BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 234 hits with Last Name = 'aicher' and Initial = 'td'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.79E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in CHO cells after 120 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>2.40E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1D receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(HUMAN)
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>2.97E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1F receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>3.02E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1A receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>3.30E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5T2B receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>3.58E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1B receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>3.98E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells after 120 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens)
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.37E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1E receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>6.31E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of human recombinant 5HT4E receptor expressed in CHO cells after 60 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>6.90E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of human 5HT5A receptor expressed in HEK293 cells after 120 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>7.47E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT2A receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>7.87E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5T2C receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314754
PNG
(CHEMBL1088784 | N-(5-benzyl-4-phenyl-1,3-thiazol-2...)
Show SMILES CCOc1cc(C)c(cc1OCC)C(=O)CCC(=O)Nc1nc(c(Cc2ccccc2)s1)-c1ccccc1
Show InChI InChI=1S/C31H32N2O4S/c1-4-36-26-18-21(3)24(20-27(26)37-5-2)25(34)16-17-29(35)32-31-33-30(23-14-10-7-11-15-23)28(38-31)19-22-12-8-6-9-13-22/h6-15,18,20H,4-5,16-17,19H2,1-3H3,(H,32,33,35)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 8.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314752
PNG
(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H17F6N5O3/c22-20(23,24)12-35-16-7-6-13(10-30-16)18(33)28-8-9-29-19(34)15-11-32(14-4-2-1-3-5-14)31-17(15)21(25,26)27/h1-7,10-11H,8-9,12H2,(H,28,33)(H,29,34)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Show InChI InChI=1S/C22H19N5O4/c1-13-19(8-7-18(14(2)28)21(13)29)30-12-15-3-5-17(6-4-15)31-20-11-16(9-10-23-20)22-24-26-27-25-22/h3-11,29H,12H2,1-2H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314753
PNG
(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES CCOc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-17-9-8-14(12-27-17)19(30)25-10-11-26-20(31)16-13-29(15-6-4-3-5-7-15)28-18(16)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,25,30)(H,26,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314738
PNG
(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccn1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-15-8-6-14(7-9-15)19(30)26-11-12-27-20(31)16-13-29(17-5-3-4-10-25-17)28-18(16)21(22,23)24/h3-10,13H,2,11-12H2,1H3,(H,26,30)(H,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314730
PNG
(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C22H21F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h3-11,14H,2,12-13H2,1H3,(H,26,30)(H,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314752
PNG
(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H17F6N5O3/c22-20(23,24)12-35-16-7-6-13(10-30-16)18(33)28-8-9-29-19(34)15-11-32(14-4-2-1-3-5-14)31-17(15)21(25,26)27/h1-7,10-11H,8-9,12H2,(H,28,33)(H,29,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314737
PNG
(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccc(OCC)c1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-10-8-16(9-11-18)22(32)28-12-13-29-23(33)20-15-31(30-21(20)24(25,26)27)17-6-5-7-19(14-17)35-4-2/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,28,32)(H,29,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314751
PNG
(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(Cl)nc1)-c1ccccc1
Show InChI InChI=1S/C19H15ClF3N5O2/c20-15-7-6-12(10-26-15)17(29)24-8-9-25-18(30)14-11-28(13-4-2-1-3-5-13)27-16(14)19(21,22)23/h1-7,10-11H,8-9H2,(H,24,29)(H,25,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 49n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207410
PNG
(CHEMBL3909995)
Show SMILES CCCc1c(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23N5O4/c1-3-5-20-21(9-8-19(15(2)30)23(20)31)32-14-16-6-4-7-18(12-16)33-22-13-17(10-11-25-22)24-26-28-29-27-24/h4,6-13,31H,3,5,14H2,1-2H3,(H,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 62n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207406
