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Compile Data Set for Download or QSAR

Found 197 hits with Last Name = 'agamennone' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM12072
PNG
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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PubMed
0.600 -52.6n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Stromelysin-1


(Homo sapiens (human))
BDBM12075
PNG
((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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PubMed
4.40 -47.7n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM12072
PNG
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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PubMed
5 -47.4n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM12072
PNG
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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PubMed
40 -42.2n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM12074
PNG
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m1/s1
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PubMed
54.9 -41.4n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM12073
PNG
((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m0/s1
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700 -35.1n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Collagenase


(homo sapiens (human))
BDBM12073
PNG
((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m0/s1
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1.20E+3 -33.8n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50031795
PNG
((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
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n/an/a 0.0460n/an/an/an/an/an/a



Università G. d'Annunzio

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP8


Eur J Med Chem 43: 1008-14 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.002
BindingDB Entry DOI: 10.7270/Q23T9H1W
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198038
PNG
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1
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n/an/a 0.370n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Collagenase


(Homo sapiens (Human))
BDBM50031795
PNG
((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
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n/an/a 0.380n/an/an/an/an/an/a



Università G. d'Annunzio

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9


Eur J Med Chem 43: 1008-14 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.002
BindingDB Entry DOI: 10.7270/Q23T9H1W
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50198038
PNG
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1
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n/an/a 0.390n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 0.390n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 0.390n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198035
PNG
(CHEMBL227501 | [(R)-2-methyl-1-(3'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(C)c1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-9-7-14(8-10-16)15-6-4-5-13(3)11-15/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Collagenase


(Homo sapiens (Human))
BDBM50198038
PNG
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1
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n/an/a 0.560n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50031795
PNG
((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Università G. d'Annunzio

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2


Eur J Med Chem 43: 1008-14 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.002
BindingDB Entry DOI: 10.7270/Q23T9H1W
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198034
PNG
(CHEMBL376557 | [(R)-1-(4'-chloro-biphenyl-4-sulfon...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)P(O)(O)=O
Show InChI InChI=1S/C16H19ClNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-9-5-13(6-10-15)12-3-7-14(17)8-4-12/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1
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n/an/a 0.810n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Collagenase


(homo sapiens (human))
BDBM8485
PNG
((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C17H20N2O5S/c1-12(2)16(17(20)18-21)19-25(22,23)15-10-8-14(9-11-15)24-13-6-4-3-5-7-13/h3-12,16,19,21H,1-2H3,(H,18,20)/t16-/m1/s1
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n/an/a 1n/an/an/an/a7.025



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50198038
PNG
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP13


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198039
PNG
(CHEMBL374377 | [(R)-1-(4'-fluoro-biphenyl-4-sulfon...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)P(O)(O)=O
Show InChI InChI=1S/C16H19FNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-9-5-13(6-10-15)12-3-7-14(17)8-4-12/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198030
PNG
(CHEMBL228188 | [(R)-1-(3'-chloro-biphenyl-4-sulfon...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(Cl)c1)P(O)(O)=O
Show InChI InChI=1S/C16H19ClNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-8-6-12(7-9-15)13-4-3-5-14(17)10-13/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM12072
PNG
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198031
PNG
(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C19H26NO6PS/c1-13(2)19(27(21,22)23)20-28(24,25)18-11-7-16(8-12-18)15-5-9-17(10-6-15)26-14(3)4/h5-14,19-20H,1-4H3,(H2,21,22,23)/t19-/m1/s1
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Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Collagenase


(homo sapiens (human))
BDBM12072
PNG
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50198031
PNG
(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C19H26NO6PS/c1-13(2)19(27(21,22)23)20-28(24,25)18-11-7-16(8-12-18)15-5-9-17(10-6-15)26-14(3)4/h5-14,19-20H,1-4H3,(H2,21,22,23)/t19-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198040
PNG
(CHEMBL389898 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)N1CCCC1)P(O)(O)=O
Show InChI InChI=1S/C20H27N2O5PS/c1-15(2)20(28(23,24)25)21-29(26,27)19-11-7-17(8-12-19)16-5-9-18(10-6-16)22-13-3-4-14-22/h5-12,15,20-21H,3-4,13-14H2,1-2H3,(H2,23,24,25)/t20-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Collagenase


(homo sapiens (human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50198037
PNG
(CHEMBL228187 | [(R)-1-(3'-fluoro-biphenyl-4-sulfon...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(F)c1)P(O)(O)=O
Show InChI InChI=1S/C16H19FNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-8-6-12(7-9-15)13-4-3-5-14(17)10-13/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP8


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Collagenase


(Homo sapiens (human))
BDBM12072
PNG
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP13


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM12076
PNG
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(=O)NO
Show InChI InChI=1S/C17H19BrN2O4S/c1-11(2)16(17(21)19-22)20-25(23,24)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,20,22H,1-2H3,(H,19,21)/t16-/m1/s1
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n/an/a 3n/an/an/an/a7.025



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP13


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP13


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM12075
PNG
((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 4n/an/an/an/a7.025



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM8485
PNG
((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C17H20N2O5S/c1-12(2)16(17(20)18-21)19-25(22,23)15-10-8-14(9-11-15)24-13-6-4-3-5-7-13/h3-12,16,19,21H,1-2H3,(H,18,20)/t16-/m1/s1
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n/an/a 4n/an/an/an/a6.025



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50198031
PNG
(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C19H26NO6PS/c1-13(2)19(27(21,22)23)20-28(24,25)18-11-7-16(8-12-18)15-5-9-17(10-6-15)26-14(3)4/h5-14,19-20H,1-4H3,(H2,21,22,23)/t19-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP13


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50198040
PNG
(CHEMBL389898 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)N1CCCC1)P(O)(O)=O
Show InChI InChI=1S/C20H27N2O5PS/c1-15(2)20(28(23,24)25)21-29(26,27)19-11-7-17(8-12-19)16-5-9-18(10-6-16)22-13-3-4-14-22/h5-12,15,20-21H,3-4,13-14H2,1-2H3,(H2,23,24,25)/t20-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP3


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM12074
PNG
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m1/s1
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n/an/a 5n/an/an/an/a7.025



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50198034
PNG
(CHEMBL376557 | [(R)-1-(4'-chloro-biphenyl-4-sulfon...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)P(O)(O)=O
Show InChI InChI=1S/C16H19ClNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-9-5-13(6-10-15)12-3-7-14(17)8-4-12/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP13


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM12072
PNG
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM12076
PNG
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(=O)NO
Show InChI InChI=1S/C17H19BrN2O4S/c1-11(2)16(17(21)19-22)20-25(23,24)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,20,22H,1-2H3,(H,19,21)/t16-/m1/s1
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n/an/a 8n/an/an/an/a6.025



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50031795
PNG
((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



Università G. d'Annunzio

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP7


Eur J Med Chem 43: 1008-14 (2008)


Article DOI: 10.1016/j.ejmech.2007.07.002
BindingDB Entry DOI: 10.7270/Q23T9H1W
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50198034
PNG
(CHEMBL376557 | [(R)-1-(4'-chloro-biphenyl-4-sulfon...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)P(O)(O)=O
Show InChI InChI=1S/C16H19ClNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-9-5-13(6-10-15)12-3-7-14(17)8-4-12/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1
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n/an/a 8.70n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50084293
PNG
((S)-2-(4'-chloro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C17H18ClNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP3


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP3


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50084293
PNG
((S)-2-(4'-chloro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C17H18ClNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50198038
PNG
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP14


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50198033
PNG
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O
Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP14


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50198038
PNG
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O
Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP3


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
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