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Compile Data Set for Download or QSAR

Found 32 hits with Last Name = 'abu thaher' and Initial = 'b'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379214
PNG
(CHEMBL2011291 | US9416123, 6)
Show SMILES Nc1c(c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H12Cl3FN4/c21-13-9-15(22)19(16(23)10-13)28-20(25)17(11-1-3-14(24)4-2-11)18(27-28)12-5-7-26-8-6-12/h1-10H,25H2
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n/an/a 34n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50379214
PNG
(CHEMBL2011291 | US9416123, 6)
Show SMILES Nc1c(c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H12Cl3FN4/c21-13-9-15(22)19(16(23)10-13)28-20(25)17(11-1-3-14(24)4-2-11)18(27-28)12-5-7-26-8-6-12/h1-10H,25H2
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n/an/a 113n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of wild type EGFR using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation cou...


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379218
PNG
(CHEMBL2011304)
Show SMILES Fc1ccc(cc1)-c1cn(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C20H11Cl3FN3/c21-14-9-17(22)20(18(23)10-14)27-11-16(12-1-3-15(24)4-2-12)19(26-27)13-5-7-25-8-6-13/h1-11H
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n/an/a 210n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50379214
PNG
(CHEMBL2011291 | US9416123, 6)
Show SMILES Nc1c(c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H12Cl3FN4/c21-13-9-15(22)19(16(23)10-13)28-20(25)17(11-1-3-14(24)4-2-11)18(27-28)12-5-7-26-8-6-12/h1-10H,25H2
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n/an/a 270n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of wild type B-Raf using MEK1-KM as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379214
PNG
(CHEMBL2011291 | US9416123, 6)
Show SMILES Nc1c(c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H12Cl3FN4/c21-13-9-15(22)19(16(23)10-13)28-20(25)17(11-1-3-14(24)4-2-11)18(27-28)12-5-7-26-8-6-12/h1-10H,25H2
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n/an/a 399n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379227
PNG
(CHEMBL2011293 | US9416123, 7)
Show SMILES Nc1c(c(nn1-c1ccc(Cl)cc1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H14ClFN4/c21-15-3-7-17(8-4-15)26-20(23)18(13-1-5-16(22)6-2-13)19(25-26)14-9-11-24-12-10-14/h1-12H,23H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379224
PNG
(CHEMBL2011297 | US9416123, 11)
Show SMILES Nc1c(c(nn1-c1ccc(cc1)C#N)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14FN5/c22-17-5-3-15(4-6-17)19-20(16-9-11-25-12-10-16)26-27(21(19)24)18-7-1-14(13-23)2-8-18/h1-12H,24H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379225
PNG
(CHEMBL2011295 | US9416123, 9)
Show SMILES Nc1c(c(nn1-c1ccc(cc1)[N+]([O-])=O)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H14FN5O2/c21-15-3-1-13(2-4-15)18-19(14-9-11-23-12-10-14)24-25(20(18)22)16-5-7-17(8-6-16)26(27)28/h1-12H,22H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379226
PNG
(CHEMBL2011294 | US9416123, 8)
Show SMILES COc1ccc(cc1)-n1nc(c(c1N)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H17FN4O/c1-27-18-8-6-17(7-9-18)26-21(23)19(14-2-4-16(22)5-3-14)20(25-26)15-10-12-24-13-11-15/h2-13H,23H2,1H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379218
PNG
(CHEMBL2011304)
Show SMILES Fc1ccc(cc1)-c1cn(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C20H11Cl3FN3/c21-14-9-17(22)20(18(23)10-14)27-11-16(12-1-3-15(24)4-2-12)19(26-27)13-5-7-25-8-6-13/h1-11H
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n/an/a 2.00E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379228
