BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 98 hits with Last Name = 'ahmat' and Initial = 'n'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092444
PNG
(CHEMBL3586121)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccc1O
Show InChI InChI=1S/C23H18N4O2/c1-13-11-18-19(12-14(13)2)25-21(24-18)15-7-9-16(10-8-15)22-26-27-23(29-22)17-5-3-4-6-20(17)28/h3-12,28H,1-2H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193670
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2,4,...)
Show SMILES Clc1cc(Cl)c(cc1Cl)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1cc(Cl)c(Cl)cc1Cl
Show InChI InChI=1S/C24H14Cl6N2O4S4/c25-13-9-17(29)23(11-15(13)27)39(33,34)31-19-5-1-3-7-21(19)37-38-22-8-4-2-6-20(22)32-40(35,36)24-12-16(28)14(26)10-18(24)30/h1-12,31-32H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092351
PNG
(CHEMBL3586128)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(O)cc1
Show InChI InChI=1S/C26H25Cl2N3O/c1-32-26-13-12-19-22(20(26)11-7-3-6-10-18-8-4-2-5-9-18)15-30-31-25(19)14-21-23(27)16-29-17-24(21)28/h2,4-5,8-9,12-13,15-17H,3,6-7,10-11,14H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193667
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2,4-...)
Show SMILES [O-][N+](=O)c1ccc(c(c1)[N+]([O-])=O)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C24H16N6O12S4/c31-27(32)15-9-11-23(19(13-15)29(35)36)45(39,40)25-17-5-1-3-7-21(17)43-44-22-8-4-2-6-18(22)26-46(41,42)24-12-10-16(28(33)34)14-20(24)30(37)38/h1-14,25-26H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.34E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092460
PNG
(CHEMBL3586119)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccn1
Show InChI InChI=1S/C22H17N5O/c1-13-11-18-19(12-14(13)2)25-20(24-18)15-6-8-16(9-7-15)21-26-27-22(28-21)17-5-3-4-10-23-17/h3-12H,1-2H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.12E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193657
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2-fl...)
Show SMILES Fc1ccccc1S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C24H18F2N2O4S4/c25-17-9-1-7-15-23(17)35(29,30)27-19-11-3-5-13-21(19)33-34-22-14-6-4-12-20(22)28-36(31,32)24-16-8-2-10-18(24)26/h1-16,27-28H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.23E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092465
PNG
(CHEMBL3586113)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(O)c1
Show InChI InChI=1S/C23H18N4O2/c1-13-10-19-20(11-14(13)2)25-21(24-19)15-6-8-16(9-7-15)22-26-27-23(29-22)17-4-3-5-18(28)12-17/h3-12,28H,1-2H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193654
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2-ch...)
Show SMILES Clc1ccccc1S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C24H18Cl2N2O4S4/c25-17-9-1-7-15-23(17)35(29,30)27-19-11-3-5-13-21(19)33-34-22-14-6-4-12-20(22)28-36(31,32)24-16-8-2-10-18(24)26/h1-16,27-28H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.18E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175324
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C23H20N4O4/c1-12-7-17-18(8-13(12)2)26-22(25-17)15-3-5-16(6-4-15)23(31)27-24-11-14-9-19(28)21(30)20(29)10-14/h3-11,28-30H,1-2H3,(H,25,26)(H,27,31)/b24-11+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.40E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175315
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c(O)c1
Show InChI InChI=1S/C24H22N4O3/c1-14-10-20-21(11-15(14)2)27-23(26-20)16-4-6-17(7-5-16)24(30)28-25-13-18-8-9-19(31-3)12-22(18)29/h4-13,29H,1-3H3,(H,26,27)(H,28,30)/b25-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.44E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175317
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1ccc(O)c(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c1
Show InChI InChI=1S/C24H22N4O3/c1-14-10-20-21(11-15(14)2)27-23(26-20)16-4-6-17(7-5-16)24(30)28-25-13-18-12-19(31-3)8-9-22(18)29/h4-13,29H,1-3H3,(H,26,27)(H,28,30)/b25-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.44E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175311
PNG
((E)-N'-(2,4-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)cc1O
Show InChI InChI=1S/C23H20N4O3/c1-13-9-19-20(10-14(13)2)26-22(25-19)15-3-5-16(6-4-15)23(30)27-24-12-17-7-8-18(28)11-21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.74E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175309
PNG
((E)-N'-(2,5-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cc(O)ccc1O
Show InChI InChI=1S/C23H20N4O3/c1-13-9-19-20(10-14(13)2)26-22(25-19)15-3-5-16(6-4-15)23(30)27-24-12-17-11-18(28)7-8-21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.74E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175310
PNG
((E)-N'-(2,3-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cccc(O)c1O
Show InChI InChI=1S/C23H20N4O3/c1-13-10-18-19(11-14(13)2)26-22(25-18)15-6-8-16(9-7-15)23(30)27-24-12-17-4-3-5-20(28)21(17)29/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.99E+3n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092464
PNG
(CHEMBL3586114)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C23H17N5O3/c1-13-10-19-20(11-14(13)2)25-21(24-19)15-6-8-16(9-7-15)22-26-27-23(31-22)17-4-3-5-18(12-17)28(29)30/h3-12H,1-2H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.11E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193668
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2,4-...)
Show SMILES Clc1ccc(c(Cl)c1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H16Cl4N2O4S4/c25-15-9-11-23(17(27)13-15)37(31,32)29-19-5-1-3-7-21(19)35-36-22-8-4-2-6-20(22)30-38(33,34)24-12-10-16(26)14-18(24)28/h1-14,29-30H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.13E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175312
PNG
((E)-N'-(3,4-dihydroxybenzylidene)-4-(5,6-dimet...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C23H20N4O3/c1-13-9-18-19(10-14(13)2)26-22(25-18)16-4-6-17(7-5-16)23(30)27-24-12-15-3-8-20(28)21(29)11-15/h3-12,28-29H,1-2H3,(H,25,26)(H,27,30)/b24-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092461
PNG
(CHEMBL3586118)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H17FN4O/c1-13-11-19-20(12-14(13)2)26-21(25-19)15-3-5-16(6-4-15)22-27-28-23(29-22)17-7-9-18(24)10-8-17/h3-12H,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.31E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193659
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(4-fl...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H18F2N2O4S4/c25-17-9-13-19(14-10-17)35(29,30)27-21-5-1-3-7-23(21)33-34-24-8-4-2-6-22(24)28-36(31,32)20-15-11-18(26)12-16-20/h1-16,27-28H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.32E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173549
PNG
(1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)p...)
Show SMILES COc1ccc(NC(=S)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)cc1
Show InChI InChI=1S/C32H21ClN2O6S/c33-18-11-15-20(16-12-18)35-32(42)34-19-13-9-17(10-14-19)25(26-28(36)21-5-1-3-7-23(21)40-30(26)38)27-29(37)22-6-2-4-8-24(22)41-31(27)39/h1-16,25,36-37H,(H2,34,35,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.35E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Taha et al. with slight modification. Various concentration of tes...


