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Compile Data Set for Download or QSAR

Found 78 hits with Last Name = 'adkins' and Initial = 'ch'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173700
PNG
(3-Phenyl-5-(2-pyridin-4-yl-pyrimidin-4-yl)-pyridaz...)
Show SMILES c1ccc(cc1)-c1cc(cnn1)-c1ccnc(n1)-c1ccncc1
Show InChI InChI=1S/C19H13N5/c1-2-4-14(5-3-1)18-12-16(13-22-24-18)17-8-11-21-19(23-17)15-6-9-20-10-7-15/h1-13H
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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173700
PNG
(3-Phenyl-5-(2-pyridin-4-yl-pyrimidin-4-yl)-pyridaz...)
Show SMILES c1ccc(cc1)-c1cc(cnn1)-c1ccnc(n1)-c1ccncc1
Show InChI InChI=1S/C19H13N5/c1-2-4-14(5-3-1)18-12-16(13-22-24-18)17-8-11-21-19(23-17)15-6-9-20-10-7-15/h1-13H
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1.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173700
PNG
(3-Phenyl-5-(2-pyridin-4-yl-pyrimidin-4-yl)-pyridaz...)
Show SMILES c1ccc(cc1)-c1cc(cnn1)-c1ccnc(n1)-c1ccncc1
Show InChI InChI=1S/C19H13N5/c1-2-4-14(5-3-1)18-12-16(13-22-24-18)17-8-11-21-19(23-17)15-6-9-20-10-7-15/h1-13H
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3.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173674
PNG
(3-[6-(2-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Show SMILES Fc1ccccc1-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H10FN3/c18-16-7-2-1-6-15(16)17-9-14(11-20-21-17)13-5-3-4-12(8-13)10-19/h1-9,11H
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3.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173681
PNG
(CHEMBL197883 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Show SMILES CCNc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C12H12BrN3/c1-2-14-12-7-10(8-15-16-12)9-4-3-5-11(13)6-9/h3-8H,2H2,1H3,(H,14,16)
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3.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173681
PNG
(CHEMBL197883 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Show SMILES CCNc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C12H12BrN3/c1-2-14-12-7-10(8-15-16-12)9-4-3-5-11(13)6-9/h3-8H,2H2,1H3,(H,14,16)
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3.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173695
PNG
(3-[6-(3-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Show SMILES Fc1cccc(c1)-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H10FN3/c18-16-6-2-5-14(8-16)17-9-15(11-20-21-17)13-4-1-3-12(7-13)10-19/h1-9,11H
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4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173691
PNG
(3-(6-Phenyl-pyridazin-4-yl)-benzonitrile | CHEMBL1...)
Show SMILES N#Cc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C17H11N3/c18-11-13-5-4-8-15(9-13)16-10-17(20-19-12-16)14-6-2-1-3-7-14/h1-10,12H
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5.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173683
PNG
(5-(3-Bromo-phenyl)-3-ethoxy-pyridazine | CHEMBL196...)
Show SMILES CCOc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C12H11BrN2O/c1-2-16-12-7-10(8-14-15-12)9-4-3-5-11(13)6-9/h3-8H,2H2,1H3
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5.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173689
PNG
(3-(6-Benzylamino-pyridazin-4-yl)-benzonitrile | CH...)
Show SMILES N#Cc1cccc(c1)-c1cnnc(NCc2ccccc2)c1
Show InChI InChI=1S/C18H14N4/c19-11-15-7-4-8-16(9-15)17-10-18(22-21-13-17)20-12-14-5-2-1-3-6-14/h1-10,13H,12H2,(H,20,22)
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6.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173691
PNG
(3-(6-Phenyl-pyridazin-4-yl)-benzonitrile | CHEMBL1...)