PNG
(CHEMBL2011292 | US9416123, 5)
Show SMILES Nc1c(c(nn1-c1ccccc1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H15FN4/c21-16-8-6-14(7-9-16)18-19(15-10-12-23-13-11-15)24-25(20(18)22)17-4-2-1-3-5-17/h1-13H,22H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379223
PNG
(CHEMBL2011298 | US9416123, 12)
Show SMILES Nc1c(c(nn1-c1ccc(cc1)C(F)(F)F)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14F4N4/c22-16-5-1-13(2-6-16)18-19(14-9-11-27-12-10-14)28-29(20(18)26)17-7-3-15(4-8-17)21(23,24)25/h1-12H,26H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379216
PNG
(CHEMBL2011296 | US9416123, 10)
Show SMILES Cc1ccc(cc1)-n1nc(c(c1N)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H17FN4/c1-14-2-8-18(9-3-14)26-21(23)19(15-4-6-17(22)7-5-15)20(25-26)16-10-12-24-13-11-16/h2-13H,23H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379222
PNG
(CHEMBL2011299 | US9416123, 14)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C15H10Cl3N5O/c16-8-5-9(17)13(10(18)6-8)23-14(19)11(15(20)24)12(22-23)7-1-3-21-4-2-7/h1-6H,19H2,(H2,20,24)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379223
PNG
(CHEMBL2011298 | US9416123, 12)
Show SMILES Nc1c(c(nn1-c1ccc(cc1)C(F)(F)F)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14F4N4/c22-16-5-1-13(2-6-16)18-19(14-9-11-27-12-10-14)28-29(20(18)26)17-7-3-15(4-8-17)21(23,24)25/h1-12H,26H2
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n/an/a 6.70E+3n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379217
PNG
(CHEMBL2011305 | US9416123, 20)
Show SMILES Fc1ccc(cc1)-c1cn(nc1-c1ccncc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N3/c22-17-5-1-14(2-6-17)19-13-28(27-20(19)15-9-11-26-12-10-15)18-7-3-16(4-8-18)21(23,24)25/h1-13H
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n/an/a 1.20E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379215
PNG
(CHEMBL2011301 | US9416123, 18)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C15H13N5O/c16-14-12(15(17)21)13(10-6-8-18-9-7-10)19-20(14)11-4-2-1-3-5-11/h1-9H,16H2,(H2,17,21)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379227
PNG
(CHEMBL2011293 | US9416123, 7)
Show SMILES Nc1c(c(nn1-c1ccc(Cl)cc1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H14ClFN4/c21-15-3-7-17(8-4-15)26-20(23)18(13-1-5-16(22)6-2-13)19(25-26)14-9-11-24-12-10-14/h1-12H,23H2
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n/an/a 2.30E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379226
PNG
(CHEMBL2011294 | US9416123, 8)
Show SMILES COc1ccc(cc1)-n1nc(c(c1N)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H17FN4O/c1-27-18-8-6-17(7-9-18)26-21(23)19(14-2-4-16(22)5-3-14)20(25-26)15-10-12-24-13-11-15/h2-13H,23H2,1H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379217
PNG
(CHEMBL2011305 | US9416123, 20)
Show SMILES Fc1ccc(cc1)-c1cn(nc1-c1ccncc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N3/c22-17-5-1-14(2-6-17)19-13-28(27-20(19)15-9-11-26-12-10-15)18-7-3-16(4-8-18)21(23,24)25/h1-13H
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n/an/a 2.70E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379222
PNG
(CHEMBL2011299 | US9416123, 14)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C15H10Cl3N5O/c16-8-5-9(17)13(10(18)6-8)23-14(19)11(15(20)24)12(22-23)7-1-3-21-4-2-7/h1-6H,19H2,(H2,20,24)
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n/an/a 3.10E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379220
PNG
(CHEMBL2011302 | US9416123, 16)
Show SMILES Nc1c(C(O)=O)c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C15H9Cl3N4O2/c16-8-5-9(17)13(10(18)6-8)22-14(19)11(15(23)24)12(21-22)7-1-3-20-4-2-7/h1-6H,19H2,(H,23,24)