Bioorg Chem 63: 36-44 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.004
BindingDB Entry DOI: 10.7270/Q2125RD0
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193663
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2-ni...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C24H18N4O8S4/c29-27(30)19-11-3-7-15-23(19)39(33,34)25-17-9-1-5-13-21(17)37-38-22-14-6-2-10-18(22)26-40(35,36)24-16-8-4-12-20(24)28(31)32/h1-16,25-26H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.42E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175329
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1cccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c1
Show InChI InChI=1S/C24H22N4O2/c1-15-11-21-22(12-16(15)2)27-23(26-21)18-7-9-19(10-8-18)24(29)28-25-14-17-5-4-6-20(13-17)30-3/h4-14H,1-3H3,(H,26,27)(H,28,29)/b25-14+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.51E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092463
PNG
(CHEMBL3586115)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C23H17ClN4O/c1-13-11-19-20(12-14(13)2)26-21(25-19)15-7-9-16(10-8-15)22-27-28-23(29-22)17-5-3-4-6-18(17)24/h3-12H,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.51E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193656
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(3-ch...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H18Cl2N2O4S4/c25-17-9-13-19(14-10-17)35(29,30)27-21-5-1-3-7-23(21)33-34-24-8-4-2-6-22(24)28-36(31,32)20-15-11-18(26)12-16-20/h1-16,27-28H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.52E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092459
PNG
(CHEMBL3586120)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(F)c1
Show InChI InChI=1S/C23H17FN4O/c1-13-10-19-20(11-14(13)2)26-21(25-19)15-6-8-16(9-7-15)22-27-28-23(29-22)17-4-3-5-18(24)12-17/h3-12H,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.61E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193669
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(2,5-...)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C24H16Cl4N2O4S4/c25-15-9-11-17(27)23(13-15)37(31,32)29-19-5-1-3-7-21(19)35-36-22-8-4-2-6-20(22)30-38(33,34)24-14-16(26)10-12-18(24)28/h1-14,29-30H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.62E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175320
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccccc1O
Show InChI InChI=1S/C23H20N4O2/c1-14-11-19-20(12-15(14)2)26-22(25-19)16-7-9-17(10-8-16)23(29)27-24-13-18-5-3-4-6-21(18)28/h3-13,28H,1-2H3,(H,25,26)(H,27,29)/b24-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.82E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175321
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1ccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)cc1
Show InChI InChI=1S/C24H22N4O/c1-15-4-6-18(7-5-15)14-25-28-24(29)20-10-8-19(9-11-20)23-26-21-12-16(2)17(3)13-22(21)27-23/h4-14H,1-3H3,(H,26,27)(H,28,29)/b25-14+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.83E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092462
PNG
(CHEMBL3586116)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccc1F
Show InChI InChI=1S/C23H17FN4O/c1-13-11-19-20(12-14(13)2)26-21(25-19)15-7-9-16(10-8-15)22-27-28-23(29-22)17-5-3-4-6-18(17)24/h3-12H,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.92E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175330
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H19N5O3/c1-14-11-20-21(12-15(14)2)26-22(25-20)17-5-7-18(8-6-17)23(29)27-24-13-16-3-9-19(10-4-16)28(30)31/h3-13H,1-2H3,(H,25,26)(H,27,29)/b24-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.94E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092349
PNG
(CHEMBL3586129)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccnc1
Show InChI InChI=1S/C20H17Cl2F2N3O2/c21-15-9-25-10-16(22)13(15)7-17-12-5-6-18(29-20(23)24)19(14(12)8-26-27-17)28-11-3-1-2-4-11/h5-6,8-11,20H,1-4,7H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.01E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175313
PNG
((E)-N'-(3-chlorobenzylidene)-4-(5,6-dimethyl-1...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cccc(Cl)c1
Show InChI InChI=1S/C23H19ClN4O/c1-14-10-20-21(11-15(14)2)27-22(26-20)17-6-8-18(9-7-17)23(29)28-25-13-16-4-3-5-19(24)12-16/h3-13H,1-2H3,(H,26,27)(H,28,29)/b25-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.24E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175319
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c1
Show InChI InChI=1S/C24H22N4O/c1-15-5-4-6-18(11-15)14-25-28-24(29)20-9-7-19(8-10-20)23-26-21-12-16(2)17(3)13-22(21)27-23/h4-14H,1-3H3,(H,26,27)(H,28,29)/b25-14+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.35E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173561
PNG
(1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)p...)
Show SMILES Oc1c(C(c2ccc(NC(=S)Nc3ccc(cc3)[N+]([O-])=O)cc2)c2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
Show InChI InChI=1S/C32H21N3O8S/c36-28-21-5-1-3-7-23(21)42-30(38)26(28)25(27-29(37)22-6-2-4-8-24(22)43-31(27)39)17-9-11-18(12-10-17)33-32(44)34-19-13-15-20(16-14-19)35(40)41/h1-16,25,36-37H,(H2,33,34,44)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.47E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Taha et al. with slight modification. Various concentration of tes...


