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Compile Data Set for Download or QSAR

Found 567 hits with Last Name = 'adachi' and Initial = 'i'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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PubMed
1.70n/an/an/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Ki value against bovine alpha-L-fucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50065257
PNG
((2R,3R,4R,5R,6S)-2-Hydroxymethyl-6-methyl-piperidi...)
Show SMILES C[C@@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4+,5+,6+,7+/m0/s1
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5.30n/an/an/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Ki value against bovine alpha-L-fucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50163439
PNG
((2S,3R,4S,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...)
Show SMILES OC[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m0/s1
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80n/an/an/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Ki value against bovine alpha-L-fucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Acidic alpha-glucosidase


(Rattus norvegicus)
BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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85n/an/an/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis


J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18364
PNG
((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidi...)
Show SMILES CCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-11-13(18)15(20)14(19)12(10-17)16-11/h11-20H,2-10H2,1H3/t11-,12-,13+,14-,15-/m1/s1
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200 -39.8 270n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18363
PNG
((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-octylpiperidi...)
Show SMILES CCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-10-12(17)14(19)13(18)11(9-16)15-10/h10-19H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1
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280 -38.9 500n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18358
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-...)
Show SMILES CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
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300 -38.7 660n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18357
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Show SMILES CCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,2-10H2,1H3/t11-,12+,13-,14-/m1/s1
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420 -37.9 820n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50369362
PNG
(CHEMBL1169500)
Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)C(O)[C@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5+,6+/m1/s1
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450n/an/an/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Ki value against bovine alpha-L-fucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Acidic alpha-glucosidase


(Rattus norvegicus)
BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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460n/an/an/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis


J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Alpha-glucosidase A (α-Gal A)


(Homo sapiens (Human))
BDBM50241865
PNG
(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6+/m1/s1
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500n/an/an/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Competitive inhibition of human lysosome alpha-galactosidase by Lineweaver-Burk plot analysis


Bioorg Med Chem 18: 3790-4 (2010)


Article DOI: 10.1016/j.bmc.2010.04.048
BindingDB Entry DOI: 10.7270/Q2XK8FQP
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18362
PNG
((2R,3S,4R,5R,6R)-2-hexyl-6-(hydroxymethyl)piperidi...)
Show SMILES CCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C12H25NO4/c1-2-3-4-5-6-8-10(15)12(17)11(16)9(7-14)13-8/h8-17H,2-7H2,1H3/t8-,9-,10+,11-,12-/m1/s1
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2.30E+3 -33.5 4.20E+3n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM36389
PNG
(8-Aza-bicyclo[3.2.1]octane-1,2,3,4-tetraol, 14 | C...)
Show SMILES O[C@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4+,5-,6+,7-/m1/s1
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3.80E+3n/an/an/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Competitive inhibition of human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 ...


Bioorg Med Chem 22: 2435-41 (2014)


Article DOI: 10.1016/j.bmc.2014.02.057
BindingDB Entry DOI: 10.7270/Q24X599T
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50065259
PNG
((2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
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4.70E+3n/an/an/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Ki value against bovine alpha-L-fucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18356
PNG
((2R,3R,4R,5S)-1-hexyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4/c1-2-3-4-5-6-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,2-8H2,1H3/t9-,10+,11-,12-/m1/s1
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5.50E+3 -31.2 1.30E+4n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50002856
PNG
(CHEMBL3233942)
Show SMILES O[C@@H]1C[C@H]2CC[C@](O)(N2)[C@H]1O
Show InChI InChI=1S/C7H13NO3/c9-5-3-4-1-2-7(11,8-4)6(5)10/h4-6,8-11H,1-3H2/t4-,5-,6+,7-/m1/s1
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6.30E+3n/an/an/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Competitive inhibition of human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 ...


Bioorg Med Chem 22: 2435-41 (2014)


Article DOI: 10.1016/j.bmc.2014.02.057
BindingDB Entry DOI: 10.7270/Q24X599T
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50163446
PNG
((2S,3R,4R,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...)
Show SMILES OC[C@@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6+/m0/s1
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1.40E+4n/an/an/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Ki value against bovine alpha-L-fucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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7.90E+4 -24.4 2.40E+5n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50002909
PNG
(CHEMBL3233945)
Show SMILES O[C@@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4-,5-,6+,7-/m1/s1
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9.80E+4n/an/an/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Competitive inhibition of human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 ...


Bioorg Med Chem 22: 2435-41 (2014)


Article DOI: 10.1016/j.bmc.2014.02.057
BindingDB Entry DOI: 10.7270/Q24X599T
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18361
PNG
((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Show SMILES CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1
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PubMed
1.10E+5 -23.5 1.00E+5n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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1.16E+5 -23.4 2.70E+5n/an/an/an/a5.537



Hokuriku University



Assay Description
Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...


Bioorg Med Chem 14: 7736-44 (2006)


Article DOI: 10.1016/j.bmc.2006.08.003
BindingDB Entry DOI: 10.7270/Q2BZ649B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocerebrosidase (Acid beta-Glucosidase)


(Homo sapiens (human))
BDBM50002857
PNG
(CHEMBL3233944)
Show SMILES O[C@H]1[C@H]2CC[C@](O)(N2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4+,5-,6-,7-/m1/s1
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1.99E+5n/an/an/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Competitive inhibition of human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 ...