Show SMILES N#Cc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C17H11N3/c18-11-13-5-4-8-15(9-13)16-10-17(20-19-12-16)14-6-2-1-3-7-14/h1-10,12H
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7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173698
PNG
(CHEMBL372340 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Show SMILES CC(C)Nc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C13H14BrN3/c1-9(2)16-13-7-11(8-15-17-13)10-4-3-5-12(14)6-10/h3-9H,1-2H3,(H,16,17)
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7.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173695
PNG
(3-[6-(3-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Show SMILES Fc1cccc(c1)-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H10FN3/c18-16-6-2-5-14(8-16)17-9-15(11-20-21-17)13-4-1-3-12(7-13)10-19/h1-9,11H
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7.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173681
PNG
(CHEMBL197883 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Show SMILES CCNc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C12H12BrN3/c1-2-14-12-7-10(8-15-16-12)9-4-3-5-11(13)6-9/h3-8H,2H2,1H3,(H,14,16)
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7.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173698
PNG
(CHEMBL372340 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Show SMILES CC(C)Nc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C13H14BrN3/c1-9(2)16-13-7-11(8-15-17-13)10-4-3-5-12(14)6-10/h3-9H,1-2H3,(H,16,17)
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7.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173675
PNG
(5-(3-Bromo-phenyl)-3-phenyl-pyridazine | CHEMBL197...)
Show SMILES Brc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C16H11BrN2/c17-15-8-4-7-13(9-15)14-10-16(19-18-11-14)12-5-2-1-3-6-12/h1-11H
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7.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173674
PNG
(3-[6-(2-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Show SMILES Fc1ccccc1-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H10FN3/c18-16-7-2-1-6-15(16)17-9-14(11-20-21-17)13-5-3-4-12(8-13)10-19/h1-9,11H
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7.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173675
PNG
(5-(3-Bromo-phenyl)-3-phenyl-pyridazine | CHEMBL197...)
Show SMILES Brc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C16H11BrN2/c17-15-8-4-7-13(9-15)14-10-16(19-18-11-14)12-5-2-1-3-6-12/h1-11H
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7.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173682
PNG
(5-(3-Isopropoxy-phenyl)-3-phenyl-pyridazine | CHEM...)
Show SMILES CC(C)Oc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O/c1-14(2)22-18-10-6-9-16(11-18)17-12-19(21-20-13-17)15-7-4-3-5-8-15/h3-14H,1-2H3
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8.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173685
PNG
(5-[3-(2-Methyl-2H-[1,2,4]triazol-3-ylmethoxy)-phen...)
Show SMILES Cn1ncnc1COc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C20H17N5O/c1-25-20(21-14-23-25)13-26-18-9-5-8-16(10-18)17-11-19(24-22-12-17)15-6-3-2-4-7-15/h2-12,14H,13H2,1H3
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8.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173683
PNG
(5-(3-Bromo-phenyl)-3-ethoxy-pyridazine | CHEMBL196...)
Show SMILES CCOc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C12H11BrN2O/c1-2-16-12-7-10(8-14-15-12)9-4-3-5-11(13)6-9/h3-8H,2H2,1H3
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8.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173685
PNG
(5-[3-(2-Methyl-2H-[1,2,4]triazol-3-ylmethoxy)-phen...)
Show SMILES Cn1ncnc1COc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C20H17N5O/c1-25-20(21-14-23-25)13-26-18-9-5-8-16(10-18)17-11-19(24-22-12-17)15-6-3-2-4-7-15/h2-12,14H,13H2,1H3
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8.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173685
PNG
(5-[3-(2-Methyl-2H-[1,2,4]triazol-3-ylmethoxy)-phen...)
Show SMILES Cn1ncnc1COc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C20H17N5O/c1-25-20(21-14-23-25)13-26-18-9-5-8-16(10-18)17-11-19(24-22-12-17)15-6-3-2-4-7-15/h2-12,14H,13H2,1H3
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10.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173677
PNG
(3-(6-Phenyl-pyridazin-4-yl)-benzoic acid methyl es...)
Show SMILES COC(=O)c1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C18H14N2O2/c1-22-18(21)15-9-5-8-14(10-15)16-11-17(20-19-12-16)13-6-3-2-4-7-13/h2-12H,1H3
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11n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173672
PNG
(3,5-Diphenyl-pyridazine-4-carboxylic acid methyl e...)
Show SMILES COC(=O)c1c(cnnc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C18H14N2O2/c1-22-18(21)16-15(13-8-4-2-5-9-13)12-19-20-17(16)14-10-6-3-7-11-14/h2-12H,1H3
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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173670
PNG
(3-Phenyl-5-(3-[1,2,4]triazol-4-yl-phenyl)-pyridazi...)