PNG
(CHEMBL3890848)
Show SMILES CCCc1c(OCc2cccc(Oc3cc(ccn3)C(O)=O)c2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23NO6/c1-3-5-20-21(9-8-19(15(2)26)23(20)27)30-14-16-6-4-7-18(12-16)31-22-13-17(24(28)29)10-11-25-22/h4,6-13,27H,3,5,14H2,1-2H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 74n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314730
PNG
(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C22H21F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h3-11,14H,2,12-13H2,1H3,(H,26,30)(H,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 77n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314749
PNG
(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(cc1)-n1cccn1)-c1ccccc1
Show InChI InChI=1S/C23H19F3N6O2/c24-23(25,26)20-19(15-32(30-20)17-5-2-1-3-6-17)22(34)28-13-12-27-21(33)16-7-9-18(10-8-16)31-14-4-11-29-31/h1-11,14-15H,12-13H2,(H,27,33)(H,28,34)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314753
PNG
(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES CCOc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-17-9-8-14(12-27-17)19(30)25-10-11-26-20(31)16-13-29(15-6-4-3-5-7-15)28-18(16)21(22,23)24/h3-9,12-13H,2,10-11H2,1H3,(H,25,30)(H,26,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314738
PNG
(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccn1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-32-15-8-6-14(7-9-15)19(30)26-11-12-27-20(31)16-13-29(17-5-3-4-10-25-17)28-18(16)21(22,23)24/h3-10,13H,2,11-12H2,1H3,(H,26,30)(H,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 91n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314734
PNG
(1-(4-Chlorophenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClF3N4O3/c1-2-33-17-9-3-14(4-10-17)20(31)27-11-12-28-21(32)18-13-30(29-19(18)22(24,25)26)16-7-5-15(23)6-8-16/h3-10,13H,2,11-12H2,1H3,(H,27,31)(H,28,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 94n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314741
PNG
(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1O
Show InChI InChI=1S/C22H21F3N4O4/c1-2-33-15-9-7-14(8-10-15)20(31)26-11-12-27-21(32)16-13-29(28-19(16)22(23,24)25)17-5-3-4-6-18(17)30/h3-10,13,30H,2,11-12H2,1H3,(H,26,31)(H,27,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 98n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207398
PNG
(CHEMBL3965244)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)c(c1O)C(F)(F)F
Show InChI InChI=1S/C22H16F3N5O4/c1-12(31)16-5-6-17(19(20(16)32)22(23,24)25)33-11-13-3-2-4-15(9-13)34-18-10-14(7-8-26-18)21-27-29-30-28-21/h2-10,32H,11H2,1H3,(H,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 112n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207404
PNG
(CHEMBL3935529)
Show SMILES CCCc1c(OCc2ccc(Oc3ccc(cn3)C(O)=O)cc2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23NO6/c1-3-4-20-21(11-10-19(15(2)26)23(20)27)30-14-16-5-8-18(9-6-16)31-22-12-7-17(13-25-22)24(28)29/h5-13,27H,3-4,14H2,1-2H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 132n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314736
PNG
(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccc(OCC)cc1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-9-5-16(6-10-18)22(32)28-13-14-29-23(33)20-15-31(30-21(20)24(25,26)27)17-7-11-19(12-8-17)35-4-2/h5-12,15H,3-4,13-14H2,1-2H3,(H,28,32)(H,29,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207411
PNG
(CHEMBL3973048)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(c1O)C(F)(F)F
Show InChI InChI=1S/C22H16F3N5O4/c1-12(31)16-6-7-17(19(20(16)32)22(23,24)25)33-11-13-3-2-4-15(9-13)34-18-8-5-14(10-26-18)21-27-29-30-28-21/h2-10,32H,11H2,1H3,(H,27,28,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 144n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207399
PNG
(CHEMBL3913281)
Show SMILES CCCc1c(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23N5O4/c1-3-4-20-21(10-9-19(15(2)30)23(20)31)32-14-16-5-7-18(8-6-16)33-22-13-17(11-12-25-22)24-26-28-29-27-24/h5-13,31H,3-4,14H2,1-2H3,(H,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207405
PNG
(CHEMBL3918914)
Show SMILES CCCc1c(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23N5O4/c1-3-5-20-21(10-9-19(15(2)30)23(20)31)32-14-16-6-4-7-18(12-16)33-22-11-8-17(13-25-22)24-26-28-29-27-24/h4,6-13,31H,3,5,14H2,1-2H3,(H,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 203n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314733
PNG
(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C22H27F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h8-11,14,16H,2-7,12-13H2,1H3,(H,26,30)(H,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314732
PNG
(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-3-29-19-11-9-17(10-12-19)21(27)23-13-14-24-22(28)20-15-26(25-16(20)2)18-7-5-4-6-8-18/h4-12,15H,3,13-14H2,1-2H3,(H,23,27)(H,24,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207413
PNG
(CHEMBL3945882)
Show SMILES CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23N5O4/c1-3-5-19-21(12-11-18(15(2)30)22(19)31)32-14-16-7-9-17(10-8-16)33-24-20(6-4-13-25-24)23-26-28-29-27-23/h4,6-13,31H,3,5,14H2,1-2H3,(H,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207397
PNG
(CHEMBL3927834)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)c(Cl)c1O
Show InChI InChI=1S/C21H16ClN5O4/c1-12(28)16-5-6-17(19(22)20(16)29)30-11-13-3-2-4-15(9-13)31-18-10-14(7-8-23-18)21-24-26-27-25-21/h2-10,29H,11H2,1H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 342n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207403
PNG
(CHEMBL3911282)
Show SMILES CCCc1c(OCc2ccc(Oc3ccc(cn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23N5O4/c1-3-4-20-21(11-10-19(15(2)30)23(20)31)32-14-16-5-8-18(9-6-16)33-22-12-7-17(13-25-22)24-26-28-29-27-24/h5-13,31H,3-4,14H2,1-2H3,(H,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 346n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314751
PNG
(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(Cl)nc1)-c1ccccc1
Show InChI InChI=1S/C19H15ClF3N5O2/c20-15-7-6-12(10-26-15)17(29)24-8-9-25-18(30)14-11-28(13-4-2-1-3-5-13)27-16(14)19(21,22)23/h1-7,10-11H,8-9H2,(H,24,29)(H,25,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314736
PNG
(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccc(OCC)cc1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-9-5-16(6-10-18)22(32)28-13-14-29-23(33)20-15-31(30-21(20)24(25,26)27)17-7-11-19(12-8-17)35-4-2/h5-12,15H,3-4,13-14H2,1-2H3,(H,28,32)(H,29,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207402
PNG
(CHEMBL3980125)
Show SMILES CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23N5O4/c1-3-6-19-21(11-10-18(15(2)30)22(19)31)32-14-16-7-4-8-17(13-16)33-24-20(9-5-12-25-24)23-26-28-29-27-23/h4-5,7-13,31H,3,6,14H2,1-2H3,(H,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314749
PNG
(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Show SMILES FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c1ccc(cc1)-n1cccn1)-c1ccccc1
Show InChI InChI=1S/C23H19F3N6O2/c24-23(25,26)20-19(15-32(30-20)17-5-2-1-3-6-17)22(34)28-13-12-27-21(33)16-7-9-18(10-8-16)31-14-4-11-29-31/h1-11,14-15H,12-13H2,(H,27,33)(H,28,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207407
PNG
(CHEMBL3936830)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(Cl)c1O
Show InChI InChI=1S/C21H16ClN5O4/c1-12(28)16-6-7-17(19(22)20(16)29)30-11-13-3-2-4-15(9-13)31-18-8-5-14(10-23-18)21-24-26-27-25-21/h2-10,29H,11H2,1H3,(H,24,25,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 475n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(HUMAN)
BDBM50207412
PNG
(CHEMBL3920609)
Show SMILES CCCc1c(OCc2ccc(Oc3cccc(c3)-c3nn[nH]n3)nc2)ccc(C(C)=O)c1O
Show InChI InChI=1S/C24H23N5O4/c1-3-5-20-21(10-9-19(15(2)30)23(20)31)32-14-16-8-11-22(25-13-16)33-18-7-4-6-17(12-18)24-26-28-29-27-24/h4,6-13,31H,3,5,14H2,1-2H3,(H,26,27,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 484n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314737
PNG
(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1cccc(OCC)c1
Show InChI InChI=1S/C24H25F3N4O4/c1-3-34-18-10-8-16(9-11-18)22(32)28-12-13-29-23(33)20-15-31(30-21(20)24(25,26)27)17-6-5-7-19(14-17)35-4-2/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,28,32)(H,29,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314741
PNG
(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1O
Show InChI InChI=1S/C22H21F3N4O4/c1-2-33-15-9-7-14(8-10-15)20(31)26-11-12-27-21(32)16-13-29(28-19(16)22(23,24)25)17-5-3-4-6-18(17)30/h3-10,13,30H,2,11-12H2,1H3,(H,26,31)(H,27,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 610n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))
BDBM50314733
PNG
(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C22H27F3N4O3/c1-2-32-17-10-8-15(9-11-17)20(30)26-12-13-27-21(31)18-14-29(16-6-4-3-5-7-16)28-19(18)22(23,24)25/h8-11,14,16H,2-7,12-13H2,1H3,(H,26,30)(H,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 650n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50314732
PNG
(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Show SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-3-29-19-11-9-17(10-12-19)21(27)23-13-14-24-22(28)20-15-26(25-16(20)2)18-7-5-4-6-8-18/h4-12,15H,3,13-14H2,1-2H3,(H,23,27)(H,24,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 650n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis


Bioorg Med Chem 18: 2785-95 (2010)


Article DOI: 10.1016/j.bmc.2010.01.067
BindingDB Entry DOI: 10.7270/Q23N23J8
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 234 total )  |  Next  |  Last  >>
Jump to: