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Found 1029 hits with Last Name = 'ahmed' and Initial = 'f'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein phosphatase non-receptor type 22


(Homo sapiens (Human))
BDBM50334193
PNG
(CHEMBL1645419)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSN=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(N)=O
Show InChI InChI=1S/C65H109N23O26S/c1-9-29(4)49(86-61(111)40(24-28(2)3)83-55(105)35(13-11-22-73-65(70)71)77-51(101)30(5)75-33(8)90)62(112)82-38(16-19-47(97)98)57(107)85-42(26-48(99)100)60(110)84-41(25-43(66)91)59(109)80-37(15-18-46(95)96)56(106)81-39(20-23-115-88-114)58(108)87-50(32(7)89)63(113)76-31(6)52(102)78-34(12-10-21-72-64(68)69)54(104)79-36(14-17-45(93)94)53(103)74-27-44(67)92/h28-32,34-42,49-50,89H,9-27H2,1-8H3,(H2,66,91)(H2,67,92)(H,74,103)(H,75,90)(H,76,113)(H,77,101)(H,78,102)(H,79,104)(H,80,109)(H,81,106)(H,82,112)(H,83,105)(H,84,110)(H,85,107)(H,86,111)(H,87,108)(H,93,94)(H,95,96)(H,97,98)(H,99,100)(H4,68,69,72)(H4,70,71,73)/t29-,30-,31-,32+,34-,35-,36-,37-,38-,39-,40-,41-,42-,49-,50-/m0/s1
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Article
PubMed
7.00E+3n/an/an/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Oxidative inactivation of lymphoid tyrosine phosphatase by DiFMUP assay


