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Compile Data Set for Download or QSAR

Found 122 hits with Last Name = 'akiyama' and Initial = 'n'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50197690
PNG
(CHEMBL3976548)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2
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n/an/a 0.180n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50197709
PNG
(CHEMBL3984621)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1
Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2
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n/an/a 0.430n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197709
PNG
(CHEMBL3984621)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1
Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2
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n/an/a 1.20n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197685
PNG
(CHEMBL3681278)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 1.5n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50197709
PNG
(CHEMBL3984621)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1
Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2
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n/an/a 2.40n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197691
PNG
(CHEMBL3891894)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 2.90n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197702
PNG
(CHEMBL3681287)
Show SMILES CCc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H18N6O/c1-2-19-25-16-8-7-13(10-17(16)26-19)27-21(22)14(11-23-27)20(28)18-9-12-5-3-4-6-15(12)24-18/h3-11,24H,2,22H2,1H3,(H,25,26)
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n/an/a 2.90n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM130903
PNG
(US8829199, 196)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32)
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n/an/a 3n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197685
PNG
(CHEMBL3681278)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 3.5n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197685
PNG
(CHEMBL3681278)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 3.60n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197709
PNG
(CHEMBL3984621)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1
Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2
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n/an/a 4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197709
PNG
(CHEMBL3984621)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1
Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2
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n/an/a 4.20n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50197703
PNG
(CHEMBL3981956)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C18H12ClN3O3/c19-13-6-5-11(23)8-14(13)22-18(20)12(9-21-22)17(24)16-7-10-3-1-2-4-15(10)25-16/h1-9,23H,20H2
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n/an/a 4.30n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197691
PNG
(CHEMBL3891894)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 4.40n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197691
PNG
(CHEMBL3891894)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 5.20n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50197710
PNG
(CHEMBL3959997)
Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3
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n/an/a 6.5n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197683
PNG
(CHEMBL3907479)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
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n/an/a 7.60n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197683
PNG
(CHEMBL3907479)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
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n/an/a 9.30n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM130903
PNG
(US8829199, 196)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32)
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n/an/a 9.40n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197692
PNG
(CHEMBL3895337)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccc(C)cc3[nH]2)c1N
Show InChI InChI=1S/C21H18N6O/c1-11-3-4-13-8-19(26-17(13)7-11)20(28)15-10-23-27(21(15)22)14-5-6-16-18(9-14)25-12(2)24-16/h3-10,26H,22H2,1-2H3,(H,24,25)
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n/an/a 10n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50197686
PNG
(CHEMBL3956001)
Show SMILES Nc1c(cnn1-c1ccccc1Cl)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H13ClN4O/c19-13-6-2-4-8-16(13)23-18(20)12(10-21-23)17(24)15-9-11-5-1-3-7-14(11)22-15/h1-10,22H,20H2
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n/an/a 11n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50197685
PNG
(CHEMBL3681278)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 13n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197692
PNG
(CHEMBL3895337)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccc(C)cc3[nH]2)c1N
Show InChI InChI=1S/C21H18N6O/c1-11-3-4-13-8-19(26-17(13)7-11)20(28)15-10-23-27(21(15)22)14-5-6-16-18(9-14)25-12(2)24-16/h3-10,26H,22H2,1-2H3,(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197710
PNG
(CHEMBL3959997)
Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197712
PNG
(CHEMBL3676329)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(Br)cc3[nH]2)c1N
Show InChI InChI=1S/C20H15BrN6O/c1-10-24-15-5-4-13(8-17(15)25-10)27-20(22)14(9-23-27)19(28)18-6-11-2-3-12(21)7-16(11)26-18/h2-9,26H,22H2,1H3,(H,24,25)
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n/an/a 19n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM130906
PNG
(US8829199, 200)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)S(C)(=O)=O)c1N
Show InChI InChI=1S/C21H18N6O3S/c1-11-24-16-6-4-13(8-18(16)25-11)27-21(22)15(10-23-27)20(28)19-7-12-3-5-14(31(2,29)30)9-17(12)26-19/h3-10,26H,22H2,1-2H3,(H,24,25)
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n/an/a 21n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197683
PNG
(CHEMBL3907479)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
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n/an/a 22n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197690
PNG
(CHEMBL3976548)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2
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n/an/a 25n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50197691
PNG
(CHEMBL3891894)
Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 26n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50197690
PNG
(CHEMBL3976548)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2
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n/an/a 28n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197690
PNG
(CHEMBL3976548)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2
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n/an/a 30n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50197713
PNG
(CHEMBL3947281)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C19H13ClN4O2/c20-15-5-4-13(25)9-17(15)24-19(21)14(10-23-24)18(26)12-3-6-16-11(8-12)2-1-7-22-16/h1-10,25H,21H2
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n/an/a 31n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197710
PNG
(CHEMBL3959997)
Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3
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n/an/a 32n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197689
PNG
(CHEMBL3934547)
Show SMILES Nc1c(cnn1-c1ccc2nc[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O/c20-19-13(18(26)17-7-11-3-1-2-4-14(11)24-17)9-23-25(19)12-5-6-15-16(8-12)22-10-21-15/h1-10,24H,20H2,(H,21,22)
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n/an/a 33n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197687
PNG
(CHEMBL3681244)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2ccccc2)c1N
Show InChI InChI=1S/C26H20N6O/c1-15-29-21-10-9-19(13-23(21)30-15)32-26(27)20(14-28-32)25(33)24-12-18-8-7-17(11-22(18)31-24)16-5-3-2-4-6-16/h2-14,31H,27H2,1H3,(H,29,30)
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n/an/a 41n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197712
PNG
(CHEMBL3676329)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(Br)cc3[nH]2)c1N
Show InChI InChI=1S/C20H15BrN6O/c1-10-24-15-5-4-13(8-17(15)25-10)27-20(22)14(9-23-27)19(28)18-6-11-2-3-12(21)7-16(11)26-18/h2-9,26H,22H2,1H3,(H,24,25)
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n/an/a 49n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197687
PNG
(CHEMBL3681244)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2ccccc2)c1N
Show InChI InChI=1S/C26H20N6O/c1-15-29-21-10-9-19(13-23(21)30-15)32-26(27)20(14-28-32)25(33)24-12-18-8-7-17(11-22(18)31-24)16-5-3-2-4-6-16/h2-14,31H,27H2,1H3,(H,29,30)
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n/an/a 50n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50197711
PNG
(CHEMBL3941474)
Show SMILES Nc1c(cnn1-c1ccc2[nH]ccc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C20H15N5O/c21-20-15(19(26)18-10-12-3-1-2-4-17(12)24-18)11-23-25(20)14-5-6-16-13(9-14)7-8-22-16/h1-11,22,24H,21H2
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n/an/a 52n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM130906
PNG
(US8829199, 200)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)S(C)(=O)=O)c1N
Show InChI InChI=1S/C21H18N6O3S/c1-11-24-16-6-4-13(8-18(16)25-11)27-21(22)15(10-23-27)20(28)19-7-12-3-5-14(31(2,29)30)9-17(12)26-19/h3-10,26H,22H2,1-2H3,(H,24,25)
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n/an/a 56n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197702
PNG
(CHEMBL3681287)
Show SMILES CCc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H18N6O/c1-2-19-25-16-8-7-13(10-17(16)26-19)27-21(22)14(11-23-27)20(28)18-9-12-5-3-4-6-15(12)24-18/h3-11,24H,2,22H2,1H3,(H,25,26)
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n/an/a 65n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130906
PNG
(US8829199, 200)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)S(C)(=O)=O)c1N
Show InChI InChI=1S/C21H18N6O3S/c1-11-24-16-6-4-13(8-18(16)25-11)27-21(22)15(10-23-27)20(28)19-7-12-3-5-14(31(2,29)30)9-17(12)26-19/h3-10,26H,22H2,1-2H3,(H,24,25)
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n/an/a 68n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197710
PNG
(CHEMBL3959997)
Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3
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n/an/a 69n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197702
PNG
(CHEMBL3681287)
Show SMILES CCc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H18N6O/c1-2-19-25-16-8-7-13(10-17(16)26-19)27-21(22)14(11-23-27)20(28)18-9-12-5-3-4-6-15(12)24-18/h3-11,24H,2,22H2,1H3,(H,25,26)
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n/an/a 79n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50197710
PNG
(CHEMBL3959997)
Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N
Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3
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n/an/a 85n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50197711
PNG
(CHEMBL3941474)
Show SMILES Nc1c(cnn1-c1ccc2[nH]ccc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C20H15N5O/c21-20-15(19(26)18-10-12-3-1-2-4-17(12)24-18)11-23-25(20)14-5-6-16-13(9-14)7-8-22-16/h1-11,22,24H,21H2
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n/an/a 110n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50197685
PNG
(CHEMBL3681278)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)
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n/an/a 120n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197689
PNG
(CHEMBL3934547)
Show SMILES Nc1c(cnn1-c1ccc2nc[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O/c20-19-13(18(26)17-7-11-3-1-2-4-14(11)24-17)9-23-25(19)12-5-6-15-16(8-12)22-10-21-15/h1-10,24H,20H2,(H,21,22)
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n/an/a 120n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130903
PNG
(US8829199, 196)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32)
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n/an/a 130n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM130903
PNG
(US8829199, 196)
Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32)
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n/an/a 130n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197690
PNG
(CHEMBL3976548)
Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2
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n/an/a 130n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
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