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Compile Data Set for Download or QSAR

Found 127 hits with Last Name = 'akama' and Initial = 't'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-tRNA synthetase, cytoplasmic


(Saccharomyces cerevisiae S288c)
BDBM50370987
PNG
(TAVABOROLE)
Show SMILES OB1OCc2cc(F)ccc12
Show InChI InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
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Article
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1.85E+3n/an/an/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase after 20 mins


Science 316: 1759-1761 (2007)


Article DOI: 10.1126/science.1142189
BindingDB Entry DOI: 10.7270/Q2P84CQ2
More data for this
Ligand-Target Pair
Leucyl-tRNA synthetase, cytoplasmic


(Saccharomyces cerevisiae S288c)
BDBM50370987
PNG
(TAVABOROLE)
Show SMILES OB1OCc2cc(F)ccc12
Show InChI InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
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3.14E+4n/an/an/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase after 2 mins


Science 316: 1759-1761 (2007)


Article DOI: 10.1126/science.1142189
BindingDB Entry DOI: 10.7270/Q2P84CQ2
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (human))
BDBM258601
PNG
(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-i...)
Show SMILES CC(C)c1c2B(O)OCc2ccc1Oc1ccc(CN)cc1Cl
Show InChI InChI=1S/C17H19BClNO3/c1-10(2)16-15(6-4-12-9-22-18(21)17(12)16)23-14-5-3-11(8-20)7-13(14)19/h3-7,10,21H,8-9,20H2,1-2H3
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n/an/a 0.0550n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1


