-14(8-10-15)18-11-16(13-5-3-2-4-6-13)17(12-20)19(23)21-18/h2-11,22H,1H3,(H,21,23)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222099
PNG
(1-(4-Aminosulfonylphenyl)-5-(4-chlorophenyl)-3-(4-...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H21ClN4O4S2/c1-32(28,29)26-18-8-4-15(5-9-18)21-14-22(16-2-6-17(23)7-3-16)27(25-21)19-10-12-20(13-11-19)33(24,30)31/h2-13,22,26H,14H2,1H3,(H2,24,30,31)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222094
PNG
(4-(4-Fluorophenyl)-6-(4-methanesulfonylaminophenyl...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccc(F)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14FN3O3S/c1-27(25,26)23-15-8-4-13(5-9-15)18-10-16(17(11-21)19(24)22-18)12-2-6-14(20)7-3-12/h2-10,23H,1H3,(H,22,24)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222086
PNG
(6-(4-Isobutylphenyl)-2-oxo-4-(p-tolyl)-1,2-dihydro...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccc(C)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C23H22N2O/c1-15(2)12-17-6-10-19(11-7-17)22-13-20(21(14-24)23(26)25-22)18-8-4-16(3)5-9-18/h4-11,13,15H,12H2,1-3H3,(H,25,26)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222095
PNG
(4-(2-Furyl)-6-(4-methanesulfonylaminophenyl)-2-oxo...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccco2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C17H13N3O4S/c1-25(22,23)20-12-6-4-11(5-7-12)15-9-13(16-3-2-8-24-16)14(10-18)17(21)19-15/h2-9,20H,1H3,(H,19,21)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222080
PNG
(6-(4-Nitrophenyl)-2-oxo-4-(p-tolyl)-1,2-dihydropyr...)
Show SMILES Cc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H13N3O3/c1-12-2-4-13(5-3-12)16-10-18(21-19(23)17(16)11-20)14-6-8-15(9-7-14)22(24)25/h2-10H,1H3,(H,21,23)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222085
PNG
(6-(4-Isobutylphenyl)-2-oxo-4-phenyl-1,2-dihydropyr...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H20N2O/c1-15(2)12-16-8-10-18(11-9-16)21-13-19(17-6-4-3-5-7-17)20(14-23)22(25)24-21/h3-11,13,15H,12H2,1-2H3,(H,24,25)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222093
PNG
(4-(4-Chlorophenyl)-6-(4-methanesulfonylaminophenyl...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccc(Cl)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14ClN3O3S/c1-27(25,26)23-15-8-4-13(5-9-15)18-10-16(17(11-21)19(24)22-18)12-2-6-14(20)7-3-12/h2-10,23H,1H3,(H,22,24)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222101
PNG
(1-(4-Aminosulfonylphenyl)-5-(2-furyl)-3-(4-methane...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccco1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H20N4O5S2/c1-30(25,26)23-15-6-4-14(5-7-15)18-13-19(20-3-2-12-29-20)24(22-18)16-8-10-17(11-9-16)31(21,27)28/h2-12,19,23H,13H2,1H3,(H2,21,27,28)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222090
PNG
(6-(4-Isobutylphenyl)-2-oxo-4-(2-thienyl)-1,2-dihyd...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2cccs2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H18N2OS/c1-13(2)10-14-5-7-15(8-6-14)18-11-16(19-4-3-9-24-19)17(12-21)20(23)22-18/h3-9,11,13H,10H2,1-2H3,(H,22,23)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222079
PNG
(6-(4-nitrophenyl)-2-oxo-4-phenyl-1,2-dihydropyridi...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11N3O3/c19-11-16-15(12-4-2-1-3-5-12)10-17(20-18(16)22)13-6-8-14(9-7-13)21(23)24/h1-10H,(H,20,22)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222100
PNG
(1-(4-Aminosulfonylphenyl)-5-(4-fluorophenyl)-3-(4-...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H21FN4O4S2/c1-32(28,29)26-18-8-4-15(5-9-18)21-14-22(16-2-6-17(23)7-3-16)27(25-21)19-10-12-20(13-11-19)33(24,30)31/h2-13,22,26H,14H2,1H3,(H2,24,30,31)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222082
