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Compile Data Set for Download or QSAR

Found 225 hits with Last Name = 'addo' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108309
PNG
(2-(3H-Benzo[e]indol-1-yl)-1-methyl-ethylamine | CH...)
Show SMILES CC(N)Cc1c[nH]c2ccc3ccccc3c12
Show InChI InChI=1S/C15H16N2/c1-10(16)8-12-9-17-14-7-6-11-4-2-3-5-13(11)15(12)14/h2-7,9-10,17H,8,16H2,1H3
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3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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3.80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards human 5-hydroxytryptamine 2C receptor using [3H]-DOB as radioligand


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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3.90n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108309
PNG
(2-(3H-Benzo[e]indol-1-yl)-1-methyl-ethylamine | CH...)
Show SMILES CC(N)Cc1c[nH]c2ccc3ccccc3c12
Show InChI InChI=1S/C15H16N2/c1-10(16)8-12-9-17-14-7-6-11-4-2-3-5-13(11)15(12)14/h2-7,9-10,17H,8,16H2,1H3
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9n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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12n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards rat 5-hydroxytryptamine 2A receptor using [3H]-Ketanserin as radioligand


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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15n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards rat 5-hydroxytryptamine 2A receptor using [3H]-DOB as radioligand


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108312
PNG
(2-Benzo[g]indol-1-yl-1-methyl-ethylamine | CHEMBL3...)
Show SMILES CC(N)Cn1ccc2ccc3ccccc3c12
Show InChI InChI=1S/C15H16N2/c1-11(16)10-17-9-8-13-7-6-12-4-2-3-5-14(12)15(13)17/h2-9,11H,10,16H2,1H3
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38n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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39n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards human 5-hydroxytryptamine 2A receptor using [3H]-DOB as radioligand


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108312
PNG
(2-Benzo[g]indol-1-yl-1-methyl-ethylamine | CHEMBL3...)
Show SMILES CC(N)Cn1ccc2ccc3ccccc3c12
Show InChI InChI=1S/C15H16N2/c1-11(16)10-17-9-8-13-7-6-12-4-2-3-5-14(12)15(13)17/h2-9,11H,10,16H2,1H3
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42n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108315
PNG
(7-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1ccc2cc3CNCCn3c2c1
Show InChI InChI=1S/C11H11ClN2/c12-9-2-1-8-5-10-7-13-3-4-14(10)11(8)6-9/h1-2,5-6,13H,3-4,7H2
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58n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108314
PNG
(8-Chloro-10-methoxy-1,2,3,4-tetrahydro-pyrazino[1,...)
Show SMILES COc1c2CNCCn2c2ccc(Cl)cc12
Show InChI InChI=1S/C12H13ClN2O/c1-16-12-9-6-8(13)2-3-10(9)15-5-4-14-7-11(12)15/h2-3,6,14H,4-5,7H2,1H3
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60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108315
PNG
(7-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1ccc2cc3CNCCn3c2c1
Show InChI InChI=1S/C11H11ClN2/c12-9-2-1-8-5-10-7-13-3-4-14(10)11(8)6-9/h1-2,5-6,13H,3-4,7H2
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80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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85n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards human 5-hydroxytryptamine 2C receptor using [3H]-Mesulergine as radioligand


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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85n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards human 5-hydroxytryptamine 2C receptor using [3H]-5-HT as radioligand


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108314
PNG
(8-Chloro-10-methoxy-1,2,3,4-tetrahydro-pyrazino[1,...)
Show SMILES COc1c2CNCCn2c2ccc(Cl)cc12
Show InChI InChI=1S/C12H13ClN2O/c1-16-12-9-6-8(13)2-3-10(9)15-5-4-14-7-11(12)15/h2-3,6,14H,4-5,7H2,1H3
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130n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108317
PNG
(CHEMBL40816 | [2-(5,6-Difluoro-indol-1-yl)-ethyl]-...)
Show SMILES CN(C)CCn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C12H14F2N2/c1-15(2)5-6-16-4-3-9-7-10(13)11(14)8-12(9)16/h3-4,7-8H,5-6H2,1-2H3
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230n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108318
PNG
(6-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1cccc2cc3CNCCn3c12
Show InChI InChI=1S/C12H14N2O/c1-15-11-4-2-3-9-7-10-8-13-5-6-14(10)12(9)11/h2-4,7,13H,5-6,8H2,1H3
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300n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108317
PNG
(CHEMBL40816 | [2-(5,6-Difluoro-indol-1-yl)-ethyl]-...)
Show SMILES CN(C)CCn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C12H14F2N2/c1-15(2)5-6-16-4-3-9-7-10(13)11(14)8-12(9)16/h3-4,7-8H,5-6H2,1-2H3
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300n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108304
PNG
(8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1ccc2n3CCNCc3cc2c1
Show InChI InChI=1S/C11H11ClN2/c12-9-1-2-11-8(5-9)6-10-7-13-3-4-14(10)11/h1-2,5-6,13H,3-4,7H2
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320n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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320n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108314
PNG
(8-Chloro-10-methoxy-1,2,3,4-tetrahydro-pyrazino[1,...)
Show SMILES COc1c2CNCCn2c2ccc(Cl)cc12
Show InChI InChI=1S/C12H13ClN2O/c1-16-12-9-6-8(13)2-3-10(9)15-5-4-14-7-11(12)15/h2-3,6,14H,4-5,7H2,1H3
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330n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108303
PNG
(6-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1cccc2cc3CNCCn3c12
Show InChI InChI=1S/C11H11ClN2/c12-10-3-1-2-8-6-9-7-13-4-5-14(9)11(8)10/h1-3,6,13H,4-5,7H2
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330n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108310
PNG
(8-Chloro-10-methyl-1,2,3,4-tetrahydro-pyrazino[1,2...)
Show SMILES Cc1c2CNCCn2c2ccc(Cl)cc12
Show InChI InChI=1S/C12H13ClN2/c1-8-10-6-9(13)2-3-11(10)15-5-4-14-7-12(8)15/h2-3,6,14H,4-5,7H2,1H3
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450n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards 5-HT2c receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108320
PNG
(CHEMBL38742 | [2-(6-Methoxy-indol-1-yl)-ethyl]-dim...)
Show SMILES COc1ccc2ccn(CCN(C)C)c2c1
Show InChI InChI=1S/C13H18N2O/c1-14(2)8-9-15-7-6-11-4-5-12(16-3)10-13(11)15/h4-7,10H,8-9H2,1-3H3
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490n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108303
PNG
(6-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1cccc2cc3CNCCn3c12
Show InChI InChI=1S/C11H11ClN2/c12-10-3-1-2-8-6-9-7-13-4-5-14(9)11(8)10/h1-3,6,13H,4-5,7H2
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520n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108315
PNG
(7-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1ccc2cc3CNCCn3c2c1
Show InChI InChI=1S/C11H11ClN2/c12-9-2-1-8-5-10-7-13-3-4-14(10)11(8)6-9/h1-2,5-6,13H,3-4,7H2
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560n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108308
PNG
((2-Indol-1-yl-ethyl)-dimethyl-amine | (2-Indol-1-y...)
Show SMILES CN(C)CCn1ccc2ccccc12
Show InChI InChI=1S/C12H16N2/c1-13(2)9-10-14-8-7-11-5-3-4-6-12(11)14/h3-8H,9-10H2,1-2H3
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600n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards human 5-hydroxytryptamine 2A receptor using [3H]-5-HT as radioligand