(Homo sapiens (human))
BDBM258601
PNG
(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-i...)
Show SMILES CC(C)c1c2B(O)OCc2ccc1Oc1ccc(CN)cc1Cl
Show InChI InChI=1S/C17H19BClNO3/c1-10(2)16-15(6-4-12-9-22-18(21)17(12)16)23-14-5-3-11(8-20)7-13(14)19/h3-7,10,21H,8-9,20H2,1-2H3
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n/an/a 0.195n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120866
PNG
(US8716478, D253 | US9499570, D253)
Show SMILES CC(=O)CCCOc1nc(Oc2ccc3B(O)OCc3c2)c(cc1Cl)C#N
Show InChI InChI=1S/C18H16BClN2O5/c1-11(23)3-2-6-25-18-16(20)8-12(9-21)17(22-18)27-14-4-5-15-13(7-14)10-26-19(15)24/h4-5,7-8,24H,2-3,6,10H2,1H3
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n/an/a 0.25n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120866
PNG
(US8716478, D253 | US9499570, D253)
Show SMILES CC(=O)CCCOc1nc(Oc2ccc3B(O)OCc3c2)c(cc1Cl)C#N
Show InChI InChI=1S/C18H16BClN2O5/c1-11(23)3-2-6-25-18-16(20)8-12(9-21)17(22-18)27-14-4-5-15-13(7-14)10-26-19(15)24/h4-5,7-8,24H,2-3,6,10H2,1H3
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n/an/a 0.25n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120845
PNG
(US8716478, D231 | US9499570, D231)
Show SMILES CC(=O)CCCOc1nc(Oc2ccc3B(O)OCc3c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H16BClN2O5/c1-11(23)3-2-6-25-17-12(9-21)8-16(20)18(22-17)27-14-4-5-15-13(7-14)10-26-19(15)24/h4-5,7-8,24H,2-3,6,10H2,1H3
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n/an/a 0.800n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120845
PNG
(US8716478, D231 | US9499570, D231)
Show SMILES CC(=O)CCCOc1nc(Oc2ccc3B(O)OCc3c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H16BClN2O5/c1-11(23)3-2-6-25-17-12(9-21)8-16(20)18(22-17)27-14-4-5-15-13(7-14)10-26-19(15)24/h4-5,7-8,24H,2-3,6,10H2,1H3
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n/an/a 0.800n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120855
PNG
(US8716478, D241 | US9499570, D241)
Show SMILES CC(C)OCCOc1nc(Oc2ccc3B(O)OCc3c2)cc(c1C#N)C(F)(F)F
Show InChI InChI=1S/C19H18BF3N2O5/c1-11(2)27-5-6-28-18-14(9-24)15(19(21,22)23)8-17(25-18)30-13-3-4-16-12(7-13)10-29-20(16)26/h3-4,7-8,11,26H,5-6,10H2,1-2H3
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n/an/a 1.10n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120855
PNG
(US8716478, D241 | US9499570, D241)
Show SMILES CC(C)OCCOc1nc(Oc2ccc3B(O)OCc3c2)cc(c1C#N)C(F)(F)F
Show InChI InChI=1S/C19H18BF3N2O5/c1-11(2)27-5-6-28-18-14(9-24)15(19(21,22)23)8-17(25-18)30-13-3-4-16-12(7-13)10-29-20(16)26/h3-4,7-8,11,26H,5-6,10H2,1-2H3
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n/an/a 1.10n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120853
PNG
(US8716478, D239 | US9499570, D239)
Show SMILES OB1OCc2cc(Oc3nc(OCCOC4CC4)c(cc3Cl)C#N)ccc12
Show InChI InChI=1S/C18H16BClN2O5/c20-16-8-11(9-21)17(25-6-5-24-13-1-2-13)22-18(16)27-14-3-4-15-12(7-14)10-26-19(15)23/h3-4,7-8,13,23H,1-2,5-6,10H2
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n/an/a 1.30n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120860
PNG
(US8716478, D246 | US9499570, D246)
Show SMILES CC(=O)CCCOc1nc(Oc2cc3COB(O)c3c(C)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C19H18BClN2O5/c1-11-6-15(7-14-10-27-20(25)17(11)14)28-19-16(21)8-13(9-22)18(23-19)26-5-3-4-12(2)24/h6-8,25H,3-5,10H2,1-2H3
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n/an/a 1.30n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120853
PNG
(US8716478, D239 | US9499570, D239)
Show SMILES OB1OCc2cc(Oc3nc(OCCOC4CC4)c(cc3Cl)C#N)ccc12
Show InChI InChI=1S/C18H16BClN2O5/c20-16-8-11(9-21)17(25-6-5-24-13-1-2-13)22-18(16)27-14-3-4-15-12(7-14)10-26-19(15)23/h3-4,7-8,13,23H,1-2,5-6,10H2
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n/an/a 1.30n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120860
PNG
(US8716478, D246 | US9499570, D246)
Show SMILES CC(=O)CCCOc1nc(Oc2cc3COB(O)c3c(C)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C19H18BClN2O5/c1-11-6-15(7-14-10-27-20(25)17(11)14)28-19-16(21)8-13(9-22)18(23-19)26-5-3-4-12(2)24/h6-8,25H,3-5,10H2,1-2H3
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n/an/a 1.30n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120862
PNG
(US8716478, D248 | US9499570, D248)
Show SMILES CC(=O)CCCOc1nc(Oc2cc3COB(O)c3c(F)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H15BClFN2O5/c1-10(24)3-2-4-26-17-11(8-22)6-14(20)18(23-17)28-13-5-12-9-27-19(25)16(12)15(21)7-13/h5-7,25H,2-4,9H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120862
PNG
(US8716478, D248 | US9499570, D248)
Show SMILES CC(=O)CCCOc1nc(Oc2cc3COB(O)c3c(F)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H15BClFN2O5/c1-10(24)3-2-4-26-17-11(8-22)6-14(20)18(23-17)28-13-5-12-9-27-19(25)16(12)15(21)7-13/h5-7,25H,2-4,9H2,1H3
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n/an/a 1.70n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 1.79n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120859
PNG
(US8716478, D245 | US9499570, D245)
Show SMILES CC(C)OCCOc1nc(Oc2cc3COB(O)c3c(C)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C19H20BClN2O5/c1-11(2)25-4-5-26-18-13(9-22)8-16(21)19(23-18)28-15-6-12(3)17-14(7-15)10-27-20(17)24/h6-8,11,24H,4-5,10H2,1-3H3
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n/an/a 2n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120859
PNG
(US8716478, D245 | US9499570, D245)
Show SMILES CC(C)OCCOc1nc(Oc2cc3COB(O)c3c(C)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C19H20BClN2O5/c1-11(2)25-4-5-26-18-13(9-22)8-16(21)19(23-18)28-15-6-12(3)17-14(7-15)10-27-20(17)24/h6-8,11,24H,4-5,10H2,1-3H3
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Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120856
PNG
(US8716478, D242 | US9499570, D242)
Show SMILES CC(=O)CCCOc1nc(Oc2ccc3B(O)OCc3c2)cc(c1C#N)C(F)(F)F
Show InChI InChI=1S/C19H16BF3N2O5/c1-11(26)3-2-6-28-18-14(9-24)15(19(21,22)23)8-17(25-18)30-13-4-5-16-12(7-13)10-29-20(16)27/h4-5,7-8,27H,2-3,6,10H2,1H3
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n/an/a 2.20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120856
PNG
(US8716478, D242 | US9499570, D242)
Show SMILES CC(=O)CCCOc1nc(Oc2ccc3B(O)OCc3c2)cc(c1C#N)C(F)(F)F
Show InChI InChI=1S/C19H16BF3N2O5/c1-11(26)3-2-6-28-18-14(9-24)15(19(21,22)23)8-17(25-18)30-13-4-5-16-12(7-13)10-29-20(16)27/h4-5,7-8,27H,2-3,6,10H2,1H3
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n/an/a 2.20n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM255615
PNG
(US9499570, D141)
Show SMILES CC(=O)CCCOc1nc(Oc2ccc3B(O)OCc3c2)ccc1C#N
Show InChI InChI=1S/C18H17BN2O5/c1-12(22)3-2-8-24-18-13(10-20)4-7-17(21-18)26-15-5-6-16-14(9-15)11-25-19(16)23/h4-7,9,23H,2-3,8,11H2,1H3
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n/an/a 3.10n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (human))
BDBM258600
PNG
(US9493490, 6-(3-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CN)c1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-12(6-5-11-8-20-16(19)14(9)11)21-13-4-2-3-10(7-18)15(13)17/h2-6,19H,7-8,18H2,1H3
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n/an/a 3.38n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1


