BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 58 hits with Last Name = 'adam' and Initial = 'fm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A1


(Homo sapiens (human))
BDBM50340226
PNG
(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(oxazol...)
Show SMILES Cc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)-c2ncco2)cn1
Show InChI InChI=1S/C16H14N6O2/c1-9-2-3-10(7-19-9)8-22-12-6-11(15-18-4-5-24-15)20-14(17)13(12)21-16(22)23/h2-7H,8H2,1H3,(H2,17,20)(H,21,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 970n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Adenosine receptor A1


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM50340223
PNG
(4-amino-6-(4-methyloxazol-2-yl)-1-((6-methylpyridi...)
Show SMILES Cc1coc(n1)-c1cc2n(Cc3ccc(C)nc3)c(=O)[nH]c2c(N)n1
Show InChI InChI=1S/C17H16N6O2/c1-9-3-4-11(6-19-9)7-23-13-5-12(16-20-10(2)8-25-16)21-15(18)14(13)22-17(23)24/h3-6,8H,7H2,1-2H3,(H2,18,21)(H,22,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Adenosine receptor A1


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM50340221
PNG
(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(2H-1,2...)
Show SMILES Cc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)-n2nccn2)cn1
Show InChI InChI=1S/C15H14N8O/c1-9-2-3-10(7-17-9)8-22-11-6-12(23-18-4-5-19-23)20-14(16)13(11)21-15(22)24/h2-7H,8H2,1H3,(H2,16,20)(H,21,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Adenosine receptor A1


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM50340230
PNG
(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(1H-pyr...)
Show SMILES Cc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)-n2cccn2)cn1
Show InChI InChI=1S/C16H15N7O/c1-10-3-4-11(8-18-10)9-22-12-7-13(23-6-2-5-19-23)20-15(17)14(12)21-16(22)24/h2-8H,9H2,1H3,(H2,17,20)(H,21,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Adenosine receptor A1


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340224
PNG
(4-amino-1-((5-methylpyridin-2-yl)methyl)-6-(triflu...)
Show SMILES Cc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)nc1
Show InChI InChI=1S/C14H12F3N5O/c1-7-2-3-8(19-5-7)6-22-9-4-10(14(15,16)17)20-12(18)11(9)21-13(22)23/h2-5H,6H2,1H3,(H2,18,20)(H,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 95n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340225
PNG
(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-((tetra...)
Show SMILES Cc1ccc(Cn2c3cc(OCC4CCOCC4)nc(N)c3[nH]c2=O)cn1
Show InChI InChI=1S/C19H23N5O3/c1-12-2-3-14(9-21-12)10-24-15-8-16(22-18(20)17(15)23-19(24)25)27-11-13-4-6-26-7-5-13/h2-3,8-9,13H,4-7,10-11H2,1H3,(H2,20,22)(H,23,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 99n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340226
PNG
(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(oxazol...)
Show SMILES Cc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)-c2ncco2)cn1
Show InChI InChI=1S/C16H14N6O2/c1-9-2-3-10(7-19-9)8-22-12-6-11(15-18-4-5-24-15)20-14(17)13(12)21-16(22)23/h2-7H,8H2,1H3,(H2,17,20)(H,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 102n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340227
PNG
(4-amino-1-((5-methylisoxazol-3-yl)methyl)-6-(trifl...)
Show SMILES Cc1cc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)no1
Show InChI InChI=1S/C12H10F3N5O2/c1-5-2-6(19-22-5)4-20-7-3-8(12(13,14)15)17-10(16)9(7)18-11(20)21/h2-3H,4H2,1H3,(H2,16,17)(H,18,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 103n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340228
PNG
(4-amino-1-((6-methylpyridazin-3-yl)methyl)-6-(trif...)
Show SMILES Cc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)nn1
Show InChI InChI=1S/C13H11F3N6O/c1-6-2-3-7(21-20-6)5-22-8-4-9(13(14,15)16)18-11(17)10(8)19-12(22)23/h2-4H,5H2,1H3,(H2,17,18)(H,19,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 411n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340229
PNG
(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-((tetra...)
Show SMILES Cc1ccc(Cn2c3cc(OCC4CCOC4)nc(N)c3[nH]c2=O)cn1
Show InChI InChI=1S/C18H21N5O3/c1-11-2-3-12(7-20-11)8-23-14-6-15(26-10-13-4-5-25-9-13)21-17(19)16(14)22-18(23)24/h2-3,6-7,13H,4-5,8-10H2,1H3,(H2,19,21)(H,22,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 474n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340230
PNG
(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(1H-pyr...)
