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Compile Data Set for Download or QSAR

Found 58 hits with Last Name = 'akiba' and Initial = 'i'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urotensin II receptor


(HUMAN)
BDBM50249878
PNG
((R)-2-bromo-4,5-dimethoxy-N-(3-(1-methylpyrrolidin...)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(O[C@@H]2CCN(C)C2)c1)C(F)(F)F
Show InChI InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50249878
PNG
((R)-2-bromo-4,5-dimethoxy-N-(3-(1-methylpyrrolidin...)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(O[C@@H]2CCN(C)C2)c1)C(F)(F)F
Show InChI InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431980
PNG
(CHEMBL2348501)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Show InChI InChI=1S/C19H22BrClN2O5S/c1-23-7-6-13(11-23)28-16-8-12(4-5-15(16)21)22-29(24,25)19-10-18(27-3)17(26-2)9-14(19)20/h4-5,8-10,13,22H,6-7,11H2,1-3H3/t13-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431963
PNG
(CHEMBL2348502)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Cc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Show InChI InChI=1S/C20H23BrClNO5S/c1-23-7-6-14(11-23)28-17-8-13(4-5-16(17)22)12-29(24,25)20-10-19(27-3)18(26-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m1/s1
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n/an/a 34n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50302272
PNG
(1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2...)
Show SMILES Cc1cc(NC(=O)NCCN2CCC(O)(Cc3ccccc3)CC2)c2ccccc2n1
Show InChI InChI=1S/C25H30N4O2/c1-19-17-23(21-9-5-6-10-22(21)27-19)28-24(30)26-13-16-29-14-11-25(31,12-15-29)18-20-7-3-2-4-8-20/h2-10,17,31H,11-16,18H2,1H3,(H2,26,27,28,30)
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431980
PNG
(CHEMBL2348501)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Show InChI InChI=1S/C19H22BrClN2O5S/c1-23-7-6-13(11-23)28-16-8-12(4-5-15(16)21)22-29(24,25)19-10-18(27-3)17(26-2)9-14(19)20/h4-5,8-10,13,22H,6-7,11H2,1-3H3/t13-/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431963
PNG
(CHEMBL2348502)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Cc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Show InChI InChI=1S/C20H23BrClNO5S/c1-23-7-6-14(11-23)28-17-8-13(4-5-16(17)22)12-29(24,25)20-10-19(27-3)18(26-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431991
PNG
(CHEMBL2348523)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(OCCN(C)C)c1)C(F)(F)F
Show InChI InChI=1S/C19H22BrF3N2O5S/c1-25(2)7-8-30-15-9-12(5-6-13(15)19(21,22)23)24-31(26,27)18-11-17(29-4)16(28-3)10-14(18)20/h5-6,9-11,24H,7-8H2,1-4H3
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431990
PNG
(CHEMBL2348524)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(O[C@@H]2CCCN(C)C2)c1)C(F)(F)F
Show InChI InChI=1S/C21H24BrF3N2O5S/c1-27-8-4-5-14(12-27)32-17-9-13(6-7-15(17)21(23,24)25)26-33(28,29)20-11-19(31-3)18(30-2)10-16(20)22/h6-7,9-11,14,26H,4-5,8,12H2,1-3H3/t14-/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431991
PNG
(CHEMBL2348523)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(OCCN(C)C)c1)C(F)(F)F
Show InChI InChI=1S/C19H22BrF3N2O5S/c1-25(2)7-8-30-15-9-12(5-6-13(15)19(21,22)23)24-31(26,27)18-11-17(29-4)16(28-3)10-14(18)20/h5-6,9-11,24H,7-8H2,1-4H3
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431990
PNG
(CHEMBL2348524)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(O[C@@H]2CCCN(C)C2)c1)C(F)(F)F
