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Compile Data Set for Download or QSAR

Found 128 hits with Last Name = 'ahn' and Initial = 'jm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Rattus norvegicus)
BDBM50104037
PNG
(CHEMBL428460 | His-Ser-Gln-Gly-Lys-Phe-Thr-Ser-Glu...)
Show InChI InChI=1S/C156H230N44O47S/c1-76(2)57-102(138(230)182-101(51-56-248-10)137(229)191-109(65-119(162)212)147(239)200-126(81(9)206)154(246)247)185-142(234)108(63-86-68-171-92-30-18-17-29-90(86)92)190-135(227)99(45-49-118(161)211)183-152(244)124(78(5)6)198-145(237)106(59-82-25-13-11-14-26-82)189-143(235)110(66-122(215)216)192-134(226)98(44-48-117(160)210)176-127(219)79(7)174-130(222)95(33-23-54-169-155(163)164)177-132(224)96(34-24-55-170-156(165)166)179-150(242)114(73-203)196-144(236)111(67-123(217)218)193-139(231)103(58-77(3)4)184-140(232)104(61-84-35-39-88(207)40-36-84)186-133(225)94(31-19-21-52-157)178-149(241)113(72-202)195-141(233)105(62-85-37-41-89(208)42-38-85)187-136(228)100-46-50-120(213)168-53-22-20-32-93(131(223)188-107(60-83-27-15-12-16-28-83)146(238)199-125(80(8)205)153(245)197-115(74-204)151(243)181-100)175-121(214)70-172-129(221)97(43-47-116(159)209)180-148(240)112(71-201)194-128(220)91(158)64-87-69-167-75-173-87/h11-18,25-30,35-42,68-69,75-81,91,93-115,124-126,171,201-208H,19-24,31-34,43-67,70-74,157-158H2,1-10H3,(H2,159,209)(H2,160,210)(H2,161,211)(H2,162,212)(H,167,173)(H,168,213)(H,172,221)(H,174,222)(H,175,214)(H,176,219)(H,177,224)(H,178,241)(H,179,242)(H,180,240)(H,181,243)(H,182,230)(H,183,244)(H,184,232)(H,185,234)(H,186,225)(H,187,228)(H,188,223)(H,189,235)(H,190,227)(H,191,229)(H,192,226)(H,193,231)(H,194,220)(H,195,233)(H,196,236)(H,197,245)(H,198,237)(H,199,238)(H,200,239)(H,215,216)(H,217,218)(H,246,247)(H4,163,164,169)(H4,165,166,170)/t79-,80+,81+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104040
PNG
(CHEMBL412488 | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C154H225N41O48S/c1-74(2)55-100(136(225)176-99(50-54-244-11)135(224)184-107(63-117(160)208)145(234)195-125(80(10)202)153(242)243)179-140(229)106(61-85-66-166-91-30-19-18-29-89(85)91)183-133(222)97(44-48-116(159)207)177-150(239)122(76(5)6)193-143(232)104(57-81-25-14-12-15-26-81)181-134(223)98-45-49-118(209)164-52-23-21-32-93(130(219)171-94(33-24-53-165-154(161)162)129(218)169-77(7)126(215)170-96(132(221)175-98)43-47-115(158)206)173-148(237)112(71-198)190-142(231)109(65-121(213)214)185-137(226)101(56-75(3)4)178-138(227)102(59-83-34-38-87(203)39-35-83)180-131(220)92(31-20-22-51-155)172-147(236)111(70-197)189-139(228)103(60-84-36-40-88(204)41-37-84)182-141(230)108(64-120(211)212)186-149(238)113(72-199)191-152(241)124(79(9)201)194-144(233)105(58-82-27-16-13-17-28-82)187-151(240)123(78(8)200)192-119(210)68-167-128(217)95(42-46-114(157)205)174-146(235)110(69-196)188-127(216)90(156)62-86-67-163-73-168-86/h12-19,25-30,34-41,66-67,73-80,90,92-113,122-125,166,196-204H,20-24,31-33,42-65,68-72,155-156H2,1-11H3,(H2,157,205)(H2,158,206)(H2,159,207)(H2,160,208)(H,163,168)(H,164,209)(H,167,217)(H,169,218)(H,170,215)(H,171,219)(H,172,236)(H,173,237)(H,174,235)(H,175,221)(H,176,225)(H,177,239)(H,178,227)(H,179,229)(H,180,220)(H,181,223)(H,182,230)(H,183,222)(H,184,224)(H,185,226)(H,186,238)(H,187,240)(H,188,216)(H,189,228)(H,190,231)(H,191,241)(H,192,210)(H,193,232)(H,194,233)(H,195,234)(H,211,212)(H,213,214)(H,242,243)(H4,161,162,165)/t77-,78+,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.240n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273767
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H226N40O46/c1-16-77(10)121(148(235)182-103(58-83-30-19-17-20-31-83)137(224)173-94-37-26-28-54-159-111(199)49-44-95(129(216)162-66-112(200)169-92(124(155)211)38-29-55-160-151(156)157)176-146(233)119(75(6)7)188-140(227)101(57-74(4)5)178-139(226)105(180-134(94)221)61-86-64-161-91-35-24-23-34-89(86)91)190-135(222)99(47-52-117(207)208)175-133(220)93(36-25-27-53-152)171-126(213)79(12)166-125(212)78(11)168-132(219)98(43-48-110(154)198)170-113(201)67-163-131(218)97(46-51-116(205)206)174-136(223)100(56-73(2)3)177-138(225)102(60-85-39-41-88(197)42-40-85)179-143(230)107(69-192)184-145(232)109(71-194)185-147(234)120(76(8)9)189-142(229)106(63-118(209)210)181-144(231)108(70-193)186-150(237)123(82(15)196)191-141(228)104(59-84-32-21-18-22-33-84)183-149(236)122(81(14)195)187-114(202)68-164-130(217)96(45-50-115(203)204)172-127(214)80(13)167-128(215)90(153)62-87-65-158-72-165-87/h17-24,30-35,39-42,64-65,72-82,90,92-109,119-123,161,192-197H,16,25-29,36-38,43-63,66-71,152-153H2,1-15H3,(H2,154,198)(H2,155,211)(H,158,165)(H,159,199)(H,162,216)(H,163,218)(H,164,217)(H,166,212)(H,167,215)(H,168,219)(H,169,200)(H,170,201)(H,171,213)(H,172,214)(H,173,224)(H,174,223)(H,175,220)(H,176,233)(H,177,225)(H,178,226)(H,179,230)(H,180,221)(H,181,231)(H,182,235)(H,183,236)(H,184,232)(H,185,234)(H,186,237)(H,187,202)(H,188,227)(H,189,229)(H,190,222)(H,191,228)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H4,156,157,160)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay


J Med Chem 43: 1714-22 (2000)