Show SMILES Cc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)-n2cccn2)cn1
Show InChI InChI=1S/C16H15N7O/c1-10-3-4-11(8-18-10)9-22-12-7-13(23-6-2-5-19-23)20-15(17)14(12)21-16(22)24/h2-8H,9H2,1H3,(H2,17,20)(H,21,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 633n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340231
PNG
(4-amino-1-(3-methoxypropyl)-6-(trifluoromethyl)-1H...)
Show SMILES COCCCn1c2cc(nc(N)c2[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C11H13F3N4O2/c1-20-4-2-3-18-6-5-7(11(12,13)14)16-9(15)8(6)17-10(18)19/h5H,2-4H2,1H3,(H2,15,16)(H,17,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 833n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340232
PNG
(4-amino-1-((tetrahydro-2H-pyran-3-yl)methyl)-6-(tr...)
Show SMILES Nc1nc(cc2n(CC3CCCOC3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C13H15F3N4O2/c14-13(15,16)9-4-8-10(11(17)18-9)19-12(21)20(8)5-7-2-1-3-22-6-7/h4,7H,1-3,5-6H2,(H2,17,18)(H,19,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.44E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340233
PNG
(4-amino-1-((2-methyloxazol-4-yl)methyl)-6-(trifluo...)
Show SMILES Cc1nc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)co1
Show InChI InChI=1S/C12H10F3N5O2/c1-5-17-6(4-22-5)3-20-7-2-8(12(13,14)15)18-10(16)9(7)19-11(20)21/h2,4H,3H2,1H3,(H2,16,18)(H,19,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 193n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340234
PNG
(4-amino-1-benzyl-6-(trifluoromethyl)-1H-imidazo[4,...)
Show SMILES Nc1nc(cc2n(Cc3ccccc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C14H11F3N4O/c15-14(16,17)10-6-9-11(12(18)19-10)20-13(22)21(9)7-8-4-2-1-3-5-8/h1-6H,7H2,(H2,18,19)(H,20,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 269n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340235
PNG
(4-amino-1-((6-methylpyridin-2-yl)methyl)-6-(triflu...)
Show SMILES Cc1cccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)n1
Show InChI InChI=1S/C14H12F3N5O/c1-7-3-2-4-8(19-7)6-22-9-5-10(14(15,16)17)20-12(18)11(9)21-13(22)23/h2-5H,6H2,1H3,(H2,18,20)(H,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 328n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340236
PNG
(4-amino-1-((5-methylpyrazin-2-yl)methyl)-6-(triflu...)
Show SMILES Cc1cnc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C13H11F3N6O/c1-6-3-19-7(4-18-6)5-22-8-2-9(13(14,15)16)20-11(17)10(8)21-12(22)23/h2-4H,5H2,1H3,(H2,17,20)(H,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 352n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340237
PNG
(4-amino-6-((1-methylpiperidin-4-yl)methoxy)-1-((6-...)
Show SMILES CN1CCC(COc2cc3n(Cc4ccc(C)nc4)c(=O)[nH]c3c(N)n2)CC1
Show InChI InChI=1S/C20H26N6O2/c1-13-3-4-15(10-22-13)11-26-16-9-17(23-19(21)18(16)24-20(26)27)28-12-14-5-7-25(2)8-6-14/h3-4,9-10,14H,5-8,11-12H2,1-2H3,(H2,21,23)(H,24,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>4.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340238
PNG
(4-amino-6-(3-methoxypropoxy)-1-((6-methylpyridin-3...)
Show SMILES COCCCOc1cc2n(Cc3ccc(C)nc3)c(=O)[nH]c2c(N)n1
Show InChI InChI=1S/C17H21N5O3/c1-11-4-5-12(9-19-11)10-22-13-8-14(25-7-3-6-24-2)20-16(18)15(13)21-17(22)23/h4-5,8-9H,3,6-7,10H2,1-2H3,(H2,18,20)(H,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>4.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340239
PNG
(4-amino-1-((2-methylpyrimidin-5-yl)methyl)-6-(trif...)