Show InChI InChI=1S/C21H24BrF3N2O5S/c1-27-8-4-5-14(12-27)32-17-9-13(6-7-15(17)21(23,24)25)26-33(28,29)20-11-19(31-3)18(30-2)10-16(20)22/h6-7,9-11,14,26H,4-5,8,12H2,1-3H3/t14-/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431981
PNG
(CHEMBL2348522)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2ccc(Cl)s2)ccc1C(F)(F)F
Show InChI InChI=1S/C17H18ClF3N2OS/c1-23-7-6-12(10-23)24-15-8-11(2-4-14(15)17(19,20)21)22-9-13-3-5-16(18)25-13/h2-5,8,12,22H,6-7,9-10H2,1H3/t12-/m0/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431962
PNG
(CHEMBL2348511)
Show SMILES COc1cc(Br)c(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)cc1OC
Show InChI InChI=1S/C21H24BrF3N2O3/c1-27-7-6-15(12-27)30-18-9-14(4-5-16(18)21(23,24)25)26-11-13-8-19(28-2)20(29-3)10-17(13)22/h4-5,8-10,15,26H,6-7,11-12H2,1-3H3/t15-/m0/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431962
PNG
(CHEMBL2348511)
Show SMILES COc1cc(Br)c(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)cc1OC
Show InChI InChI=1S/C21H24BrF3N2O3/c1-27-7-6-15(12-27)30-18-9-14(4-5-16(18)21(23,24)25)26-11-13-8-19(28-2)20(29-3)10-17(13)22/h4-5,8-10,15,26H,6-7,11-12H2,1-3H3/t15-/m0/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431976
PNG
(CHEMBL2348506)
Show SMILES COc1cc(Br)c(CNc2ccc(Cl)c(O[C@@H]3CCN(C)C3)c2)cc1OC
Show InChI InChI=1S/C20H24BrClN2O3/c1-24-7-6-15(12-24)27-18-9-14(4-5-17(18)22)23-11-13-8-19(25-2)20(26-3)10-16(13)21/h4-5,8-10,15,23H,6-7,11-12H2,1-3H3/t15-/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431978
PNG
(CHEMBL2348504)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)Cc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Show InChI InChI=1S/C20H23BrClNO4S/c1-23-7-6-14(11-23)27-17-8-13(4-5-16(17)22)12-28(24)20-10-19(26-3)18(25-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-,28?/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431986
PNG
(CHEMBL2348528)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(OC[C@H]2CCCN2C)c1)C(F)(F)F
Show InChI InChI=1S/C21H24BrF3N2O5S/c1-27-8-4-5-14(27)12-32-17-9-13(6-7-15(17)21(23,24)25)26-33(28,29)20-11-19(31-3)18(30-2)10-16(20)22/h6-7,9-11,14,26H,4-5,8,12H2,1-3H3/t14-/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431977
PNG
(CHEMBL2348505)
Show SMILES COc1cc(Br)c(SCc2ccc(Cl)c(O[C@@H]3CCN(C)C3)c2)cc1OC
Show InChI InChI=1S/C20H23BrClNO3S/c1-23-7-6-14(11-23)26-17-8-13(4-5-16(17)22)12-27-20-10-19(25-3)18(24-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m1/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431964
PNG
(CHEMBL2348519)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2cc3OCOc3cc2Br)ccc1C(F)(F)F
Show InChI InChI=1S/C20H20BrF3N2O3/c1-26-5-4-14(10-26)29-17-7-13(2-3-15(17)20(22,23)24)25-9-12-6-18-19(8-16(12)21)28-11-27-18/h2-3,6-8,14,25H,4-5,9-11H2,1H3/t14-/m0/s1
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Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431968
PNG
(CHEMBL2348515)
Show SMILES CN(C)CCOc1cc(NCc2ccccc2C(F)(F)F)ccc1Cl
Show InChI InChI=1S/C18H20ClF3N2O/c1-24(2)9-10-25-17-11-14(7-8-16(17)19)23-12-13-5-3-4-6-15(13)18(20,21)22/h3-8,11,23H,9-10,12H2,1-2H3
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n/an/a 520n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431983
PNG
(CHEMBL2348520)
Show SMILES COc1cc(OC)c(OC)cc1CNc1ccc(c(O[C@H]2CCN(C)C2)c1)C(F)(F)F
Show InChI InChI=1S/C22H27F3N2O4/c1-27-8-7-16(13-27)31-19-10-15(5-6-17(19)22(23,24)25)26-12-14-9-20(29-3)21(30-4)11-18(14)28-2/h5-6,9-11,16,26H,7-8,12-13H2,1-4H3/t16-/m0/s1
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n/an/a 520n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431983
PNG
(CHEMBL2348520)
Show SMILES COc1cc(OC)c(OC)cc1CNc1ccc(c(O[C@H]2CCN(C)C2)c1)C(F)(F)F
Show InChI InChI=1S/C22H27F3N2O4/c1-27-8-7-16(13-27)31-19-10-15(5-6-17(19)22(23,24)25)26-12-14-9-20(29-3)21(30-4)11-18(14)28-2/h5-6,9-11,16,26H,7-8,12-13H2,1-4H3/t16-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431981
PNG
(CHEMBL2348522)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2ccc(Cl)s2)ccc1C(F)(F)F
Show InChI InChI=1S/C17H18ClF3N2OS/c1-23-7-6-12(10-23)24-15-8-11(2-4-14(15)17(19,20)21)22-9-13-3-5-16(18)25-13/h2-5,8,12,22H,6-7,9-10H2,1H3/t12-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431965
PNG
(CHEMBL2348518)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2c3OCOc3ccc2Br)ccc1C(F)(F)F
Show InChI InChI=1S/C20H20BrF3N2O3/c1-26-7-6-13(10-26)29-18-8-12(2-3-15(18)20(22,23)24)25-9-14-16(21)4-5-17-19(14)28-11-27-17/h2-5,8,13,25H,6-7,9-11H2,1H3/t13-/m0/s1
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n/an/a 620n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431974
PNG
(CHEMBL2348508)
Show SMILES COc1cc(Br)c(OCc2ccc(Cl)c(O[C@@H]3CCN(C)C3)c2)cc1OC
Show InChI InChI=1S/C20H23BrClNO4/c1-23-7-6-14(11-23)27-18-8-13(4-5-16(18)22)12-26-17-10-20(25-3)19(24-2)9-15(17)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m1/s1
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n/an/a 669n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431966
PNG
(CHEMBL2348517)
Show SMILES COc1cccc(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H23F3N2O2/c1-25-9-8-17(13-25)27-19-11-15(6-7-18(19)20(21,22)23)24-12-14-4-3-5-16(10-14)26-2/h3-7,10-11,17,24H,8-9,12-13H2,1-2H3/t17-/m0/s1
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n/an/a 691n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431967
PNG
(CHEMBL2348516)
Show SMILES COc1ccc(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H23F3N2O2/c1-25-10-9-17(13-25)27-19-11-15(5-8-18(19)20(21,22)23)24-12-14-3-6-16(26-2)7-4-14/h3-8,11,17,24H,9-10,12-13H2,1-2H3/t17-/m0/s1
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n/an/a 714n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431979
PNG
(CHEMBL2348503)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Cc1ccc(Cl)c(O[C@H]2CCN(C)C2)c1
Show InChI InChI=1S/C20H23BrClNO5S/c1-23-7-6-14(11-23)28-17-8-13(4-5-16(17)22)12-29(24,25)20-10-19(27-3)18(26-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m0/s1
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n/an/a 742n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431968
PNG
(CHEMBL2348515)
Show SMILES CN(C)CCOc1cc(NCc2ccccc2C(F)(F)F)ccc1Cl
Show InChI InChI=1S/C18H20ClF3N2O/c1-24(2)9-10-25-17-11-14(7-8-16(17)19)23-12-13-5-3-4-6-15(13)18(20,21)22/h3-8,11,23H,9-10,12H2,1-2H3
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n/an/a 765n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431986
PNG
(CHEMBL2348528)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(OC[C@H]2CCCN2C)c1)C(F)(F)F
Show InChI InChI=1S/C21H24BrF3N2O5S/c1-27-8-4-5-14(27)12-32-17-9-13(6-7-15(17)21(23,24)25)26-33(28,29)20-11-19(31-3)18(30-2)10-16(20)22/h6-7,9-11,14,26H,4-5,8,12H2,1-3H3/t14-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431969
PNG
(CHEMBL2348514)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2ccccc2Br)ccc1C(F)(F)F
Show InChI InChI=1S/C19H20BrF3N2O/c1-25-9-8-15(12-25)26-18-10-14(6-7-16(18)19(21,22)23)24-11-13-4-2-3-5-17(13)20/h2-7,10,15,24H,8-9,11-12H2,1H3/t15-/m0/s1
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n/an/a 821n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431987
