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Compile Data Set for Download or QSAR

Found 193 hits with Last Name = 'acher' and Initial = 'fc'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(RAT)
BDBM17660
PNG
((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
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10n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 1


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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13n/an/an/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 2


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50034503
PNG
((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1
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110n/an/an/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 2


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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340n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 1


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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470n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 4


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50079183
PNG
((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Show SMILES N[C@H](C(O)=O)c1cc(O)cc(O)c1
Show InChI InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1
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900n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 1


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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1.20E+3n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 2


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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1.60E+3n/an/an/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 4


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50053588
PNG
((S)-4-(amino(carboxy)methyl)benzoic acid | (S)-4-c...)
Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C9H9NO4/c10-7(9(13)14)5-1-3-6(4-2-5)8(11)12/h1-4,7H,10H2,(H,11,12)(H,13,14)/t7-/m0/s1
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3.70E+3n/an/an/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 1


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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2.70E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174519
PNG
((3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m0/s1
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3.30E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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9.40E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
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9.50E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM17660
PNG
((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
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1.12E+5n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 4


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM17660
PNG
((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
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1.13E+5n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 2


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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1.29E+5n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 2


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50053588
PNG
((S)-4-(amino(carboxy)methyl)benzoic acid | (S)-4-c...)
Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C9H9NO4/c10-7(9(13)14)5-1-3-6(4-2-5)8(11)12/h1-4,7H,10H2,(H,11,12)(H,13,14)/t7-/m0/s1
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8.38E+5n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 4


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174516
PNG
(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Show SMILES NC1(CC2ON=C(C2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50174517
PNG
(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Show SMILES NC(CC1CC(=NO1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H10N2O5/c8-4(6(10)11)1-3-2-5(7(12)13)9-14-3/h3-4H,1-2,8H2,(H,10,11)(H,12,13)
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174519
PNG
((3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR2 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50174515
PNG
((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@H]2ON=C([C@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130515
PNG
((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Show SMILES N[C@@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8+/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 1


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50079183
PNG
((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Show SMILES N[C@H](C(O)=O)c1cc(O)cc(O)c1
Show InChI InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Parc Club Orsay Universit£

Curated by ChEMBL


Assay Description
Binding affinity at Metabotropic glutamate receptor 2


J Med Chem 45: 3171-83 (2002)


Article DOI: 10.1021/jm010323l
BindingDB Entry DOI: 10.7270/Q2B27W18
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076389
PNG
((1S,2S)-2-[(R)-Amino-carboxy-(9-methyl-9H-xanthen-...)
Show SMILES CC1c2ccccc2Oc2cccc(c12)[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c1-10-11-5-2-3-7-15(11)26-16-8-4-6-13(17(10)16)20(21,19(24)25)14-9-12(14)18(22)23/h2-8,10,12,14H,9,21H2,1H3,(H,22,23)(H,24,25)/t10?,12-,14-,20-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50049748
PNG
((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CCCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50069111
PNG
((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H21NO4/c20-17(19(23)24)12-15(18(21)22)11-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,20H2,(H,21,22)(H,23,24)/t15-,17-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)
BDBM50111606
PNG
(4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospi...)
Show SMILES [O-]c1c(I)cc2c(Oc3c(I)c([O-])c(I)cc3C22OC(=O)c3c2c(Cl)c(Cl)c(Cl)c3Cl)c1I
Show InChI InChI=1S/C20H4Cl4I4O5/c21-9-7-8(10(22)12(24)11(9)23)20(33-19(7)31)3-1-5(25)15(29)13(27)17(3)32-18-4(20)2-6(26)16(30)14(18)28/h1-2,29-30H/p-2
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n/an/a 9.70E+3n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of VACHT in rat synaptic vesicles assessed as [3H]HT uptake pretreated for 30 mins measured after 10 mins by scintillation spectrophotomet...


Bioorg Med Chem 18: 6922-33 (2010)


Article DOI: 10.1016/j.bmc.2010.06.069
BindingDB Entry DOI: 10.7270/Q29024S4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076393
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-phenyl-c...)
Show SMILES N[C@@H]([C@@H]1[C@H]([C@@H]1c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H13NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1
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n/an/a 9.90E+3n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50053585
PNG
((S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid...)
Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15)/t7-/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076392
PNG
((1S,2S)-2-((S)-1-Amino-1-carboxy-ethyl)-cyclopropa...)
Show SMILES C[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-7(8,6(11)12)4-2-3(4)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
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n/an/a 7.70E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076395
PNG
((1R,2S,4R)-4-Amino-cyclopentane-1,2,4-tricarboxyli...)
Show SMILES N[C@@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4+,8+
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n/an/a 8.80E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076390
PNG
((S)-2-Amino-4-carboxy-pentanedioic acid | CHEMBL38...)
Show SMILES N[C@@H](CC(C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO6/c7-3(6(12)13)1-2(4(8)9)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)(H,12,13)/t3-/m0/s1
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n/an/a 1.02E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50076395
PNG
((1R,2S,4R)-4-Amino-cyclopentane-1,2,4-tricarboxyli...)
Show SMILES N[C@@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4+,8+
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n/an/a 1.15E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50076394
PNG
(2-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic aci...)
Show SMILES NC1(CC2CCC1C2C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-9(8(13)14)3-4-1-2-5(9)6(4)7(11)12/h4-6H,1-3,10H2,(H,11,12)(H,13,14)
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n/an/a 3.00E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
NMDA receptor subunit N2A (GluN2A)


(Rattus norvegicus (Rat))
BDBM50217031
PNG
((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m0/s1
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n/an/a 3.15E+5n/an/an/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant NMDA NR2A receptor expressed in xenopus laevis oocyte assessed as inhibition of glycine-stimulated current


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50217031
PNG
((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m0/s1
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n/an/a 3.15E+5n/an/an/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant NMDA NR1 receptor expressed in xenopus laevis oocyte assessed as inhibition of L-glutamate-stimulated current


J Med Chem 50: 3585-95 (2007)


Article DOI: 10.1021/jm070262c
BindingDB Entry DOI: 10.7270/Q23R0SMQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50034503
PNG
((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1
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n/an/a 3.89E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/a 4.58E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50076391
PNG
(7-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic aci...)
Show SMILES NC1(C2CCC1C(C2)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-9(8(13)14)4-1-2-6(9)5(3-4)7(11)12/h4-6H,1-3,10H2,(H,11,12)(H,13,14)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076391
PNG
(7-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic aci...)
Show SMILES NC1(C2CCC1C(C2)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-9(8(13)14)4-1-2-6(9)5(3-4)7(11)12/h4-6H,1-3,10H2,(H,11,12)(H,13,14)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
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