Bioorg Chem 63: 36-44 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.004
BindingDB Entry DOI: 10.7270/Q2125RD0
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175327
PNG
((Z)-N'-(4-chlorobenzylidene)-4-(5,6-dimethyl-1...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C/c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClN4O/c1-14-11-20-21(12-15(14)2)27-22(26-20)17-5-7-18(8-6-17)23(29)28-25-13-16-3-9-19(24)10-4-16/h3-13H,1-2H3,(H,26,27)(H,28,29)/b25-13-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.48E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175318
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1ccccc1\C=N\NC(=O)c1ccc(cc1)-c1nc2cc(C)c(C)cc2[nH]1
Show InChI InChI=1S/C24H22N4O/c1-15-6-4-5-7-20(15)14-25-28-24(29)19-10-8-18(9-11-19)23-26-21-12-16(2)17(3)13-22(21)27-23/h4-14H,1-3H3,(H,26,27)(H,28,29)/b25-14+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.48E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193655
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(3-ch...)
Show SMILES Clc1cccc(c1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C24H18Cl2N2O4S4/c25-17-7-5-9-19(15-17)35(29,30)27-21-11-1-3-13-23(21)33-34-24-14-4-2-12-22(24)28-36(31,32)20-10-6-8-18(26)16-20/h1-16,27-28H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173548
PNG
(1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)p...)
Show SMILES COc1cccc(NC(=S)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)c1
Show InChI InChI=1S/C32H20Cl2N2O6S/c33-21-14-13-18(15-22(21)34)36-32(43)35-17-11-9-16(10-12-17)25(26-28(37)19-5-1-3-7-23(19)41-30(26)39)27-29(38)20-6-2-4-8-24(20)42-31(27)40/h1-15,25,37-38H,(H2,35,36,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.53E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Taha et al. with slight modification. Various concentration of tes...


