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Compile Data Set for Download or QSAR

Found 22 hits with Last Name = 'abousleiman' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014370
PNG
(CHEMBL3261122)
Show SMILES CCCS(=O)(=O)N1CCC(=CC1)c1ccc2OC(Cc2c1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H36N2O3S/c1-2-18-34(31,32)30-16-12-23(13-17-30)25-8-9-27-26(19-25)20-28(33-27)24-10-14-29(15-11-24)21-22-6-4-3-5-7-22/h3-9,12,19,24,28H,2,10-11,13-18,20-21H2,1H3
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n/an/an/an/a 521n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014391
PNG
(CHEMBL3261143)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1(C)Cc2cc(ccc2O1)C1=CCN(CC1)S(=O)(=O)CCCCO
Show InChI InChI=1S/C30H42N4O4S/c1-3-6-23-21-31-29(32-22-23)33-13-11-27(12-14-33)30(2)20-26-19-25(7-8-28(26)38-30)24-9-15-34(16-10-24)39(36,37)18-5-4-17-35/h7-9,19,21-22,27,35H,3-6,10-18,20H2,1-2H3
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n/an/an/an/a 28n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014372
PNG
(CHEMBL3261124)
Show SMILES CCCS(=O)(=O)N1CCC(CC1)C1Cc2cc(ccc2O1)C1=CCN(CC1)S(=O)(=O)CCC
Show InChI InChI=1S/C24H36N2O5S2/c1-3-15-32(27,28)25-11-7-19(8-12-25)21-5-6-23-22(17-21)18-24(31-23)20-9-13-26(14-10-20)33(29,30)16-4-2/h5-7,17,20,24H,3-4,8-16,18H2,1-2H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014373
PNG
(CHEMBL3261125)
Show SMILES CCCS(=O)(=O)N1CCC(=CC1)c1ccc2OC(Cc2c1)C1CCN(CC1)C(=O)OC1CCCCC1
Show InChI InChI=1S/C28H40N2O5S/c1-2-18-36(32,33)30-16-12-21(13-17-30)23-8-9-26-24(19-23)20-27(35-26)22-10-14-29(15-11-22)28(31)34-25-6-4-3-5-7-25/h8-9,12,19,22,25,27H,2-7,10-11,13-18,20H2,1H3
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n/an/an/an/a 51n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014374
PNG
(CHEMBL3261126)
Show SMILES CCCS(=O)(=O)N1CCC(=CC1)c1ccc2OC(Cc2c1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C25H31ClN4O3S/c1-2-13-34(31,32)30-11-7-18(8-12-30)20-3-4-23-21(14-20)15-24(33-23)19-5-9-29(10-6-19)25-27-16-22(26)17-28-25/h3-4,7,14,16-17,19,24H,2,5-6,8-13,15H2,1H3
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n/an/an/an/a 78n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014375
PNG
(CHEMBL3261127)
Show SMILES CCCS(=O)(=O)N1CCC(=CC1)c1ccc2OC(Cc2c1)C1CCN(CC1)c1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C26H31F3N4O3S/c1-2-13-37(34,35)33-11-7-18(8-12-33)20-3-4-23-21(14-20)15-24(36-23)19-5-9-32(10-6-19)25-30-16-22(17-31-25)26(27,28)29/h3-4,7,14,16-17,19,24H,2,5-6,8-13,15H2,1H3
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n/an/an/an/a 14n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014376
PNG
(CHEMBL3261128)
Show SMILES CCCS(=O)(=O)N1CCC(=CC1)c1ccc2OC(Cc2c1)C1CCN(CC1)c1ncc(cn1)C1CC1
Show InChI InChI=1S/C28H36N4O3S/c1-2-15-36(33,34)32-13-9-21(10-14-32)23-5-6-26-24(16-23)17-27(35-26)22-7-11-31(12-8-22)28-29-18-25(19-30-28)20-3-4-20/h5-6,9,16,18-20,22,27H,2-4,7-8,10-15,17H2,1H3
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n/an/an/an/a 67n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014377
PNG
(CHEMBL3261129)
Show SMILES CCCS(=O)(=O)N1CCC(=CC1)c1ccc2OC(Cc2c1)C1CCN(CC1)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C27H32F3N3O3S/c1-2-15-37(34,35)33-13-9-19(10-14-33)21-3-5-24-22(16-21)17-25(36-24)20-7-11-32(12-8-20)26-6-4-23(18-31-26)27(28,29)30/h3-6,9,16,18,20,25H,2,7-8,10-15,17H2,1H3