Bioorg Med Chem Lett 21: 285-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.025
BindingDB Entry DOI: 10.7270/Q2Q81DBQ
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166059
PNG
(US9067937, 2)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
Show InChI InChI=1S/C24H26Cl2N4O2/c1-13(31)17-12-27-21-9-8-20(14-10-18(25)24(32)19(26)11-14)29-23(21)22(17)28-15-4-6-16(7-5-15)30(2)3/h8-12,15-16,32H,4-7H2,1-3H3,(H,27,28)/t15-,16-
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n/an/a 0.300n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166100
PNG
(US9067937, 44)
Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)CO
Show InChI InChI=1S/C25H28Cl2N4O3/c1-31(2)12-14-3-5-16(6-4-14)29-23-17(22(33)13-32)11-28-21-8-7-20(30-24(21)23)15-9-18(26)25(34)19(27)10-15/h7-11,14,16,32,34H,3-6,12-13H2,1-2H3,(H,28,29)/t14-,16-
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n/an/a 0.300n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM148993
PNG
(US8962648, 72 | US8962648, 73)
Show SMILES NCc1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C18H14N2O2S/c19-9-10-1-3-11(4-2-10)15-14(21)6-5-13-16(15)12-7-8-23-17(12)18(22)20-13/h1-8,21H,9,19H2,(H,20,22)
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n/an/a 0.380n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM60438
PNG
(US9067937, 28)
Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
Show InChI InChI=1S/C25H28Cl2N4O2/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29)/t15-,17-
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n/an/a 0.400n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166117
PNG
(US9067937, 61)
Show SMILES CC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](CN2CCCC2)CC1)-c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C27H30Cl2N4O2/c1-16(34)20-14-30-24-9-8-23(18-12-21(28)27(35)22(29)13-18)32-26(24)25(20)31-19-6-4-17(5-7-19)15-33-10-2-3-11-33/h8-9,12-14,17,19,35H,2-7,10-11,15H2,1H3,(H,30,31)/t17-,19-
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n/an/a 0.400n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149054
PNG
(US8962648, 319)
Show SMILES CC(C)(N)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C20H18N2O2S/c1-20(2,21)12-5-3-11(4-6-12)16-15(23)8-7-14-17(16)13-9-10-25-18(13)19(24)22-14/h3-10,23H,21H2,1-2H3,(H,22,24)
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n/an/a 0.430n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166154
PNG
(US9067937, 202)
Show SMILES N[C@@H]1CCCN(C1)c1ccc(Nc2c(cnc3ccc(nc23)-c2cc(F)c(O)c(Cl)c2)C(=O)C2CC2)cn1
Show InChI InChI=1S/C28H26ClFN6O2/c29-20-10-16(11-21(30)28(20)38)22-6-7-23-26(35-22)25(19(13-32-23)27(37)15-3-4-15)34-18-5-8-24(33-12-18)36-9-1-2-17(31)14-36/h5-8,10-13,15,17,38H,1-4,9,14,31H2,(H,32,34)/t17-/m1/s1
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n/an/a 0.460n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166127
PNG
(US9067937, 71)
Show SMILES CC(=O)c1cnc2ccc(nc2c1Nc1ccc(nc1)N1CCC[C@H](N)C1)-c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C26H24Cl2N6O2/c1-14(35)18-12-30-22-6-5-21(15-9-19(27)26(36)20(28)10-15)33-25(22)24(18)32-17-4-7-23(31-11-17)34-8-2-3-16(29)13-34/h4-7,9-12,16,36H,2-3,8,13,29H2,1H3,(H,30,32)/t16-/m0/s1
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166137
PNG
(US9067937, 81)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(F)c(O)c(Cl)c1)C(=O)C1CC1
Show InChI InChI=1S/C26H28ClFN4O2/c1-32(2)17-7-5-16(6-8-17)30-23-18(25(33)14-3-4-14)13-29-22-10-9-21(31-24(22)23)15-11-19(27)26(34)20(28)12-15/h9-14,16-17,34H,3-8H2,1-2H3,(H,29,30)/t16-,17-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166072
PNG
(US9067937, 15)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)S(C)(=O)=O
Show InChI InChI=1S/C23H26Cl2N4O3S/c1-29(2)15-6-4-14(5-7-15)27-22-20(33(3,31)32)12-26-19-9-8-18(28-21(19)22)13-10-16(24)23(30)17(25)11-13/h8-12,14-15,30H,4-7H2,1-3H3,(H,26,27)/t14-,15-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149042
PNG
(US8962648, 276)
Show SMILES NCCc1ccc(cc1F)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C19H15FN2O2S/c20-13-9-11(2-1-10(13)5-7-21)16-15(23)4-3-14-17(16)12-6-8-25-18(12)19(24)22-14/h1-4,6,8-9,23H,5,7,21H2,(H,22,24)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166061
PNG
(US9067937, 4)
Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1
Show InChI InChI=1S/C27H30Cl2N4O2/c1-33(2)14-15-3-7-18(8-4-15)31-24-19(26(34)16-5-6-16)13-30-23-10-9-22(32-25(23)24)17-11-20(28)27(35)21(29)12-17/h9-13,15-16,18,35H,3-8,14H2,1-2H3,(H,30,31)/t15-,18-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149041
PNG
(US8962648, 275)
Show SMILES C[C@@H](N)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C19H16N2O2S/c1-10(20)11-2-4-12(5-3-11)16-15(22)7-6-14-17(16)13-8-9-24-18(13)19(23)21-14/h2-10,22H,20H2,1H3,(H,21,23)/t10-/m1/s1
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149027
PNG
(US8962648, 235)
Show SMILES NCC1CCN(Cc2ccc(cc2F)-c2c(O)ccc3[nH]c(=O)c4sccc4c23)CC1