Show SMILES c1nncn1-c1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C18H13N5/c1-2-5-14(6-3-1)18-10-16(11-19-22-18)15-7-4-8-17(9-15)23-12-20-21-13-23/h1-13H
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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173682
PNG
(5-(3-Isopropoxy-phenyl)-3-phenyl-pyridazine | CHEM...)
Show SMILES CC(C)Oc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O/c1-14(2)22-18-10-6-9-16(11-18)17-12-19(21-20-13-17)15-7-4-3-5-8-15/h3-14H,1-2H3
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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173676
PNG
(3-(6-Phenyl-pyridazin-4-yl)-thiophene-2-carboxylic...)
Show SMILES COC(=O)c1sccc1-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C16H12N2O2S/c1-20-16(19)15-13(7-8-21-15)12-9-14(18-17-10-12)11-5-3-2-4-6-11/h2-10H,1H3
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12n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173688
PNG
(3-[6-(3,4-Difluoro-phenyl)-pyridazin-4-yl]-benzoni...)
Show SMILES Fc1ccc(cc1F)-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H9F2N3/c18-15-5-4-13(7-16(15)19)17-8-14(10-21-22-17)12-3-1-2-11(6-12)9-20/h1-8,10H
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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173694
PNG
(3-[6-(4-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Show SMILES Fc1ccc(cc1)-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H10FN3/c18-16-6-4-13(5-7-16)17-9-15(11-20-21-17)14-3-1-2-12(8-14)10-19/h1-9,11H
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14n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173691
PNG
(3-(6-Phenyl-pyridazin-4-yl)-benzonitrile | CHEMBL1...)
Show SMILES N#Cc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C17H11N3/c18-11-13-5-4-8-15(9-13)16-10-17(20-19-12-16)14-6-2-1-3-7-14/h1-10,12H
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14n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173689
PNG
(3-(6-Benzylamino-pyridazin-4-yl)-benzonitrile | CH...)
Show SMILES N#Cc1cccc(c1)-c1cnnc(NCc2ccccc2)c1
Show InChI InChI=1S/C18H14N4/c19-11-15-7-4-8-16(9-15)17-10-18(22-21-13-17)20-12-14-5-2-1-3-6-14/h1-10,13H,12H2,(H,20,22)
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15n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173675
PNG
(5-(3-Bromo-phenyl)-3-phenyl-pyridazine | CHEMBL197...)
Show SMILES Brc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C16H11BrN2/c17-15-8-4-7-13(9-15)14-10-16(19-18-11-14)12-5-2-1-3-6-12/h1-11H
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15n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173687
PNG
(3-(6-Benzyloxy-pyridazin-4-yl)-benzonitrile | CHEM...)
Show SMILES N#Cc1cccc(c1)-c1cnnc(OCc2ccccc2)c1
Show InChI InChI=1S/C18H13N3O/c19-11-15-7-4-8-16(9-15)17-10-18(21-20-12-17)22-13-14-5-2-1-3-6-14/h1-10,12H,13H2
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17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173686
PNG
(3-[6-(2,4-Difluoro-phenyl)-pyridazin-4-yl]-benzoni...)
Show SMILES Fc1ccc(c(F)c1)-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H9F2N3/c18-14-4-5-15(16(19)8-14)17-7-13(10-21-22-17)12-3-1-2-11(6-12)9-20/h1-8,10H
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17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173683
PNG
(5-(3-Bromo-phenyl)-3-ethoxy-pyridazine | CHEMBL196...)
Show SMILES CCOc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C12H11BrN2O/c1-2-16-12-7-10(8-14-15-12)9-4-3-5-11(13)6-9/h3-8H,2H2,1H3
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19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173671
PNG
(Benzyl-[5-(3-bromo-phenyl)-pyridazin-3-yl]-amine |...)
Show SMILES Brc1cccc(c1)-c1cnnc(NCc2ccccc2)c1
Show InChI InChI=1S/C17H14BrN3/c18-16-8-4-7-14(9-16)15-10-17(21-20-12-15)19-11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,19,21)
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19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173698
PNG
(CHEMBL372340 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Show SMILES CC(C)Nc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C13H14BrN3/c1-9(2)16-13-7-11(8-15-17-13)10-4-3-5-12(14)6-10/h3-9H,1-2H3,(H,16,17)
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22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173686
PNG
(3-[6-(2,4-Difluoro-phenyl)-pyridazin-4-yl]-benzoni...)