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n/an/an/an/a 34n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014378
PNG
(CHEMBL3261130)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(ccc2O1)C1=CCN(CC1)S(=O)(=O)CCC
Show InChI InChI=1S/C28H38N4O3S/c1-3-5-21-19-29-28(30-20-21)31-12-8-23(9-13-31)27-18-25-17-24(6-7-26(25)35-27)22-10-14-32(15-11-22)36(33,34)16-4-2/h6-7,10,17,19-20,23,27H,3-5,8-9,11-16,18H2,1-2H3
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n/an/an/an/a 82n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014379
PNG
(CHEMBL3261131)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(ccc2O1)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C27H30FN3O3S/c1-3-4-18-16-29-27(30-17-18)31-11-9-19(10-12-31)26-14-21-13-20(5-8-25(21)34-26)23-7-6-22(15-24(23)28)35(2,32)33/h5-8,13,15-17,19,26H,3-4,9-12,14H2,1-2H3
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n/an/an/an/a 541n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014380
PNG
(CHEMBL3261132)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(ccc2O1)N1CCN(CC1)S(=O)(=O)CCC
Show InChI InChI=1S/C27H39N5O3S/c1-3-5-21-19-28-27(29-20-21)31-10-8-22(9-11-31)26-18-23-17-24(6-7-25(23)35-26)30-12-14-32(15-13-30)36(33,34)16-4-2/h6-7,17,19-20,22,26H,3-5,8-16,18H2,1-2H3
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n/an/an/an/a 544n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014381
PNG
(CHEMBL3261133)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(ccc2O1)C1CCN(CC1)S(=O)(=O)CCC
Show InChI InChI=1S/C28H40N4O3S/c1-3-5-21-19-29-28(30-20-21)31-12-8-23(9-13-31)27-18-25-17-24(6-7-26(25)35-27)22-10-14-32(15-11-22)36(33,34)16-4-2/h6-7,17,19-20,22-23,27H,3-5,8-16,18H2,1-2H3
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n/an/an/an/a 386n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014382
PNG
(CHEMBL3261134)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2c(O1)ccc(C1=CCN(CC1)S(=O)(=O)CCC)c2F
Show InChI InChI=1S/C28H37FN4O3S/c1-3-5-20-18-30-28(31-19-20)32-12-8-22(9-13-32)26-17-24-25(36-26)7-6-23(27(24)29)21-10-14-33(15-11-21)37(34,35)16-4-2/h6-7,10,18-19,22,26H,3-5,8-9,11-17H2,1-2H3
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n/an/an/an/a 5n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014383
PNG
(CHEMBL3261135)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(cc(F)c2O1)C1=CCN(CC1)S(=O)(=O)CCC
Show InChI InChI=1S/C28H37FN4O3S/c1-3-5-20-18-30-28(31-19-20)32-10-6-22(7-11-32)26-17-24-15-23(16-25(29)27(24)36-26)21-8-12-33(13-9-21)37(34,35)14-4-2/h8,15-16,18-19,22,26H,3-7,9-14,17H2,1-2H3
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n/an/an/an/a 62n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014384
PNG
(CHEMBL3261136)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2c(O1)c(F)cc(C1=CCN(CC1)S(=O)(=O)CCC)c2F
Show InChI InChI=1S/C28H36F2N4O3S/c1-3-5-19-17-31-28(32-18-19)33-10-6-21(7-11-33)25-16-23-26(30)22(15-24(29)27(23)37-25)20-8-12-34(13-9-20)38(35,36)14-4-2/h8,15,17-18,21,25H,3-7,9-14,16H2,1-2H3
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n/an/an/an/a 2n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014385
PNG