Article DOI: 10.1021/jm990559d
BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104030
PNG
(CHEMBL439885 | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C149H221N41O49S/c1-70(2)51-94(131(221)171-93(46-50-240-11)130(220)178-100(58-111(155)202)140(230)190-120(76(10)197)148(238)239)174-134(224)99(56-80-62-161-85-30-19-18-29-83(80)85)177-129(219)91(40-44-110(154)201)172-145(235)117(72(5)6)188-138(228)97(53-77-25-14-12-15-26-77)176-135(225)101(59-114(205)206)179-128(218)90(39-43-109(153)200)165-121(211)73(7)164-124(214)88(33-24-49-160-149(156)157)167-127(217)92-41-45-112(203)159-48-23-21-32-87(126(216)173-95(52-71(3)4)132(222)180-103(61-116(209)210)137(227)185-106(67-193)143(233)170-92)166-125(215)86(31-20-22-47-150)168-142(232)105(66-192)184-133(223)96(55-79-34-36-82(198)37-35-79)175-136(226)102(60-115(207)208)181-144(234)107(68-194)186-147(237)119(75(9)196)189-139(229)98(54-78-27-16-13-17-28-78)182-146(236)118(74(8)195)187-113(204)64-162-123(213)89(38-42-108(152)199)169-141(231)104(65-191)183-122(212)84(151)57-81-63-158-69-163-81/h12-19,25-30,34-37,62-63,69-76,84,86-107,117-120,161,191-198H,20-24,31-33,38-61,64-68,150-151H2,1-11H3,(H2,152,199)(H2,153,200)(H2,154,201)(H2,155,202)(H,158,163)(H,159,203)(H,162,213)(H,164,214)(H,165,211)(H,166,215)(H,167,217)(H,168,232)(H,169,231)(H,170,233)(H,171,221)(H,172,235)(H,173,216)(H,174,224)(H,175,226)(H,176,225)(H,177,219)(H,178,220)(H,179,218)(H,180,222)(H,181,234)(H,182,236)(H,183,212)(H,184,223)(H,185,227)(H,186,237)(H,187,204)(H,188,228)(H,189,229)(H,190,230)(H,205,206)(H,207,208)(H,209,210)(H,238,239)(H4,156,157,160)/t73-,74+,75+,76+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,117-,118-,119-,120-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273766
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,40S)-4-...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C152H233N41O44/c1-18-79(10)122(149(235)184-105(60-87-34-21-19-22-35-87)137(223)171-83(14)129(215)179-108(63-90-66-163-95-39-26-25-38-93(90)95)140(226)181-104(59-76(4)5)141(227)190-120(77(6)7)147(233)178-97(40-27-30-54-153)131(217)164-68-114(202)172-96(125(157)211)43-33-57-162-152(158)159)192-136(222)102(48-51-113(156)201)177-135(221)99(41-28-31-55-154)174-127(213)81(12)168-126(212)80(11)170-134(220)98(42-29-32-56-161-86(17)199)173-115(203)69-165-133(219)101(50-53-118(207)208)176-138(224)103(58-75(2)3)180-139(225)106(62-89-44-46-92(200)47-45-89)182-144(230)110(71-194)186-146(232)112(73-196)187-148(234)121(78(8)9)191-143(229)109(65-119(209)210)183-145(231)111(72-195)188-151(237)124(85(16)198)193-142(228)107(61-88-36-23-20-24-37-88)185-150(236)123(84(15)197)189-116(204)70-166-132(218)100(49-52-117(205)206)175-128(214)82(13)169-130(216)94(155)64-91-67-160-74-167-91/h19-26,34-39,44-47,66-67,74-85,94,96-112,120-124,163,194-198,200H,18,27-33,40-43,48-65,68-73,153-155H2,1-17H3,(H2,156,201)(H2,157,211)(H,160,167)(H,161,199)(H,164,217)(H,165,219)(H,166,218)(H,168,212)(H,169,216)(H,170,220)(H,171,223)(H,172,202)(H,173,203)(H,174,213)(H,175,214)(H,176,224)(H,177,221)(H,178,233)(H,179,215)(H,180,225)(H,181,226)(H,182,230)(H,183,231)(H,184,235)(H,185,236)(H,186,232)(H,187,234)(H,188,237)(H,189,204)(H,190,227)(H,191,229)(H,192,222)(H,193,228)(H,205,206)(H,207,208)(H,209,210)(H4,158,159,162)/t79-,80-,81-,82-,83-,84+,85+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273766
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,40S)-4-...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C152H233N41O44/c1-18-79(10)122(149(235)184-105(60-87-34-21-19-22-35-87)137(223)171-83(14)129(215)179-108(63-90-66-163-95-39-26-25-38-93(90)95)140(226)181-104(59-76(4)5)141(227)190-120(77(6)7)147(233)178-97(40-27-30-54-153)131(217)164-68-114(202)172-96(125(157)211)43-33-57-162-152(158)159)192-136(222)102(48-51-113(156)201)177-135(221)99(41-28-31-55-154)174-127(213)81(12)168-126(212)80(11)170-134(220)98(42-29-32-56-161-86(17)199)173-115(203)69-165-133(219)101(50-53-118(207)208)176-138(224)103(58-75(2)3)180-139(225)106(62-89-44-46-92(200)47-45-89)182-144(230)110(71-194)186-146(232)112(73-196)187-148(234)121(78(8)9)191-143(229)109(65-119(209)210)183-145(231)111(72-195)188-151(237)124(85(16)198)193-142(228)107(61-88-36-23-20-24-37-88)185-150(236)123(84(15)197)189-116(204)70-166-132(218)100(49-52-117(205)206)175-128(214)82(13)169-130(216)94(155)64-91-67-160-74-167-91/h19-26,34-39,44-47,66-67,74-85,94,96-112,120-124,163,194-198,200H,18,27-33,40-43,48-65,68-73,153-155H2,1-17H3,(H2,156,201)(H2,157,211)(H,160,167)(H,161,199)(H,164,217)(H,165,219)(H,166,218)(H,168,212)(H,169,216)(H,170,220)(H,171,223)(H,172,202)(H,173,203)(H,174,213)(H,175,214)(H,176,224)(H,177,221)(H,178,233)(H,179,215)(H,180,225)(H,181,226)(H,182,230)(H,183,231)(H,184,235)(H,185,236)(H,186,232)(H,187,234)(H,188,237)(H,189,204)(H,190,227)(H,191,229)(H,192,222)(H,193,228)(H,205,206)(H,207,208)(H,209,210)(H4,158,159,162)/t79-,80-,81-,82-,83-,84+,85+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,120-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273752
PNG
(CHEMBL503836 | HAEGTFTSDVSSYLEGQAAKEIFAWLVKGR)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)179-101(57-83-31-20-18-21-32-83)133(218)166-80(14)125(210)174-104(60-86-63-158-91-36-25-24-35-89(86)91)136(221)176-100(56-73(4)5)137(222)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-66-111(197)168-98(148(233)234)39-30-54-157-149(154)155)187-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-123(208)78(12)163-122(207)77(11)165-130(215)96(44-48-109(153)195)167-110(196)65-160-129(214)95(46-50-114(201)202)171-134(219)99(55-72(2)3)175-135(220)102(59-85-40-42-88(194)43-41-85)177-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)105(62-116(205)206)178-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)103(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)79(13)164-126(211)90(152)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,158,189-194H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,195)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,163,207)(H,164,211)(H,165,215)(H,166,218)(H,167,196)(H,168,197)(H,169,208)(H,170,209)(H,171,219)(H,172,216)(H,173,228)(H,174,210)(H,175,220)(H,176,221)(H,177,225)(H,178,226)(H,179,230)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,222)(H,186,224)(H,187,217)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273752
PNG
(CHEMBL503836 | HAEGTFTSDVSSYLEGQAAKEIFAWLVKGR)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)179-101(57-83-31-20-18-21-32-83)133(218)166-80(14)125(210)174-104(60-86-63-158-91-36-25-24-35-89(86)91)136(221)176-100(56-73(4)5)137(222)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-66-111(197)168-98(148(233)234)39-30-54-157-149(154)155)187-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-123(208)78(12)163-122(207)77(11)165-130(215)96(44-48-109(153)195)167-110(196)65-160-129(214)95(46-50-114(201)202)171-134(219)99(55-72(2)3)175-135(220)102(59-85-40-42-88(194)43-41-85)177-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)105(62-116(205)206)178-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)103(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)79(13)164-126(211)90(152)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,158,189-194H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,195)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,163,207)(H,164,211)(H,165,215)(H,166,218)(H,167,196)(H,168,197)(H,169,208)(H,170,209)(H,171,219)(H,172,216)(H,173,228)(H,174,210)(H,175,220)(H,176,221)(H,177,225)(H,178,226)(H,179,230)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,222)(H,186,224)(H,187,217)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273765
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,40S)-4-...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C150H228N40O43/c1-17-78(10)120(147(231)181-103(59-85-33-20-18-21-34-85)135(219)168-82(14)127(211)176-106(62-88-65-160-93-38-25-24-37-91(88)93)138(222)178-102(58-75(4)5)139(223)187-118(76(6)7)145(229)175-95(39-26-29-53-151)129(213)161-67-112(198)169-94(123(154)207)42-32-56-159-150(155)156)189-134(218)100-47-50-111(197)158-55-31-28-41-96(132(216)167-79(11)124(208)165-80(12)125(209)171-97(133(217)174-100)40-27-30-54-152)170-113(199)68-162-131(215)99(49-52-116(203)204)173-136(220)101(57-74(2)3)177-137(221)104(61-87-43-45-90(196)46-44-87)179-142(226)108(70-191)183-144(228)110(72-193)184-146(230)119(77(8)9)188-141(225)107(64-117(205)206)180-143(227)109(71-192)185-149(233)122(84(16)195)190-140(224)105(60-86-35-22-19-23-36-86)182-148(232)121(83(15)194)186-114(200)69-163-130(214)98(48-51-115(201)202)172-126(210)81(13)166-128(212)92(153)63-89-66-157-73-164-89/h18-25,33-38,43-46,65-66,73-84,92,94-110,118-122,160,191-196H,17,26-32,39-42,47-64,67-72,151-153H2,1-16H3,(H2,154,207)(H,157,164)(H,158,197)(H,161,213)(H,162,215)(H,163,214)(H,165,208)(H,166,212)(H,167,216)(H,168,219)(H,169,198)(H,170,199)(H,171,209)(H,172,210)(H,173,220)(H,174,217)(H,175,229)(H,176,211)(H,177,221)(H,178,222)(H,179,226)(H,180,227)(H,181,231)(H,182,232)(H,183,228)(H,184,230)(H,185,233)(H,186,200)(H,187,223)(H,188,225)(H,189,218)(H,190,224)(H,201,202)(H,203,204)(H,205,206)(H4,155,156,159)/t78-,79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,118-,119-,120-,121-,122-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.30n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273765
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,40S)-4-...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C150H228N40O43/c1-17-78(10)120(147(231)181-103(59-85-33-20-18-21-34-85)135(219)168-82(14)127(211)176-106(62-88-65-160-93-38-25-24-37-91(88)93)138(222)178-102(58-75(4)5)139(223)187-118(76(6)7)145(229)175-95(39-26-29-53-151)129(213)161-67-112(198)169-94(123(154)207)42-32-56-159-150(155)156)189-134(218)100-47-50-111(197)158-55-31-28-41-96(132(216)167-79(11)124(208)165-80(12)125(209)171-97(133(217)174-100)40-27-30-54-152)170-113(199)68-162-131(215)99(49-52-116(203)204)173-136(220)101(57-74(2)3)177-137(221)104(61-87-43-45-90(196)46-44-87)179-142(226)108(70-191)183-144(228)110(72-193)184-146(230)119(77(8)9)188-141(225)107(64-117(205)206)180-143(227)109(71-192)185-149(233)122(84(16)195)190-140(224)105(60-86-35-22-19-23-36-86)182-148(232)121(83(15)194)186-114(200)69-163-130(214)98(48-51-115(201)202)172-126(210)81(13)166-128(212)92(153)63-89-66-157-73-164-89/h18-25,33-38,43-46,65-66,73-84,92,94-110,118-122,160,191-196H,17,26-32,39-42,47-64,67-72,151-153H2,1-16H3,(H2,154,207)(H,157,164)(H,158,197)(H,161,213)(H,162,215)(H,163,214)(H,165,208)(H,166,212)(H,167,216)(H,168,219)(H,169,198)(H,170,199)(H,171,209)(H,172,210)(H,173,220)(H,174,217)(H,175,229)(H,176,211)(H,177,221)(H,178,222)(H,179,226)(H,180,227)(H,181,231)(H,182,232)(H,183,228)(H,184,230)(H,185,233)(H,186,200)(H,187,223)(H,188,225)(H,189,218)(H,190,224)(H,201,202)(H,203,204)(H,205,206)(H4,155,156,159)/t78-,79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,118-,119-,120-,121-,122-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.30n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104039