PNG
(4-(4-Fluorophenyl)-6-(4-nitrophenyl)-2-oxo-1,2-dih...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccc(F)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H10FN3O3/c19-13-5-1-11(2-6-13)15-9-17(21-18(23)16(15)10-20)12-3-7-14(8-4-12)22(24)25/h1-9H,(H,21,23)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222087
PNG
(4-(4-Chlorophenyl)-6-(4-isobutylphenyl)-2-oxo-1,2-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccc(Cl)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H19ClN2O/c1-14(2)11-15-3-5-17(6-4-15)21-12-19(20(13-24)22(26)25-21)16-7-9-18(23)10-8-16/h3-10,12,14H,11H2,1-2H3,(H,25,26)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222088
PNG
(4-(4-Fluorophenyl)-6-(4-isobutylphenyl)-2-oxo-1,2-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccc(F)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H19FN2O/c1-14(2)11-15-3-5-17(6-4-15)21-12-19(20(13-24)22(26)25-21)16-7-9-18(23)10-8-16/h3-10,12,14H,11H2,1-2H3,(H,25,26)
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Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222084
PNG
(6-(4-nitrophenyl)-2-oxo-4-(thiophen-2-yl)-1,2-dihy...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2cccs2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C16H9N3O3S/c17-9-13-12(15-2-1-7-23-15)8-14(18-16(13)20)10-3-5-11(6-4-10)19(21)22/h1-8H,(H,18,20)
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Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222089
PNG
(4-(2-Furyl)-6-(4-isobutylphenyl)-2-oxo-1,2-dihydro...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccco2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H18N2O2/c1-13(2)10-14-5-7-15(8-6-14)18-11-16(19-4-3-9-24-19)17(12-21)20(23)22-18/h3-9,11,13H,10H2,1-2H3,(H,22,23)
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Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222081
PNG
(4-(4-chlorophenyl)-6-(4-nitrophenyl)-2-oxo-1,2-dih...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccc(Cl)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H10ClN3O3/c19-13-5-1-11(2-6-13)15-9-17(21-18(23)16(15)10-20)12-3-7-14(8-4-12)22(24)25/h1-9H,(H,21,23)
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The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222098
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methanesulfonylamin...)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C23H24N4O4S2/c1-16-3-5-18(6-4-16)23-15-22(17-7-9-19(10-8-17)26-32(2,28)29)25-27(23)20-11-13-21(14-12-20)33(24,30)31/h3-14,23,26H,15H2,1-2H3,(H2,24,30,31)
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The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222097
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methanesulfonylamin...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H22N4O4S2/c1-31(27,28)25-18-9-7-16(8-10-18)21-15-22(17-5-3-2-4-6-17)26(24-21)19-11-13-20(14-12-19)32(23,29)30/h2-14,22,25H,15H2,1H3,(H2,23,29,30)
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The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222102
PNG
(1-(4-Aminosulfonylphenyl)-5-(2-thienyl)-3-(4-metha...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1cccs1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H20N4O4S3/c1-30(25,26)23-15-6-4-14(5-7-15)18-13-19(20-3-2-12-29-20)24(22-18)16-8-10-17(11-9-16)31(21,27)28/h2-12,19,23H,13H2,1H3,(H2,21,27,28)
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The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222092
PNG
(6-(4-Methanesulfonylaminophenyl)-2-oxo-4-(4-tolyl)...)