Show SMILES Cc1ncc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C13H11F3N6O/c1-6-18-3-7(4-19-6)5-22-8-2-9(13(14,15)16)20-11(17)10(8)21-12(22)23/h2-4H,5H2,1H3,(H2,17,20)(H,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 366n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at Toll-like receptor 7


Bioorg Med Chem Lett 21: 2389-93 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.092
BindingDB Entry DOI: 10.7270/Q2W66M2C
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354919
PNG
(CHEMBL1836893)
Show SMILES Nc1nc(cc2n(Cc3ccc(NCCN4CCCCC4)nc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C20H24F3N7O/c21-20(22,23)15-10-14-17(18(24)27-15)28-19(31)30(14)12-13-4-5-16(26-11-13)25-6-9-29-7-2-1-3-8-29/h4-5,10-11H,1-3,6-9,12H2,(H2,24,27)(H,25,26)(H,28,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354920
PNG
(CHEMBL1836892)
Show SMILES CN(CCN1CCN(C)CC1)c1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C21H27F3N8O/c1-29-5-8-31(9-6-29)10-7-30(2)17-4-3-14(12-26-17)13-32-15-11-16(21(22,23)24)27-19(25)18(15)28-20(32)33/h3-4,11-12H,5-10,13H2,1-2H3,(H2,25,27)(H,28,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354921
PNG
(CHEMBL1836889)
Show SMILES CN(C)CCN1CCN(CC1)c1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C21H27F3N8O/c1-29(2)5-6-30-7-9-31(10-8-30)17-4-3-14(12-26-17)13-32-15-11-16(21(22,23)24)27-19(25)18(15)28-20(32)33/h3-4,11-12H,5-10,13H2,1-2H3,(H2,25,27)(H,28,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.5n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354922
PNG
(CHEMBL1836890)
Show SMILES CN(CCN1CCCCC1)c1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C21H26F3N7O/c1-29(9-10-30-7-3-2-4-8-30)17-6-5-14(12-26-17)13-31-15-11-16(21(22,23)24)27-19(25)18(15)28-20(31)32/h5-6,11-12H,2-4,7-10,13H2,1H3,(H2,25,27)(H,28,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354923
PNG
(CHEMBL1836881)
Show SMILES Nc1nc(cc2n(Cc3ccc(nc3)N3CCC[C@H]3CN3CCCC3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C22H26F3N7O/c23-22(24,25)17-10-16-19(20(26)28-17)29-21(33)32(16)12-14-5-6-18(27-11-14)31-9-3-4-15(31)13-30-7-1-2-8-30/h5-6,10-11,15H,1-4,7-9,12-13H2,(H2,26,28)(H,29,33)/t15-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.70n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354924
PNG
(CHEMBL1836885)
Show SMILES Nc1nc(cc2n(Cc3ccc(NCCN4CCCC4)nc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C19H22F3N7O/c20-19(21,22)14-9-13-16(17(23)26-14)27-18(30)29(13)11-12-3-4-15(25-10-12)24-5-8-28-6-1-2-7-28/h3-4,9-10H,1-2,5-8,11H2,(H2,23,26)(H,24,25)(H,27,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.70n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354925
PNG
(CHEMBL1837074)
Show SMILES Nc1nc(cc2n(Cc3ccnc(c3)N3CCC[C@H]3CN3CCCC3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C22H26F3N7O/c23-22(24,25)17-11-16-19(20(26)28-17)29-21(33)32(16)12-14-5-6-27-18(10-14)31-9-3-4-15(31)13-30-7-1-2-8-30/h5-6,10-11,15H,1-4,7-9,12-13H2,(H2,26,28)(H,29,33)/t15-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.30n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354926
PNG
(CHEMBL1836887)
Show SMILES CN1CCN(CC1)c1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C18H20F3N7O/c1-26-4-6-27(7-5-26)14-3-2-11(9-23-14)10-28-12-8-13(18(19,20)21)24-16(22)15(12)25-17(28)29/h2-3,8-9H,4-7,10H2,1H3,(H2,22,24)(H,25,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.70n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354927
PNG
(CHEMBL1836888)
Show SMILES COCCN1CCN(CC1)c1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C20H24F3N7O2/c1-32-9-8-28-4-6-29(7-5-28)16-3-2-13(11-25-16)12-30-14-10-15(20(21,22)23)26-18(24)17(14)27-19(30)31/h2-3,10-11H,4-9,12H2,1H3,(H2,24,26)(H,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.10n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354928
PNG
(CHEMBL1836883)