(Homo sapiens (human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 3.62n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (human))
BDBM258601
PNG
(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-i...)
Show SMILES CC(C)c1c2B(O)OCc2ccc1Oc1ccc(CN)cc1Cl
Show InChI InChI=1S/C17H19BClNO3/c1-10(2)16-15(6-4-12-9-22-18(21)17(12)16)23-14-5-3-11(8-20)7-13(14)19/h3-7,10,21H,8-9,20H2,1-2H3
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n/an/a 4.22n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1


(Homo sapiens (human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1


(Homo sapiens (human))
BDBM258600
PNG
(US9493490, 6-(3-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CN)c1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-12(6-5-11-8-20-16(19)14(9)11)21-13-4-2-3-10(7-18)15(13)17/h2-6,19H,7-8,18H2,1H3
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n/an/a 5.19n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120844
PNG
(US8716478, D230 | US8716478, D238 | US9499570, D23...)
Show SMILES CC(C)OCCOc1nc(Oc2ccc3B(O)OCc3c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H18BClN2O5/c1-11(2)24-5-6-25-17-12(9-21)8-16(20)18(22-17)27-14-3-4-15-13(7-14)10-26-19(15)23/h3-4,7-8,11,23H,5-6,10H2,1-2H3
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n/an/a 5.20n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120844
PNG
(US8716478, D230 | US8716478, D238 | US9499570, D23...)
Show SMILES CC(C)OCCOc1nc(Oc2ccc3B(O)OCc3c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H18BClN2O5/c1-11(2)24-5-6-25-17-12(9-21)8-16(20)18(22-17)27-14-3-4-15-13(7-14)10-26-19(15)23/h3-4,7-8,11,23H,5-6,10H2,1-2H3
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Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (human))
BDBM258596
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3
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n/an/a 6.09n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120857
PNG
(US8716478, D243 | US9499570, D243)
Show SMILES CC(C)OCCOc1nc(Oc2ccc3B(O)OCc3c2)c(cc1C#N)C#N
Show InChI InChI=1S/C19H18BN3O5/c1-12(2)25-5-6-26-18-13(9-21)7-14(10-22)19(23-18)28-16-3-4-17-15(8-16)11-27-20(17)24/h3-4,7-8,12,24H,5-6,11H2,1-2H3
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Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120857
PNG
(US8716478, D243 | US9499570, D243)
Show SMILES CC(C)OCCOc1nc(Oc2ccc3B(O)OCc3c2)c(cc1C#N)C#N
Show InChI InChI=1S/C19H18BN3O5/c1-12(2)25-5-6-26-18-13(9-21)7-14(10-22)19(23-18)28-16-3-4-17-15(8-16)11-27-20(17)24/h3-4,7-8,12,24H,5-6,11H2,1-2H3
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Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (human))
BDBM258599
PNG
(US9493490, Example 11 | US9493490, L | US9493490, ...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CNC(=O)OC(C)(C)C)c1F
Show InChI InChI=1S/C20H23BFNO5/c1-12-15(9-8-14-11-26-21(25)17(12)14)27-16-7-5-6-13(18(16)22)10-23-19(24)28-20(2,3)4/h5-9,25H,10-11H2,1-4H3,(H,23,24)
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n/an/a 7.88n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1


(Homo sapiens (human))
BDBM258596
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3
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n/an/a 8.31n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM255614
PNG
(US9499570, D140)
Show SMILES CC(C)OCCOc1nc(Oc2ccc3B(O)OCc3c2)ccc1C#N
Show InChI InChI=1S/C18H19BN2O5/c1-12(2)23-7-8-24-18-13(10-20)3-6-17(21-18)26-15-4-5-16-14(9-15)11-25-19(16)22/h3-6,9,12,22H,7-8,11H2,1-2H3
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n/an/a 9n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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n/an/a 9.25n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM258601
PNG
(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-i...)
Show SMILES CC(C)c1c2B(O)OCc2ccc1Oc1ccc(CN)cc1Cl
Show InChI InChI=1S/C17H19BClNO3/c1-10(2)16-15(6-4-12-9-22-18(21)17(12)16)23-14-5-3-11(8-20)7-13(14)19/h3-7,10,21H,8-9,20H2,1-2H3
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n/an/a 10.8n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 10.9n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens (human))
BDBM258597
PNG
(US9493490, Example 9 | US9493490, F)
Show SMILES C[C@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m0/s1
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n/an/a 11.0n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 13.9n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 15.6n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1


(Homo sapiens (human))
BDBM258597
PNG
(US9493490, Example 9 | US9493490, F)
Show SMILES C[C@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m0/s1
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n/an/a 17.2n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM120861
PNG
(US8716478, D247 | US9499570, D247)
Show SMILES CC(C)OCCOc1nc(Oc2cc3COB(O)c3c(F)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H17BClFN2O5/c1-10(2)25-3-4-26-17-11(8-22)6-14(20)18(23-17)28-13-5-12-9-27-19(24)16(12)15(21)7-13/h5-7,10,24H,3-4,9H2,1-2H3
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n/an/a 19n/an/an/an/a7.537



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US8716478 (2014)


BindingDB Entry DOI: 10.7270/Q2Z60MQ7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM120861
PNG
(US8716478, D247 | US9499570, D247)
Show SMILES CC(C)OCCOc1nc(Oc2cc3COB(O)c3c(F)c2)c(Cl)cc1C#N
Show InChI InChI=1S/C18H17BClFN2O5/c1-10(2)25-3-4-26-17-11(8-22)6-14(20)18(23-17)28-13-5-12-9-27-19(24)16(12)15(21)7-13/h5-7,10,24H,3-4,9H2,1-2H3
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n/an/a 19n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...


US Patent US9499570 (2016)


BindingDB Entry DOI: 10.7270/Q2CZ363N
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258594
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)ben...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2)c(F)c1
Show InChI InChI=1S/C15H15BFNO3/c1-9(18)10-3-5-15(14(17)6-10)21-12-4-2-11-8-20-16(19)13(11)7-12/h2-7,9,19H,8,18H2,1H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM258594
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)ben...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2)c(F)c1
Show InChI InChI=1S/C15H15BFNO3/c1-9(18)10-3-5-15(14(17)6-10)21-12-4-2-11-8-20-16(19)13(11)7-12/h2-7,9,19H,8,18H2,1H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM258596
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
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