Show SMILES Cc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C20H17N3O3S/c1-13-3-5-14(6-4-13)17-11-19(22-20(24)18(17)12-21)15-7-9-16(10-8-15)23-27(2,25)26/h3-11,23H,1-2H3,(H,22,24)
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Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222083
PNG
(4-(2-Furyl)-6-(4-nitrophenyl)-2-oxo-1,2-dihydropyr...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccco2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C16H9N3O4/c17-9-13-12(15-2-1-7-23-15)8-14(18-16(13)20)10-3-5-11(6-4-10)19(21)22/h1-8H,(H,18,20)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222091
PNG
(6-(4-Methanesulfonylaminophenyl)-2-oxo-4-phenyl-1,...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H15N3O3S/c1-26(24,25)22-15-9-7-14(8-10-15)18-11-16(13-5-3-2-4-6-13)17(12-20)19(23)21-18/h2-11,22H,1H3,(H,21,23)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222099
PNG
(1-(4-Aminosulfonylphenyl)-5-(4-chlorophenyl)-3-(4-...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H21ClN4O4S2/c1-32(28,29)26-18-8-4-15(5-9-18)21-14-22(16-2-6-17(23)7-3-16)27(25-21)19-10-12-20(13-11-19)33(24,30)31/h2-13,22,26H,14H2,1H3,(H2,24,30,31)
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n/an/a 9.70E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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n/an/a 9.70E+3n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222095
PNG
(4-(2-Furyl)-6-(4-methanesulfonylaminophenyl)-2-oxo...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccco2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C17H13N3O4S/c1-25(22,23)20-12-6-4-11(5-7-12)15-9-13(16-3-2-8-24-16)14(10-18)17(21)19-15/h2-9,20H,1H3,(H,19,21)
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Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM222096
PNG
(6-(4-Methanesulfonylaminophenyl)-2-oxo-4-(2-thieny...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2cccs2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C17H13N3O3S2/c1-25(22,23)20-12-6-4-11(5-7-12)15-9-13(16-3-2-8-24-16)14(10-18)17(21)19-15/h2-9,20H,1H3,(H,19,21)
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n/an/a 1.02E+4n/an/an/an/an/an/a



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Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222094
PNG
(4-(4-Fluorophenyl)-6-(4-methanesulfonylaminophenyl...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccc(F)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14FN3O3S/c1-27(25,26)23-15-8-4-13(5-9-15)18-10-16(17(11-21)19(24)22-18)12-2-6-14(20)7-3-12/h2-10,23H,1H3,(H,22,24)
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n/an/a 1.07E+4n/an/an/an/an/an/a



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Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222086
PNG
(6-(4-Isobutylphenyl)-2-oxo-4-(p-tolyl)-1,2-dihydro...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccc(C)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C23H22N2O/c1-15(2)12-17-6-10-19(11-7-17)22-13-20(21(14-24)23(26)25-22)18-8-4-16(3)5-9-18/h4-11,13,15H,12H2,1-3H3,(H,25,26)
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n/an/a 1.12E+4n/an/an/an/an/an/a



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Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222079
PNG
(6-(4-nitrophenyl)-2-oxo-4-phenyl-1,2-dihydropyridi...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11N3O3/c19-11-16-15(12-4-2-1-3-5-12)10-17(20-18(16)22)13-6-8-14(9-7-13)21(23)24/h1-10H,(H,20,22)
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The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222090
PNG
(6-(4-Isobutylphenyl)-2-oxo-4-(2-thienyl)-1,2-dihyd...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2cccs2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H18N2OS/c1-13(2)10-14-5-7-15(8-6-14)18-11-16(19-4-3-9-24-19)17(12-21)20(23)22-18/h3-9,11,13H,10H2,1-2H3,(H,22,23)
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UniChem
Article
PubMed
n/an/a 1.27E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222080
PNG
(6-(4-Nitrophenyl)-2-oxo-4-(p-tolyl)-1,2-dihydropyr...)
Show SMILES Cc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H13N3O3/c1-12-2-4-13(5-3-12)16-10-18(21-19(23)17(16)11-20)14-6-8-15(9-7-14)22(24)25/h2-10H,1H3,(H,21,23)
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n/an/a 1.29E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222085
PNG
(6-(4-Isobutylphenyl)-2-oxo-4-phenyl-1,2-dihydropyr...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H20N2O/c1-15(2)12-16-8-10-18(11-9-16)21-13-19(17-6-4-3-5-7-17)20(14-23)22(25)24-21/h3-11,13,15H,12H2,1-2H3,(H,24,25)
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n/an/a 1.31E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222082
PNG
(4-(4-Fluorophenyl)-6-(4-nitrophenyl)-2-oxo-1,2-dih...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccc(F)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H10FN3O3/c19-13-5-1-11(2-6-13)15-9-17(21-18(23)16(15)10-20)12-3-7-14(8-4-12)22(24)25/h1-9H,(H,21,23)
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n/an/a 1.34E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222087
PNG
(4-(4-Chlorophenyl)-6-(4-isobutylphenyl)-2-oxo-1,2-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(-c2ccc(Cl)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H19ClN2O/c1-14(2)11-15-3-5-17(6-4-15)21-12-19(20(13-24)22(26)25-21)16-7-9-18(23)10-8-16/h3-10,12,14H,11H2,1-2H3,(H,25,26)
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n/an/a 1.42E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222093
PNG
(4-(4-Chlorophenyl)-6-(4-methanesulfonylaminophenyl...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2ccc(Cl)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14ClN3O3S/c1-27(25,26)23-15-8-4-13(5-9-15)18-10-16(17(11-21)19(24)22-18)12-2-6-14(20)7-3-12/h2-10,23H,1H3,(H,22,24)
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n/an/a 1.53E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222101
PNG
(1-(4-Aminosulfonylphenyl)-5-(2-furyl)-3-(4-methane...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccco1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H20N4O5S2/c1-30(25,26)23-15-6-4-14(5-7-15)18-13-19(20-3-2-12-29-20)24(22-18)16-8-10-17(11-9-16)31(21,27)28/h2-12,19,23H,13H2,1H3,(H2,21,27,28)
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n/an/a 1.65E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222100
PNG
(1-(4-Aminosulfonylphenyl)-5-(4-fluorophenyl)-3-(4-...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H21FN4O4S2/c1-32(28,29)26-18-8-4-15(5-9-18)21-14-22(16-2-6-17(23)7-3-16)27(25-21)19-10-12-20(13-11-19)33(24,30)31/h2-13,22,26H,14H2,1H3,(H2,24,30,31)
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n/an/a 1.87E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222081
PNG
(4-(4-chlorophenyl)-6-(4-nitrophenyl)-2-oxo-1,2-dih...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccc(Cl)cc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H10ClN3O3/c19-13-5-1-11(2-6-13)15-9-17(21-18(23)16(15)10-20)12-3-7-14(8-4-12)22(24)25/h1-9H,(H,21,23)
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n/an/a 2.34E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222098
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methanesulfonylamin...)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C23H24N4O4S2/c1-16-3-5-18(6-4-16)23-15-22(17-7-9-19(10-8-17)26-32(2,28)29)25-27(23)20-11-13-21(14-12-20)33(24,30)31/h3-14,23,26H,15H2,1-2H3,(H2,24,30,31)
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n/an/a 2.36E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222102
PNG
(1-(4-Aminosulfonylphenyl)-5-(2-thienyl)-3-(4-metha...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1cccs1)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H20N4O4S3/c1-30(25,26)23-15-6-4-14(5-7-15)18-13-19(20-3-2-12-29-20)24(22-18)16-8-10-17(11-9-16)31(21,27)28/h2-12,19,23H,13H2,1H3,(H2,21,27,28)
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n/an/a 2.51E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM222096
PNG
(6-(4-Methanesulfonylaminophenyl)-2-oxo-4-(2-thieny...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(-c2cccs2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C17H13N3O3S2/c1-25(22,23)20-12-6-4-11(5-7-12)15-9-13(16-3-2-8-24-16)14(10-18)17(21)19-15/h2-9,20H,1H3,(H,19,21)
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n/an/a 3.21E+4n/an/an/an/an/an/a



Fayoum University



Assay Description
The ability of the tested compounds to inhibit both isozymes, COX-1 and COX-2 was measured using colorimetric COX (ovine) Inhibitor Screening Assay K...


Bioorg Chem 70: 173-183 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.008
BindingDB Entry DOI: 10.7270/Q208645J
More data for this
Ligand-Target Pair