(CHEMBL3261137)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1(C)Cc2cc(ccc2O1)C1=CCN(CC1)S(=O)(=O)CCC
Show InChI InChI=1S/C29H40N4O3S/c1-4-6-22-20-30-28(31-21-22)32-13-11-26(12-14-32)29(3)19-25-18-24(7-8-27(25)36-29)23-9-15-33(16-10-23)37(34,35)17-5-2/h7-9,18,20-21,26H,4-6,10-17,19H2,1-3H3
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n/an/an/an/a 70n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014386
PNG
(CHEMBL3261138)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(cc(F)c2O1)C1=CCN(CC1)S(=O)(=O)CCCO
Show InChI InChI=1S/C28H37FN4O4S/c1-2-4-20-18-30-28(31-19-20)32-9-5-22(6-10-32)26-17-24-15-23(16-25(29)27(24)37-26)21-7-11-33(12-8-21)38(35,36)14-3-13-34/h7,15-16,18-19,22,26,34H,2-6,8-14,17H2,1H3
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n/an/an/an/a 122n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014387
PNG
(CHEMBL3261139)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(cc(F)c2O1)C1=CCN(CC1)S(=O)(=O)CCCCO
Show InChI InChI=1S/C29H39FN4O4S/c1-2-5-21-19-31-29(32-20-21)33-10-6-23(7-11-33)27-18-25-16-24(17-26(30)28(25)38-27)22-8-12-34(13-9-22)39(36,37)15-4-3-14-35/h8,16-17,19-20,23,27,35H,2-7,9-15,18H2,1H3
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n/an/an/an/a 60n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014388
PNG
(CHEMBL3261140)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2c(O1)c(F)cc(C1=CCN(CC1)S(=O)(=O)CCCO)c2F
Show InChI InChI=1S/C28H36F2N4O4S/c1-2-4-19-17-31-28(32-18-19)33-9-5-21(6-10-33)25-16-23-26(30)22(15-24(29)27(23)38-25)20-7-11-34(12-8-20)39(36,37)14-3-13-35/h7,15,17-18,21,25,35H,2-6,8-14,16H2,1H3
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n/an/an/an/a 16n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014389
PNG
(CHEMBL3261141)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1Cc2c(O1)c(F)cc(C1=CCN(CC1)S(=O)(=O)CCC(C)(C)O)c2F
Show InChI InChI=1S/C30H40F2N4O4S/c1-4-5-20-18-33-29(34-19-20)35-11-6-22(7-12-35)26-17-24-27(32)23(16-25(31)28(24)40-26)21-8-13-36(14-9-21)41(38,39)15-10-30(2,3)37/h8,16,18-19,22,26,37H,4-7,9-15,17H2,1-3H3
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n/an/an/an/a 101n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014390
PNG
(CHEMBL3261142)
Show SMILES CCCc1cnc(nc1)N1CCC(CC1)C1(C)Cc2cc(ccc2O1)C1=CCN(CC1)S(=O)(=O)CCCO
Show InChI InChI=1S/C29H40N4O4S/c1-3-5-22-20-30-28(31-21-22)32-12-10-26(11-13-32)29(2)19-25-18-24(6-7-27(25)37-29)23-8-14-33(15-9-23)38(35,36)17-4-16-34/h6-8,18,20-21,26,34H,3-5,9-17,19H2,1-2H3
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n/an/an/an/a 78n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50014371
PNG
(CHEMBL3261123)
Show SMILES CCCS(=O)(=O)N1CCC(=CC1)c1ccc2OC(Cc2c1)C1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C25H36N2O5S/c1-4-15-33(29,30)27-13-9-19(10-14-27)21-5-6-23-22(16-21)17-24(32-23)20-7-11-26(12-8-20)25(28)31-18(2)3/h5-6,9,16,18,20,24H,4,7-8,10-15,17H2,1-3H3
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n/an/an/an/a 103n/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells co-expressing Flp-In-T-Rex assessed as cAMP accumulation after 60 mins


Bioorg Med Chem Lett 24: 2539-45 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.096
BindingDB Entry DOI: 10.7270/Q2T72JZD
More data for this
Ligand-Target Pair