PNG
(CHEMBL267189 | His-Ser-Gln-Cys-Thr-Phe-Thr-Ser-Cys...)
Show InChI InChI=1S/C153H227N43O47S3/c1-72(2)52-97(132(223)175-96(47-51-246-11)131(222)183-104(60-116(159)209)141(232)196-122(78(10)203)151(242)243)178-136(227)103(58-83-63-167-89-29-19-18-28-87(83)89)182-129(220)95(43-46-115(158)208)176-148(239)119(74(5)6)193-139(230)101(54-79-24-14-12-15-25-79)180-137(228)105(61-117(210)211)184-128(219)93(41-44-113(156)206)170-123(214)75(7)169-125(216)91(31-22-49-165-152(160)161)171-126(217)92(32-23-50-166-153(162)163)173-144(235)109(67-199)189-138(229)106(62-118(212)213)185-133(224)98(53-73(3)4)177-134(225)99(56-81-33-37-85(204)38-34-81)179-127(218)90(30-20-21-48-154)172-143(234)108(66-198)188-135(226)100(57-82-35-39-86(205)40-36-82)181-146(237)111(69-244)192-145(236)110(68-200)190-150(241)121(77(9)202)194-140(231)102(55-80-26-16-13-17-27-80)186-149(240)120(76(8)201)195-147(238)112(70-245)191-130(221)94(42-45-114(157)207)174-142(233)107(65-197)187-124(215)88(155)59-84-64-164-71-168-84/h12-19,24-29,33-40,63-64,71-78,88,90-112,119-122,167,197-205,244-245H,20-23,30-32,41-62,65-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,168)(H,169,216)(H,170,214)(H,171,217)(H,172,234)(H,173,235)(H,174,233)(H,175,223)(H,176,239)(H,177,225)(H,178,227)(H,179,218)(H,180,228)(H,181,237)(H,182,220)(H,183,222)(H,184,219)(H,185,224)(H,186,240)(H,187,215)(H,188,226)(H,189,229)(H,190,241)(H,191,221)(H,192,236)(H,193,230)(H,194,231)(H,195,238)(H,196,232)(H,210,211)(H,212,213)(H,242,243)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,119-,120-,121-,122-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.60n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098563
PNG
(CHEMBL413890 | Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C148H221N41O47S/c1-70(2)54-95(131(221)171-94(49-53-237-11)130(220)179-102(61-111(154)202)140(230)188-117(74(8)194)120(155)210)174-135(225)101(60-81-64-162-86-29-19-18-28-84(81)86)178-128(218)92(43-47-110(153)201)172-144(234)116(72(5)6)187-138(228)99(56-77-24-14-12-15-25-77)177-136(226)103(62-114(206)207)180-127(217)91(42-46-109(152)200)165-121(211)73(7)164-124(214)88(31-22-51-160-147(156)157)167-125(215)89(32-23-52-161-148(158)159)169-142(232)106(68-192)184-137(227)104(63-115(208)209)181-132(222)96(55-71(3)4)173-133(223)97(58-79-33-37-82(197)38-34-79)175-126(216)87(30-20-21-50-149)168-141(231)105(67-191)183-134(224)98(59-80-35-39-83(198)40-36-80)176-129(219)93(44-48-113(204)205)170-143(233)107(69-193)185-146(236)119(76(10)196)189-139(229)100(57-78-26-16-13-17-27-78)182-145(235)118(75(9)195)186-112(203)65-163-123(213)90(41-45-108(151)199)166-122(212)85(150)66-190/h12-19,24-29,33-40,64,70-76,85,87-107,116-119,162,190-198H,20-23,30-32,41-63,65-69,149-150H2,1-11H3,(H2,151,199)(H2,152,200)(H2,153,201)(H2,154,202)(H2,155,210)(H,163,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,231)(H,169,232)(H,170,233)(H,171,221)(H,172,234)(H,173,223)(H,174,225)(H,175,216)(H,176,219)(H,177,226)(H,178,218)(H,179,220)(H,180,217)(H,181,222)(H,182,235)(H,183,224)(H,184,227)(H,185,236)(H,186,203)(H,187,228)(H,188,230)(H,189,229)(H,204,205)(H,206,207)(H,208,209)(H4,156,157,160)(H4,158,159,161)/t73-,74+,75+,76+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.75n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273757
PNG
((4S,7S,10S,13S,16S,22S)-4-((6S,12S,15S,18S,21S,24S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C149H223N41O46/c1-13-75(6)119(146(234)182-101(58-82-29-16-14-17-30-82)136(224)168-79(10)126(214)178-104(61-85-64-160-90-34-21-20-33-88(85)90)138(226)179-100(57-73(2)3)140(228)188-118(74(4)5)145(233)177-92(35-22-25-53-150)128(216)161-66-111(199)169-91(122(154)210)38-28-56-159-149(155)156)189-135(223)99(47-52-116(206)207)175-132(220)93(36-23-26-54-151)171-124(212)77(8)165-123(211)76(7)167-131(219)97(43-48-109(153)197)170-112(200)67-162-130(218)96(46-51-115(204)205)174-134(222)98-44-49-110(198)158-55-27-24-37-94(133(221)184-107(70-192)144(232)185-106(69-191)142(230)180-102(137(225)176-98)60-84-39-41-87(196)42-40-84)173-139(227)105(63-117(208)209)181-143(231)108(71-193)186-148(236)121(81(12)195)190-141(229)103(59-83-31-18-15-19-32-83)183-147(235)120(80(11)194)187-113(201)68-163-129(217)95(45-50-114(202)203)172-125(213)78(9)166-127(215)89(152)62-86-65-157-72-164-86/h14-21,29-34,39-42,64-65,72-81,89,91-108,118-121,160,191-196H,13,22-28,35-38,43-63,66-71,150-152H2,1-12H3,(H2,153,197)(H2,154,210)(H,157,164)(H,158,198)(H,161,216)(H,162,218)(H,163,217)(H,165,211)(H,166,215)(H,167,219)(H,168,224)(H,169,199)(H,170,200)(H,171,212)(H,172,213)(H,173,227)(H,174,222)(H,175,220)(H,176,225)(H,177,233)(H,178,214)(H,179,226)(H,180,230)(H,181,231)(H,182,234)(H,183,235)(H,184,221)(H,185,232)(H,186,236)(H,187,201)(H,188,228)(H,189,223)(H,190,229)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H4,155,156,159)/t75-,76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-,119-,120-,121-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.5n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273757
PNG
((4S,7S,10S,13S,16S,22S)-4-((6S,12S,15S,18S,21S,24S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C149H223N41O46/c1-13-75(6)119(146(234)182-101(58-82-29-16-14-17-30-82)136(224)168-79(10)126(214)178-104(61-85-64-160-90-34-21-20-33-88(85)90)138(226)179-100(57-73(2)3)140(228)188-118(74(4)5)145(233)177-92(35-22-25-53-150)128(216)161-66-111(199)169-91(122(154)210)38-28-56-159-149(155)156)189-135(223)99(47-52-116(206)207)175-132(220)93(36-23-26-54-151)171-124(212)77(8)165-123(211)76(7)167-131(219)97(43-48-109(153)197)170-112(200)67-162-130(218)96(46-51-115(204)205)174-134(222)98-44-49-110(198)158-55-27-24-37-94(133(221)184-107(70-192)144(232)185-106(69-191)142(230)180-102(137(225)176-98)60-84-39-41-87(196)42-40-84)173-139(227)105(63-117(208)209)181-143(231)108(71-193)186-148(236)121(81(12)195)190-141(229)103(59-83-31-18-15-19-32-83)183-147(235)120(80(11)194)187-113(201)68-163-129(217)95(45-50-114(202)203)172-125(213)78(9)166-127(215)89(152)62-86-65-157-72-164-86/h14-21,29-34,39-42,64-65,72-81,89,91-108,118-121,160,191-196H,13,22-28,35-38,43-63,66-71,150-152H2,1-12H3,(H2,153,197)(H2,154,210)(H,157,164)(H,158,198)(H,161,216)(H,162,218)(H,163,217)(H,165,211)(H,166,215)(H,167,219)(H,168,224)(H,169,199)(H,170,200)(H,171,212)(H,172,213)(H,173,227)(H,174,222)(H,175,220)(H,176,225)(H,177,233)(H,178,214)(H,179,226)(H,180,230)(H,181,231)(H,182,234)(H,183,235)(H,184,221)(H,185,232)(H,186,236)(H,187,201)(H,188,228)(H,189,223)(H,190,229)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H4,155,156,159)/t75-,76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-,119-,120-,121-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.5n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104031
PNG
(CHEMBL263603 | His-Cys-Gln-Gly-Thr-Phe-Cys-Ser-Asp...)
Show InChI InChI=1S/C152H223N43O47S3/c1-72(2)51-96(132(223)175-95(46-50-245-10)131(222)183-103(59-115(158)206)142(233)195-122(77(9)200)150(241)242)178-137(228)102(57-82-63-166-88-28-18-17-27-86(82)88)182-130(221)94(42-45-114(157)205)176-148(239)120(74(5)6)194-141(232)101(54-79-25-15-12-16-26-79)181-138(229)104(60-117(208)209)184-129(220)93(41-44-113(156)204)170-123(214)75(7)169-126(217)90(30-21-48-164-151(159)160)171-127(218)91(31-22-49-165-152(161)162)173-144(235)108(67-197)189-140(231)106(62-119(212)213)185-133(224)97(52-73(3)4)177-134(225)98(55-80-32-36-84(201)37-33-80)179-128(219)89(29-19-20-47-153)172-143(234)107(66-196)188-135(226)99(56-81-34-38-85(202)39-35-81)180-139(230)105(61-118(210)211)186-145(236)109(68-198)190-147(238)111(70-244)192-136(227)100(53-78-23-13-11-14-24-78)187-149(240)121(76(8)199)193-116(207)65-167-125(216)92(40-43-112(155)203)174-146(237)110(69-243)191-124(215)87(154)58-83-64-163-71-168-83/h11-18,23-28,32-39,63-64,71-77,87,89-111,120-122,166,196-202,243-244H,19-22,29-31,40-62,65-70,153-154H2,1-10H3,(H2,155,203)(H2,156,204)(H2,157,205)(H2,158,206)(H,163,168)(H,167,216)(H,169,217)(H,170,214)(H,171,218)(H,172,234)(H,173,235)(H,174,237)(H,175,223)(H,176,239)(H,177,225)(H,178,228)(H,179,219)(H,180,230)(H,181,229)(H,182,221)(H,183,222)(H,184,220)(H,185,224)(H,186,236)(H,187,240)(H,188,226)(H,189,231)(H,190,238)(H,191,215)(H,192,227)(H,193,207)(H,194,232)(H,195,233)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.60n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104043
PNG
(CHEMBL437648 | His-Ser-Lys-Gly-Thr-Phe-Glu-Ser-Asp...)
Show InChI InChI=1S/C155H227N43O48S/c1-75(2)55-100(136(228)179-99(49-54-247-10)135(227)187-107(63-117(160)209)146(238)198-125(80(9)204)153(245)246)182-141(233)106(61-85-67-169-91-30-18-17-29-89(85)91)186-133(225)97(44-47-116(159)208)180-151(243)123(77(5)6)197-145(237)105(58-82-27-15-12-16-28-82)185-142(234)108(64-120(212)213)188-132(224)96(43-46-115(158)207)173-126(218)78(7)172-129(221)94(33-23-52-167-154(161)162)175-130(222)95(34-24-53-168-155(163)164)177-149(241)113(72-201)195-144(236)110(66-122(216)217)189-137(229)101(56-76(3)4)181-139(231)102(59-83-35-39-87(205)40-36-83)183-131(223)93(31-19-21-50-156)176-148(240)112(71-200)194-140(232)103(60-84-37-41-88(206)42-38-84)184-143(235)109(65-121(214)215)190-150(242)114(73-202)193-134(226)98-45-48-118(210)166-51-22-20-32-92(174-147(239)111(70-199)192-127(219)90(157)62-86-68-165-74-171-86)128(220)170-69-119(211)196-124(79(8)203)152(244)191-104(138(230)178-98)57-81-25-13-11-14-26-81/h11-18,25-30,35-42,67-68,74-80,90,92-114,123-125,169,199-206H,19-24,31-34,43-66,69-73,156-157H2,1-10H3,(H2,158,207)(H2,159,208)(H2,160,209)(H,165,171)(H,166,210)(H,170,220)(H,172,221)(H,173,218)(H,174,239)(H,175,222)(H,176,240)(H,177,241)(H,178,230)(H,179,228)(H,180,243)(H,181,231)(H,182,233)(H,183,223)(H,184,235)(H,185,234)(H,186,225)(H,187,227)(H,188,224)(H,189,229)(H,190,242)(H,191,244)(H,192,219)(H,193,226)(H,194,232)(H,195,236)(H,196,211)(H,197,237)(H,198,238)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,161,162,167)(H4,163,164,168)/t78-,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104041
PNG
(CHEMBL414077 | His-Ser-Gln-Gly-Thr-Phe-Cys-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C149H216N42O48S3/c1-69(2)47-92(128(219)170-91(43-46-242-10)127(218)178-99(55-112(154)203)138(229)191-119(74(9)197)147(238)239)173-133(224)98(53-79-59-162-85-26-18-17-25-83(79)85)177-126(217)90(39-42-111(153)202)171-145(236)117(71(5)6)190-137(228)97(50-76-23-15-12-16-24-76)175-134(225)100(56-114(205)206)179-125(216)89(38-41-110(152)201)166-120(211)72(7)165-123(214)86(27-19-44-160-148(155)156)167-124(215)87(28-20-45-161-149(157)158)168-140(231)104(63-193)185-136(227)102(58-116(209)210)180-129(220)93(48-70(3)4)172-130(221)94(51-77-29-33-81(198)34-30-77)176-143(234)107(66-240)188-142(233)106(65-195)184-131(222)95(52-78-31-35-82(199)36-32-78)174-135(226)101(57-115(207)208)181-141(232)105(64-194)186-144(235)108(67-241)187-132(223)96(49-75-21-13-11-14-22-75)182-146(237)118(73(8)196)189-113(204)61-163-122(213)88(37-40-109(151)200)169-139(230)103(62-192)183-121(212)84(150)54-80-60-159-68-164-80/h11-18,21-26,29-36,59-60,68-74,84,86-108,117-119,162,192-199,240-241H,19-20,27-28,37-58,61-67,150H2,1-10H3,(H2,151,200)(H2,152,201)(H2,153,202)(H2,154,203)(H,159,164)(H,163,213)(H,165,214)(H,166,211)(H,167,215)(H,168,231)(H,169,230)(H,170,219)(H,171,236)(H,172,221)(H,173,224)(H,174,226)(H,175,225)(H,176,234)(H,177,217)(H,178,218)(H,179,216)(H,180,220)(H,181,232)(H,182,237)(H,183,212)(H,184,222)(H,185,227)(H,186,235)(H,187,223)(H,188,233)(H,189,204)(H,190,228)(H,191,229)(H,205,206)(H,207,208)(H,209,210)(H,238,239)(H4,155,156,160)(H4,157,158,161)/t72-,73+,74+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.40n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273758