Show InChI InChI=1S/C24H24FN3O2S/c25-18-11-15(1-2-16(18)13-28-8-5-14(12-26)6-9-28)21-20(29)4-3-19-22(21)17-7-10-31-23(17)24(30)27-19/h1-4,7,10-11,14,29H,5-6,8-9,12-13,26H2,(H,27,30)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166150
PNG
(US9067937, 94)
Show SMILES CN(C)C[C@H]1CC[C@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
Show InChI InChI=1S/C25H28Cl2N4O2/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29)/t15-,17+
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166145
PNG
(US9067937, 89)
Show SMILES CN(C)[C@H]1CC[C@H](CNc2c(cnc3ccc(nc23)-c2cc(Cl)c(O)c(Cl)c2)C(C)=O)CC1
Show InChI InChI=1S/C25H28Cl2N4O2/c1-14(32)18-13-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-12-15-4-6-17(7-5-15)31(2)3/h8-11,13,15,17,33H,4-7,12H2,1-3H3,(H,28,29)/t15-,17-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166136
PNG
(US9067937, 80)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1
Show InChI InChI=1S/C26H28Cl2N4O2/c1-32(2)17-7-5-16(6-8-17)30-23-18(25(33)14-3-4-14)13-29-22-10-9-21(31-24(22)23)15-11-19(27)26(34)20(28)12-15/h9-14,16-17,34H,3-8H2,1-2H3,(H,29,30)/t16-,17-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166126
PNG
(US9067937, 70)
Show SMILES CC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](CN2CCNCC2)CC1)-c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C27H31Cl2N5O2/c1-16(35)20-14-31-24-7-6-23(18-12-21(28)27(36)22(29)13-18)33-26(24)25(20)32-19-4-2-17(3-5-19)15-34-10-8-30-9-11-34/h6-7,12-14,17,19,30,36H,2-5,8-11,15H2,1H3,(H,31,32)/t17-,19-
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n/an/a 0.600n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166104
PNG
(US9067937, 48)
Show SMILES CN(CCO)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
Show InChI InChI=1S/C26H30Cl2N4O3/c1-15(34)19-13-29-23-8-7-22(17-11-20(27)26(35)21(28)12-17)31-25(23)24(19)30-18-5-3-16(4-6-18)14-32(2)9-10-33/h7-8,11-13,16,18,33,35H,3-6,9-10,14H2,1-2H3,(H,29,30)/t16-,18-
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n/an/a 0.600n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM148993
PNG
(US8962648, 72 | US8962648, 73)
Show SMILES NCc1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C18H14N2O2S/c19-9-10-1-3-11(4-2-10)15-14(21)6-5-13-16(15)12-7-8-23-17(12)18(22)20-13/h1-8,21H,9,19H2,(H,20,22)
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n/an/a 0.630n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149118
PNG
(US8962648, 1160)
Show SMILES C[C@@H](CN)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C20H18N2O2S/c1-11(10-21)12-2-4-13(5-3-12)17-16(23)7-6-15-18(17)14-8-9-25-19(14)20(24)22-15/h2-9,11,23H,10,21H2,1H3,(H,22,24)/t11-/m0/s1
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n/an/a 0.640n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177519
PNG
(US9120749, 886)
Show SMILES C[C@H](N)C(=O)N[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
Show InChI InChI=1S/C26H28Cl2N4O3/c1-13(29)26(35)32-18-6-4-17(5-7-18)31-24-19-9-15(16-10-21(27)25(34)22(28)11-16)3-8-23(19)30-12-20(24)14(2)33/h3,8-13,17-18,34H,4-7,29H2,1-2H3,(H,30,31)(H,32,35)/t13-,17-,18-/m0/s1
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ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149043
PNG
(US8962648, 277)
Show SMILES CC(C)(CN)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C21H20N2O2S/c1-21(2,11-22)13-5-3-12(4-6-13)17-16(24)8-7-15-18(17)14-9-10-26-19(14)20(25)23-15/h3-10,24H,11,22H2,1-2H3,(H,23,25)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166084
PNG
(US9067937, 27)
Show SMILES CN1CCC(CNc2c(cnc3ccc(nc23)-c2cc(Cl)c(O)c(Cl)c2)C(C)=O)CC1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-13(30)16-12-26-20-4-3-19(15-9-17(24)23(31)18(25)10-15)28-22(20)21(16)27-11-14-5-7-29(2)8-6-14/h3-4,9-10,12,14,31H,5-8,11H2,1-2H3,(H,26,27)
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166066
PNG
(US9067937, 9)
Show SMILES CN(C)CC[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
Show InChI InChI=1S/C26H30Cl2N4O2/c1-15(33)19-14-29-23-9-8-22(17-12-20(27)26(34)21(28)13-17)31-25(23)24(19)30-18-6-4-16(5-7-18)10-11-32(2)3/h8-9,12-14,16,18,34H,4-7,10-11H2,1-3H3,(H,29,30)/t16-,18-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149016
PNG
(US8962648, 195)
Show SMILES CC(N)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C19H16N2O2S/c1-10(20)11-2-4-12(5-3-11)16-15(22)7-6-14-17(16)13-8-9-24-18(13)19(23)21-14/h2-10,22H,20H2,1H3,(H,21,23)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177234
PNG
(US9120749, 600)
Show SMILES OC1CCN(C[C@H]2CC[C@@H](CC2)Nc2c(cnc3ccc(cc23)-c2cc(Cl)c(O)c(Cl)c2)C(=O)C2CC2)C1
Show InChI InChI=1S/C30H33Cl2N3O3/c31-25-12-20(13-26(32)30(25)38)19-5-8-27-23(11-19)28(24(14-33-27)29(37)18-3-4-18)34-21-6-1-17(2-7-21)15-35-10-9-22(36)16-35/h5,8,11-14,17-18,21-22,36,38H,1-4,6-7,9-10,15-16H2,(H,33,34)/t17-,21-,22?
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n/an/a 0.730n/an/an/an/an/an/a



ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149192
PNG
(US8962648, 1309)
Show SMILES CCC(CN)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C21H20N2O2S/c1-2-12(11-22)13-3-5-14(6-4-13)18-17(24)8-7-16-19(18)15-9-10-26-20(15)21(25)23-16/h3-10,12,24H,2,11,22H2,1H3,(H,23,25)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149039
PNG
(US8962648, 273)
Show SMILES NCCCc1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C20H18N2O2S/c21-10-1-2-12-3-5-13(6-4-12)17-16(23)8-7-15-18(17)14-9-11-25-19(14)20(24)22-15/h3-9,11,23H,1-2,10,21H2,(H,22,24)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177269
PNG
(US9120749, 635)
Show SMILES CN(CCO)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1
Show InChI InChI=1S/C29H33Cl2N3O3/c1-34(10-11-35)16-17-2-7-21(8-3-17)33-27-22-12-19(20-13-24(30)29(37)25(31)14-20)6-9-26(22)32-15-23(27)28(36)18-4-5-18/h6,9,12-15,17-18,21,35,37H,2-5,7-8,10-11,16H2,1H3,(H,32,33)/t17-,21-
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ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177285
PNG
(US9120749, 651)
Show SMILES N[C@@H]1CCCN(C1)c1ccc(Nc2c(cnc3ccc(cc23)-c2cc(F)c(O)c(Cl)c2)C(=O)C2CC2)cn1
Show InChI InChI=1S/C29H27ClFN5O2/c30-23-11-18(12-24(31)29(23)38)17-5-7-25-21(10-17)27(22(14-33-25)28(37)16-3-4-16)35-20-6-8-26(34-13-20)36-9-1-2-19(32)15-36/h5-8,10-14,16,19,38H,1-4,9,15,32H2,(H,33,35)/t19-/m1/s1
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ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149034
PNG
(US8962648, 266)
Show SMILES NCc1ccc(s1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C16H12N2O2S2/c17-7-8-1-4-12(22-8)14-11(19)3-2-10-13(14)9-5-6-21-15(9)16(20)18-10/h1-6,19H,7,17H2,(H,18,20)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM148997
PNG
(US8962648, 84)
Show SMILES Oc1ccc2[nH]c(=O)c3sccc3c2c1C1=CCNCC1
Show InChI InChI=1S/C16H14N2O2S/c19-12-2-1-11-14(13(12)9-3-6-17-7-4-9)10-5-8-21-15(10)16(20)18-11/h1-3,5,8,17,19H,4,6-7H2,(H,18,20)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177268
PNG
(US9120749, 634)
Show SMILES CN(CCO)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1
Show InChI InChI=1S/C29H33Cl2N3O3/c1-34(10-11-35)16-17-2-7-21(8-3-17)33-27-22-12-19(20-13-24(30)29(37)25(31)14-20)6-9-26(22)32-15-23(27)28(36)18-4-5-18/h6,9,12-15,17-18,21,35,37H,2-5,7-8,10-11,16H2,1H3,(H,32,33)/t17-,21-
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ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166062
PNG
(US9067937, 5)
Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(F)c(O)c(Cl)c1)C(=O)C1CC1
Show InChI InChI=1S/C27H30ClFN4O2/c1-33(2)14-15-3-7-18(8-4-15)31-24-19(26(34)16-5-6-16)13-30-23-10-9-22(32-25(23)24)17-11-20(28)27(35)21(29)12-17/h9-13,15-16,18,35H,3-8,14H2,1-2H3,(H,30,31)/t15-,18-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166119
PNG
(US9067937, 63)
Show SMILES CN1CCN(C[C@H]2CC[C@@H](CC2)Nc2c(cnc3ccc(nc23)-c2cc(Cl)c(O)c(Cl)c2)C(C)=O)CC1
Show InChI InChI=1S/C28H33Cl2N5O2/c1-17(36)21-15-31-25-8-7-24(19-13-22(29)28(37)23(30)14-19)33-27(25)26(21)32-20-5-3-18(4-6-20)16-35-11-9-34(2)10-12-35/h7-8,13-15,18,20,37H,3-6,9-12,16H2,1-2H3,(H,31,32)/t18-,20-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM176910
PNG
(US9120749, 276)
Show SMILES COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(N3CCC(CN(C)C)CC3)c2c1
Show InChI InChI=1S/C28H32ClN3O3/c1-31(2)16-17-8-10-32(11-9-17)26-21-12-19(20-13-23(29)28(34)25(14-20)35-3)6-7-24(21)30-15-22(26)27(33)18-4-5-18/h6-7,12-15,17-18,34H,4-5,8-11,16H2,1-3H3
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n/an/a 0.800n/an/an/an/an/an/a



ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149026
PNG
(US8962648, 233)
Show SMILES C[C@H](N)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C19H16N2O2S/c1-10(20)11-2-4-12(5-3-11)16-15(22)7-6-14-17(16)13-8-9-24-18(13)19(23)21-14/h2-10,22H,20H2,1H3,(H,21,23)/t10-/m0/s1
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n/an/a 0.810n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149062
PNG
(US8962648, 336)
Show SMILES CCC(N)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C20H18N2O2S/c1-2-14(21)11-3-5-12(6-4-11)17-16(23)8-7-15-18(17)13-9-10-25-19(13)20(24)22-15/h3-10,14,23H,2,21H2,1H3,(H,22,24)
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n/an/a 0.820n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM176958
PNG
(US9120749, 324)
Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1
Show InChI InChI=1S/C28H31Cl2N3O2/c1-33(2)15-16-3-8-20(9-4-16)32-26-21-11-18(19-12-23(29)28(35)24(30)13-19)7-10-25(21)31-14-22(26)27(34)17-5-6-17/h7,10-14,16-17,20,35H,3-6,8-9,15H2,1-2H3,(H,31,32)/t16-,20-
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n/an/a 0.850n/an/an/an/an/an/a



ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177315
PNG
(US9120749, 681)
Show SMILES CC(=O)c1cnc2ccc(cc2c1Nc1ccc(nc1)N1CCCC(N)C1)-c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C27H25Cl2N5O2/c1-15(35)21-13-31-24-6-4-16(17-10-22(28)27(36)23(29)11-17)9-20(24)26(21)33-19-5-7-25(32-12-19)34-8-2-3-18(30)14-34/h4-7,9-13,18,36H,2-3,8,14,30H2,1H3,(H,31,33)
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n/an/a 0.860n/an/an/an/an/an/a



ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149097
PNG
(US8962648, 1120)
Show SMILES CC[C@H](N)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C20H18N2O2S/c1-2-14(21)11-3-5-12(6-4-11)17-16(23)8-7-15-18(17)13-9-10-25-19(13)20(24)22-15/h3-10,14,23H,2,21H2,1H3,(H,22,24)/t14-/m0/s1
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n/an/a 0.880n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149038
PNG
(US8962648, 272)
Show SMILES C[C@@H](N(C)C)c1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C21H20N2O2S/c1-12(23(2)3)13-4-6-14(7-5-13)18-17(24)9-8-16-19(18)15-10-11-26-20(15)21(25)22-16/h4-12,24H,1-3H3,(H,22,25)/t12-/m1/s1
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149010
PNG
(US8962648, 187)
Show SMILES CNCc1ccc(cc1)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C19H16N2O2S/c1-20-10-11-2-4-12(5-3-11)16-15(22)7-6-14-17(16)13-8-9-24-18(13)19(23)21-14/h2-9,20,22H,10H2,1H3,(H,21,23)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166071
PNG
(US9067937, 14)
Show SMILES COc1cc(cc(Cl)c1O)-c1ccc2ncc(c(N[C@H]3CC[C@H](CN(C)C)CC3)c2n1)S(C)(=O)=O
Show InChI InChI=1S/C25H31ClN4O4S/c1-30(2)14-15-5-7-17(8-6-15)28-24-22(35(4,32)33)13-27-20-10-9-19(29-23(20)24)16-11-18(26)25(31)21(12-16)34-3/h9-13,15,17,31H,5-8,14H2,1-4H3,(H,27,28)/t15-,17-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM177448
PNG
(US9120749, 814)
Show SMILES CN1CCC(C1)n1cc(Nc2c(cnc3ccc(cc23)-c2cc(Cl)c(O)c(Cl)c2)C(C)=O)cn1
Show InChI InChI=1S/C25H23Cl2N5O2/c1-14(33)20-11-28-23-4-3-15(16-8-21(26)25(34)22(27)9-16)7-19(23)24(20)30-17-10-29-32(12-17)18-5-6-31(2)13-18/h3-4,7-12,18,34H,5-6,13H2,1-2H3,(H,28,30)
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ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166118
PNG
(US9067937, 62)
Show SMILES CC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](CN2CCCC2)CC1)-c1cc(F)c(O)c(Cl)c1
Show InChI InChI=1S/C27H30ClFN4O2/c1-16(34)20-14-30-24-9-8-23(18-12-21(28)27(35)22(29)13-18)32-26(24)25(20)31-19-6-4-17(5-7-19)15-33-10-2-3-11-33/h8-9,12-14,17,19,35H,2-7,10-11,15H2,1H3,(H,30,31)/t17-,19-
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OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens)
BDBM149074
PNG
(US8962648, 359)
Show SMILES CC(N)c1ccc(cc1F)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Show InChI InChI=1S/C19H15FN2O2S/c1-9(21)11-3-2-10(8-13(11)20)16-15(23)5-4-14-17(16)12-6-7-25-18(12)19(24)22-14/h2-9,23H,21H2,1H3,(H,22,24)
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OncoTherapy Science, Inc.

US Patent


Assay Description
PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...


US Patent US8962648 (2015)


BindingDB Entry DOI: 10.7270/Q27H1H9K
More data for this
Ligand-Target Pair
Maternal embryonic leucine zipper kinase (MELK)


(Homo sapiens (Human))
BDBM166153
PNG
(US9067937, 201)
Show SMILES N[C@@H]1CCCN(C1)c1ccc(Nc2c(cnc3ccc(nc23)-c2cc(Cl)c(O)c(Cl)c2)C(=O)C2CC2)cn1
Show InChI InChI=1S/C28H26Cl2N6O2/c29-20-10-16(11-21(30)28(20)38)22-6-7-23-26(35-22)25(19(13-32-23)27(37)15-3-4-15)34-18-5-8-24(33-12-18)36-9-1-2-17(31)14-36/h5-8,10-13,15,17,38H,1-4,9,14,31H2,(H,32,34)/t17-/m1/s1
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n/an/a 0.930n/an/an/an/an/an/a



OncoTherapy Science, Inc.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...


US Patent US9067937 (2015)


BindingDB Entry DOI: 10.7270/Q2BR8QX4
More data for this
Ligand-Target Pair
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