Show SMILES CN(C)CCNc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C17H20F3N7O/c1-26(2)6-5-22-13-4-3-10(8-23-13)9-27-11-7-12(17(18,19)20)24-15(21)14(11)25-16(27)28/h3-4,7-8H,5-6,9H2,1-2H3,(H2,21,24)(H,22,23)(H,25,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.60n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354929
PNG
(CHEMBL1836886)
Show SMILES CN(C)CCN(C)c1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C18H22F3N7O/c1-26(2)6-7-27(3)14-5-4-11(9-23-14)10-28-12-8-13(18(19,20)21)24-16(22)15(12)25-17(28)29/h4-5,8-9H,6-7,10H2,1-3H3,(H2,22,24)(H,25,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.60n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354930
PNG
(CHEMBL1836884)
Show SMILES Nc1nc(cc2n(Cc3ccc(OCCN4CCCC4)nc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C19H21F3N6O2/c20-19(21,22)14-9-13-16(17(23)25-14)26-18(29)28(13)11-12-3-4-15(24-10-12)30-8-7-27-5-1-2-6-27/h3-4,9-10H,1-2,5-8,11H2,(H2,23,25)(H,26,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.90n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354931
PNG
(CHEMBL1836880)
Show SMILES CN1CCN(CC2CCCN2c2ccc(Cn3c4cc(nc(N)c4[nH]c3=O)C(F)(F)F)cn2)CC1
Show InChI InChI=1S/C23H29F3N8O/c1-31-7-9-32(10-8-31)14-16-3-2-6-33(16)19-5-4-15(12-28-19)13-34-17-11-18(23(24,25)26)29-21(27)20(17)30-22(34)35/h4-5,11-12,16H,2-3,6-10,13-14H2,1H3,(H2,27,29)(H,30,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354932
PNG
(CHEMBL1836882)
Show SMILES CN(C)CCOc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C17H19F3N6O2/c1-25(2)5-6-28-13-4-3-10(8-22-13)9-26-11-7-12(17(18,19)20)23-15(21)14(11)24-16(26)27/h3-4,7-8H,5-6,9H2,1-2H3,(H2,21,23)(H,24,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 26.9n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354933
PNG
(CHEMBL1837075)
Show SMILES COCCNc1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C16H17F3N6O2/c1-27-5-4-21-12-3-2-9(7-22-12)8-25-10-6-11(16(17,18)19)23-14(20)13(10)24-15(25)26/h2-3,6-7H,4-5,8H2,1H3,(H2,20,23)(H,21,22)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 28.6n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354934
PNG
(CHEMBL1836895)
Show SMILES Nc1nc(cc2n(Cc3ccc(NCc4ccccc4)nc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)15-8-14-17(18(24)27-15)28-19(30)29(14)11-13-6-7-16(26-10-13)25-9-12-4-2-1-3-5-12/h1-8,10H,9,11H2,(H2,24,27)(H,25,26)(H,28,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 31n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354935
PNG
(CHEMBL1836896)
Show SMILES Nc1nc(cc2n(Cc3ccc(nc3)N3CCOCC3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C17H17F3N6O2/c18-17(19,20)12-7-11-14(15(21)23-12)24-16(27)26(11)9-10-1-2-13(22-8-10)25-3-5-28-6-4-25/h1-2,7-8H,3-6,9H2,(H2,21,23)(H,24,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 32.1n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354936
PNG
(CHEMBL1837072)
Show SMILES COCCN1CCN(CC1)c1cc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C20H24F3N7O2/c1-32-9-8-28-4-6-29(7-5-28)16-10-13(2-3-25-16)12-30-14-11-15(20(21,22)23)26-18(24)17(14)27-19(30)31/h2-3,10-11H,4-9,12H2,1H3,(H2,24,26)(H,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 45.8n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354937
PNG
(CHEMBL1837071)
Show SMILES COCCCN1CCN(CC1)c1cc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C21H26F3N7O2/c1-33-10-2-5-29-6-8-30(9-7-29)17-11-14(3-4-26-17)13-31-15-12-16(21(22,23)24)27-19(25)18(15)28-20(31)32/h3-4,11-12H,2,5-10,13H2,1H3,(H2,25,27)(H,28,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 47n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354938
PNG
(CHEMBL1837070)
Show SMILES COCCNc1cc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C16H17F3N6O2/c1-27-5-4-22-12-6-9(2-3-21-12)8-25-10-7-11(16(17,18)19)23-14(20)13(10)24-15(25)26/h2-3,6-7H,4-5,8H2,1H3,(H2,20,23)(H,21,22)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 105n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354939
PNG
(CHEMBL1837063)