Bioorg Chem 63: 36-44 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.004
BindingDB Entry DOI: 10.7270/Q2125RD0
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175323
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccccn1
Show InChI InChI=1S/C22H19N5O/c1-14-11-19-20(12-15(14)2)26-21(25-19)16-6-8-17(9-7-16)22(28)27-24-13-18-5-3-4-10-23-18/h3-13H,1-2H3,(H,25,26)(H,27,28)/b24-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.57E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175306
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)cc1
Show InChI InChI=1S/C23H20N4O2/c1-14-11-20-21(12-15(14)2)26-22(25-20)17-5-7-18(8-6-17)23(29)27-24-13-16-3-9-19(28)10-4-16/h3-13,28H,1-2H3,(H,25,26)(H,27,29)/b24-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173555
PNG
(1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)p...)
Show SMILES Oc1c(C(c2ccc(NC(=S)Nc3ccc(Cl)cc3)cc2)c2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
Show InChI InChI=1S/C33H24N2O6S/c1-18-7-6-8-21(17-18)35-33(42)34-20-15-13-19(14-16-20)26(27-29(36)22-9-2-4-11-24(22)40-31(27)38)28-30(37)23-10-3-5-12-25(23)41-32(28)39/h2-17,26,36-37H,1H3,(H2,34,35,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.68E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Taha et al. with slight modification. Various concentration of tes...


Bioorg Chem 63: 36-44 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.004
BindingDB Entry DOI: 10.7270/Q2125RD0
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM193664
PNG
(N,N'-(disulfanediylbis(2,1-phenylene))bis(4-ni...)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C24H18N4O8S4/c29-27(30)17-9-13-19(14-10-17)39(33,34)25-21-5-1-3-7-23(21)37-38-24-8-4-2-6-22(24)26-40(35,36)20-15-11-18(12-16-20)28(31)32/h1-16,25-26H
KEGG

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.84E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 無...


