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Compile Data Set for Download or QSAR

Found 136 hits with Last Name = 'ahmed' and Initial = 'su'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50229787
PNG
((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339398
PNG
((+)-R-3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopr...)
Show SMILES OCC1(CO[C@]2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23ClN2O5/c27-20-9-7-19(8-10-20)26(34-17-25(16-30)13-14-25)23-4-2-1-3-22(23)24(31)28(26)15-18-5-11-21(12-6-18)29(32)33/h1-12,30H,13-17H2/t26-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339369
PNG
((+/-)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cycl...)
Show SMILES OCC1(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23ClN2O5/c27-20-9-7-19(8-10-20)26(34-17-25(16-30)13-14-25)23-4-2-1-3-22(23)24(31)28(26)15-18-5-11-21(12-6-18)29(32)33/h1-12,30H,13-17H2
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n/an/a 230n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339371
PNG
((+/-)-trans-3-(4-Chlorophenyl)-3-(4-hydroxycyclohe...)
Show SMILES O[C@H]1CC[C@H](OC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)C=C1
Show InChI InChI=1S/C27H23ClN2O5/c28-20-9-7-19(8-10-20)27(35-23-15-13-22(31)14-16-23)25-4-2-1-3-24(25)26(32)29(27)17-18-5-11-21(12-6-18)30(33)34/h1-13,15,22-23,31H,14,16-17H2/t22-,23-,27?/m1/s1
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n/an/a 310n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339355
PNG
((+/-)-3-(4-Chlorophenyl)-3-(4-hydroxybutoxy)-2-(4-...)
Show SMILES OCCCCOC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H23ClN2O5/c26-20-11-9-19(10-12-20)25(33-16-4-3-15-29)23-6-2-1-5-22(23)24(30)27(25)17-18-7-13-21(14-8-18)28(31)32/h1-2,5-14,29H,3-4,15-17H2
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n/an/a 360n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339365
PNG
((+/-)-trans-3-(4-Chlorophenyl)-3-(5-hydroxycyclooc...)
Show SMILES O[C@H]1CCC[C@@H](CCC1)OC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H29ClN2O5/c30-22-15-13-21(14-16-22)29(37-25-7-3-5-24(33)6-4-8-25)27-10-2-1-9-26(27)28(34)31(29)19-20-11-17-23(18-12-20)32(35)36/h1-2,9-18,24-25,33H,3-8,19H2/t24-,25-,29?
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n/an/a 380n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339370
PNG
((+/-)-trans-3-(4-Chlorophenyl)-3-(4-hydroxycyclohe...)
Show SMILES O[C@H]1CC[C@@H](CC1)OC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H25ClN2O5/c28-20-9-7-19(8-10-20)27(35-23-15-13-22(31)14-16-23)25-4-2-1-3-24(25)26(32)29(27)17-18-5-11-21(12-6-18)30(33)34/h1-12,22-23,31H,13-17H2/t22-,23-,27?
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n/an/a 390n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339437
PNG
((+/-)-3-(4-chlorophenyl)-3-((cis)-3-hydroxycyclope...)
Show SMILES O[C@@H]1CC[C@@H](C1)OC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClN2O5/c27-19-9-7-18(8-10-19)26(34-22-14-13-21(30)15-22)24-4-2-1-3-23(24)25(31)28(26)16-17-5-11-20(12-6-17)29(32)33/h1-12,21-22,30H,13-16H2/t21-,22+,26?/m1/s1
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n/an/a 400n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339368
PNG
((+/-)-3-(4-Chlorophenyl)-3-(3-hydroxy-2,2-dimethyl...)
Show SMILES CC(C)(CO)COC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H25ClN2O5/c1-25(2,16-30)17-34-26(19-9-11-20(27)12-10-19)23-6-4-3-5-22(23)24(31)28(26)15-18-7-13-21(14-8-18)29(32)33/h3-14,30H,15-17H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339353
PNG
((+/-)-(Z)-3-(4-Chlorophenyl)-3-(4-hydroxybut-2-eny...)
Show SMILES OC\C=C/COC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H21ClN2O5/c26-20-11-9-19(10-12-20)25(33-16-4-3-15-29)23-6-2-1-5-22(23)24(30)27(25)17-18-7-13-21(14-8-18)28(31)32/h1-14,29H,15-17H2/b4-3-
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n/an/a 400n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339354
PNG
((+/-)-3-(4-Chlorophenyl)-3-(3-hydroxypropoxy)-2-(4...)