Show SMILES Fc1ccc(c(F)c1)-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H9F2N3/c18-14-4-5-15(16(19)8-14)17-7-13(10-21-22-17)12-3-1-2-11(6-12)9-20/h1-8,10H
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23n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173694
PNG
(3-[6-(4-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Show SMILES Fc1ccc(cc1)-c1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H10FN3/c18-16-6-4-13(5-7-16)17-9-15(11-20-21-17)14-3-1-2-12(8-14)10-19/h1-9,11H
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26n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173696
PNG
(5-(3-Bromo-phenyl)-3-isopropoxy-pyridazine | CHEMB...)
Show SMILES CC(C)Oc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C13H13BrN2O/c1-9(2)17-13-7-11(8-15-16-13)10-4-3-5-12(14)6-10/h3-9H,1-2H3
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26n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173699
PNG
(4-(6-Phenyl-pyridazin-4-yl)-benzonitrile | CHEMBL1...)
Show SMILES N#Cc1ccc(cc1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C17H11N3/c18-11-13-6-8-14(9-7-13)16-10-17(20-19-12-16)15-4-2-1-3-5-15/h1-10,12H
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27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173682
PNG
(5-(3-Isopropoxy-phenyl)-3-phenyl-pyridazine | CHEM...)
Show SMILES CC(C)Oc1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C19H18N2O/c1-14(2)22-18-10-6-9-16(11-18)17-12-19(21-20-13-17)15-7-4-3-5-8-15/h3-14H,1-2H3
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27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173692
PNG
(CHEMBL372302 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Show SMILES CNc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C11H10BrN3/c1-13-11-6-9(7-14-15-11)8-3-2-4-10(12)5-8/h2-7H,1H3,(H,13,15)
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27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173693
PNG
(3,5-Diphenyl-pyridazine | CHEMBL194198)
Show SMILES c1ccc(cc1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C16H12N2/c1-3-7-13(8-4-1)15-11-16(18-17-12-15)14-9-5-2-6-10-14/h1-12H
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29n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit


(Homo sapiens-HUMAN)
BDBM50173677
PNG
(3-(6-Phenyl-pyridazin-4-yl)-benzoic acid methyl es...)
Show SMILES COC(=O)c1cccc(c1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C18H14N2O2/c1-22-18(21)15-9-5-8-14(10-15)16-11-17(20-19-12-16)13-6-3-2-4-7-13/h2-12H,1H3
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29n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173684
PNG
(3-(6-Ethylamino-pyridazin-4-yl)-benzonitrile | CHE...)
Show SMILES CCNc1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C13H12N4/c1-2-15-13-7-12(9-16-17-13)11-5-3-4-10(6-11)8-14/h3-7,9H,2H2,1H3,(H,15,17)
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33n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173678
PNG
(3-(6-Ethoxy-pyridazin-4-yl)-benzonitrile | CHEMBL3...)
Show SMILES CCOc1cc(cnn1)-c1cccc(c1)C#N
Show InChI InChI=1S/C13H11N3O/c1-2-17-13-7-12(9-15-16-13)11-5-3-4-10(6-11)8-14/h3-7,9H,2H2,1H3
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36n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50173696
PNG
(5-(3-Bromo-phenyl)-3-isopropoxy-pyridazine | CHEMB...)
Show SMILES CC(C)Oc1cc(cnn1)-c1cccc(Br)c1
Show InChI InChI=1S/C13H13BrN2O/c1-9(2)17-13-7-11(8-15-16-13)10-4-3-5-12(14)6-10/h3-9H,1-2H3
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36n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50173693
PNG
(3,5-Diphenyl-pyridazine | CHEMBL194198)
Show SMILES c1ccc(cc1)-c1cnnc(c1)-c1ccccc1
Show InChI InChI=1S/C16H12N2/c1-3-7-13(8-4-1)15-11-16(18-17-12-15)14-9-5-2-6-10-14/h1-12H
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PubMed
36n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...


J Med Chem 48: 6004-11 (2005)


Article DOI: 10.1021/jm050249x
BindingDB Entry DOI: 10.7270/Q26H4GZH
More data for this
Ligand-Target Pair
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