Bioorg Chem 68: 15-22 (2016)


Article DOI: 10.1016/j.bioorg.2016.07.002
BindingDB Entry DOI: 10.7270/Q2542MCP
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173554
PNG
(1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)p...)
Show SMILES Oc1c(C(c2ccc(NC(=S)Nc3cccc(Cl)c3)cc2)c2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
Show InChI InChI=1S/C33H24N2O6S/c1-18-8-2-5-11-23(18)35-33(42)34-20-16-14-19(15-17-20)26(27-29(36)21-9-3-6-12-24(21)40-31(27)38)28-30(37)22-10-4-7-13-25(22)41-32(28)39/h2-17,26,36-37H,1H3,(H2,34,35,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.85E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Taha et al. with slight modification. Various concentration of tes...


Bioorg Chem 63: 36-44 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.004
BindingDB Entry DOI: 10.7270/Q2125RD0
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175314
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)cc1O
Show InChI InChI=1S/C24H22N4O3/c1-14-10-19-20(11-15(14)2)27-23(26-19)17-5-7-18(8-6-17)24(30)28-25-13-16-4-9-22(31-3)21(29)12-16/h4-13,29H,1-3H3,(H,26,27)(H,28,30)/b25-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092433
PNG
(CHEMBL3586123)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H17N5O3/c1-13-11-19-20(12-14(13)2)25-21(24-19)15-3-5-16(6-4-15)22-26-27-23(31-22)17-7-9-18(10-8-17)28(29)30/h3-12H,1-2H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.01E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092352
PNG
(CHEMBL3586126)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H17ClN4O/c1-13-10-19-20(11-14(13)2)26-21(25-19)15-6-8-16(9-7-15)22-27-28-23(29-22)17-4-3-5-18(24)12-17/h3-12H,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.11E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM173559
PNG
(1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)p...)
Show SMILES Oc1c(C(c2ccc(NC(=S)Nc3ccc(cc3)C(F)(F)F)cc2)c2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
Show InChI InChI=1S/C33H24N2O7S/c1-40-21-16-14-20(15-17-21)35-33(43)34-19-12-10-18(11-13-19)26(27-29(36)22-6-2-4-8-24(22)41-31(27)38)28-30(37)23-7-3-5-9-25(23)42-32(28)39/h2-17,26,36-37H,1H3,(H2,34,35,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.17E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Taha et al. with slight modification. Various concentration of tes...


Bioorg Chem 63: 36-44 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.004
BindingDB Entry DOI: 10.7270/Q2125RD0
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175326
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccco1
Show InChI InChI=1S/C21H18N4O2/c1-13-10-18-19(11-14(13)2)24-20(23-18)15-5-7-16(8-6-15)21(26)25-22-12-17-4-3-9-27-17/h3-12H,1-2H3,(H,23,24)(H,25,26)/b22-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.21E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092354
PNG
(CHEMBL3586124)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H19Cl2N3O2/c1-26-19-6-12-9-24-25-18(7-15-16(21)10-23-11-17(15)22)14(12)8-20(19)27-13-4-2-3-5-13/h6,8-11,13H,2-5,7H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.21E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM175307
PNG
((E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1cccc(O)c1
Show InChI InChI=1S/C23H20N4O2/c1-14-10-20-21(11-15(14)2)26-22(25-20)17-6-8-18(9-7-17)23(29)27-24-13-16-4-3-5-19(28)12-16/h3-13,28H,1-2H3,(H,25,26)(H,27,29)/b24-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.25E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
The enzyme inhibition was evaluated according to the method previously reported by Rahim et al. [25] with slight modification. Various concentration ...


Bioorg Chem 64: 29-36 (2016)


Article DOI: 10.1016/j.bioorg.2015.11.006
BindingDB Entry DOI: 10.7270/Q2W37V2M
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 98 total )  |  Next  |  Last  >>
Jump to: