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Compile Data Set for Download or QSAR

Found 90 hits with Last Name = 'ahmad' and Initial = 'p'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266158
PNG
(CHEMBL510225 | Dimethyl-[2-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C21H20N2O2/c1-23(2)13-14-24-17-10-7-16(8-11-17)21-22-20-18-6-4-3-5-15(18)9-12-19(20)25-21/h3-12H,13-14H2,1-2H3
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2.51E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266161
PNG
(2-[4-(2-Piperidine-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H24N2O2/c1-4-14-26(15-5-1)16-17-27-20-11-8-19(9-12-20)24-25-23-21-7-3-2-6-18(21)10-13-22(23)28-24/h2-3,6-13H,1,4-5,14-17H2
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2.71E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266161
PNG
(2-[4-(2-Piperidine-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H24N2O2/c1-4-14-26(15-5-1)16-17-27-20-11-8-19(9-12-20)24-25-23-21-7-3-2-6-18(21)10-13-22(23)28-24/h2-3,6-13H,1,4-5,14-17H2
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2.75E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266158
PNG
(CHEMBL510225 | Dimethyl-[2-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C21H20N2O2/c1-23(2)13-14-24-17-10-7-16(8-11-17)21-22-20-18-6-4-3-5-15(18)9-12-19(20)25-21/h3-12H,13-14H2,1-2H3
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2.87E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266231
PNG
(CHEMBL510460 | Dimethyl-[3-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C22H22N2O2/c1-24(2)14-5-15-25-18-11-8-17(9-12-18)22-23-21-19-7-4-3-6-16(19)10-13-20(21)26-22/h3-4,6-13H,5,14-15H2,1-2H3
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3.41E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266160
PNG
(2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H22N2O2/c1-2-6-20-17(5-1)9-12-21-22(20)24-23(27-21)18-7-10-19(11-8-18)26-16-15-25-13-3-4-14-25/h1-2,5-12H,3-4,13-16H2
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PubMed
3.42E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266159
PNG
(CHEMBL506882 | Diethyl-[2-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H24N2O2/c1-3-25(4-2)15-16-26-19-12-9-18(10-13-19)23-24-22-20-8-6-5-7-17(20)11-14-21(22)27-23/h5-14H,3-4,15-16H2,1-2H3
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3.50E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266231
PNG
(CHEMBL510460 | Dimethyl-[3-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C22H22N2O2/c1-24(2)14-5-15-25-18-11-8-17(9-12-18)22-23-21-19-7-4-3-6-16(19)10-13-20(21)26-22/h3-4,6-13H,5,14-15H2,1-2H3
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3.63E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266160
PNG
(2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H22N2O2/c1-2-6-20-17(5-1)9-12-21-22(20)24-23(27-21)18-7-10-19(11-8-18)26-16-15-25-13-3-4-14-25/h1-2,5-12H,3-4,13-16H2
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3.70E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266232
PNG
(CHEMBL458009 | Diethyl-[3-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-26(4-2)16-7-17-27-20-13-10-19(11-14-20)24-25-23-21-9-6-5-8-18(21)12-15-22(23)28-24/h5-6,8-15H,3-4,7,16-17H2,1-2H3
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4.05E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266232
PNG
(CHEMBL458009 | Diethyl-[3-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-26(4-2)16-7-17-27-20-13-10-19(11-14-20)24-25-23-21-9-6-5-8-18(21)12-15-22(23)28-24/h5-6,8-15H,3-4,7,16-17H2,1-2H3
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4.10E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266162
PNG
(Butyl-methyl-[2-(4-naphtho[1,2-d]oxazol-2-yl-pheno...)
Show SMILES CCCCN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-4-15-26(2)16-17-27-20-12-9-19(10-13-20)24-25-23-21-8-6-5-7-18(21)11-14-22(23)28-24/h5-14H,3-4,15-17H2,1-2H3
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4.10E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266162
PNG
(Butyl-methyl-[2-(4-naphtho[1,2-d]oxazol-2-yl-pheno...)