Bioorg Med Chem 22: 2435-41 (2014)


Article DOI: 10.1016/j.bmc.2014.02.057
BindingDB Entry DOI: 10.7270/Q24X599T
More data for this
Ligand-Target Pair
α-galactosidase


(Coffea arabica (Coffee beans))
BDBM50163440
PNG
((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of coffee bean alpha-galactosidase assessed as p-nitrophenol release at pH 6.5 by spectrometric analysis


Bioorg Med Chem 18: 3790-4 (2010)


Article DOI: 10.1016/j.bmc.2010.04.048
BindingDB Entry DOI: 10.7270/Q2XK8FQP
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442341
PNG
(CHEMBL2442786)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2F)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-5-3-2-4-8(9)15/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 7.90n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442341
PNG
(CHEMBL2442786)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2F)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-5-3-2-4-8(9)15/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442339
PNG
(CHEMBL2442788)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-4-2-8(15)3-5-9/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442344
PNG
(CHEMBL2442783)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(C)cc2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H22N2O4/c1-8-3-5-10(6-4-8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442343
PNG
(CHEMBL2442784)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(C)cc2C)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C16H24N2O4/c1-8-4-5-11(9(2)6-8)18-13(19)7-12-15(21)16(22)14(20)10(3)17-12/h4-6,10,12,14-17,20-22H,7H2,1-3H3,(H,18,19)/t10-,12+,14+,15+,16+/m0/s1
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n/an/a 19n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442343
PNG
(CHEMBL2442784)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(C)cc2C)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C16H24N2O4/c1-8-4-5-11(9(2)6-8)18-13(19)7-12-15(21)16(22)14(20)10(3)17-12/h4-6,10,12,14-17,20-22H,7H2,1-3H3,(H,18,19)/t10-,12+,14+,15+,16+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442344
PNG
(CHEMBL2442783)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(C)cc2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H22N2O4/c1-8-3-5-10(6-4-8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 26n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50048090
PNG
(CHEMBL3311519)
Show SMILES OC[C@@H]1N[C@@H](CCCCc2cc(F)cc(F)c2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H21F2NO3/c16-10-5-9(6-11(17)7-10)3-1-2-4-12-14(20)15(21)13(8-19)18-12/h5-7,12-15,18-21H,1-4,8H2/t12-,13-,14-,15-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442348
PNG
(CHEMBL2442779)
Show SMILES COc1ccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)cc1
Show InChI InChI=1S/C15H22N2O5/c1-8-13(19)15(21)14(20)11(16-8)7-12(18)17-9-3-5-10(22-2)6-4-9/h3-6,8,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t8-,11+,13+,14+,15+/m0/s1
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n/an/a 26n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442340
PNG
(CHEMBL2442787)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2cccc(F)c2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-4-2-3-8(15)5-9/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442350
PNG
(CHEMBL2442777)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H20N2O4/c1-8-12(18)14(20)13(19)10(15-8)7-11(17)16-9-5-3-2-4-6-9/h2-6,8,10,12-15,18-20H,7H2,1H3,(H,16,17)/t8-,10+,12+,13+,14+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442345
PNG
(CHEMBL2442782)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2cccc(C)c2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H22N2O4/c1-8-4-3-5-10(6-8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442339
PNG
(CHEMBL2442788)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-4-2-8(15)3-5-9/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-glucosidase


(Oryza sativa subsp. japonica)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against rice alpha-glucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442340
PNG
(CHEMBL2442787)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2cccc(F)c2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-4-2-3-8(15)5-9/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase using sucrose as substrate


J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins


Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50442338
PNG
(CHEMBL2442773)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2F)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H18F2N2O4/c1-6-12(20)14(22)13(21)10(17-6)5-11(19)18-9-3-2-7(15)4-8(9)16/h2-4,6,10,12-14,17,20-22H,5H2,1H3,(H,18,19)/t6-,10+,12+,13+,14+/m0/s1
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n/an/a 35n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442345
PNG
(CHEMBL2442782)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2cccc(C)c2)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H22N2O4/c1-8-4-3-5-10(6-8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 40n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against human alpha-glucosidase


J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50375510
PNG
(CHEMBL405957)
Show SMILES OC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rat isomaltase


Bioorg Med Chem 16: 2734-40 (2008)


Article DOI: 10.1016/j.bmc.2008.01.032
BindingDB Entry DOI: 10.7270/Q2FB53T0
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442338
PNG
(CHEMBL2442773)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2F)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H18F2N2O4/c1-6-12(20)14(22)13(21)10(17-6)5-11(19)18-9-3-2-7(15)4-8(9)16/h2-4,6,10,12-14,17,20-22H,5H2,1H3,(H,18,19)/t6-,10+,12+,13+,14+/m0/s1
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n/an/a 42n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442348
PNG
(CHEMBL2442779)
Show SMILES COc1ccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)cc1
Show InChI InChI=1S/C15H22N2O5/c1-8-13(19)15(21)14(20)11(16-8)7-12(18)17-9-3-5-10(22-2)6-4-9/h3-6,8,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t8-,11+,13+,14+,15+/m0/s1
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n/an/a 43n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Rattus norvegicus)
BDBM50442341
PNG
(CHEMBL2442786)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2F)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-5-3-2-4-8(9)15/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 44n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat epididymis alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase)


(Rattus norvegicus (Rat))
BDBM50048086
PNG
(CHEMBL3311515)
Show SMILES Cc1ccc(CCCC[C@@H]2N[C@@H](CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C16H25NO3/c1-11-6-8-12(9-7-11)4-2-3-5-13-15(19)16(20)14(10-18)17-13/h6-9,13-20H,2-5,10H2,1H3/t13-,14-,15-,16-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
Alpha-L-fucosidase 1


(Bos taurus)
BDBM50442346
PNG
(CHEMBL2442781)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2C)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H22N2O4/c1-8-5-3-4-6-10(8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 47n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometry


Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
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