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C151H228N42O47/c1-14-76(6)121(148(238)185-103(59-84-30-17-15-18-31-84)138(228)171-80(10)128(218)181-106(62-87-65-163-92-35-22-21-34-90(87)92)140(230)182-102(58-74(2)3)142(232)191-120(75(4)5)147(237)180-94(36-23-26-54-152)130(220)164-67-113(203)172-93(124(157)214)39-29-57-162-151(158)159)192-137(227)101(48-53-118(210)211)178-134(224)95(37-24-27-55-153)174-126(216)78(8)168-125(215)77(7)170-133(223)99(44-49-111(155)201)173-114(204)68-165-132(222)98(47-52-117(208)209)177-136(226)100(45-50-112(156)202)179-139(229)104(61-86-40-42-89(200)43-41-86)183-144(234)108(70-194)188-146(236)109(71-195)187-135(225)96(38-25-28-56-161-83(13)199)176-141(231)107(64-119(212)213)184-145(235)110(72-196)189-150(240)123(82(12)198)193-143(233)105(60-85-32-19-16-20-33-85)186-149(239)122(81(11)197)190-115(205)69-166-131(221)97(46-51-116(206)207)175-127(217)79(9)169-129(219)91(154)63-88-66-160-73-167-88/h15-22,30-35,40-43,65-66,73-82,91,93-110,120-123,163,194-198,200H,14,23-29,36-39,44-64,67-72,152-154H2,1-13H3,(H2,155,201)(H2,156,202)(H2,157,214)(H,160,167)(H,161,199)(H,164,220)(H,165,222)(H,166,221)(H,168,215)(H,169,219)(H,170,223)(H,171,228)(H,172,203)(H,173,204)(H,174,216)(H,175,217)(H,176,231)(H,177,226)(H,178,224)(H,179,229)(H,180,237)(H,181,218)(H,182,230)(H,183,234)(H,184,235)(H,185,238)(H,186,239)(H,187,225)(H,188,236)(H,189,240)(H,190,205)(H,191,232)(H,192,227)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,162)/t76-,77-,78-,79-,80-,81+,82+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273758
PNG
((4S,7S,10S,13S,16S,22S,25S,28S,31S,34S,37S,40S,43S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C151H228N42O47/c1-14-76(6)121(148(238)185-103(59-84-30-17-15-18-31-84)138(228)171-80(10)128(218)181-106(62-87-65-163-92-35-22-21-34-90(87)92)140(230)182-102(58-74(2)3)142(232)191-120(75(4)5)147(237)180-94(36-23-26-54-152)130(220)164-67-113(203)172-93(124(157)214)39-29-57-162-151(158)159)192-137(227)101(48-53-118(210)211)178-134(224)95(37-24-27-55-153)174-126(216)78(8)168-125(215)77(7)170-133(223)99(44-49-111(155)201)173-114(204)68-165-132(222)98(47-52-117(208)209)177-136(226)100(45-50-112(156)202)179-139(229)104(61-86-40-42-89(200)43-41-86)183-144(234)108(70-194)188-146(236)109(71-195)187-135(225)96(38-25-28-56-161-83(13)199)176-141(231)107(64-119(212)213)184-145(235)110(72-196)189-150(240)123(82(12)198)193-143(233)105(60-85-32-19-16-20-33-85)186-149(239)122(81(11)197)190-115(205)69-166-131(221)97(46-51-116(206)207)175-127(217)79(9)169-129(219)91(154)63-88-66-160-73-167-88/h15-22,30-35,40-43,65-66,73-82,91,93-110,120-123,163,194-198,200H,14,23-29,36-39,44-64,67-72,152-154H2,1-13H3,(H2,155,201)(H2,156,202)(H2,157,214)(H,160,167)(H,161,199)(H,164,220)(H,165,222)(H,166,221)(H,168,215)(H,169,219)(H,170,223)(H,171,228)(H,172,203)(H,173,204)(H,174,216)(H,175,217)(H,176,231)(H,177,226)(H,178,224)(H,179,229)(H,180,237)(H,181,218)(H,182,230)(H,183,234)(H,184,235)(H,185,238)(H,186,239)(H,187,225)(H,188,236)(H,189,240)(H,190,205)(H,191,232)(H,192,227)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,162)/t76-,77-,78-,79-,80-,81+,82+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104044
PNG
(CHEMBL409654 | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp...)
Show InChI InChI=1S/C150H219N43O49S3/c1-70(2)49-93(129(222)172-92(44-48-245-8)128(221)179-99(56-112(156)206)138(231)193-120(74(7)200)148(241)242)174-132(225)98(54-79-60-164-85-26-16-15-25-83(79)85)178-127(220)91(40-43-111(155)205)173-145(238)117(71(3)4)191-136(229)96(50-75-21-11-9-12-22-75)177-133(226)100(57-114(208)209)180-126(219)90(39-42-110(154)204)171-143(236)107(67-243)188-125(218)88(29-20-47-163-150(159)160)167-123(216)87(28-19-46-162-149(157)158)169-141(234)105(65-196)186-135(228)102(59-116(212)213)182-144(237)108(68-244)189-131(224)95(53-78-32-36-82(202)37-33-78)175-124(217)86(27-17-18-45-151)168-140(233)104(64-195)185-130(223)94(52-77-30-34-81(201)35-31-77)176-134(227)101(58-115(210)211)181-142(235)106(66-197)187-147(240)119(73(6)199)192-137(230)97(51-76-23-13-10-14-24-76)183-146(239)118(72(5)198)190-113(207)62-165-122(215)89(38-41-109(153)203)170-139(232)103(63-194)184-121(214)84(152)55-80-61-161-69-166-80/h9-16,21-26,30-37,60-61,69-74,84,86-108,117-120,164,194-202,243-244H,17-20,27-29,38-59,62-68,151-152H2,1-8H3,(H2,153,203)(H2,154,204)(H2,155,205)(H2,156,206)(H,161,166)(H,165,215)(H,167,216)(H,168,233)(H,169,234)(H,170,232)(H,171,236)(H,172,222)(H,173,238)(H,174,225)(H,175,217)(H,176,227)(H,177,226)(H,178,220)(H,179,221)(H,180,219)(H,181,235)(H,182,237)(H,183,239)(H,184,214)(H,185,223)(H,186,228)(H,187,240)(H,188,218)(H,189,224)(H,190,207)(H,191,229)(H,192,230)(H,193,231)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,157,158,162)(H4,159,160,163)/t72-,73-,74-,84+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,117+,118+,119+,120+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104033
PNG
(CHEMBL442135 | His-Ser-Gln-Gly-Thr-Phe-Lys-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C157H230N44O48S/c1-76(2)57-102(139(232)183-101(51-56-250-10)138(231)191-109(65-119(163)212)149(242)201-127(81(9)206)155(248)249)186-144(237)108(63-86-69-172-92-30-18-17-29-90(86)92)190-137(230)99(45-49-118(162)211)184-153(246)125(78(5)6)200-148(241)107(60-83-27-15-12-16-28-83)189-145(238)110(66-122(215)216)192-136(229)98(44-48-117(161)210)176-128(221)79(7)175-131(224)95(33-23-54-170-156(164)165)178-132(225)96(34-24-55-171-157(166)167)180-151(244)114(73-203)198-147(240)112(68-124(219)220)193-140(233)103(58-77(3)4)185-143(236)105(62-85-37-41-89(208)42-38-85)187-133(226)93(31-19-21-52-158)177-135(228)100-46-50-120(213)169-53-22-20-32-94(134(227)197-115(74-204)152(245)194-111(67-123(217)218)146(239)188-104(141(234)182-100)61-84-35-39-88(207)40-36-84)179-142(235)106(59-82-25-13-11-14-26-82)195-154(247)126(80(8)205)199-121(214)71-173-130(223)97(43-47-116(160)209)181-150(243)113(72-202)196-129(222)91(159)64-87-70-168-75-174-87/h11-18,25-30,35-42,69-70,75-81,91,93-115,125-127,172,202-208H,19-24,31-34,43-68,71-74,158-159H2,1-10H3,(H2,160,209)(H2,161,210)(H2,162,211)(H2,163,212)(H,168,174)(H,169,213)(H,173,223)(H,175,224)(H,176,221)(H,177,228)(H,178,225)(H,179,235)(H,180,244)(H,181,243)(H,182,234)(H,183,232)(H,184,246)(H,185,236)(H,186,237)(H,187,226)(H,188,239)(H,189,238)(H,190,230)(H,191,231)(H,192,229)(H,193,233)(H,194,245)(H,195,247)(H,196,222)(H,197,227)(H,198,240)(H,199,214)(H,200,241)(H,201,242)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,164,165,170)(H4,166,167,171)/t79-,80+,81+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273759
PNG
((3S,6S,9S,12S,15S,21S)-3-((S)-1-((S)-1-((2S,5S,8S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C155H235N41O45/c1-17-80(10)124(152(239)188-107(63-87-33-20-18-21-34-87)141(228)173-84(14)131(218)183-110(66-90-69-166-95-38-25-24-37-93(90)95)144(231)185-106(62-77(4)5)145(232)193-122(78(6)7)150(237)182-97(39-26-29-57-156)133(220)167-71-116(204)174-96(127(160)214)42-32-60-165-155(161)162)195-140(227)104(51-56-120(210)211)180-136(223)98(40-27-30-58-157)175-129(216)82(12)170-128(215)81(11)172-135(222)101(47-52-114(159)202)178-138(225)102-48-53-115(203)164-59-31-28-41-99(137(224)186-108(65-89-43-45-92(201)46-44-89)143(230)184-105(61-76(2)3)142(229)181-103(139(226)179-102)50-55-119(208)209)177-148(235)112(73-197)190-151(238)123(79(8)9)194-147(234)111(68-121(212)213)187-149(236)113(74-198)191-154(241)126(86(16)200)196-146(233)109(64-88-35-22-19-23-36-88)189-153(240)125(85(15)199)192-117(205)72-168-134(221)100(49-54-118(206)207)176-130(217)83(13)171-132(219)94(158)67-91-70-163-75-169-91/h18-25,33-38,43-46,69-70,75-86,94,96-113,122-126,166,197-201H,17,26-32,39-42,47-68,71-74,156-158H2,1-16H3,(H2,159,202)(H2,160,214)(H,163,169)(H,164,203)(H,167,220)(H,168,221)(H,170,215)(H,171,219)(H,172,222)(H,173,228)(H,174,204)(H,175,216)(H,176,217)(H,177,235)(H,178,225)(H,179,226)(H,180,223)(H,181,229)(H,182,237)(H,183,218)(H,184,230)(H,185,231)(H,186,224)(H,187,236)(H,188,239)(H,189,240)(H,190,238)(H,191,241)(H,192,205)(H,193,232)(H,194,234)(H,195,227)(H,196,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,161,162,165)/t80-,81-,82-,83-,84-,85+,86+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-,126-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098573
PNG
(CHEMBL267876 | N-trinitrophenyl-His-Ser-Gln-Gly-Th...)
Show InChI InChI=1S/C160H229N49O54S/c1-74(2)52-99(139(239)186-98(47-51-264-11)138(238)194-107(62-120(164)222)150(250)205-126(78(8)214)130(165)230)189-143(243)105(58-85-66-176-91-29-19-18-28-90(85)91)193-137(237)97(43-46-119(163)221)187-155(255)125(76(5)6)204-148(248)103(54-81-24-14-12-15-25-81)192-145(245)108(63-122(224)225)195-136(236)96(42-45-118(162)220)181-131(231)77(7)179-133(233)93(31-22-49-174-159(168)169)182-134(234)94(32-23-50-175-160(170)171)184-152(252)112(70-211)201-147(247)110(65-124(228)229)196-140(240)100(53-75(3)4)188-141(241)101(56-83-33-37-88(217)38-34-83)190-135(235)92(30-20-21-48-173-158(166)167)183-151(251)111(69-210)199-142(242)102(57-84-35-39-89(218)40-36-84)191-146(246)109(64-123(226)227)197-154(254)114(72-213)202-157(257)128(80(10)216)206-149(249)104(55-82-26-16-13-17-27-82)198-156(256)127(79(9)215)203-121(223)68-177-132(232)95(41-44-117(161)219)185-153(253)113(71-212)200-144(244)106(59-86-67-172-73-178-86)180-129-115(208(260)261)60-87(207(258)259)61-116(129)209(262)263/h12-19,24-29,33-40,60-61,66-67,73-80,92-114,125-128,176,180,210-218H,20-23,30-32,41-59,62-65,68-72H2,1-11H3,(H2,161,219)(H2,162,220)(H2,163,221)(H2,164,222)(H2,165,230)(H,172,178)(H,177,232)(H,179,233)(H,181,231)(H,182,234)(H,183,251)(H,184,252)(H,185,253)(H,186,239)(H,187,255)(H,188,241)(H,189,243)(H,190,235)(H,191,246)(H,192,245)(H,193,237)(H,194,238)(H,195,236)(H,196,240)(H,197,254)(H,198,256)(H,199,242)(H,200,244)(H,201,247)(H,202,257)(H,203,223)(H,204,248)(H,205,250)(H,206,249)(H,224,225)(H,226,227)(H,228,229)(H4,166,167,173)(H4,168,169,174)(H4,170,171,175)/t77-,78+,79+,80+,92+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,125-,126-,127-,128-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon (inactive up to 100 microM)


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273760
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C157H240N42O46/c1-18-81(10)126(154(243)191-109(64-89-34-21-19-22-35-89)143(232)176-85(14)133(222)186-112(67-92-70-169-97-39-26-25-38-95(92)97)146(235)188-108(63-78(4)5)147(236)196-124(79(6)7)152(241)185-99(40-27-30-58-158)135(224)170-72-118(208)177-98(129(163)218)43-33-61-168-157(164)165)198-142(231)106(52-57-122(214)215)183-138(227)100(41-28-31-59-159)178-131(220)83(12)173-130(219)82(11)175-137(226)103(48-53-116(161)206)181-140(229)104(49-54-117(162)207)182-141(230)105(51-56-121(212)213)184-144(233)107(62-77(2)3)187-145(234)110(66-91-44-46-94(205)47-45-91)189-139(228)101(42-29-32-60-167-88(17)204)180-150(239)114(74-200)193-153(242)125(80(8)9)197-149(238)113(69-123(216)217)190-151(240)115(75-201)194-156(245)128(87(16)203)199-148(237)111(65-90-36-23-20-24-37-90)192-155(244)127(86(15)202)195-119(209)73-171-136(225)102(50-55-120(210)211)179-132(221)84(13)174-134(223)96(160)68-93-71-166-76-172-93/h19-26,34-39,44-47,70-71,76-87,96,98-115,124-128,169,200-203,205H,18,27-33,40-43,48-69,72-75,158-160H2,1-17H3,(H2,161,206)(H2,162,207)(H2,163,218)(H,166,172)(H,167,204)(H,170,224)(H,171,225)(H,173,219)(H,174,223)(H,175,226)(H,176,232)(H,177,208)(H,178,220)(H,179,221)(H,180,239)(H,181,229)(H,182,230)(H,183,227)(H,184,233)(H,185,241)(H,186,222)(H,187,234)(H,188,235)(H,189,228)(H,190,240)(H,191,243)(H,192,244)(H,193,242)(H,194,245)(H,195,209)(H,196,236)(H,197,238)(H,198,231)(H,199,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,164,165,168)/t81-,82-,83-,84-,85-,86+,87+,96-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273760
PNG
((4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C157H240N42O46/c1-18-81(10)126(154(243)191-109(64-89-34-21-19-22-35-89)143(232)176-85(14)133(222)186-112(67-92-70-169-97-39-26-25-38-95(92)97)146(235)188-108(63-78(4)5)147(236)196-124(79(6)7)152(241)185-99(40-27-30-58-158)135(224)170-72-118(208)177-98(129(163)218)43-33-61-168-157(164)165)198-142(231)106(52-57-122(214)215)183-138(227)100(41-28-31-59-159)178-131(220)83(12)173-130(219)82(11)175-137(226)103(48-53-116(161)206)181-140(229)104(49-54-117(162)207)182-141(230)105(51-56-121(212)213)184-144(233)107(62-77(2)3)187-145(234)110(66-91-44-46-94(205)47-45-91)189-139(228)101(42-29-32-60-167-88(17)204)180-150(239)114(74-200)193-153(242)125(80(8)9)197-149(238)113(69-123(216)217)190-151(240)115(75-201)194-156(245)128(87(16)203)199-148(237)111(65-90-36-23-20-24-37-90)192-155(244)127(86(15)202)195-119(209)73-171-136(225)102(50-55-120(210)211)179-132(221)84(13)174-134(223)96(160)68-93-71-166-76-172-93/h19-26,34-39,44-47,70-71,76-87,96,98-115,124-128,169,200-203,205H,18,27-33,40-43,48-69,72-75,158-160H2,1-17H3,(H2,161,206)(H2,162,207)(H2,163,218)(H,166,172)(H,167,204)(H,170,224)(H,171,225)(H,173,219)(H,174,223)(H,175,226)(H,176,232)(H,177,208)(H,178,220)(H,179,221)(H,180,239)(H,181,229)(H,182,230)(H,183,227)(H,184,233)(H,185,241)(H,186,222)(H,187,234)(H,188,235)(H,189,228)(H,190,240)(H,191,243)(H,192,244)(H,193,242)(H,194,245)(H,195,209)(H,196,236)(H,197,238)(H,198,231)(H,199,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,164,165,168)/t81-,82-,83-,84-,85-,86+,87+,96-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-,128-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059352
PNG
(CHEMBL442499 | [des-His1, Trp6, Glu9] glucagon-NH2)
Show InChI InChI=1S/C150H222N42O47S/c1-70(2)53-97(133(224)174-96(48-52-240-11)132(223)182-104(60-113(156)205)142(233)191-119(74(8)197)122(157)213)177-137(228)102(58-80-63-164-87-27-17-15-25-84(80)87)181-130(221)94(42-46-112(155)204)175-146(237)118(72(5)6)190-140(231)101(55-77-23-13-12-14-24-77)180-138(229)105(61-116(209)210)183-129(220)93(41-45-111(154)203)168-123(214)73(7)167-126(217)90(30-21-50-162-149(158)159)170-127(218)91(31-22-51-163-150(160)161)172-144(235)108(68-195)187-139(230)106(62-117(211)212)184-134(225)98(54-71(3)4)176-135(226)99(56-78-32-36-82(200)37-33-78)178-128(219)89(29-19-20-49-151)171-143(234)107(67-194)186-136(227)100(57-79-34-38-83(201)39-35-79)179-131(222)95(43-47-115(207)208)173-145(236)109(69-196)188-148(239)121(76(10)199)192-141(232)103(59-81-64-165-88-28-18-16-26-85(81)88)185-147(238)120(75(9)198)189-114(206)65-166-125(216)92(40-44-110(153)202)169-124(215)86(152)66-193/h12-18,23-28,32-39,63-64,70-76,86,89-109,118-121,164-165,193-201H,19-22,29-31,40-62,65-69,151-152H2,1-11H3,(H2,153,202)(H2,154,203)(H2,155,204)(H2,156,205)(H2,157,213)(H,166,216)(H,167,217)(H,168,214)(H,169,215)(H,170,218)(H,171,234)(H,172,235)(H,173,236)(H,174,224)(H,175,237)(H,176,226)(H,177,228)(H,178,219)(H,179,222)(H,180,229)(H,181,221)(H,182,223)(H,183,220)(H,184,225)(H,185,238)(H,186,227)(H,187,230)(H,188,239)(H,189,206)(H,190,231)(H,191,233)(H,192,232)(H,207,208)(H,209,210)(H,211,212)(H4,158,159,162)(H4,160,161,163)/t73-,74+,75+,76+,86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 19n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098566
PNG
(CHEMBL413208 | phenylbutyryl-Tyr-Ser-Lys-Tyr-Leu-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C123H180N32O33S/c1-63(2)51-83(110(177)142-82(46-50-189-9)109(176)149-89(57-96(127)163)118(185)155-101(67(8)158)102(128)169)145-114(181)88(56-72-60-135-76-29-17-16-28-75(72)76)148-108(175)81(43-45-95(126)162)143-121(188)100(65(5)6)154-117(184)87(53-69-25-14-11-15-26-69)147-115(182)90(58-98(165)166)150-107(174)80(42-44-94(125)161)138-103(170)66(7)136-104(171)78(31-21-48-133-122(129)130)139-105(172)79(32-22-49-134-123(131)132)141-120(187)93(62-157)153-116(183)91(59-99(167)168)151-111(178)84(52-64(3)4)144-113(180)86(55-71-36-40-74(160)41-37-71)146-106(173)77(30-18-19-47-124)140-119(186)92(61-156)152-112(179)85(54-70-34-38-73(159)39-35-70)137-97(164)33-20-27-68-23-12-10-13-24-68/h10-17,23-26,28-29,34-41,60,63-67,77-93,100-101,135,156-160H,18-22,27,30-33,42-59,61-62,124H2,1-9H3,(H2,125,161)(H2,126,162)(H2,127,163)(H2,128,169)(H,136,171)(H,137,164)(H,138,170)(H,139,172)(H,140,186)(H,141,187)(H,142,177)(H,143,188)(H,144,180)(H,145,181)(H,146,173)(H,147,182)(H,148,175)(H,149,176)(H,150,174)(H,151,178)(H,152,179)(H,153,183)(H,154,184)(H,155,185)(H,165,166)(H,167,168)(H4,129,130,133)(H4,131,132,134)/t66-,67+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,100-,101-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 21.2n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098572
PNG
(Ac-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C135H198N36O41S/c1-65(2)50-87(118(197)154-86(45-49-213-11)117(196)162-94(57-103(139)182)128(207)170-108(69(8)175)110(140)189)157-122(201)93(56-76-61-147-80-29-19-18-28-79(76)80)161-116(195)85(42-44-102(138)181)155-132(211)107(67(5)6)169-127(206)92(53-73-26-16-13-17-27-73)160-123(202)95(58-104(183)184)163-115(194)84(41-43-101(137)180)150-111(190)68(7)148-112(191)82(31-22-47-145-134(141)142)151-113(192)83(32-23-48-146-135(143)144)153-130(209)99(63-173)167-125(204)97(60-106(187)188)164-119(198)88(51-66(3)4)156-120(199)90(54-74-33-37-77(178)38-34-74)158-114(193)81(30-20-21-46-136)152-129(208)98(62-172)166-121(200)91(55-75-35-39-78(179)40-36-75)159-124(203)96(59-105(185)186)165-131(210)100(64-174)168-133(212)109(70(9)176)171-126(205)89(149-71(10)177)52-72-24-14-12-15-25-72/h12-19,24-29,33-40,61,65-70,81-100,107-109,147,172-176,178-179H,20-23,30-32,41-60,62-64,136H2,1-11H3,(H2,137,180)(H2,138,181)(H2,139,182)(H2,140,189)(H,148,191)(H,149,177)(H,150,190)(H,151,192)(H,152,208)(H,153,209)(H,154,197)(H,155,211)(H,156,199)(H,157,201)(H,158,193)(H,159,203)(H,160,202)(H,161,195)(H,162,196)(H,163,194)(H,164,198)(H,165,210)(H,166,200)(H,167,204)(H,168,212)(H,169,206)(H,170,207)(H,171,205)(H,183,184)(H,185,186)(H,187,188)(H4,141,142,145)(H4,143,144,146)/t68-,69+,70+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,107-,108-,109-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 31n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059358
PNG
(CHEMBL267885 | [des-His1, Tyr6,Glu9] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C148H221N41O48S/c1-69(2)53-95(131(222)171-94(48-52-238-11)130(221)179-102(60-111(154)203)140(231)188-117(73(8)194)120(155)211)174-135(226)101(59-80-63-162-86-24-16-15-23-84(80)86)178-128(219)92(42-46-110(153)202)172-144(235)116(71(5)6)187-138(229)99(55-76-21-13-12-14-22-76)177-136(227)103(61-114(207)208)180-127(218)91(41-45-109(152)201)165-121(212)72(7)164-124(215)88(26-19-50-160-147(156)157)167-125(216)89(27-20-51-161-148(158)159)169-142(233)106(67-192)184-137(228)104(62-115(209)210)181-132(223)96(54-70(3)4)173-133(224)97(56-77-28-34-81(197)35-29-77)175-126(217)87(25-17-18-49-149)168-141(232)105(66-191)183-134(225)98(57-78-30-36-82(198)37-31-78)176-129(220)93(43-47-113(205)206)170-143(234)107(68-193)185-146(237)119(75(10)196)189-139(230)100(58-79-32-38-83(199)39-33-79)182-145(236)118(74(9)195)186-112(204)64-163-123(214)90(40-44-108(151)200)166-122(213)85(150)65-190/h12-16,21-24,28-39,63,69-75,85,87-107,116-119,162,190-199H,17-20,25-27,40-62,64-68,149-150H2,1-11H3,(H2,151,200)(H2,152,201)(H2,153,202)(H2,154,203)(H2,155,211)(H,163,214)(H,164,215)(H,165,212)(H,166,213)(H,167,216)(H,168,232)(H,169,233)(H,170,234)(H,171,222)(H,172,235)(H,173,224)(H,174,226)(H,175,217)(H,176,220)(H,177,227)(H,178,219)(H,179,221)(H,180,218)(H,181,223)(H,182,236)(H,183,225)(H,184,228)(H,185,237)(H,186,204)(H,187,229)(H,188,231)(H,189,230)(H,205,206)(H,207,208)(H,209,210)(H4,156,157,160)(H4,158,159,161)/t72-,73+,74+,75+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059362
PNG
(CHEMBL268636 | [des-His1, des-Phe6, Glu9] glucagon...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C139H212N40O46S/c1-64(2)49-88(123(211)162-87(44-48-226-11)122(210)170-94(55-103(145)192)131(219)178-109(68(8)184)112(146)200)165-127(215)93(54-74-58-153-79-24-16-15-23-77(74)79)169-120(208)85(38-42-102(144)191)163-135(223)108(66(5)6)177-130(218)92(51-71-21-13-12-14-22-71)168-128(216)95(56-106(196)197)171-119(207)84(37-41-101(143)190)156-113(201)67(7)155-116(204)81(26-19-46-151-138(147)148)158-117(205)82(27-20-47-152-139(149)150)160-133(221)98(62-182)174-129(217)96(57-107(198)199)172-124(212)89(50-65(3)4)164-125(213)90(52-72-28-32-75(187)33-29-72)166-118(206)80(25-17-18-45-140)159-132(220)97(61-181)173-126(214)91(53-73-30-34-76(188)35-31-73)167-121(209)86(39-43-105(194)195)161-134(222)99(63-183)175-136(224)111(70(10)186)179-137(225)110(69(9)185)176-104(193)59-154-115(203)83(36-40-100(142)189)157-114(202)78(141)60-180/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,153,180-188H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,192)(H2,146,200)(H,154,203)(H,155,204)(H,156,201)(H,157,202)(H,158,205)(H,159,220)(H,160,221)(H,161,222)(H,162,211)(H,163,223)(H,164,213)(H,165,215)(H,166,206)(H,167,209)(H,168,216)(H,169,208)(H,170,210)(H,171,207)(H,172,212)(H,173,214)(H,174,217)(H,175,224)(H,176,193)(H,177,218)(H,178,219)(H,179,225)(H,194,195)(H,196,197)(H,198,199)(H4,147,148,151)(H4,149,150,152)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059356
PNG
(CHEMBL2369990 | [des-His1, Nle6, Glu9] glucagon-NH...)
Show SMILES CCCCC(NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C148H221N41O47S/c1-70(2)54-95(131(221)171-94(49-53-237-11)130(220)179-102(61-111(154)202)140(230)188-117(74(8)194)120(155)210)174-135(225)101(60-81-64-162-86-29-19-18-28-84(81)86)178-128(218)92(43-47-110(153)201)172-144(234)116(72(5)6)187-138(228)99(56-77-24-14-12-15-25-77)177-136(226)103(62-114(206)207)180-127(217)91(42-46-109(152)200)165-121(211)73(7)164-124(214)88(31-22-51-160-147(156)157)167-125(215)89(32-23-52-161-148(158)159)169-142(232)106(68-192)184-137(227)104(63-115(208)209)181-132(222)96(55-71(3)4)173-133(223)97(58-79-33-37-82(197)38-34-79)175-126(216)87(30-20-21-50-149)168-141(231)105(67-191)183-134(224)98(59-80-35-39-83(198)40-36-80)176-129(219)93(44-48-113(204)205)170-143(233)107(69-193)185-146(236)119(76(10)196)189-139(229)100(57-78-26-16-13-17-27-78)182-145(235)118(75(9)195)186-112(203)65-163-123(213)90(41-45-108(151)199)166-122(212)85(150)66-190/h12-19,24-29,33-40,64,70-76,85,87-107,116-119,162,190-198H,20-23,30-32,41-63,65-69,149-150H2,1-11H3,(H2,151,199)(H2,152,200)(H2,153,201)(H2,154,202)(H2,155,210)(H,163,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,231)(H,169,232)(H,170,233)(H,171,221)(H,172,234)(H,173,223)(H,174,225)(H,175,216)(H,176,219)(H,177,226)(H,178,218)(H,179,220)(H,180,217)(H,181,222)(H,182,235)(H,183,224)(H,184,227)(H,185,236)(H,186,203)(H,187,228)(H,188,230)(H,189,229)(H,204,205)(H,206,207)(H,208,209)(H4,156,157,160)(H4,158,159,161)/t73-,74+,75+,76+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100+,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098570
PNG
(CHEMBL438045 | Ser-Gln-Gly-Thr-Thr-Ser-Glu-Tyr-Ser...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C139H212N40O46S/c1-64(2)49-88(123(211)162-87(44-48-226-11)122(210)170-94(55-103(145)192)131(219)178-109(68(8)184)112(146)200)165-127(215)93(54-74-58-153-79-24-16-15-23-77(74)79)169-120(208)85(38-42-102(144)191)163-135(223)108(66(5)6)177-130(218)92(51-71-21-13-12-14-22-71)168-128(216)95(56-106(196)197)171-119(207)84(37-41-101(143)190)156-113(201)67(7)155-116(204)81(26-19-46-151-138(147)148)158-117(205)82(27-20-47-152-139(149)150)160-133(221)98(62-182)174-129(217)96(57-107(198)199)172-124(212)89(50-65(3)4)164-125(213)90(52-72-28-32-75(187)33-29-72)166-118(206)80(25-17-18-45-140)159-132(220)97(61-181)173-126(214)91(53-73-30-34-76(188)35-31-73)167-121(209)86(39-43-105(194)195)161-134(222)99(63-183)175-136(224)111(70(10)186)179-137(225)110(69(9)185)176-104(193)59-154-115(203)83(36-40-100(142)189)157-114(202)78(141)60-180/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,153,180-188H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,192)(H2,146,200)(H,154,203)(H,155,204)(H,156,201)(H,157,202)(H,158,205)(H,159,220)(H,160,221)(H,161,222)(H,162,211)(H,163,223)(H,164,213)(H,165,215)(H,166,206)(H,167,209)(H,168,216)(H,169,208)(H,170,210)(H,171,207)(H,172,212)(H,173,214)(H,174,217)(H,175,224)(H,176,193)(H,177,218)(H,178,219)(H,179,225)(H,194,195)(H,196,197)(H,198,199)(H4,147,148,151)(H4,149,150,152)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059359
PNG
(CHEMBL411289 | [des-His1, des-Gly4, Glu9] glucagon...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C146H218N40O46S/c1-69(2)54-94(129(217)168-93(49-53-233-11)127(215)176-101(61-110(152)199)138(226)184-115(73(8)191)118(153)206)171-133(221)100(60-80-64-160-85-29-19-18-28-83(80)85)175-125(213)90(42-46-108(150)197)169-142(230)114(71(5)6)183-136(224)98(56-76-24-14-12-15-25-76)174-134(222)102(62-112(202)203)177-124(212)89(41-45-107(149)196)162-119(207)72(7)161-121(209)87(31-22-51-158-145(154)155)164-122(210)88(32-23-52-159-146(156)157)166-140(228)105(67-189)181-135(223)103(63-113(204)205)178-130(218)95(55-70(3)4)170-131(219)96(58-78-33-37-81(194)38-34-78)172-123(211)86(30-20-21-50-147)165-139(227)104(66-188)180-132(220)97(59-79-35-39-82(195)40-36-79)173-126(214)92(44-48-111(200)201)167-141(229)106(68-190)182-144(232)117(75(10)193)186-137(225)99(57-77-26-16-13-17-27-77)179-143(231)116(74(9)192)185-128(216)91(43-47-109(151)198)163-120(208)84(148)65-187/h12-19,24-29,33-40,64,69-75,84,86-106,114-117,160,187-195H,20-23,30-32,41-63,65-68,147-148H2,1-11H3,(H2,149,196)(H2,150,197)(H2,151,198)(H2,152,199)(H2,153,206)(H,161,209)(H,162,207)(H,163,208)(H,164,210)(H,165,227)(H,166,228)(H,167,229)(H,168,217)(H,169,230)(H,170,219)(H,171,221)(H,172,211)(H,173,214)(H,174,222)(H,175,213)(H,176,215)(H,177,212)(H,178,218)(H,179,231)(H,180,220)(H,181,223)(H,182,232)(H,183,224)(H,184,226)(H,185,216)(H,186,225)(H,200,201)(H,202,203)(H,204,205)(H4,154,155,158)(H4,156,157,159)/t72-,73+,74+,75+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,114-,115-,116-,117-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 52n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50087848
PNG
(CHEMBL427644 | c[Asp15, Lys18,] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C154H226N40O47S/c1-75(2)56-101(138(225)175-100(51-55-242-11)137(224)183-108(64-118(161)207)147(234)193-124(79(8)199)127(162)214)178-142(229)107(62-86-67-165-92-31-19-18-30-90(86)92)182-135(222)98(45-49-117(160)206)176-152(239)123(77(5)6)192-145(232)105(58-82-26-14-12-15-27-82)180-136(223)99-46-50-119(208)164-54-25-22-34-93(131(218)168-78(7)128(215)169-97(134(221)174-99)44-48-116(159)205)170-132(219)94(32-20-23-52-155)171-150(237)113(72-197)189-144(231)110(66-122(212)213)184-139(226)102(57-76(3)4)177-140(227)103(60-84-35-39-88(202)40-36-84)179-133(220)95(33-21-24-53-156)172-149(236)112(71-196)188-141(228)104(61-85-37-41-89(203)42-38-85)181-143(230)109(65-121(210)211)185-151(238)114(73-198)190-154(241)126(81(10)201)194-146(233)106(59-83-28-16-13-17-29-83)186-153(240)125(80(9)200)191-120(209)69-166-130(217)96(43-47-115(158)204)173-148(235)111(70-195)187-129(216)91(157)63-87-68-163-74-167-87/h12-19,26-31,35-42,67-68,74-81,91,93-114,123-126,165,195-203H,20-25,32-34,43-66,69-73,155-157H2,1-11H3,(H2,158,204)(H2,159,205)(H2,160,206)(H2,161,207)(H2,162,214)(H,163,167)(H,164,208)(H,166,217)(H,168,218)(H,169,215)(H,170,219)(H,171,237)(H,172,236)(H,173,235)(H,174,221)(H,175,225)(H,176,239)(H,177,227)(H,178,229)(H,179,220)(H,180,223)(H,181,230)(H,182,222)(H,183,224)(H,184,226)(H,185,238)(H,186,240)(H,187,216)(H,188,228)(H,189,231)(H,190,241)(H,191,209)(H,192,232)(H,193,234)(H,194,233)(H,210,211)(H,212,213)/t78-,79-,80-,81-,91+,93-,94-,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105-,106+,107+,108+,109+,110+,111+,112+,113+,114+,123+,124+,125+,126+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 54n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay


J Med Chem 43: 1714-22 (2000)


Article DOI: 10.1021/jm990559d
BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098565
PNG
(Ac-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C115H172N32O33S/c1-56(2)44-76(102(169)134-75(39-43-181-10)101(168)141-82(50-89(119)156)110(177)147-93(60(8)150)94(120)161)137-106(173)81(49-65-53-127-69-23-15-14-22-68(65)69)140-100(167)74(36-38-88(118)155)135-113(180)92(58(5)6)146-109(176)80(46-62-20-12-11-13-21-62)139-107(174)83(51-90(157)158)142-99(166)73(35-37-87(117)154)130-95(162)59(7)128-96(163)71(25-18-41-125-114(121)122)131-97(164)72(26-19-42-126-115(123)124)133-112(179)86(55-149)145-108(175)84(52-91(159)160)143-103(170)77(45-57(3)4)136-105(172)79(48-64-29-33-67(153)34-30-64)138-98(165)70(24-16-17-40-116)132-111(178)85(54-148)144-104(171)78(129-61(9)151)47-63-27-31-66(152)32-28-63/h11-15,20-23,27-34,53,56-60,70-86,92-93,127,148-150,152-153H,16-19,24-26,35-52,54-55,116H2,1-10H3,(H2,117,154)(H2,118,155)(H2,119,156)(H2,120,161)(H,128,163)(H,129,151)(H,130,162)(H,131,164)(H,132,178)(H,133,179)(H,134,169)(H,135,180)(H,136,172)(H,137,173)(H,138,165)(H,139,174)(H,140,167)(H,141,168)(H,142,166)(H,143,170)(H,144,171)(H,145,175)(H,146,176)(H,147,177)(H,157,158)(H,159,160)(H4,121,122,125)(H4,123,124,126)/t59-,60+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,92-,93-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104036
PNG
(CHEMBL414490 | His-Ser-Gln-Cys-Thr-Phe-Thr-Ser-Cys...)
Show InChI InChI=1S/C153H225N43O47S3/c1-72(2)52-97(132(223)175-96(47-51-244-11)131(222)183-104(60-116(159)209)141(232)196-122(78(10)203)151(242)243)178-136(227)103(58-83-63-167-89-29-19-18-28-87(83)89)182-129(220)95(43-46-115(158)208)176-148(239)119(74(5)6)193-139(230)101(54-79-24-14-12-15-25-79)180-137(228)105(61-117(210)211)184-128(219)93(41-44-113(156)206)170-123(214)75(7)169-125(216)91(31-22-49-165-152(160)161)171-126(217)92(32-23-50-166-153(162)163)173-144(235)109(67-199)189-138(229)106(62-118(212)213)185-133(224)98(53-73(3)4)177-134(225)99(56-81-33-37-85(204)38-34-81)179-127(218)90(30-20-21-48-154)172-143(234)108(66-198)188-135(226)100(57-82-35-39-86(205)40-36-82)181-146(237)111-69-245-246-70-112(191-130(221)94(42-45-114(157)207)174-142(233)107(65-197)187-124(215)88(155)59-84-64-164-71-168-84)147(238)195-120(76(8)201)149(240)186-102(55-80-26-16-13-17-27-80)140(231)194-121(77(9)202)150(241)190-110(68-200)145(236)192-111/h12-19,24-29,33-40,63-64,71-78,88,90-112,119-122,167,197-205H,20-23,30-32,41-62,65-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,168)(H,169,216)(H,170,214)(H,171,217)(H,172,234)(H,173,235)(H,174,233)(H,175,223)(H,176,239)(H,177,225)(H,178,227)(H,179,218)(H,180,228)(H,181,237)(H,182,220)(H,183,222)(H,184,219)(H,185,224)(H,186,240)(H,187,215)(H,188,226)(H,189,229)(H,190,241)(H,191,221)(H,192,236)(H,193,230)(H,194,231)(H,195,238)(H,196,232)(H,210,211)(H,212,213)(H,242,243)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,119-,120-,121-,122-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059364
PNG
(CHEMBL2369985 | [des-His1, D-Phe6, Glu9] glucagon-...)
Show SMILES CCCC[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C145H223N41O47S/c1-13-14-27-84(169-142(232)115(73(10)192)183-109(200)63-160-120(210)88(40-44-105(148)196)163-119(209)82(147)64-187)128(218)186-116(74(11)193)143(233)182-104(67-190)140(230)167-91(43-47-110(201)202)126(216)174-96(57-77-34-38-80(195)39-35-77)132(222)180-102(65-188)138(228)165-85(29-20-21-49-146)123(213)173-95(56-76-32-36-79(194)37-33-76)131(221)171-94(54-69(4)5)130(220)179-101(61-112(205)206)135(225)181-103(66-189)139(229)166-87(31-23-51-158-145(155)156)122(212)164-86(30-22-50-157-144(153)154)121(211)161-71(8)118(208)162-89(41-45-106(149)197)124(214)178-100(60-111(203)204)134(224)175-97(55-75-24-16-15-17-25-75)136(226)184-113(70(6)7)141(231)170-90(42-46-107(150)198)125(215)176-98(58-78-62-159-83-28-19-18-26-81(78)83)133(223)172-93(53-68(2)3)129(219)168-92(48-52-234-12)127(217)177-99(59-108(151)199)137(227)185-114(72(9)191)117(152)207/h15-19,24-26,28,32-39,62,68-74,82,84-104,113-116,159,187-195H,13-14,20-23,27,29-31,40-61,63-67,146-147H2,1-12H3,(H2,148,196)(H2,149,197)(H2,150,198)(H2,151,199)(H2,152,207)(H,160,210)(H,161,211)(H,162,208)(H,163,209)(H,164,212)(H,165,228)(H,166,229)(H,167,230)(H,168,219)(H,169,232)(H,170,231)(H,171,221)(H,172,223)(H,173,213)(H,174,216)(H,175,224)(H,176,215)(H,177,217)(H,178,214)(H,179,220)(H,180,222)(H,181,225)(H,182,233)(H,183,200)(H,184,226)(H,185,227)(H,186,218)(H,201,202)(H,203,204)(H,205,206)(H4,153,154,157)(H4,155,156,158)/t71-,72+,73+,74+,82-,84+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-,116-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50104032
PNG
(CHEMBL441011 | His-Cys-Gln-Gly-Thr-Phe-Cys-Ser-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2cnc[nH]2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C152H221N43O47S3/c1-72(2)51-96(132(223)175-95(46-50-243-10)131(222)183-103(59-115(158)206)142(233)195-122(77(9)200)150(241)242)178-137(228)102(57-82-63-166-88-28-18-17-27-86(82)88)182-130(221)94(42-45-114(157)205)176-148(239)120(74(5)6)194-141(232)101(54-79-25-15-12-16-26-79)181-138(229)104(60-117(208)209)184-129(220)93(41-44-113(156)204)170-123(214)75(7)169-126(217)90(30-21-48-164-151(159)160)171-127(218)91(31-22-49-165-152(161)162)173-144(235)108(67-197)189-140(231)106(62-119(212)213)185-133(224)97(52-73(3)4)177-134(225)98(55-80-32-36-84(201)37-33-80)179-128(219)89(29-19-20-47-153)172-143(234)107(66-196)188-135(226)99(56-81-34-38-85(202)39-35-81)180-139(230)105(61-118(210)211)186-145(236)109(68-198)190-147(238)111-70-245-244-69-110(191-124(215)87(154)58-83-64-163-71-168-83)146(237)174-92(40-43-112(155)203)125(216)167-65-116(207)193-121(76(8)199)149(240)187-100(136(227)192-111)53-78-23-13-11-14-24-78/h11-18,23-28,32-39,63-64,71-77,87,89-111,120-122,166,196-202H,19-22,29-31,40-62,65-70,153-154H2,1-10H3,(H2,155,203)(H2,156,204)(H2,157,205)(H2,158,206)(H,163,168)(H,167,216)(H,169,217)(H,170,214)(H,171,218)(H,172,234)(H,173,235)(H,174,237)(H,175,223)(H,176,239)(H,177,225)(H,178,228)(H,179,219)(H,180,230)(H,181,229)(H,182,221)(H,183,222)(H,184,220)(H,185,224)(H,186,236)(H,187,240)(H,188,226)(H,189,231)(H,190,238)(H,191,215)(H,192,227)(H,193,207)(H,194,232)(H,195,233)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 101n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Glucagon receptor binding measured as 50% inhibitory concentration


J Med Chem 44: 3109-16 (2001)


Article DOI: 10.1021/jm010091q
BindingDB Entry DOI: 10.7270/Q2154HR7
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50273753
PNG
((4S,7S,10S,13S,16S,22S)-4-((6S,12S,15S,18S,21S,24S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C152H231N41O43/c1-16-80(10)123(150(235)186-106(62-86-32-19-17-20-33-86)139(224)171-84(14)129(214)181-109(65-89-67-163-94-37-24-23-36-92(89)94)142(227)183-105(61-77(4)5)143(228)191-121(78(6)7)148(233)180-96(38-25-28-56-153)131(216)164-69-115(201)172-95(125(157)210)41-31-59-162-152(158)159)192-138(223)103(50-55-120(208)209)178-136(221)98(39-26-29-57-154)175-127(212)82(12)168-126(211)81(11)170-134(219)101(46-51-113(156)199)174-117(203)71-166-133(218)100(49-54-119(206)207)177-140(225)104(60-76(2)3)182-141(226)107(64-88-42-44-91(198)45-43-88)185-146(231)110(72-194)187-147(232)112(74-196)188-149(234)122(79(8)9)190-137(222)102-47-52-114(200)161-58-30-27-40-97(135(220)184-108(63-87-34-21-18-22-35-87)144(229)193-124(85(15)197)151(236)189-111(73-195)145(230)179-102)173-116(202)70-165-132(217)99(48-53-118(204)205)176-128(213)83(13)169-130(215)93(155)66-90-68-160-75-167-90/h17-24,32-37,42-45,67-68,75-85,93,95-112,121-124,163,194-198H,16,25-31,38-41,46-66,69-74,153-155H2,1-15H3,(H2,156,199)(H2,157,210)(H,160,167)(H,161,200)(H,164,216)(H,165,217)(H,166,218)(H,168,211)(H,169,215)(H,170,219)(H,171,224)(H,172,201)(H,173,202)(H,174,203)(H,175,212)(H,176,213)(H,177,225)(H,178,221)(H,179,230)(H,180,233)(H,181,214)(H,182,226)(H,183,227)(H,184,220)(H,185,231)(H,186,235)(H,187,232)(H,188,234)(H,189,236)(H,190,222)(H,191,228)(H,192,223)(H,193,229)(H,204,205)(H,206,207)(H,208,209)(H4,158,159,162)/t80-,81-,82-,83-,84-,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



University of Texas at Dallas

Curated by ChEMBL


Assay Description
Displacement of [125I]exendin(9-39) from human GLP1R expressed in HEK293 cells


