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Compile Data Set for Download or QSAR

Found 152 hits with Last Name = 'akasaka' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047595
PNG
(1-Butyl-3-{2-[3-(5-isopropyl-4-phenyl-imidazol-1-y...)
Show SMILES CCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C(C)C)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-5-6-16-28-27(32)30-24-21(4)12-10-15-23(24)33-18-11-17-31-19-29-25(26(31)20(2)3)22-13-8-7-9-14-22/h7-10,12-15,19-20H,5-6,11,16-18H2,1-4H3,(H2,28,30,32)
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n/an/a 12n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047599
PNG
(1-{2-[3-(5-Methyl-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1SC
Show InChI InChI=1S/C26H34N4O2S/c1-4-5-9-16-27-26(31)29-25-22(14-10-15-23(25)33-3)32-18-11-17-30-19-28-24(20(30)2)21-12-7-6-8-13-21/h6-8,10,12-15,19H,4-5,9,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 19n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047534
PNG
(1-{2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propo...)
Show SMILES CC(C)CCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C(C)C)-c1ccccc1
Show InChI InChI=1S/C28H38N4O2/c1-20(2)15-16-29-28(33)31-25-22(5)11-9-14-24(25)34-18-10-17-32-19-30-26(27(32)21(3)4)23-12-7-6-8-13-23/h6-9,11-14,19-21H,10,15-18H2,1-5H3,(H2,29,31,33)
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n/an/a 19n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047585
PNG
(1-{2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propo...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C(C)C)-c1ccccc1
Show InChI InChI=1S/C28H38N4O2/c1-5-6-10-17-29-28(33)31-25-22(4)13-11-16-24(25)34-19-12-18-32-20-30-26(27(32)21(2)3)23-14-8-7-9-15-23/h7-9,11,13-16,20-21H,5-6,10,12,17-19H2,1-4H3,(H2,29,31,33)
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n/an/a 31n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047499
PNG
(1-{2-Dimethylamino-6-[3-(5-methyl-4-phenyl-imidazo...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1N(C)C
Show InChI InChI=1S/C27H37N5O2/c1-5-6-10-17-28-27(33)30-26-23(31(3)4)15-11-16-24(26)34-19-12-18-32-20-29-25(21(32)2)22-13-8-7-9-14-22/h7-9,11,13-16,20H,5-6,10,12,17-19H2,1-4H3,(H2,28,30,33)
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n/an/a 43n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047597
PNG
(1-{2-Ethyl-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)-...)
Show SMILES CCCCCNC(=O)Nc1c(CC)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-4-6-10-17-28-27(32)30-26-22(5-2)15-11-16-24(26)33-19-12-18-31-20-29-25(21(31)3)23-13-8-7-9-14-23/h7-9,11,13-16,20H,4-6,10,12,17-19H2,1-3H3,(H2,28,30,32)
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n/an/a 44n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047589
PNG
(1-{2-[3-(5-Methyl-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1[N+]([O-])=O
Show InChI InChI=1S/C25H31N5O4/c1-3-4-8-15-26-25(31)28-24-21(30(32)33)13-9-14-22(24)34-17-10-16-29-18-27-23(19(29)2)20-11-6-5-7-12-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,26,28,31)
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n/an/a 44n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047544
PNG
(1-{2-Isopropyl-6-[3-(5-methyl-4-phenyl-imidazol-1-...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1C(C)C
Show InChI InChI=1S/C28H38N4O2/c1-5-6-10-17-29-28(33)31-27-24(21(2)3)15-11-16-25(27)34-19-12-18-32-20-30-26(22(32)4)23-13-8-7-9-14-23/h7-9,11,13-16,20-21H,5-6,10,12,17-19H2,1-4H3,(H2,29,31,33)
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n/an/a 45n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047546
PNG
(1-{2-[3-(5-Chloro-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES Cc1cccc(OCCCn2cnc(c2Cl)-c2ccccc2)c1NC(=O)NCC(C)(C)C
Show InChI InChI=1S/C25H31ClN4O2/c1-18-10-8-13-20(21(18)29-24(31)27-16-25(2,3)4)32-15-9-14-30-17-28-22(23(30)26)19-11-6-5-7-12-19/h5-8,10-13,17H,9,14-16H2,1-4H3,(H2,27,29,31)
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n/an/a 48n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047588
PNG
(1-Butyl-3-{2-methyl-6-[3-(4-phenyl-imidazol-1-yl)-...)
Show SMILES CCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1)-c1ccccc1
Show InChI InChI=1S/C24H30N4O2/c1-3-4-14-25-24(29)27-23-19(2)10-8-13-22(23)30-16-9-15-28-17-21(26-18-28)20-11-6-5-7-12-20/h5-8,10-13,17-18H,3-4,9,14-16H2,1-2H3,(H2,25,27,29)
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n/an/a 48n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047558
PNG
(1-{2-[3-(5-Chloro-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1Cl)-c1ccccc1
Show InChI InChI=1S/C25H31ClN4O2/c1-3-4-8-15-27-25(31)29-22-19(2)11-9-14-21(22)32-17-10-16-30-18-28-23(24(30)26)20-12-6-5-7-13-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,27,29,31)
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n/an/a 49n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047587
PNG
(1-{2-Methyl-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4O2/c1-4-5-9-16-27-26(31)29-24-20(2)12-10-15-23(24)32-18-11-17-30-19-28-25(21(30)3)22-13-7-6-8-14-22/h6-8,10,12-15,19H,4-5,9,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 50n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047539
PNG
(1-{2-Methanesulfonyl-6-[3-(5-methyl-4-phenyl-imida...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1S(C)(=O)=O
Show InChI InChI=1S/C26H34N4O4S/c1-4-5-9-16-27-26(31)29-25-22(14-10-15-23(25)35(3,32)33)34-18-11-17-30-19-28-24(20(30)2)21-12-7-6-8-13-21/h6-8,10,12-15,19H,4-5,9,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 50n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047582
PNG
(3-{3-[3-Methyl-2-(3-pentyl-ureido)-phenoxy]-propyl...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C(=O)OCC)-c1ccccc1
Show InChI InChI=1S/C28H36N4O4/c1-4-6-10-17-29-28(34)31-24-21(3)13-11-16-23(24)36-19-12-18-32-20-30-25(22-14-8-7-9-15-22)26(32)27(33)35-5-2/h7-9,11,13-16,20H,4-6,10,12,17-19H2,1-3H3,(H2,29,31,34)
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n/an/a 55n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047561
PNG
(1-Butyl-3-{2-[3-(5-chloro-4-phenyl-imidazol-1-yl)-...)
Show SMILES CCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1Cl)-c1ccccc1
Show InChI InChI=1S/C24H29ClN4O2/c1-3-4-14-26-24(30)28-21-18(2)10-8-13-20(21)31-16-9-15-29-17-27-22(23(29)25)19-11-6-5-7-12-19/h5-8,10-13,17H,3-4,9,14-16H2,1-2H3,(H2,26,28,30)
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n/an/a 55n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047589
PNG
(1-{2-[3-(5-Methyl-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1[N+]([O-])=O
Show InChI InChI=1S/C25H31N5O4/c1-3-4-8-15-26-25(31)28-24-21(30(32)33)13-9-14-22(24)34-17-10-16-29-18-27-23(19(29)2)20-11-6-5-7-12-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,26,28,31)
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n/an/a 60n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047579
PNG
(1-{2-Methyl-6-[3-(4-phenyl-5-propyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1CCC)-c1ccccc1
Show InChI InChI=1S/C28H38N4O2/c1-4-6-10-18-29-28(33)31-26-22(3)14-11-17-25(26)34-20-12-19-32-21-30-27(24(32)13-5-2)23-15-8-7-9-16-23/h7-9,11,14-17,21H,4-6,10,12-13,18-20H2,1-3H3,(H2,29,31,33)
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n/an/a 63n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047559
PNG
(1-(2,2-Dimethyl-propyl)-3-{2-[3-(5-ethyl-4-phenyl-...)
Show SMILES CCc1c(ncn1CCCOc1cccc(C)c1NC(=O)NCC(C)(C)C)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-6-22-25(21-13-8-7-9-14-21)29-19-31(22)16-11-17-33-23-15-10-12-20(2)24(23)30-26(32)28-18-27(3,4)5/h7-10,12-15,19H,6,11,16-18H2,1-5H3,(H2,28,30,32)
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n/an/a 68n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047581
PNG
(1-Hexyl-3-{2-methyl-6-[3-(5-methyl-4-phenyl-imidaz...)
Show SMILES CCCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-4-5-6-10-17-28-27(32)30-25-21(2)13-11-16-24(25)33-19-12-18-31-20-29-26(22(31)3)23-14-8-7-9-15-23/h7-9,11,13-16,20H,4-6,10,12,17-19H2,1-3H3,(H2,28,30,32)
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n/an/a 68n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047542
PNG
(1-{2-Fluoro-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(F)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C25H31FN4O2/c1-3-4-8-15-27-25(31)29-24-21(26)13-9-14-22(24)32-17-10-16-30-18-28-23(19(30)2)20-11-6-5-7-12-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,27,29,31)
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n/an/a 69n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047554
PNG
(1-(2-Methyl-6-{3-[4-(4-nitro-phenyl)-imidazol-1-yl...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C25H31N5O4/c1-3-4-5-14-26-25(31)28-24-19(2)8-6-9-23(24)34-16-7-15-29-17-22(27-18-29)20-10-12-21(13-11-20)30(32)33/h6,8-13,17-18H,3-5,7,14-16H2,1-2H3,(H2,26,28,31)
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n/an/a 70n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047592
PNG
(1-{2-Methyl-6-[2-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1CSCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4OS/c1-4-5-9-15-27-26(31)29-24-20(2)11-10-14-23(24)18-32-17-16-30-19-28-25(21(30)3)22-12-7-6-8-13-22/h6-8,10-14,19H,4-5,9,15-18H2,1-3H3,(H2,27,29,31)
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n/an/a 70n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047542
PNG
(1-{2-Fluoro-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(F)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C25H31FN4O2/c1-3-4-8-15-27-25(31)29-24-21(26)13-9-14-22(24)32-17-10-16-30-18-28-23(19(30)2)20-11-6-5-7-12-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,27,29,31)
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n/an/a 71n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047544
PNG
(1-{2-Isopropyl-6-[3-(5-methyl-4-phenyl-imidazol-1-...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1C(C)C
Show InChI InChI=1S/C28H38N4O2/c1-5-6-10-17-29-28(33)31-27-24(21(2)3)15-11-16-25(27)34-19-12-18-32-20-30-26(22(32)4)23-13-8-7-9-14-23/h7-9,11,13-16,20-21H,5-6,10,12,17-19H2,1-4H3,(H2,29,31,33)
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n/an/a 71n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047548
PNG
(1-{2-[3-(5-Ethyl-4-phenyl-imidazol-1-yl)-propoxy]-...)
Show SMILES CCc1c(ncn1CCCOc1cccc(C)c1NC(=O)NCCC(C)C)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-5-23-26(22-12-7-6-8-13-22)29-19-31(23)17-10-18-33-24-14-9-11-21(4)25(24)30-27(32)28-16-15-20(2)3/h6-9,11-14,19-20H,5,10,15-18H2,1-4H3,(H2,28,30,32)
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n/an/a 72n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047541
PNG
(1-Butyl-3-{2-methyl-6-[3-(5-methyl-4-phenyl-imidaz...)
Show SMILES CCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C25H32N4O2/c1-4-5-15-26-25(30)28-23-19(2)11-9-14-22(23)31-17-10-16-29-18-27-24(20(29)3)21-12-7-6-8-13-21/h6-9,11-14,18H,4-5,10,15-17H2,1-3H3,(H2,26,28,30)
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n/an/a 73n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047567
PNG
(1-(2,2-Dimethyl-propyl)-3-{2-methyl-6-[3-(4-phenyl...)
Show SMILES Cc1cccc(OCCCn2cnc(c2)-c2ccccc2)c1NC(=O)NCC(C)(C)C
Show InChI InChI=1S/C25H32N4O2/c1-19-10-8-13-22(23(19)28-24(30)26-17-25(2,3)4)31-15-9-14-29-16-21(27-18-29)20-11-6-5-7-12-20/h5-8,10-13,16,18H,9,14-15,17H2,1-4H3,(H2,26,28,30)
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n/an/a 73n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047602
PNG
(1-{2-Chloro-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(Cl)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C25H31ClN4O2/c1-3-4-8-15-27-25(31)29-24-21(26)13-9-14-22(24)32-17-10-16-30-18-28-23(19(30)2)20-11-6-5-7-12-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,27,29,31)
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n/an/a 73n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047550
PNG
(1-{2-Methyl-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1SCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4OS/c1-4-5-9-16-27-26(31)29-24-20(2)12-10-15-23(24)32-18-11-17-30-19-28-25(21(30)3)22-13-7-6-8-14-22/h6-8,10,12-15,19H,4-5,9,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 77n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047578
PNG
(1-{2-[3-(5-Ethyl-4-phenyl-imidazol-1-yl)-propoxy]-...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1CC)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-4-6-10-17-28-27(32)30-25-21(3)13-11-16-24(25)33-19-12-18-31-20-29-26(23(31)5-2)22-14-8-7-9-15-22/h7-9,11,13-16,20H,4-6,10,12,17-19H2,1-3H3,(H2,28,30,32)
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n/an/a 79n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047597
PNG
(1-{2-Ethyl-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)-...)
Show SMILES CCCCCNC(=O)Nc1c(CC)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-4-6-10-17-28-27(32)30-26-22(5-2)15-11-16-24(26)33-19-12-18-31-20-29-25(21(31)3)23-13-8-7-9-14-23/h7-9,11,13-16,20H,4-6,10,12,17-19H2,1-3H3,(H2,28,30,32)
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n/an/a 80n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047581
PNG
(1-Hexyl-3-{2-methyl-6-[3-(5-methyl-4-phenyl-imidaz...)
Show SMILES CCCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2/c1-4-5-6-10-17-28-27(32)30-25-21(2)13-11-16-24(25)33-19-12-18-31-20-29-26(22(31)3)23-14-8-7-9-15-23/h7-9,11,13-16,20H,4-6,10,12,17-19H2,1-3H3,(H2,28,30,32)
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n/an/a 84n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047558
PNG
(1-{2-[3-(5-Chloro-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1Cl)-c1ccccc1
Show InChI InChI=1S/C25H31ClN4O2/c1-3-4-8-15-27-25(31)29-22-19(2)11-9-14-21(22)32-17-10-16-30-18-28-23(24(30)26)20-12-6-5-7-13-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,27,29,31)
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n/an/a 84n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047550
PNG
(1-{2-Methyl-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1SCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4OS/c1-4-5-9-16-27-26(31)29-24-20(2)12-10-15-23(24)32-18-11-17-30-19-28-25(21(30)3)22-13-7-6-8-14-22/h6-8,10,12-15,19H,4-5,9,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 86n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047577
PNG
(1-{2-[3-(5-Chloro-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES CC(C)CCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1Cl)-c1ccccc1
Show InChI InChI=1S/C25H31ClN4O2/c1-18(2)13-14-27-25(31)29-22-19(3)9-7-12-21(22)32-16-8-15-30-17-28-23(24(30)26)20-10-5-4-6-11-20/h4-7,9-12,17-18H,8,13-16H2,1-3H3,(H2,27,29,31)
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n/an/a 88n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047557
PNG
(1-Butyl-3-{2-[3-(5-ethyl-4-phenyl-imidazol-1-yl)-p...)
Show SMILES CCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1CC)-c1ccccc1
Show InChI InChI=1S/C26H34N4O2/c1-4-6-16-27-26(31)29-24-20(3)12-10-15-23(24)32-18-11-17-30-19-28-25(22(30)5-2)21-13-8-7-9-14-21/h7-10,12-15,19H,4-6,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 88n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047580
PNG
(1-{2-Methoxy-6-[3-(5-methyl-4-phenyl-imidazol-1-yl...)
Show SMILES CCCCCNC(=O)Nc1c(OC)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4O3/c1-4-5-9-16-27-26(31)29-25-22(32-3)14-10-15-23(25)33-18-11-17-30-19-28-24(20(30)2)21-12-7-6-8-13-21/h6-8,10,12-15,19H,4-5,9,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 90n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047530
PNG
(1-{2-Methyl-6-[2-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1CS(=O)(=O)CCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4O3S/c1-4-5-9-15-27-26(31)29-24-20(2)11-10-14-23(24)18-34(32,33)17-16-30-19-28-25(21(30)3)22-12-7-6-8-13-22/h6-8,10-14,19H,4-5,9,15-18H2,1-3H3,(H2,27,29,31)
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n/an/a 90n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047572
PNG
(3-Methyl-N-[2-(5-methyl-4-phenyl-imidazol-1-yl)-et...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1C(=O)NCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H33N5O2/c1-4-5-9-15-28-26(33)30-23-19(2)11-10-14-22(23)25(32)27-16-17-31-18-29-24(20(31)3)21-12-7-6-8-13-21/h6-8,10-14,18H,4-5,9,15-17H2,1-3H3,(H,27,32)(H2,28,30,33)
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n/an/a 97n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047574
PNG
(1-{2-[3-(5-Methyl-4-phenyl-imidazol-1-yl)-propoxy]...)
Show SMILES CCCCCNC(=O)Nc1c(CCC)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C28H38N4O2/c1-4-6-10-18-29-28(33)31-27-23(13-5-2)16-11-17-25(27)34-20-12-19-32-21-30-26(22(32)3)24-14-8-7-9-15-24/h7-9,11,14-17,21H,4-6,10,12-13,18-20H2,1-3H3,(H2,29,31,33)
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n/an/a 98n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047569
PNG
(1-{2-Methyl-6-[3-(4-o-tolyl-imidazol-1-yl)-propoxy...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1)-c1ccccc1C
Show InChI InChI=1S/C26H34N4O2/c1-4-5-8-15-27-26(31)29-25-21(3)12-9-14-24(25)32-17-10-16-30-18-23(28-19-30)22-13-7-6-11-20(22)2/h6-7,9,11-14,18-19H,4-5,8,10,15-17H2,1-3H3,(H2,27,29,31)
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n/an/a 100n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047537
PNG
(1-Cyclohexyl-3-{2-methyl-6-[3-(5-methyl-4-phenyl-i...)
Show SMILES Cc1c(ncn1CCCOc1cccc(C)c1NC(=O)NC1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C27H34N4O2/c1-20-11-9-16-24(25(20)30-27(32)29-23-14-7-4-8-15-23)33-18-10-17-31-19-28-26(21(31)2)22-12-5-3-6-13-22/h3,5-6,9,11-13,16,19,23H,4,7-8,10,14-15,17-18H2,1-2H3,(H2,29,30,32)
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n/an/a 100n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047602
PNG
(1-{2-Chloro-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(Cl)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C25H31ClN4O2/c1-3-4-8-15-27-25(31)29-24-21(26)13-9-14-22(24)32-17-10-16-30-18-28-23(19(30)2)20-11-6-5-7-12-20/h5-7,9,11-14,18H,3-4,8,10,15-17H2,1-2H3,(H2,27,29,31)
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n/an/a 100n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047545
PNG
(1-{2-Methyl-6-[2-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1COCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4O2/c1-4-5-9-15-27-26(31)29-24-20(2)11-10-14-23(24)18-32-17-16-30-19-28-25(21(30)3)22-12-7-6-8-13-22/h6-8,10-14,19H,4-5,9,15-18H2,1-3H3,(H2,27,29,31)
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n/an/a 100n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047573
PNG
(1-(3-Methyl-butyl)-3-{2-methyl-6-[3-(5-methyl-4-ph...)
Show SMILES CC(C)CCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4O2/c1-19(2)14-15-27-26(31)29-24-20(3)10-8-13-23(24)32-17-9-16-30-18-28-25(21(30)4)22-11-6-5-7-12-22/h5-8,10-13,18-19H,9,14-17H2,1-4H3,(H2,27,29,31)
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n/an/a 100n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047533
PNG
(1-{2-Amino-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)-...)
Show SMILES CCCCCNC(=O)Nc1c(N)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C25H33N5O2/c1-3-4-8-15-27-25(31)29-24-21(26)13-9-14-22(24)32-17-10-16-30-18-28-23(19(30)2)20-11-6-5-7-12-20/h5-7,9,11-14,18H,3-4,8,10,15-17,26H2,1-2H3,(H2,27,29,31)
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n/an/a 100n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047499
PNG
(1-{2-Dimethylamino-6-[3-(5-methyl-4-phenyl-imidazo...)
Show SMILES CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1N(C)C
Show InChI InChI=1S/C27H37N5O2/c1-5-6-10-17-28-27(33)30-26-23(31(3)4)15-11-16-24(26)34-19-12-18-32-20-29-25(21(32)2)22-13-8-7-9-14-22/h7-9,11,13-16,20H,5-6,10,12,17-19H2,1-4H3,(H2,28,30,33)
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n/an/a 110n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047587
PNG
(1-{2-Methyl-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1C)-c1ccccc1
Show InChI InChI=1S/C26H34N4O2/c1-4-5-9-16-27-26(31)29-24-20(2)12-10-15-23(24)32-18-11-17-30-19-28-25(21(30)3)22-13-7-6-8-14-22/h6-8,10,12-15,19H,4-5,9,11,16-18H2,1-3H3,(H2,27,29,31)
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n/an/a 120n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047556
PNG
(1-{2-Methyl-6-[3-(5-methylsulfanylmethyl-4-phenyl-...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1CSC)-c1ccccc1
Show InChI InChI=1S/C27H36N4O2S/c1-4-5-9-16-28-27(32)30-25-21(2)12-10-15-24(25)33-18-11-17-31-20-29-26(23(31)19-34-3)22-13-7-6-8-14-22/h6-8,10,12-15,20H,4-5,9,11,16-19H2,1-3H3,(H2,28,30,32)
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n/an/a 120n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50047560
PNG
(1-(2-{3-[4-(4-Chloro-phenyl)-imidazol-1-yl]-propox...)
Show SMILES CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H31ClN4O2/c1-3-4-5-14-27-25(31)29-24-19(2)8-6-9-23(24)32-16-7-15-30-17-22(28-18-30)20-10-12-21(26)13-11-20/h6,8-13,17-18H,3-5,7,14-16H2,1-2H3,(H2,27,29,31)
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n/an/a 120n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes


J Med Chem 36: 1641-53 (1993)


Article DOI: 10.1021/jm00063a014
BindingDB Entry DOI: 10.7270/Q2XP7406
More data for this
Ligand-Target Pair
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