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n/an/a 4.30E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379215
PNG
(CHEMBL2011301 | US9416123, 18)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C15H13N5O/c16-14-12(15(17)21)13(10-6-8-18-9-7-10)19-20(14)11-4-2-1-3-5-11/h1-9H,16H2,(H2,17,21)
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n/an/a 4.80E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379228
PNG
(CHEMBL2011292 | US9416123, 5)
Show SMILES Nc1c(c(nn1-c1ccccc1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H15FN4/c21-16-8-6-14(7-9-16)18-19(15-10-12-23-13-11-15)24-25(20(18)22)17-4-2-1-3-5-17/h1-13H,22H2
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n/an/a 5.20E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379216
PNG
(CHEMBL2011296 | US9416123, 10)
Show SMILES Cc1ccc(cc1)-n1nc(c(c1N)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H17FN4/c1-14-2-8-18(9-3-14)26-21(23)19(15-4-6-17(22)7-5-15)20(25-26)16-10-12-24-13-11-16/h2-13H,23H2,1H3
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n/an/a 5.30E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379220
PNG
(CHEMBL2011302 | US9416123, 16)
Show SMILES Nc1c(C(O)=O)c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C15H9Cl3N4O2/c16-8-5-9(17)13(10(18)6-8)22-14(19)11(15(23)24)12(21-22)7-1-3-20-4-2-7/h1-6H,19H2,(H,23,24)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379225
PNG
(CHEMBL2011295 | US9416123, 9)
Show SMILES Nc1c(c(nn1-c1ccc(cc1)[N+]([O-])=O)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H14FN5O2/c21-15-3-1-13(2-4-15)18-19(14-9-11-23-12-10-14)24-25(20(18)22)16-5-7-17(8-6-16)26(27)28/h1-12H,22H2
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n/an/a 8.20E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379219
PNG
(CHEMBL2011303 | US9416123, 19)
Show SMILES Nc1cc(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C14H9Cl3N4/c15-9-5-10(16)14(11(17)6-9)21-13(18)7-12(20-21)8-1-3-19-4-2-8/h1-7H,18H2
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n/an/a 8.70E+4n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379224
PNG
(CHEMBL2011297 | US9416123, 11)
Show SMILES Nc1c(c(nn1-c1ccc(cc1)C#N)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H14FN5/c22-17-5-3-15(4-6-17)19-20(16-9-11-25-12-10-16)26-27(21(19)24)18-7-1-14(13-23)2-8-18/h1-12H,24H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379221
PNG
(CHEMBL2011300 | US9416123, 15)
Show SMILES CCOC(=O)c1c(N)n(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C17H13Cl3N4O2/c1-2-26-17(25)13-14(9-3-5-22-6-4-9)23-24(16(13)21)15-11(19)7-10(18)8-12(15)20/h3-8H,2,21H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50379219
PNG
(CHEMBL2011303 | US9416123, 19)
Show SMILES Nc1cc(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C14H9Cl3N4/c15-9-5-10(16)14(11(17)6-9)21-13(18)7-12(20-21)8-1-3-19-4-2-8/h1-7H,18H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of SRC using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50379221
PNG
(CHEMBL2011300 | US9416123, 15)
Show SMILES CCOC(=O)c1c(N)n(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C17H13Cl3N4O2/c1-2-26-17(25)13-14(9-3-5-22-6-4-9)23-24(16(13)21)15-11(19)7-10(18)8-12(15)20/h3-8H,2,21H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Islamic University of Gaza

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 using poly(Glu,Tyr) as substrate assessed as [33P-gamma]-ATP incorporation after 60 mins by microplate scintillation counting


J Med Chem 55: 961-5 (2012)


Article DOI: 10.1021/jm201391u
BindingDB Entry DOI: 10.7270/Q2FT8N18
More data for this
Ligand-Target Pair