Bioorg Med Chem 16: 10106-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.006
BindingDB Entry DOI: 10.7270/Q2B857ZT
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059365
PNG
(CHEMBL412352 | [des-Phe6, Glu9] glucagon-NH2)
Show InChI InChI=1S/C145H219N43O47S/c1-67(2)49-92(128(220)170-91(44-48-236-11)127(219)178-98(56-108(151)201)136(228)187-114(71(8)193)117(152)209)173-132(224)97(54-77-59-160-83-24-16-15-23-81(77)83)177-125(217)89(38-42-107(150)200)171-141(233)113(69(5)6)186-135(227)96(51-74-21-13-12-14-22-74)176-133(225)99(57-111(205)206)179-124(216)88(37-41-106(149)199)164-118(210)70(7)163-121(213)85(26-19-46-158-144(153)154)165-122(214)86(27-20-47-159-145(155)156)167-139(231)103(64-191)183-134(226)100(58-112(207)208)180-129(221)93(50-68(3)4)172-130(222)94(52-75-28-32-79(196)33-29-75)174-123(215)84(25-17-18-45-146)166-138(230)102(63-190)182-131(223)95(53-76-30-34-80(197)35-31-76)175-126(218)90(39-43-110(203)204)169-140(232)104(65-192)184-142(234)116(73(10)195)188-143(235)115(72(9)194)185-109(202)61-161-120(212)87(36-40-105(148)198)168-137(229)101(62-189)181-119(211)82(147)55-78-60-157-66-162-78/h12-16,21-24,28-35,59-60,66-73,82,84-104,113-116,160,189-197H,17-20,25-27,36-58,61-65,146-147H2,1-11H3,(H2,148,198)(H2,149,199)(H2,150,200)(H2,151,201)(H2,152,209)(H,157,162)(H,161,212)(H,163,213)(H,164,210)(H,165,214)(H,166,230)(H,167,231)(H,168,229)(H,169,232)(H,170,220)(H,171,233)(H,172,222)(H,173,224)(H,174,215)(H,175,218)(H,176,225)(H,177,217)(H,178,219)(H,179,216)(H,180,221)(H,181,211)(H,182,223)(H,183,226)(H,184,234)(H,185,202)(H,186,227)(H,187,228)(H,188,235)(H,203,204)(H,205,206)(H,207,208)(H4,153,154,158)(H4,155,156,159)/t70-,71+,72+,73+,82-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-,116-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 113n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059363
PNG
(CHEMBL437095 | [des-His1,Ala6, Glu9] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C142H217N41O47S/c1-65(2)50-90(126(216)166-89(45-49-231-12)125(215)174-96(56-105(148)196)134(224)182-111(70(9)188)114(149)204)169-130(220)95(55-76-59-156-81-25-17-16-24-79(76)81)173-123(213)87(39-43-104(147)195)167-138(228)110(67(5)6)181-133(223)94(52-73-22-14-13-15-23-73)172-131(221)97(57-108(200)201)175-122(212)86(38-42-103(146)194)160-115(205)68(7)158-119(209)83(27-20-47-154-141(150)151)162-120(210)84(28-21-48-155-142(152)153)164-136(226)100(63-186)178-132(222)98(58-109(202)203)176-127(217)91(51-66(3)4)168-128(218)92(53-74-29-33-77(191)34-30-74)170-121(211)82(26-18-19-46-143)163-135(225)99(62-185)177-129(219)93(54-75-31-35-78(192)36-32-75)171-124(214)88(40-44-107(198)199)165-137(227)101(64-187)179-140(230)113(72(11)190)183-116(206)69(8)159-139(229)112(71(10)189)180-106(197)60-157-118(208)85(37-41-102(145)193)161-117(207)80(144)61-184/h13-17,22-25,29-36,59,65-72,80,82-101,110-113,156,184-192H,18-21,26-28,37-58,60-64,143-144H2,1-12H3,(H2,145,193)(H2,146,194)(H2,147,195)(H2,148,196)(H2,149,204)(H,157,208)(H,158,209)(H,159,229)(H,160,205)(H,161,207)(H,162,210)(H,163,225)(H,164,226)(H,165,227)(H,166,216)(H,167,228)(H,168,218)(H,169,220)(H,170,211)(H,171,214)(H,172,221)(H,173,213)(H,174,215)(H,175,212)(H,176,217)(H,177,219)(H,178,222)(H,179,230)(H,180,197)(H,181,223)(H,182,224)(H,183,206)(H,198,199)(H,200,201)(H,202,203)(H4,150,151,154)(H4,152,153,155)/t68-,69-,70+,71+,72+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,110-,111-,112-,113-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 126n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059360
PNG
(CHEMBL429198 | [des-His1, des-Phe6] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C138H210N40O46S/c1-63(2)47-86(121(209)160-85(42-46-225-11)120(208)168-92(53-102(144)191)130(218)177-108(67(8)183)111(145)199)163-125(213)91(52-73-57-152-78-24-16-15-23-76(73)78)167-119(207)84(38-41-101(143)190)161-134(222)107(65(5)6)176-129(217)90(49-70-21-13-12-14-22-70)166-126(214)93(54-104(193)194)169-118(206)83(37-40-100(142)189)155-112(200)66(7)154-115(203)80(26-19-44-150-137(146)147)157-116(204)81(27-20-45-151-138(148)149)159-132(220)97(61-181)173-128(216)95(56-106(197)198)170-122(210)87(48-64(3)4)162-123(211)88(50-71-28-32-74(186)33-29-71)164-117(205)79(25-17-18-43-139)158-131(219)96(60-180)172-124(212)89(51-72-30-34-75(187)35-31-72)165-127(215)94(55-105(195)196)171-133(221)98(62-182)174-135(223)110(69(10)185)178-136(224)109(68(9)184)175-103(192)58-153-114(202)82(36-39-99(141)188)156-113(201)77(140)59-179/h12-16,21-24,28-35,57,63-69,77,79-98,107-110,152,179-187H,17-20,25-27,36-56,58-62,139-140H2,1-11H3,(H2,141,188)(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,199)(H,153,202)(H,154,203)(H,155,200)(H,156,201)(H,157,204)(H,158,219)(H,159,220)(H,160,209)(H,161,222)(H,162,211)(H,163,213)(H,164,205)(H,165,215)(H,166,214)(H,167,207)(H,168,208)(H,169,206)(H,170,210)(H,171,221)(H,172,212)(H,173,216)(H,174,223)(H,175,192)(H,176,217)(H,177,218)(H,178,224)(H,193,194)(H,195,196)(H,197,198)(H4,146,147,150)(H4,148,149,151)/t66-,67+,68+,69+,77-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,107-,108-,109-,110-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 128n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50087843
PNG
(CHEMBL429724 | c[Asp9, Lys12,] glucagon-NH2)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](CO)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-140(233)106(62-118(213)214)187-131(224)94(42-45-113(156)208)172-125(218)75(7)171-128(221)91(31-22-49-166-152(160)161)173-129(222)92(32-23-50-167-153(162)163)175-147(240)110(69-200)192-141(234)107(63-119(215)216)188-135(228)98(53-73(3)4)179-136(229)99(56-81-33-37-85(205)38-34-81)181-130(223)90-30-20-21-48-165-116(211)61-105(139(232)182-100(57-82-35-39-86(206)40-36-82)137(230)191-109(68-199)146(239)174-90)186-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,232)(H,183,233)(H,184,225)(H,185,226)(H,186,241)(H,187,224)(H,188,228)(H,189,243)(H,190,219)(H,191,230)(H,192,234)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99+,100+,101-,102-,103-,104-,105+,106-,107-,108-,109-,110-,111+,120-,121-,122-,123-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay


J Med Chem 43: 1714-22 (2000)


Article DOI: 10.1021/jm990559d
BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098567
PNG
(CHEMBL439690 | phenylhexanoyl-Tyr-Ser-Lys-Tyr-Leu-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C125H184N32O33S/c1-65(2)53-85(112(179)144-84(48-52-191-9)111(178)151-91(59-98(129)165)120(187)157-103(69(8)160)104(130)171)147-116(183)90(58-74-62-137-78-31-20-19-30-77(74)78)150-110(177)83(45-47-97(128)164)145-123(190)102(67(5)6)156-119(186)89(55-71-28-16-11-17-29-71)149-117(184)92(60-100(167)168)152-109(176)82(44-46-96(127)163)140-105(172)68(7)138-106(173)80(33-23-50-135-124(131)132)141-107(174)81(34-24-51-136-125(133)134)143-122(189)95(64-159)155-118(185)93(61-101(169)170)153-113(180)86(54-66(3)4)146-115(182)88(57-73-38-42-76(162)43-39-73)148-108(175)79(32-21-22-49-126)142-121(188)94(63-158)154-114(181)87(56-72-36-40-75(161)41-37-72)139-99(166)35-18-12-15-27-70-25-13-10-14-26-70/h10-11,13-14,16-17,19-20,25-26,28-31,36-43,62,65-69,79-95,102-103,137,158-162H,12,15,18,21-24,27,32-35,44-61,63-64,126H2,1-9H3,(H2,127,163)(H2,128,164)(H2,129,165)(H2,130,171)(H,138,173)(H,139,166)(H,140,172)(H,141,174)(H,142,188)(H,143,189)(H,144,179)(H,145,190)(H,146,182)(H,147,183)(H,148,175)(H,149,184)(H,150,177)(H,151,178)(H,152,176)(H,153,180)(H,154,181)(H,155,185)(H,156,186)(H,157,187)(H,167,168)(H,169,170)(H4,131,132,135)(H4,133,134,136)/t68-,69+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,102-,103-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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CHEMBL
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UniChem

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Article
PubMed
n/an/a 131n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50087844
PNG
(CHEMBL266411 | c[ Lys12, Asp21] glucagon-NH2)
Show InChI InChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-139(232)105-61-116(211)165-48-21-20-30-90(130(223)181-99(56-81-33-37-85(205)38-34-81)136(229)179-98(53-73(3)4)135(228)187-107(63-119(215)216)141(234)192-110(69-200)147(240)175-92(32-23-50-167-153(162)163)129(222)173-91(31-22-49-166-152(160)161)128(221)171-75(7)125(218)172-94(131(224)186-105)42-45-113(156)208)174-146(239)109(68-199)191-137(230)100(57-82-35-39-86(206)40-36-82)182-140(233)106(62-118(213)214)188-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,233)(H,183,232)(H,184,225)(H,185,226)(H,186,224)(H,187,228)(H,188,241)(H,189,243)(H,190,219)(H,191,230)(H,192,234)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90-,91+,92-,93-,94+,95-,96-,97-,98+,99-,100-,101+,102-,103-,104-,105+,106-,107-,108-,109+,110+,111-,120-,121-,122-,123-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 190n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay


J Med Chem 43: 1714-22 (2000)


Article DOI: 10.1021/jm990559d
BindingDB Entry DOI: 10.7270/Q2XG9RVJ
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50059361
PNG
(CHEMBL439271 | [des-His1, des-Phe6] glucagon)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(O)=O
Show InChI InChI=1S/C138H209N39O47S/c1-63(2)47-86(120(207)159-85(42-46-225-11)119(206)167-92(53-102(144)190)129(216)177-110(69(10)184)136(223)224)162-124(211)91(52-73-57-151-78-24-16-15-23-76(73)78)166-118(205)84(38-41-101(143)189)160-133(220)107(65(5)6)175-128(215)90(49-70-21-13-12-14-22-70)165-125(212)93(54-104(192)193)168-117(204)83(37-40-100(142)188)154-111(198)66(7)153-114(201)80(26-19-44-149-137(145)146)156-115(202)81(27-20-45-150-138(147)148)158-131(218)97(61-180)172-127(214)95(56-106(196)197)169-121(208)87(48-64(3)4)161-122(209)88(50-71-28-32-74(185)33-29-71)163-116(203)79(25-17-18-43-139)157-130(217)96(60-179)171-123(210)89(51-72-30-34-75(186)35-31-72)164-126(213)94(55-105(194)195)170-132(219)98(62-181)173-134(221)109(68(9)183)176-135(222)108(67(8)182)174-103(191)58-152-113(200)82(36-39-99(141)187)155-112(199)77(140)59-178/h12-16,21-24,28-35,57,63-69,77,79-98,107-110,151,178-186H,17-20,25-27,36-56,58-62,139-140H2,1-11H3,(H2,141,187)(H2,142,188)(H2,143,189)(H2,144,190)(H,152,200)(H,153,201)(H,154,198)(H,155,199)(H,156,202)(H,157,217)(H,158,218)(H,159,207)(H,160,220)(H,161,209)(H,162,211)(H,163,203)(H,164,213)(H,165,212)(H,166,205)(H,167,206)(H,168,204)(H,169,208)(H,170,219)(H,171,210)(H,172,214)(H,173,221)(H,174,191)(H,175,215)(H,176,222)(H,177,216)(H,192,193)(H,194,195)(H,196,197)(H,223,224)(H4,145,146,149)(H4,147,148,150)/t66-,67+,68+,69+,77-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,107-,108-,109-,110-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards Glucagon receptor in rat liver plasma membranes by displacement of 125 I-labelled glucagon


J Med Chem 40: 2555-62 (1997)


Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ
More data for this
Ligand-Target Pair
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