Show SMILES OCCCOC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN2O5/c25-19-10-8-18(9-11-19)24(32-15-3-14-28)22-5-2-1-4-21(22)23(29)26(24)16-17-6-12-20(13-7-17)27(30)31/h1-2,4-13,28H,3,14-16H2
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n/an/a 450n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339361
PNG
((+/-)-3-(4-Bromophenyl)-3-(4-hydroxybutoxy)-2-(4-n...)
Show SMILES OCCCCOC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Br)cc1
Show InChI InChI=1S/C25H23BrN2O5/c26-20-11-9-19(10-12-20)25(33-16-4-3-15-29)23-6-2-1-5-22(23)24(30)27(25)17-18-7-13-21(14-8-18)28(31)32/h1-2,5-14,29H,3-4,15-17H2
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n/an/a 570n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339367
PNG
((+/-)-cis-3-(4-Chlorophenyl)-3-(2-hydroxymethylcyc...)
Show SMILES OC[C@H]1CCCC[C@H]1COC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H29ClN2O5/c30-24-13-11-23(12-14-24)29(37-19-22-6-2-1-5-21(22)18-33)27-8-4-3-7-26(27)28(34)31(29)17-20-9-15-25(16-10-20)32(35)36/h3-4,7-16,21-22,33H,1-2,5-6,17-19H2/t21-,22+,29?/m1/s1
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n/an/a 570n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339363
PNG
((+/-)-trans-3-(4-Chlorophenyl)-3-(4-hydroxymethylc...)
Show SMILES OC[C@H]1CC[C@H](COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H29ClN2O5/c30-24-13-11-23(12-14-24)29(37-19-22-7-5-21(18-33)6-8-22)27-4-2-1-3-26(27)28(34)31(29)17-20-9-15-25(16-10-20)32(35)36/h1-4,9-16,21-22,33H,5-8,17-19H2/t21-,22-,29?
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n/an/a 580n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339366
PNG
((+/-)-3-(4-Chlorophenyl)-3-(4-hydroxybut-2-ynyloxy...)
Show SMILES OCC#CCOC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H19ClN2O5/c26-20-11-9-19(10-12-20)25(33-16-4-3-15-29)23-6-2-1-5-22(23)24(30)27(25)17-18-7-13-21(14-8-18)28(31)32/h1-2,5-14,29H,15-17H2
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n/an/a 660n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339436
PNG
((+/-)-3-(4-Chlorophenyl)-3-(3-hydroxycyclopentoxy)...)
Show SMILES OC1CCC(C1)OC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClN2O5/c27-19-9-7-18(8-10-19)26(34-22-14-13-21(30)15-22)24-4-2-1-3-23(24)25(31)28(26)16-17-5-11-20(12-6-17)29(32)33/h1-12,21-22,30H,13-16H2
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n/an/a 700n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339364
PNG
((+/-)-3-(4-Chlorophenyl)-3-(3-hydroxymethylbenzylo...)
Show SMILES OCc1cccc(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C29H23ClN2O5/c30-24-12-10-23(11-13-24)29(37-19-22-5-3-4-21(16-22)18-33)27-7-2-1-6-26(27)28(34)31(29)17-20-8-14-25(15-9-20)32(35)36/h1-16,33H,17-19H2
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n/an/a 730n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339357
PNG
((+/-)-(S)-3-(4-Chlorophenyl)-2-[1-(4-chlorophenyl)...)
Show SMILES C[C@H](N1C(=O)c2ccccc2C1(OCCCCO)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H25Cl2NO3/c1-18(19-8-12-21(27)13-9-19)29-25(31)23-6-2-3-7-24(23)26(29,32-17-5-4-16-30)20-10-14-22(28)15-11-20/h2-3,6-15,18,30H,4-5,16-17H2,1H3/t18-,26?/m0/s1
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n/an/a 900n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339362
PNG
((+/-)-3-(4-Chlorophenyl)-3-(4-hydroxymethylbenzylo...)
Show SMILES OCc1ccc(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C29H23ClN2O5/c30-24-13-11-23(12-14-24)29(37-19-22-7-5-21(18-33)6-8-22)27-4-2-1-3-26(27)28(34)31(29)17-20-9-15-25(16-10-20)32(35)36/h1-16,33H,17-19H2
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n/an/a 980n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339375
PNG
((+/-)-2-(4-Bromobenzyl)-3-(4-chlorophenyl)-3-((1-(...)
Show SMILES OCC1(COC2(N(Cc3ccc(Br)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23BrClNO3/c27-20-9-5-18(6-10-20)15-29-24(31)22-3-1-2-4-23(22)26(29,19-7-11-21(28)12-8-19)32-17-25(16-30)13-14-25/h1-12,30H,13-17H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339399
PNG
((-)-S-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cycl...)
Show SMILES OCC1(CO[C@@]2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23ClN2O5/c27-20-9-7-19(8-10-20)26(34-17-25(16-30)13-14-25)23-4-2-1-3-22(23)24(31)28(26)15-18-5-11-21(12-6-18)29(32)33/h1-12,30H,13-17H2/t26-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339360
PNG
((+/-)-3-(4-Bromophenyl)-3-(3-hydroxypropoxy)-2-(4-...)
Show SMILES OCCCOC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Br)cc1
Show InChI InChI=1S/C24H21BrN2O5/c25-19-10-8-18(9-11-19)24(32-15-3-14-28)22-5-2-1-4-21(22)23(29)26(24)16-17-6-12-20(13-7-17)27(30)31/h1-2,4-13,28H,3,14-16H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339351
PNG
((+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent...)
Show SMILES Cc1ccc(CN2C(=O)c3ccccc3C2(O[C@@H]2C[C@H](O)C=C2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C27H24ClNO3/c1-18-6-8-19(9-7-18)17-29-26(31)24-4-2-3-5-25(24)27(29,20-10-12-21(28)13-11-20)32-23-15-14-22(30)16-23/h2-15,22-23,30H,16-17H2,1H3/t22-,23+,27?/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339376
PNG
((+/-)-3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopr...)
Show SMILES OCC1(COC2(N(Cc3ccc(I)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23ClINO3/c27-20-9-7-19(8-10-20)26(32-17-25(16-30)13-14-25)23-4-2-1-3-22(23)24(31)29(26)15-18-5-11-21(28)12-6-18/h1-12,30H,13-17H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339440
PNG
((+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent...)
Show SMILES O[C@H]1C[C@@H](OC2(N(Cc3ccc(Cl)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)C=C1
Show InChI InChI=1S/C26H21Cl2NO3/c27-19-9-5-17(6-10-19)16-29-25(31)23-3-1-2-4-24(23)26(29,18-7-11-20(28)12-8-18)32-22-14-13-21(30)15-22/h1-14,21-22,30H,15-16H2/t21-,22+,26?/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339372
PNG
((+/-)-4-((1-(4-Chlorophenyl)-1-((1-(hydroxymethyl)...)
Show SMILES OCC1(COC2(N(Cc3ccc(cc3)C#N)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C27H23ClN2O3/c28-22-11-9-21(10-12-22)27(33-18-26(17-31)13-14-26)24-4-2-1-3-23(24)25(32)30(27)16-20-7-5-19(15-29)6-8-20/h1-12,31H,13-14,16-18H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339352
PNG
((+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent...)
Show SMILES O[C@H]1C[C@@H](OC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)C=C1
Show InChI InChI=1S/C26H21ClN2O5/c27-19-9-7-18(8-10-19)26(34-22-14-13-21(30)15-22)24-4-2-1-3-23(24)25(31)28(26)16-17-5-11-20(12-6-17)29(32)33/h1-14,21-22,30H,15-16H2/t21-,22+,26?/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339374
PNG
((+/-)-2-(4-Chlorobenzyl)-3-(4-chlorophenyl)-3-((1-...)
Show SMILES OCC1(COC2(N(Cc3ccc(Cl)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23Cl2NO3/c27-20-9-5-18(6-10-20)15-29-24(31)22-3-1-2-4-23(22)26(29,19-7-11-21(28)12-8-19)32-17-25(16-30)13-14-25/h1-12,30H,13-17H2
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n/an/a 2.30E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339438
PNG
((+/-)-cis-4-((1-(4-Chlorophenyl)-1-(4-hydroxycyclo...)
Show SMILES O[C@@H]1CC[C@@H](C1)OC1(N(Cc2ccc(cc2)C#N)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H23ClN2O3/c28-21-11-9-20(10-12-21)27(33-23-14-13-22(31)15-23)25-4-2-1-3-24(25)26(32)30(27)17-19-7-5-18(16-29)6-8-19/h1-12,22-23,31H,13-15,17H2/t22-,23+,27?/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339377
PNG
((+/-)-3-(4-Chlorophenyl)-3-(1-hydroxy-2-cyclopropy...)
Show SMILES Cc1ccc(CN2C(=O)c3ccccc3C2(OCC2(CO)CC2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C27H26ClNO3/c1-19-6-8-20(9-7-19)16-29-25(31)23-4-2-3-5-24(23)27(29,21-10-12-22(28)13-11-21)32-18-26(17-30)14-15-26/h2-13,30H,14-18H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339408
PNG
(3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoi...)