Show SMILES CCCCN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-4-15-26(2)16-17-27-20-12-9-19(10-13-20)24-25-23-21-8-6-5-7-18(21)11-14-22(23)28-24/h5-14H,3-4,15-17H2,1-2H3
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4.44E+4n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266159
PNG
(CHEMBL506882 | Diethyl-[2-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H24N2O2/c1-3-25(4-2)15-16-26-19-12-9-18(10-13-19)23-24-22-20-8-6-5-7-17(20)11-14-21(22)27-23/h5-14H,3-4,15-16H2,1-2H3
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3.55E+5n/an/an/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346150
PNG
(5-(2-(2-(1H-pyrrol-1-yl)ethoxy)-4-methoxyphenyl)-3...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN2CCCC2)c1
Show InChI InChI=1S/C22H24N2O3/c1-25-18-9-10-19(21(15-18)26-14-13-24-11-5-6-12-24)22-16-20(23-27-22)17-7-3-2-4-8-17/h2-4,7-10,15-16H,5-6,11-14H2,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346150
PNG
(5-(2-(2-(1H-pyrrol-1-yl)ethoxy)-4-methoxyphenyl)-3...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN2CCCC2)c1
Show InChI InChI=1S/C22H24N2O3/c1-25-18-9-10-19(21(15-18)26-14-13-24-11-5-6-12-24)22-16-20(23-27-22)17-7-3-2-4-8-17/h2-4,7-10,15-16H,5-6,11-14H2,1H3
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n/an/a 1.51E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266161
PNG
(2-[4-(2-Piperidine-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H24N2O2/c1-4-14-26(15-5-1)16-17-27-20-11-8-19(9-12-20)24-25-23-21-7-3-2-6-18(21)10-13-22(23)28-24/h2-3,6-13H,1,4-5,14-17H2
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n/an/a 1.86E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266161
PNG
(2-[4-(2-Piperidine-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H24N2O2/c1-4-14-26(15-5-1)16-17-27-20-11-8-19(9-12-20)24-25-23-21-7-3-2-6-18(21)10-13-22(23)28-24/h2-3,6-13H,1,4-5,14-17H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346151
PNG
(4-(2-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)e...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN2CCOCC2)c1
Show InChI InChI=1S/C22H24N2O4/c1-25-18-7-8-19(21(15-18)27-14-11-24-9-12-26-13-10-24)22-16-20(23-28-22)17-5-3-2-4-6-17/h2-8,15-16H,9-14H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266162
PNG
(Butyl-methyl-[2-(4-naphtho[1,2-d]oxazol-2-yl-pheno...)
Show SMILES CCCCN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-4-15-26(2)16-17-27-20-12-9-19(10-13-20)24-25-23-21-8-6-5-7-18(21)11-14-22(23)28-24/h5-14H,3-4,15-17H2,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266162
PNG
(Butyl-methyl-[2-(4-naphtho[1,2-d]oxazol-2-yl-pheno...)
Show SMILES CCCCN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-4-15-26(2)16-17-27-20-12-9-19(10-13-20)24-25-23-21-8-6-5-7-18(21)11-14-22(23)28-24/h5-14H,3-4,15-17H2,1-2H3
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n/an/a 2.52E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346151
PNG
(4-(2-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)e...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN2CCOCC2)c1
Show InChI InChI=1S/C22H24N2O4/c1-25-18-7-8-19(21(15-18)27-14-11-24-9-12-26-13-10-24)22-16-20(23-28-22)17-5-3-2-4-6-17/h2-8,15-16H,9-14H2,1H3
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n/an/a 2.61E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346148
PNG
(CHEMBL1783773 | N,N-diethyl-2-(5-methoxy-2-(3-phen...)
Show SMILES CCN(CC)CCOc1cc(OC)ccc1-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C22H26N2O3/c1-4-24(5-2)13-14-26-21-15-18(25-3)11-12-19(21)22-16-20(23-27-22)17-9-7-6-8-10-17/h6-12,15-16H,4-5,13-14H2,1-3H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346148
PNG
(CHEMBL1783773 | N,N-diethyl-2-(5-methoxy-2-(3-phen...)