Show SMILES Nc1nc(cc2n(Cc3cccnc3OCCN3CCCC3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C19H21F3N6O2/c20-19(21,22)14-10-13-15(16(23)25-14)26-18(29)28(13)11-12-4-3-5-24-17(12)30-9-8-27-6-1-2-7-27/h3-5,10H,1-2,6-9,11H2,(H2,23,25)(H,26,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 121n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354940
PNG
(CHEMBL1836894)
Show SMILES Nc1nc(cc2n(Cc3ccc(NCCO)nc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C15H15F3N6O2/c16-15(17,18)10-5-9-12(13(19)22-10)23-14(26)24(9)7-8-1-2-11(21-6-8)20-3-4-25/h1-2,5-6,25H,3-4,7H2,(H2,19,22)(H,20,21)(H,23,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 121n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354941
PNG
(CHEMBL1837064)
Show SMILES COCCNc1ncccc1Cn1c2cc(nc(N)c2[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C16H17F3N6O2/c1-27-6-5-22-14-9(3-2-4-21-14)8-25-10-7-11(16(17,18)19)23-13(20)12(10)24-15(25)26/h2-4,7H,5-6,8H2,1H3,(H2,20,23)(H,21,22)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 125n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354942
PNG
(CHEMBL1837065)
Show SMILES COCCCN1CCN(CC1)c1ncccc1Cn1c2cc(nc(N)c2[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C21H26F3N7O2/c1-33-11-3-6-29-7-9-30(10-8-29)19-14(4-2-5-26-19)13-31-15-12-16(21(22,23)24)27-18(25)17(15)28-20(31)32/h2,4-5,12H,3,6-11,13H2,1H3,(H2,25,27)(H,28,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 586n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354943
PNG
(CHEMBL1837068)
Show SMILES Nc1nc(cc2n(Cc3cccnc3N3CCC[C@H]3CN3CCCC3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C22H26F3N7O/c23-22(24,25)17-11-16-18(19(26)28-17)29-21(33)32(16)12-14-5-3-7-27-20(14)31-10-4-6-15(31)13-30-8-1-2-9-30/h3,5,7,11,15H,1-2,4,6,8-10,12-13H2,(H2,26,28)(H,29,33)/t15-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 920n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354944
PNG
(CHEMBL1837066)
Show SMILES COCCN1CCN(CC1)c1ncccc1Cn1c2cc(nc(N)c2[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C20H24F3N7O2/c1-32-10-9-28-5-7-29(8-6-28)18-13(3-2-4-25-18)12-30-14-11-15(20(21,22)23)26-17(24)16(14)27-19(30)31/h2-4,11H,5-10,12H2,1H3,(H2,24,26)(H,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.78E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354945
PNG
(CHEMBL1837067)
Show SMILES CN1CCN(CC2CCCN2c2ncccc2Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)CC1
Show InChI InChI=1S/C23H29F3N8O/c1-31-8-10-32(11-9-31)14-16-5-3-7-33(16)21-15(4-2-6-28-21)13-34-17-12-18(23(24,25)26)29-20(27)19(17)30-22(34)35/h2,4,6,12,16H,3,5,7-11,13-14H2,1H3,(H2,27,29)(H,30,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.61E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50340234
PNG
(4-amino-1-benzyl-6-(trifluoromethyl)-1H-imidazo[4,...)
Show SMILES Nc1nc(cc2n(Cc3ccccc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C14H11F3N4O/c15-14(16,17)10-6-9-11(12(18)19-10)20-13(22)21(9)7-8-4-2-1-3-5-8/h1-6H,7H2,(H2,18,19)(H,20,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 269n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354930
PNG
(CHEMBL1836884)
Show SMILES Nc1nc(cc2n(Cc3ccc(OCCN4CCCC4)nc3)c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C19H21F3N6O2/c20-19(21,22)14-9-13-16(17(23)25-14)26-18(29)28(13)11-12-3-4-15(24-10-12)30-8-7-27-5-1-2-6-27/h3-4,9-10H,1-2,5-8,11H2,(H2,23,25)(H,26,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.90n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM50354927
PNG
(CHEMBL1836888)
Show SMILES COCCN1CCN(CC1)c1ccc(Cn2c3cc(nc(N)c3[nH]c2=O)C(F)(F)F)cn1
Show InChI InChI=1S/C20H24F3N7O2/c1-32-9-8-28-4-6-29(7-5-28)16-3-2-13(11-25-16)12-30-14-10-15(20(21,22)23)26-18(24)17(14)27-19(30)31/h2-3,10-11H,4-9,12H2,1H3,(H2,24,26)(H,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.10n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production


Bioorg Med Chem Lett 21: 5939-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.076
BindingDB Entry DOI: 10.7270/Q2PK0GJN
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 58 total )  |  Next  |  Last  >>
Jump to: