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Compile Data Set for Download or QSAR

Found 133 hits with Last Name = 'adami' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H4)


(Homo sapiens (human))
BDBM22564
PNG
(2-arylbenzimidazole derivative, 10 | 2-{2-chloro-4...)
Show SMILES CN1CCCN(CCCOc2ccc(-c3nc4c(C)cc(C)cc4[nH]3)c(Cl)c2)CC1
Show InChI InChI=1S/C24H31ClN4O/c1-17-14-18(2)23-22(15-17)26-24(27-23)20-7-6-19(16-21(20)25)30-13-5-10-29-9-4-8-28(3)11-12-29/h6-7,14-16H,4-5,8-13H2,1-3H3,(H,26,27)
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1n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50361015
PNG
(CHEMBL592379)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C21H25ClN6O2S/c1-27-10-12-28(13-11-27)21-24-19-8-7-16(22)15-18(19)20(25-21)23-9-14-31(29,30)26-17-5-3-2-4-6-17/h2-8,15,26H,9-14H2,1H3,(H,23,24,25)
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1.55n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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4.17n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415482
PNG
(CHEMBL591011)
Show SMILES CNS(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C16H23ClN6O2S/c1-18-26(24,25)10-5-19-15-13-11-12(17)3-4-14(13)20-16(21-15)23-8-6-22(2)7-9-23/h3-4,11,18H,5-10H2,1-2H3,(H,19,20,21)
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4.27n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415489
PNG
(CHEMBL591969)
Show SMILES CN1CCN(CC1)c1nc(NCCS(N)(=O)=O)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C15H21ClN6O2S/c1-21-5-7-22(8-6-21)15-19-13-3-2-11(16)10-12(13)14(20-15)18-4-9-25(17,23)24/h2-3,10H,4-9H2,1H3,(H2,17,23,24)(H,18,19,20)
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4.47n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50361015
PNG
(CHEMBL592379)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C21H25ClN6O2S/c1-27-10-12-28(13-11-27)21-24-19-8-7-16(22)15-18(19)20(25-21)23-9-14-31(29,30)26-17-5-3-2-4-6-17/h2-8,15,26H,9-14H2,1H3,(H,23,24,25)
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4.90n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415486
PNG
(CHEMBL592663)
Show SMILES CN(c1ccccc1)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C22H27ClN6O2S/c1-27-11-13-29(14-12-27)22-25-20-9-8-17(23)16-19(20)21(26-22)24-10-15-32(30,31)28(2)18-6-4-3-5-7-18/h3-9,16H,10-15H2,1-2H3,(H,24,25,26)
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5.37n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50361014
PNG
(CHEMBL260549 | VUF-10214)
Show SMILES CN1CCN(CC1)c1nc2cc(Cl)c(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C13H14Cl2N4O/c1-18-2-4-19(5-3-18)12-13(20)17-11-7-9(15)8(14)6-10(11)16-12/h6-7H,2-5H2,1H3,(H,17,20)
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5.62n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415494
PNG
(CHEMBL592434)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(I)ccc2n1
Show InChI InChI=1S/C21H25IN6O2S/c1-27-10-12-28(13-11-27)21-24-19-8-7-16(22)15-18(19)20(25-21)23-9-14-31(29,30)26-17-5-3-2-4-6-17/h2-8,15,26H,9-14H2,1H3,(H,23,24,25)
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5.75n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412494
PNG
(CHEMBL452847 | VUF-10497)
Show SMILES CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)
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7.59n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415480
PNG
(CHEMBL591500)
Show SMILES CCN(CC)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C19H29ClN6O2S/c1-4-26(5-2)29(27,28)13-8-21-18-16-14-15(20)6-7-17(16)22-19(23-18)25-11-9-24(3)10-12-25/h6-7,14H,4-5,8-13H2,1-3H3,(H,21,22,23)
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7.59n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412494
PNG
(CHEMBL452847 | VUF-10497)
Show SMILES CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)
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7.59n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50191289
PNG
(7-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Oc2ccccc12
Show InChI InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-12-13(19)6-7-15(17)20-18/h2-7,12H,8-11H2,1H3
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7.76n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Binding affinity to histamine H1 receptor


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415500
PNG
(CHEMBL591496)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2c(cccc2n1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2S/c1-30-11-13-31(14-12-30)21-27-18-9-5-8-17(22(23,24)25)19(18)20(28-21)26-10-15-34(32,33)29-16-6-3-2-4-7-16/h2-9,29H,10-15H2,1H3,(H,26,27,28)
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8.13n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415485
PNG
(CHEMBL591250)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)N2CCOCC2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H27ClN6O3S/c1-24-5-7-25(8-6-24)19-22-17-3-2-15(20)14-16(17)18(23-19)21-4-13-30(27,28)26-9-11-29-12-10-26/h2-3,14H,4-13H2,1H3,(H,21,22,23)
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9.33n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415484
PNG
(CHEMBL591249)
Show SMILES CC1CCCCN1S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C21H31ClN6O2S/c1-16-5-3-4-9-28(16)31(29,30)14-8-23-20-18-15-17(22)6-7-19(18)24-21(25-20)27-12-10-26(2)11-13-27/h6-7,15-16H,3-5,8-14H2,1-2H3,(H,23,24,25)
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10n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415499
PNG
(CHEMBL589746)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)cc(Cl)c2n1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-28-8-10-29(11-9-28)21-25-19-17(13-15(22)14-18(19)23)20(26-21)24-7-12-32(30,31)27-16-5-3-2-4-6-16/h2-6,13-14,27H,7-12H2,1H3,(H,24,25,26)
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11.2n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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12.0n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415481
PNG
(CHEMBL592188)
Show SMILES CN(C)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C17H25ClN6O2S/c1-22(2)27(25,26)11-6-19-16-14-12-13(18)4-5-15(14)20-17(21-16)24-9-7-23(3)8-10-24/h4-5,12H,6-11H2,1-3H3,(H,19,20,21)
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12.6n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415498
PNG
(CHEMBL589782)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Br)c(Cl)cc2n1
Show InChI InChI=1S/C21H24BrClN6O2S/c1-28-8-10-29(11-9-28)21-25-19-14-18(23)17(22)13-16(19)20(26-21)24-7-12-32(30,31)27-15-5-3-2-4-6-15/h2-6,13-14,27H,7-12H2,1H3,(H,24,25,26)
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15.5n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50412494
PNG
(CHEMBL452847 | VUF-10497)
Show SMILES CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)
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15.8n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415483
PNG
(CHEMBL591248)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)N2CCCC2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H27ClN6O2S/c1-24-9-11-25(12-10-24)19-22-17-5-4-15(20)14-16(17)18(23-19)21-6-13-29(27,28)26-7-2-3-8-26/h4-5,14H,2-3,6-13H2,1H3,(H,21,22,23)
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17.8n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415497
PNG
(CHEMBL590995)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)c(Cl)cc2n1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-28-8-10-29(11-9-28)21-25-19-14-18(23)17(22)13-16(19)20(26-21)24-7-12-32(30,31)27-15-5-3-2-4-6-15/h2-6,13-14,27H,7-12H2,1H3,(H,24,25,26)
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19.1n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50412494
PNG
(CHEMBL452847 | VUF-10497)
Show SMILES CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)
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19.9n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50397292
PNG
(CHEMBL454890 | VUF-10499)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccoc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5O/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22)
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24.6n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50397292
PNG
(CHEMBL454890 | VUF-10499)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccoc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5O/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22)
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26.9n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415488
PNG
(CHEMBL601946)
Show SMILES CN1CCN(CC1)c1nc(NCCS(C)(=O)=O)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C16H22ClN5O2S/c1-21-6-8-22(9-7-21)16-19-14-4-3-12(17)11-13(14)15(20-16)18-5-10-25(2,23)24/h3-4,11H,5-10H2,1-2H3,(H,18,19,20)
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26.9n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50191289
PNG
(7-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Oc2ccccc12
Show InChI InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-12-13(19)6-7-15(17)20-18/h2-7,12H,8-11H2,1H3
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28.2n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415501
PNG
(CHEMBL591711)
Show SMILES CNS(=O)(=O)CCCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C17H25ClN6O2S/c1-19-27(25,26)11-3-6-20-16-14-12-13(18)4-5-15(14)21-17(22-16)24-9-7-23(2)8-10-24/h4-5,12,19H,3,6-11H2,1-2H3,(H,20,21,22)
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33.1n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412516
PNG
(CHEMBL509852 | VUF-10515)
Show SMILES CN1CCN(CC1)c1nc(NCc2sccc2C)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H22ClN5S/c1-13-5-10-26-17(13)12-21-18-15-11-14(20)3-4-16(15)22-19(23-18)25-8-6-24(2)7-9-25/h3-5,10-11H,6-9,12H2,1-2H3,(H,21,22,23)
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33.9n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412516
PNG
(CHEMBL509852 | VUF-10515)
Show SMILES CN1CCN(CC1)c1nc(NCc2sccc2C)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H22ClN5S/c1-13-5-10-26-17(13)12-21-18-15-11-14(20)3-4-16(15)22-19(23-18)25-8-6-24(2)7-9-25/h3-5,10-11H,6-9,12H2,1-2H3,(H,21,22,23)
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33.9n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412512
PNG
(CHEMBL509142 | VUF-10507)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccsc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22)
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35.5n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412512
PNG
(CHEMBL509142 | VUF-10507)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccsc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5S/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22)
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35.5n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412515
PNG
(CHEMBL452869 | VUF-10516)
Show SMILES CN1CCN(CC1)c1nc(NCc2cc(C)cs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H22ClN5S/c1-13-9-15(26-12-13)11-21-18-16-10-14(20)3-4-17(16)22-19(23-18)25-7-5-24(2)6-8-25/h3-4,9-10,12H,5-8,11H2,1-2H3,(H,21,22,23)
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38.9n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412515
PNG
(CHEMBL452869 | VUF-10516)
Show SMILES CN1CCN(CC1)c1nc(NCc2cc(C)cs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H22ClN5S/c1-13-9-15(26-12-13)11-21-18-16-10-14(20)3-4-17(16)22-19(23-18)25-7-5-24(2)6-8-25/h3-4,9-10,12H,5-8,11H2,1-2H3,(H,21,22,23)
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38.9n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412496
PNG
(CHEMBL261551 | VUF-10148)
Show SMILES CN1CCN(CC1)c1nc2ccccc2nc1Cc1ccccc1
Show InChI InChI=1S/C20H22N4/c1-23-11-13-24(14-12-23)20-19(15-16-7-3-2-4-8-16)21-17-9-5-6-10-18(17)22-20/h2-10H,11-15H2,1H3
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39.8n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415493
PNG
(CHEMBL589800)
Show SMILES CN1CCN(CC1)c1nc(NCCc2ccc(cc2)[N+]([O-])=O)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C21H23ClN6O2/c1-26-10-12-27(13-11-26)21-24-19-7-4-16(22)14-18(19)20(25-21)23-9-8-15-2-5-17(6-3-15)28(29)30/h2-7,14H,8-13H2,1H3,(H,23,24,25)
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50.1n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412513
PNG
(CHEMBL452848 | VUF-10498)
Show SMILES CN1CCN(CC1)c1nc(NCCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H22ClN5S/c1-24-8-10-25(11-9-24)19-22-17-5-4-14(20)13-16(17)18(23-19)21-7-6-15-3-2-12-26-15/h2-5,12-13H,6-11H2,1H3,(H,21,22,23)
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60.3n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412513
PNG
(CHEMBL452848 | VUF-10498)
Show SMILES CN1CCN(CC1)c1nc(NCCc2cccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H22ClN5S/c1-24-8-10-25(11-9-24)19-22-17-5-4-14(20)13-16(17)18(23-19)21-7-6-15-3-2-12-26-15/h2-5,12-13H,6-11H2,1H3,(H,21,22,23)
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60.3n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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63.1n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415487
PNG
(CHEMBL608373)
Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccc(I)cc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C21H24ClIN6O2S/c1-28-9-11-29(12-10-28)21-25-19-7-2-15(22)14-18(19)20(26-21)24-8-13-32(30,31)27-17-5-3-16(23)4-6-17/h2-7,14,27H,8-13H2,1H3,(H,24,25,26)
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70.8n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50397307
PNG
(CHEMBL489062 | VUF-10349)
Show SMILES CNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C14H18ClN5/c1-16-13-11-9-10(15)3-4-12(11)17-14(18-13)20-7-5-19(2)6-8-20/h3-4,9H,5-8H2,1-2H3,(H,16,17,18)
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70.8n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50397307
PNG
(CHEMBL489062 | VUF-10349)
Show SMILES CNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C14H18ClN5/c1-16-13-11-9-10(15)3-4-12(11)17-14(18-13)20-7-5-19(2)6-8-20/h3-4,9H,5-8H2,1-2H3,(H,16,17,18)
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79.4n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50397292
PNG
(CHEMBL454890 | VUF-10499)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccoc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5O/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22)
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89.1n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412508
PNG
(CHEMBL452925 | VUF-10457)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccco2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5O/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)
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89.1n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50397292
PNG
(CHEMBL454890 | VUF-10499)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccoc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C18H20ClN5O/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22)
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97.7n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50415489
PNG
(CHEMBL591969)
Show SMILES CN1CCN(CC1)c1nc(NCCS(N)(=O)=O)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C15H21ClN6O2S/c1-21-5-7-22(8-6-21)15-19-13-3-2-11(16)10-12(13)14(20-15)18-4-9-25(17,23)24/h2-3,10H,4-9H2,1H3,(H2,17,23,24)(H,18,19,20)
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100n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H4 receptor