Show SMILES CCN(CC)CCOc1cc(OC)ccc1-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C22H26N2O3/c1-4-24(5-2)13-14-26-21-15-18(25-3)11-12-19(21)22-16-20(23-27-22)17-9-7-6-8-10-17/h6-12,15-16H,4-5,13-14H2,1-3H3
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n/an/a 2.97E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346166
PNG
(1-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)-3-(...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCC(O)CN2CCCCC2)c1
Show InChI InChI=1S/C24H28N2O4/c1-28-20-10-11-21(24-15-22(25-30-24)18-8-4-2-5-9-18)23(14-20)29-17-19(27)16-26-12-6-3-7-13-26/h2,4-5,8-11,14-15,19,27H,3,6-7,12-13,16-17H2,1H3
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n/an/a 3.31E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266232
PNG
(CHEMBL458009 | Diethyl-[3-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-26(4-2)16-7-17-27-20-13-10-19(11-14-20)24-25-23-21-9-6-5-8-18(21)12-15-22(23)28-24/h5-6,8-15H,3-4,7,16-17H2,1-2H3
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n/an/a 3.36E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266232
PNG
(CHEMBL458009 | Diethyl-[3-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C24H26N2O2/c1-3-26(4-2)16-7-17-27-20-13-10-19(11-14-20)24-25-23-21-9-6-5-8-18(21)12-15-22(23)28-24/h5-6,8-15H,3-4,7,16-17H2,1-2H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346165
PNG
(1-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)-3-(...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCC(O)CN2CCCC2)c1
Show InChI InChI=1S/C23H26N2O4/c1-27-19-9-10-20(23-14-21(24-29-23)17-7-3-2-4-8-17)22(13-19)28-16-18(26)15-25-11-5-6-12-25/h2-4,7-10,13-14,18,26H,5-6,11-12,15-16H2,1H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346158
PNG
(5-(2-(3-(1H-pyrrol-1-yl)propoxy)-4-methoxyphenyl)-...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCCN2CCCC2)c1
Show InChI InChI=1S/C23H26N2O3/c1-26-19-10-11-20(22(16-19)27-15-7-14-25-12-5-6-13-25)23-17-21(24-28-23)18-8-3-2-4-9-18/h2-4,8-11,16-17H,5-7,12-15H2,1H3
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n/an/a 3.46E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346158
PNG
(5-(2-(3-(1H-pyrrol-1-yl)propoxy)-4-methoxyphenyl)-...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCCN2CCCC2)c1
Show InChI InChI=1S/C23H26N2O3/c1-26-19-10-11-20(22(16-19)27-15-7-14-25-12-5-6-13-25)23-17-21(24-28-23)18-8-3-2-4-9-18/h2-4,8-11,16-17H,5-7,12-15H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266231
PNG
(CHEMBL510460 | Dimethyl-[3-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C22H22N2O2/c1-24(2)14-5-15-25-18-11-8-17(9-12-18)22-23-21-19-7-4-3-6-16(19)10-13-20(21)26-22/h3-4,6-13H,5,14-15H2,1-2H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266158
PNG
(CHEMBL510225 | Dimethyl-[2-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C21H20N2O2/c1-23(2)13-14-24-17-10-7-16(8-11-17)21-22-20-18-6-4-3-5-15(18)9-12-19(20)25-21/h3-12H,13-14H2,1-2H3
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n/an/a 3.51E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266231
PNG
(CHEMBL510460 | Dimethyl-[3-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C22H22N2O2/c1-24(2)14-5-15-25-18-11-8-17(9-12-18)22-23-21-19-7-4-3-6-16(19)10-13-20(21)26-22/h3-4,6-13H,5,14-15H2,1-2H3
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n/an/a 3.52E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266158
PNG
(CHEMBL510225 | Dimethyl-[2-(4-naphtho[1,2-d]oxazol...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C21H20N2O2/c1-23(2)13-14-24-17-10-7-16(8-11-17)21-22-20-18-6-4-3-5-15(18)9-12-19(20)25-21/h3-12H,13-14H2,1-2H3
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n/an/a 3.56E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346165
PNG
(1-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)-3-(...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCC(O)CN2CCCC2)c1
Show InChI InChI=1S/C23H26N2O4/c1-27-19-9-10-20(23-14-21(24-29-23)17-7-3-2-4-8-17)22(13-19)28-16-18(26)15-25-11-5-6-12-25/h2-4,7-10,13-14,18,26H,5-6,11-12,15-16H2,1H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346163
PNG
(1-(diethylamino)-3-(5-methoxy-2-(3-phenylisoxazol-...)
Show SMILES CCN(CC)CC(O)COc1cc(OC)ccc1-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C23H28N2O4/c1-4-25(5-2)15-18(26)16-28-22-13-19(27-3)11-12-20(22)23-14-21(24-29-23)17-9-7-6-8-10-17/h6-14,18,26H,4-5,15-16H2,1-3H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346157
PNG
(5-(4-methoxy-2-(3-(piperidin-1-yl)propoxy)phenyl)-...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCCN2CCCCC2)c1
Show InChI InChI=1S/C24H28N2O3/c1-27-20-11-12-21(24-18-22(25-29-24)19-9-4-2-5-10-19)23(17-20)28-16-8-15-26-13-6-3-7-14-26/h2,4-5,9-12,17-18H,3,6-8,13-16H2,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346157
PNG
(5-(4-methoxy-2-(3-(piperidin-1-yl)propoxy)phenyl)-...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCCN2CCCCC2)c1
Show InChI InChI=1S/C24H28N2O3/c1-27-20-11-12-21(24-18-22(25-29-24)19-9-4-2-5-10-19)23(17-20)28-16-8-15-26-13-6-3-7-14-26/h2,4-5,9-12,17-18H,3,6-8,13-16H2,1H3
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n/an/a 4.42E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266159
PNG
(CHEMBL506882 | Diethyl-[2-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H24N2O2/c1-3-25(4-2)15-16-26-19-12-9-18(10-13-19)23-24-22-20-8-6-5-7-17(20)11-14-21(22)27-23/h5-14H,3-4,15-16H2,1-2H3
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n/an/a 4.55E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266159
PNG
(CHEMBL506882 | Diethyl-[2-(4-naphtho[1,2-d]oxazol-...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H24N2O2/c1-3-25(4-2)15-16-26-19-12-9-18(10-13-19)23-24-22-20-8-6-5-7-17(20)11-14-21(22)27-23/h5-14H,3-4,15-16H2,1-2H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346159
PNG
(CHEMBL1783784 | ethyl 2-(5-methoxy-2-(3-phenylisox...)
Show SMILES CCOC(=O)COc1cc(OC)ccc1-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C20H19NO5/c1-3-24-20(22)13-25-18-11-15(23-2)9-10-16(18)19-12-17(21-26-19)14-7-5-4-6-8-14/h4-12H,3,13H2,1-2H3
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n/an/a 5.25E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346159
PNG
(CHEMBL1783784 | ethyl 2-(5-methoxy-2-(3-phenylisox...)
Show SMILES CCOC(=O)COc1cc(OC)ccc1-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C20H19NO5/c1-3-24-20(22)13-25-18-11-15(23-2)9-10-16(18)19-12-17(21-26-19)14-7-5-4-6-8-14/h4-12H,3,13H2,1-2H3
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n/an/a 5.35E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346149
PNG
(CHEMBL1783774 | N-isopropyl-N-(2-(5-methoxy-2-(3-p...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN(C(C)C)C(C)C)c1
Show InChI InChI=1S/C24H30N2O3/c1-17(2)26(18(3)4)13-14-28-23-15-20(27-5)11-12-21(23)24-16-22(25-29-24)19-9-7-6-8-10-19/h6-12,15-18H,13-14H2,1-5H3
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n/an/a 5.44E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346149
PNG
(CHEMBL1783774 | N-isopropyl-N-(2-(5-methoxy-2-(3-p...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN(C(C)C)C(C)C)c1
Show InChI InChI=1S/C24H30N2O3/c1-17(2)26(18(3)4)13-14-28-23-15-20(27-5)11-12-21(23)24-16-22(25-29-24)19-9-7-6-8-10-19/h6-12,15-18H,13-14H2,1-5H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266160
PNG
(2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H22N2O2/c1-2-6-20-17(5-1)9-12-21-22(20)24-23(27-21)18-7-10-19(11-8-18)26-16-15-25-13-3-4-14-25/h1-2,5-12H,3-4,13-16H2
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n/an/a 5.70E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity in presence of Triton X-100


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50266160
PNG
(2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-naphtho[1,...)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1nc2c(ccc3ccccc23)o1
Show InChI InChI=1S/C23H22N2O2/c1-2-6-20-17(5-1)9-12-21-22(20)24-23(27-21)18-7-10-19(11-8-18)26-16-15-25-13-3-4-14-25/h1-2,5-12H,3-4,13-16H2
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n/an/a 5.71E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of of PTP1B (unknown origin) assessed as residual enzyme activity


Eur J Med Chem 44: 109-16 (2008)


Article DOI: 10.1016/j.ejmech.2008.03.009
BindingDB Entry DOI: 10.7270/Q2FN1602
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346166
PNG
(1-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)-3-(...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCC(O)CN2CCCCC2)c1
Show InChI InChI=1S/C24H28N2O4/c1-28-20-10-11-21(24-15-22(25-30-24)18-8-4-2-5-9-18)23(14-20)29-17-19(27)16-26-12-6-3-7-13-26/h2,4-5,8-11,14-15,19,27H,3,6-7,12-13,16-17H2,1H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346163
PNG
(1-(diethylamino)-3-(5-methoxy-2-(3-phenylisoxazol-...)
Show SMILES CCN(CC)CC(O)COc1cc(OC)ccc1-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C23H28N2O4/c1-4-25(5-2)15-18(26)16-28-22-13-19(27-3)11-12-20(22)23-14-21(24-29-23)17-9-7-6-8-10-17/h6-14,18,26H,4-5,15-16H2,1-3H3
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n/an/a 6.89E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in presence of 0.01% Triton X-100 by modified Golds...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50401043
PNG
(CHEMBL2206342)
Show SMILES CCC(=O)c1c(O)cccc1OCCCNc1ccc(OC)cc1
Show InChI InChI=1S/C19H23NO4/c1-3-16(21)19-17(22)6-4-7-18(19)24-13-5-12-20-14-8-10-15(23-2)11-9-14/h4,6-11,20,22H,3,5,12-13H2,1-2H3
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n/an/a 8.30E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PTP1B


Bioorg Med Chem 20: 2172-9 (2012)


Article DOI: 10.1016/j.bmc.2011.12.027
BindingDB Entry DOI: 10.7270/Q2T72JKG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50346153
PNG
(5-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)-3...)
Show SMILES COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN2CCCCC2)c1
Show InChI InChI=1S/C23H26N2O3/c1-26-19-10-11-20(22(16-19)27-15-14-25-12-6-3-7-13-25)23-17-21(24-28-23)18-8-4-2-5-9-18/h2,4-5,8-11,16-17H,3,6-7,12-15H2,1H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein tyrosine phosphatase-1B at 10 uM incubated for 10 mins using pNPP substrate in absence of Triton X-100 by modified Goldstein me...


Bioorg Med Chem 17: 5285-92 (2009)


Article DOI: 10.1016/j.bmc.2009.05.033
BindingDB Entry DOI: 10.7270/Q2J966QV
More data for this
Ligand-Target Pair
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