Show SMILES OC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H15ClN2O4/c22-16-9-7-15(8-10-16)21(26)19-4-2-1-3-18(19)20(25)23(21)13-14-5-11-17(12-6-14)24(27)28/h1-12,26H,13H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339358
PNG
((+/-)-(R)-3-(4-Chlorophenyl)-2-[1-(4-chlorophenyl)...)
Show SMILES C[C@@H](N1C(=O)c2ccccc2C1(OCCCCO)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H25Cl2NO3/c1-18(19-8-12-21(27)13-9-19)29-25(31)23-6-2-3-7-24(23)26(29,32-17-5-4-16-30)20-10-14-22(28)15-11-20/h2-3,6-15,18,30H,4-5,16-17H2,1H3/t18-,26?/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339373
PNG
((+/-)-3-(4-Chlorophenyl)-2-(4-fluorobenzyl)-3-(1-h...)
Show SMILES OCC1(COC2(N(Cc3ccc(F)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23ClFNO3/c27-20-9-7-19(8-10-20)26(32-17-25(16-30)13-14-25)23-4-2-1-3-22(23)24(31)29(26)15-18-5-11-21(28)12-6-18/h1-12,30H,13-17H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339378
PNG
((+/-)-3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopr...)
Show SMILES COc1ccc(CN2C(=O)c3ccccc3C2(OCC2(CO)CC2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C27H26ClNO4/c1-32-22-12-6-19(7-13-22)16-29-25(31)23-4-2-3-5-24(23)27(29,20-8-10-21(28)11-9-20)33-18-26(17-30)14-15-26/h2-13,30H,14-18H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339435
PNG
((+/-)-(cis/trans)-2-Benzyl-3-(4-chlorophenyl)-3-(3...)
Show SMILES OC1CCC(C1)OC1(N(Cc2ccccc2)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24ClNO3/c27-20-12-10-19(11-13-20)26(31-22-15-14-21(29)16-22)24-9-5-4-8-23(24)25(30)28(26)17-18-6-2-1-3-7-18/h1-13,21-22,29H,14-17H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339407
PNG
(3-(4-Bromophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoin...)
Show SMILES OC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Br)cc1
Show InChI InChI=1S/C21H15BrN2O4/c22-16-9-7-15(8-10-16)21(26)19-4-2-1-3-18(19)20(25)23(21)13-14-5-11-17(12-6-14)24(27)28/h1-12,26H,13H2
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n/an/a 3.10E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339359
PNG
((+/-)-3-(4-Chlorophenyl)-3-(4-hydroxybutoxy)-2-[2-...)
Show SMILES OCCCCOC1(N(CCc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H25ClN2O5/c27-21-11-9-20(10-12-21)26(34-18-4-3-17-30)24-6-2-1-5-23(24)25(31)28(26)16-15-19-7-13-22(14-8-19)29(32)33/h1-2,5-14,30H,3-4,15-18H2
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n/an/a 3.20E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339356
PNG
((+/-)-4-[1-(4-Chlorophenyl)-1-(4-hydroxybutoxy)-3-...)
Show SMILES OCCCCOC1(N(Cc2ccc(cc2)C#N)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClN2O3/c27-22-13-11-21(12-14-22)26(32-16-4-3-15-30)24-6-2-1-5-23(24)25(31)29(26)18-20-9-7-19(17-28)8-10-20/h1-2,5-14,30H,3-4,15-16,18H2
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n/an/a 3.50E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339415
PNG
(3-(4-Chlorophenyl)-3-hydroxy-2-(4-chlorobenzyl)iso...)
Show SMILES OC1(N(Cc2ccc(Cl)cc2)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H15Cl2NO2/c22-16-9-5-14(6-10-16)13-24-20(25)18-3-1-2-4-19(18)21(24,26)15-7-11-17(23)12-8-15/h1-12,26H,13H2
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n/an/a 4.20E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339414
PNG
(2-(4-bromobenzyl)-3-(4-chlorophenyl)-3-hydroxyisoi...)
Show SMILES OC1(N(Cc2ccc(Br)cc2)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H15BrClNO2/c22-16-9-5-14(6-10-16)13-24-20(25)18-3-1-2-4-19(18)21(24,26)15-7-11-17(23)12-8-15/h1-12,26H,13H2
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n/an/a 4.50E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339439
PNG
((+/-)-cis-2-Benzyl-3-(4-chlorophenyl)-3-(4-hydroxy...)
Show SMILES O[C@H]1C[C@@H](OC2(N(Cc3ccccc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)C=C1
Show InChI InChI=1S/C26H22ClNO3/c27-20-12-10-19(11-13-20)26(31-22-15-14-21(29)16-22)24-9-5-4-8-23(24)25(30)28(26)17-18-6-2-1-3-7-18/h1-15,21-22,29H,16-17H2/t21-,22+,26?/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339411
PNG
(2-(4-(Aminomethyl)benzonitrile)-3-(4-chlorophenyl)...)
Show SMILES OC1(N(Cc2ccc(cc2)C#N)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H15ClN2O2/c23-18-11-9-17(10-12-18)22(27)20-4-2-1-3-19(20)21(26)25(22)14-16-7-5-15(13-24)6-8-16/h1-12,27H,14H2
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n/an/a 6.00E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339403
PNG
(2-(4-aminophenethyl)-3-(4-chlorophenyl)-3-hydroxyi...)
Show SMILES Nc1ccc(CCN2C(=O)c3ccccc3C2(O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C22H19ClN2O2/c23-17-9-7-16(8-10-17)22(27)20-4-2-1-3-19(20)21(26)25(22)14-13-15-5-11-18(24)12-6-15/h1-12,27H,13-14,24H2
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n/an/a 6.20E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339404
PNG
(3-(4-Chlorophenyl)-3-hydroxy-2-[2-(4-nitrophenyl)e...)
Show SMILES OC1(N(CCc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H17ClN2O4/c23-17-9-7-16(8-10-17)22(27)20-4-2-1-3-19(20)21(26)24(22)14-13-15-5-11-18(12-6-15)25(28)29/h1-12,27H,13-14H2
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n/an/a 6.20E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339405
PNG
(3-(4-chlorophenyl)-3-hydroxy-2-phenethylisoindolin...)
Show SMILES OC1(N(CCc2ccccc2)C(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClNO2/c23-18-12-10-17(11-13-18)22(26)20-9-5-4-8-19(20)21(25)24(22)15-14-16-6-2-1-3-7-16/h1-13,26H,14-15H2
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n/an/a 7.20E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339379
PNG
((+/-)-3-(4-Chlorophenyl)-2-((R)-1-(4-chlorophenyl)...)
Show SMILES C[C@@H](N1C(=O)c2ccccc2C1(OCC1(CO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H25Cl2NO3/c1-18(19-6-10-21(28)11-7-19)30-25(32)23-4-2-3-5-24(23)27(30,20-8-12-22(29)13-9-20)33-17-26(16-31)14-15-26/h2-13,18,31H,14-17H2,1H3/t18-,27?/m1/s1
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n/an/a 8.80E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339380
PNG
((+/-)-3-(4-Chlorophenyl)-2-((S)-1-(4-chlorophenyl)...)
Show SMILES C[C@H](N1C(=O)c2ccccc2C1(OCC1(CO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H25Cl2NO3/c1-18(19-6-10-21(28)11-7-19)30-25(32)23-4-2-3-5-24(23)27(30,20-8-12-22(29)13-9-20)33-17-26(16-31)14-15-26/h2-13,18,31H,14-17H2,1H3/t18-,27?/m0/s1
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n/an/a 8.90E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339409
PNG
(3-(4-Fluorophenyl)-3-hydroxy-2-(4-nitrobenzyl)-2,3...)
Show SMILES OC1(N(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H15FN2O4/c22-16-9-7-15(8-10-16)21(26)19-4-2-1-3-18(19)20(25)23(21)13-14-5-11-17(12-6-14)24(27)28/h1-12,26H,13H2
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n/an/a 9.50E+3n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339392
PNG
((+/-)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cycl...)
Show SMILES OCC1(COC2(N(Cc3ccccn3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C25H23ClN2O3/c26-19-10-8-18(9-11-19)25(31-17-24(16-29)12-13-24)22-7-2-1-6-21(22)23(30)28(25)15-20-5-3-4-14-27-20/h1-11,14,29H,12-13,15-17H2
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n/an/a 1.10E+4n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50339424
PNG
(CHEMBL1688159 | Methyl 4-((1-(4-chlorophenyl)-1-hy...)
Show SMILES COC(=O)c1ccc(CN2C(=O)c3ccccc3C2(O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C23H18ClNO4/c1-29-22(27)16-8-6-15(7-9-16)14-25-21(26)19-4-2-3-5-20(19)23(25,28)17-10-12-18(24)13-11-17/h2-13,28H,14H2,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair
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