PNG
(CHEMBL2348527)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(OCCN2CCN(C)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C22H27BrF3N3O5S/c1-28-6-8-29(9-7-28)10-11-34-18-12-15(4-5-16(18)22(24,25)26)27-35(30,31)21-14-20(33-3)19(32-2)13-17(21)23/h4-5,12-14,27H,6-11H2,1-3H3
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n/an/a 840n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431964
PNG
(CHEMBL2348519)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2cc3OCOc3cc2Br)ccc1C(F)(F)F
Show InChI InChI=1S/C20H20BrF3N2O3/c1-26-5-4-14(10-26)29-17-7-13(2-3-15(17)20(22,23)24)25-9-12-6-18-19(8-16(12)21)28-11-27-18/h2-3,6-8,14,25H,4-5,9-11H2,1H3/t14-/m0/s1
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n/an/a 950n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431966
PNG
(CHEMBL2348517)
Show SMILES COc1cccc(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H23F3N2O2/c1-25-9-8-17(13-25)27-19-11-15(6-7-18(19)20(21,22)23)24-12-14-4-3-5-16(10-14)26-2/h3-7,10-11,17,24H,8-9,12-13H2,1-2H3/t17-/m0/s1
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n/an/a 1.13E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431972
PNG
(CHEMBL2348510)
Show SMILES COc1cc(Br)c(CNc2ccc(Cl)c(OCCN(C)C)c2)cc1OC
Show InChI InChI=1S/C19H24BrClN2O3/c1-23(2)7-8-26-17-10-14(5-6-16(17)21)22-12-13-9-18(24-3)19(25-4)11-15(13)20/h5-6,9-11,22H,7-8,12H2,1-4H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431979
PNG
(CHEMBL2348503)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Cc1ccc(Cl)c(O[C@H]2CCN(C)C2)c1
Show InChI InChI=1S/C20H23BrClNO5S/c1-23-7-6-14(11-23)28-17-8-13(4-5-16(17)22)12-29(24,25)20-10-19(27-3)18(26-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m0/s1
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n/an/a 1.28E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431972
PNG
(CHEMBL2348510)
Show SMILES COc1cc(Br)c(CNc2ccc(Cl)c(OCCN(C)C)c2)cc1OC
Show InChI InChI=1S/C19H24BrClN2O3/c1-23(2)7-8-26-17-10-14(5-6-16(17)21)22-12-13-9-18(24-3)19(25-4)11-15(13)20/h5-6,9-11,22H,7-8,12H2,1-4H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431976
PNG
(CHEMBL2348506)
Show SMILES COc1cc(Br)c(CNc2ccc(Cl)c(O[C@@H]3CCN(C)C3)c2)cc1OC
Show InChI InChI=1S/C20H24BrClN2O3/c1-24-7-6-15(12-24)27-18-9-14(4-5-17(18)22)23-11-13-8-19(25-2)20(26-3)10-16(13)21/h4-5,8-10,15,23H,6-7,11-12H2,1-3H3/t15-/m1/s1
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n/an/a 1.33E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431975
PNG
(CHEMBL2348507)
Show SMILES COc1cc(Br)c(CNc2ccc(Cl)c(O[C@H]3CCN(C)C3)c2)cc1OC
Show InChI InChI=1S/C20H24BrClN2O3/c1-24-7-6-15(12-24)27-18-9-14(4-5-17(18)22)23-11-13-8-19(25-2)20(26-3)10-16(13)21/h4-5,8-10,15,23H,6-7,11-12H2,1-3H3/t15-/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431965
PNG
(CHEMBL2348518)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2c3OCOc3ccc2Br)ccc1C(F)(F)F
Show InChI InChI=1S/C20H20BrF3N2O3/c1-26-7-6-13(10-26)29-18-8-12(2-3-15(18)20(22,23)24)25-9-14-16(21)4-5-17-19(14)28-11-27-17/h2-5,8,13,25H,6-7,9-11H2,1H3/t13-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431975
PNG
(CHEMBL2348507)
Show SMILES COc1cc(Br)c(CNc2ccc(Cl)c(O[C@H]3CCN(C)C3)c2)cc1OC
Show InChI InChI=1S/C20H24BrClN2O3/c1-24-7-6-15(12-24)27-18-9-14(4-5-17(18)22)23-11-13-8-19(25-2)20(26-3)10-16(13)21/h4-5,8-10,15,23H,6-7,11-12H2,1-3H3/t15-/m0/s1
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n/an/a 1.45E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431969
PNG
(CHEMBL2348514)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2ccccc2Br)ccc1C(F)(F)F
Show InChI InChI=1S/C19H20BrF3N2O/c1-25-9-8-15(12-25)26-18-10-14(6-7-16(18)19(21,22)23)24-11-13-4-2-3-5-17(13)20/h2-7,10,15,24H,8-9,11-12H2,1H3/t15-/m0/s1
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n/an/a 1.87E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
UTS2R


(RAT)
BDBM50431963
PNG
(CHEMBL2348502)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Cc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1
Show InChI InChI=1S/C20H23BrClNO5S/c1-23-7-6-14(11-23)28-17-8-13(4-5-16(17)22)12-29(24,25)20-10-19(27-3)18(26-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at rat urotensin2 receptor assessed as inhibition of urotensin2-stimulated Ca2+ mobilization by cell-based assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431982
PNG
(CHEMBL2348521)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2cccs2)ccc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N2OS/c1-22-7-6-13(11-22)23-16-9-12(4-5-15(16)17(18,19)20)21-10-14-3-2-8-24-14/h2-5,8-9,13,21H,6-7,10-11H2,1H3/t13-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431985
PNG
(CHEMBL2348529)
Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(OC[C@@H]2CCCN2C)c1)C(F)(F)F
Show InChI InChI=1S/C21H24BrF3N2O5S/c1-27-8-4-5-14(27)12-32-17-9-13(6-7-15(17)21(23,24)25)26-33(28,29)20-11-19(31-3)18(30-2)10-16(20)22/h6-7,9-11,14,26H,4-5,8,12H2,1-3H3/t14-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431982
PNG
(CHEMBL2348521)
Show SMILES CN1CC[C@@H](C1)Oc1cc(NCc2cccs2)ccc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N2OS/c1-22-7-6-13(11-22)23-16-9-12(4-5-15(16)17(18,19)20)21-10-14-3-2-8-24-14/h2-5,8-9,13,21H,6-7,10-11H2,1H3/t13-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431973
PNG
(CHEMBL2348509)
Show SMILES COc1cc(Br)c(NCc2ccc(Cl)c(O[C@@H]3CCN(C)C3)c2)cc1OC
Show InChI InChI=1S/C20H24BrClN2O3/c1-24-7-6-14(12-24)27-18-8-13(4-5-16(18)22)11-23-17-10-20(26-3)19(25-2)9-15(17)21/h4-5,8-10,14,23H,6-7,11-12H2,1-3H3/t14-/m1/s1
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n/an/a 3.06E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431967
PNG
(CHEMBL2348516)
Show SMILES COc1ccc(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H23F3N2O2/c1-25-10-9-17(13-25)27-19-11-15(5-8-18(19)20(21,22)23)24-12-14-3-6-16(26-2)7-4-14/h3-8,11,17,24H,9-10,12-13H2,1-2H3/t17-/m0/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization...


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
Urotensin II receptor


(HUMAN)
BDBM50431970
PNG
(CHEMBL2348513)
Show SMILES CN(C)CCOc1cc(NCc2ccccc2Br)ccc1Cl
Show InChI InChI=1S/C17H20BrClN2O/c1-21(2)9-10-22-17-11-14(7-8-16(17)19)20-12-13-5-3-4-6-15(13)18/h3-8,11,20H,9-10,12H2,1-2H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
UTS2R


(RAT)
BDBM50431962
PNG
(CHEMBL2348511)
Show SMILES COc1cc(Br)c(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)cc1OC
Show InChI InChI=1S/C21H24BrF3N2O3/c1-27-7-6-15(12-27)30-18-9-14(4-5-16(18)21(23,24)25)26-11-13-8-19(28-2)20(29-3)10-17(13)22/h4-5,8-10,15,26H,6-7,11-12H2,1-3H3/t15-/m0/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at rat urotensin2 receptor assessed as inhibition of urotensin2-stimulated Ca2+ mobilization by cell-based assay


Bioorg Med Chem Lett 23: 2177-80 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.105
BindingDB Entry DOI: 10.7270/Q2XS5WSW
More data for this
Ligand-Target Pair
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