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108303
PNG
(6-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1cccc2cc3CNCCn3c12
Show InChI InChI=1S/C11H11ClN2/c12-10-3-1-2-8-6-9-7-13-4-5-14(9)11(8)10/h1-3,6,13H,4-5,7H2
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630n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108307
PNG
(1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole | CHEMBL6...)
Show SMILES C1Cn2c(CN1)cc1ccccc21
Show InChI InChI=1S/C11H12N2/c1-2-4-11-9(3-1)7-10-8-12-5-6-13(10)11/h1-4,7,12H,5-6,8H2
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635n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108317
PNG
(CHEMBL40816 | [2-(5,6-Difluoro-indol-1-yl)-ethyl]-...)
Show SMILES CN(C)CCn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C12H14F2N2/c1-15(2)5-6-16-4-3-9-7-10(13)11(14)8-12(9)16/h3-4,7-8H,5-6H2,1-2H3
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640n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108308
PNG
((2-Indol-1-yl-ethyl)-dimethyl-amine | (2-Indol-1-y...)
Show SMILES CN(C)CCn1ccc2ccccc12
Show InChI InChI=1S/C12H16N2/c1-13(2)9-10-14-8-7-11-5-3-4-6-12(11)14/h3-8H,9-10H2,1-2H3
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650n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108308
PNG
((2-Indol-1-yl-ethyl)-dimethyl-amine | (2-Indol-1-y...)
Show SMILES CN(C)CCn1ccc2ccccc12
Show InChI InChI=1S/C12H16N2/c1-13(2)9-10-14-8-7-11-5-3-4-6-12(11)14/h3-8H,9-10H2,1-2H3
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720n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108316
PNG
(8-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1ccc2n3CCNCc3cc2c1
Show InChI InChI=1S/C12H14N2O/c1-15-11-2-3-12-9(7-11)6-10-8-13-4-5-14(10)12/h2-3,6-7,13H,4-5,8H2,1H3
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930n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108318
PNG
(6-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1cccc2cc3CNCCn3c12
Show InChI InChI=1S/C12H14N2O/c1-15-11-4-2-3-9-7-10-8-13-5-6-14(10)12(9)11/h2-4,7,13H,5-6,8H2,1H3
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1.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108320
PNG
(CHEMBL38742 | [2-(6-Methoxy-indol-1-yl)-ethyl]-dim...)
Show SMILES COc1ccc2ccn(CCN(C)C)c2c1
Show InChI InChI=1S/C13H18N2O/c1-14(2)8-9-15-7-6-11-4-5-12(16-3)10-13(11)15/h4-7,10H,8-9H2,1-3H3
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1.04E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108307
PNG
(1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole | CHEMBL6...)
Show SMILES C1Cn2c(CN1)cc1ccccc21
Show InChI InChI=1S/C11H12N2/c1-2-4-11-9(3-1)7-10-8-12-5-6-13(10)11/h1-4,7,12H,5-6,8H2
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1.04E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108310
PNG
(8-Chloro-10-methyl-1,2,3,4-tetrahydro-pyrazino[1,2...)
Show SMILES Cc1c2CNCCn2c2ccc(Cl)cc12
Show InChI InChI=1S/C12H13ClN2/c1-8-10-6-9(13)2-3-11(10)15-5-4-14-7-12(8)15/h2-3,6,14H,4-5,7H2,1H3
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1.25E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108311
PNG
(7-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1ccc2cc3CNCCn3c2c1
Show InChI InChI=1S/C12H14N2O/c1-15-11-3-2-9-6-10-8-13-4-5-14(10)12(9)7-11/h2-3,6-7,13H,4-5,8H2,1H3
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1.30E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108304
PNG
(8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1ccc2n3CCNCc3cc2c1
Show InChI InChI=1S/C11H11ClN2/c12-9-1-2-11-8(5-9)6-10-7-13-3-4-14(10)11/h1-2,5-6,13H,3-4,7H2
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1.46E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108304
PNG
(8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole ...)
Show SMILES Clc1ccc2n3CCNCc3cc2c1
Show InChI InChI=1S/C11H11ClN2/c12-9-1-2-11-8(5-9)6-10-7-13-3-4-14(10)11/h1-2,5-6,13H,3-4,7H2
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1.67E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108318
PNG
(6-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1cccc2cc3CNCCn3c12
Show InChI InChI=1S/C12H14N2O/c1-15-11-4-2-3-9-7-10-8-13-5-6-14(10)12(9)11/h2-4,7,13H,5-6,8H2,1H3
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1.99E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108319
PNG
(2-Benzo[g]indol-1-yl-propylamine | CHEMBL42923)
Show SMILES CC(CN)n1ccc2ccc3ccccc3c12
Show InChI InChI=1S/C15H16N2/c1-11(10-16)17-9-8-13-7-6-12-4-2-3-5-14(12)15(13)17/h2-9,11H,10,16H2,1H3
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4.30E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound towards 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108307
PNG
(1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole | CHEMBL6...)
Show SMILES C1Cn2c(CN1)cc1ccccc21
Show InChI InChI=1S/C11H12N2/c1-2-4-11-9(3-1)7-10-8-12-5-6-13(10)11/h1-4,7,12H,5-6,8H2
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4.78E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108311
PNG
(7-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1ccc2cc3CNCCn3c2c1
Show InChI InChI=1S/C12H14N2O/c1-15-11-3-2-9-6-10-8-13-4-5-14(10)12(9)7-11/h2-3,6-7,13H,4-5,8H2,1H3
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5.16E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108311
PNG
(7-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1ccc2cc3CNCCn3c2c1
Show InChI InChI=1S/C12H14N2O/c1-15-11-3-2-9-6-10-8-13-4-5-14(10)12(9)7-11/h2-3,6-7,13H,4-5,8H2,1H3
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5.19E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108316
PNG
(8-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1ccc2n3CCNCc3cc2c1
Show InChI InChI=1S/C12H14N2O/c1-15-11-2-3-12-9(7-11)6-10-8-13-4-5-14(10)12/h2-3,6-7,13H,4-5,8H2,1H3
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5.83E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50108316
PNG
(8-Methoxy-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole...)
Show SMILES COc1ccc2n3CCNCc3cc2c1
Show InChI InChI=1S/C12H14N2O/c1-15-11-2-3-12-9(7-11)6-10-8-13-4-5-14(10)12/h2-3,6-7,13H,4-5,8H2,1H3
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9.93E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108313
PNG
(CHEMBL41806 | [2-(5-Methoxy-indol-1-yl)-ethyl]-dim...)
Show SMILES COc1ccc2n(CCN(C)C)ccc2c1
Show InChI InChI=1S/C13H18N2O/c1-14(2)8-9-15-7-6-11-10-12(16-3)4-5-13(11)15/h4-7,10H,8-9H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108313
PNG
(CHEMBL41806 | [2-(5-Methoxy-indol-1-yl)-ethyl]-dim...)
Show SMILES COc1ccc2n(CCN(C)C)ccc2c1
Show InChI InChI=1S/C13H18N2O/c1-14(2)8-9-15-7-6-11-10-12(16-3)4-5-13(11)15/h4-7,10H,8-9H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards human 5-hydroxytryptamine 2C receptor.


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50108305
PNG
(1,2,3,4-Tetrahydro-benzo[4,5]imidazo[1,2-a]pyrazin...)
Show SMILES C1Cn2c(CN1)nc1ccccc21
Show InChI InChI=1S/C10H11N3/c1-2-4-9-8(3-1)12-10-7-11-5-6-13(9)10/h1-4,11H,5-7H2
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Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor


Bioorg Med Chem Lett 12: 155-8 (2001)


Article DOI: 10.1016/s0960-894x(01)00713-2
BindingDB Entry DOI: 10.7270/Q21G0KKD
More data for this
Ligand-Target Pair
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