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412504
PNG
(CHEMBL489070 | VUF-10513)
Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(F)cc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C20H21ClFN5/c1-26-8-10-27(11-9-26)20-24-18-7-4-15(21)12-17(18)19(25-20)23-13-14-2-5-16(22)6-3-14/h2-7,12H,8-11,13H2,1H3,(H,23,24,25)
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105n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412481
PNG
(CHEMBL453877 | VUF-10520)
Show SMILES CN1CCN(CC1)c1nc(NCc2nccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C17H19ClN6S/c1-23-5-7-24(8-6-23)17-21-14-3-2-12(18)10-13(14)16(22-17)20-11-15-19-4-9-25-15/h2-4,9-10H,5-8,11H2,1H3,(H,20,21,22)
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105n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50412481
PNG
(CHEMBL453877 | VUF-10520)
Show SMILES CN1CCN(CC1)c1nc(NCc2nccs2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C17H19ClN6S/c1-23-5-7-24(8-6-23)17-21-14-3-2-12(18)10-13(14)16(22-17)20-11-15-19-4-9-25-15/h2-4,9-10H,5-8,11H2,1H3,(H,20,21,22)
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105n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells


J Med Chem 51: 7855-65 (2008)


Article DOI: 10.1021/jm800876b
BindingDB Entry DOI: 10.7270/Q29Z964R
More data for this
Ligand-Target Pair
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