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Compile Data Set for Download or QSAR

Found 130 hits with Last Name = 'akritopolou-zanze' and Initial = 'i'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 11n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188753
PNG
(3-(3-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-10-12-36(13-11-34)17-19-6-7-20-15-25-27(24(20)14-19)32-33-28(25)26-9-8-23(38-26)18-35(2)29(37)31-22-5-3-4-21(30)16-22/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 12n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188731
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(cc4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-10-12-38(13-11-37)17-18-2-8-23-19(14-18)15-24-26(23)35-36-27(24)25-9-7-22(40-25)16-33-28(39)34-21-5-3-20(4-6-21)29(30,31)32/h2-9,14H,10-13,15-17H2,1H3,(H,35,36)(H2,33,34,39)
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n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 14n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188764
PNG
(3-(4-fluorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C29H31FN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188748
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(c4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-9-11-38(12-10-37)17-18-5-7-23-19(13-18)14-24-26(23)35-36-27(24)25-8-6-22(40-25)16-33-28(39)34-21-4-2-3-20(15-21)29(30,31)32/h2-8,13,15H,9-12,14,16-17H2,1H3,(H,35,36)(H2,33,34,39)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188754
PNG
(3-(4-bromophenyl)-1-methyl-1-((5-(7-((4-methylpipe...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C29H31BrN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188759
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-11-13-39(14-12-37)17-19-3-4-20-16-25-27(24(20)15-19)35-36-28(25)26-10-9-23(42-26)18-38(2)29(40)34-21-5-7-22(8-6-21)41-30(31,32)33/h3-10,15H,11-14,16-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188769
PNG
(3-(3,4-dichlorophenyl)-1-methyl-1-((5-(7-((4-methy...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H30Cl2N6OS/c1-35-9-11-37(12-10-35)16-18-3-4-19-14-23-27(22(19)13-18)33-34-28(23)26-8-6-21(39-26)17-36(2)29(38)32-20-5-7-24(30)25(31)15-20/h3-8,13,15H,9-12,14,16-17H2,1-2H3,(H,32,38)(H,33,34)
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n/an/a 18n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188749
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N6OS/c1-37-10-12-39(13-11-37)17-19-6-7-20-15-25-27(24(20)14-19)35-36-28(25)26-9-8-23(41-26)18-38(2)29(40)34-22-5-3-4-21(16-22)30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 18n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188759
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-11-13-39(14-12-37)17-19-3-4-20-16-25-27(24(20)15-19)35-36-28(25)26-10-9-23(42-26)18-38(2)29(40)34-21-5-7-22(8-6-21)41-30(31,32)33/h3-10,15H,11-14,16-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 19n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188727
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-10-12-39(13-11-37)17-19-6-8-24-20(14-19)15-25-27(24)35-36-28(25)26-9-7-23(42-26)18-38(2)29(40)34-21-4-3-5-22(16-21)41-30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 19n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188754
PNG
(3-(4-bromophenyl)-1-methyl-1-((5-(7-((4-methylpipe...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C29H31BrN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 19n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188753
PNG
(3-(3-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-10-12-36(13-11-34)17-19-6-7-20-15-25-27(24(20)14-19)32-33-28(25)26-9-8-23(38-26)18-35(2)29(37)31-22-5-3-4-21(30)16-22/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188736
PNG
(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-1-...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H30F4N6OS/c1-38-7-9-40(10-8-38)16-18-3-5-24-19(11-18)12-25-27(24)36-37-28(25)26-6-4-23(42-26)17-39(2)29(41)35-22-14-20(30(32,33)34)13-21(31)15-22/h3-6,11,13-15H,7-10,12,16-17H2,1-2H3,(H,35,41)(H,36,37)
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188732
PNG
(1-cyclopropyl-1-((5-(6-((4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CN(C4CC4)C(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C32H36N6OS/c1-21-4-3-5-24(16-21)33-32(39)38(25-7-8-25)20-26-9-11-29(40-26)31-28-18-23-17-22(6-10-27(23)30(28)34-35-31)19-37-14-12-36(2)13-15-37/h3-6,9-11,16-17,25H,7-8,12-15,18-20H2,1-2H3,(H,33,39)(H,34,35)
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188752
PNG
(3-(4-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188761
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4ccc(C)cc4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-3-6-22(7-4-19)31-29(36)30-17-23-8-10-26(37-23)28-25-16-21-15-20(5-9-24(21)27(25)32-33-28)18-35-13-11-34(2)12-14-35/h3-10,15H,11-14,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
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n/an/a 24n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188759
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-11-13-39(14-12-37)17-19-3-4-20-16-25-27(24(20)15-19)35-36-28(25)26-10-9-23(42-26)18-38(2)29(40)34-21-5-7-22(8-6-21)41-30(31,32)33/h3-10,15H,11-14,16-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188736
PNG
(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-1-...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H30F4N6OS/c1-38-7-9-40(10-8-38)16-18-3-5-24-19(11-18)12-25-27(24)36-37-28(25)26-6-4-23(42-26)17-39(2)29(41)35-22-14-20(30(32,33)34)13-21(31)15-22/h3-6,11,13-15H,7-10,12,16-17H2,1-2H3,(H,35,41)(H,36,37)
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n/an/a 25n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188727
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-10-12-39(13-11-37)17-19-6-8-24-20(14-19)15-25-27(24)35-36-28(25)26-9-7-23(42-26)18-38(2)29(40)34-21-4-3-5-22(16-21)41-30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 27n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188737
PNG
(1-(3,5-dimethylphenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(C)cc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H34N6OS/c1-19-12-20(2)14-23(13-19)32-30(37)31-17-24-5-7-27(38-24)29-26-16-22-15-21(4-6-25(22)28(26)33-34-29)18-36-10-8-35(3)9-11-36/h4-7,12-15H,8-11,16-18H2,1-3H3,(H,33,34)(H2,31,32,37)
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n/an/a 27n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188769
PNG
(3-(3,4-dichlorophenyl)-1-methyl-1-((5-(7-((4-methy...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H30Cl2N6OS/c1-35-9-11-37(12-10-35)16-18-3-4-19-14-23-27(22(19)13-18)33-34-28(23)26-8-6-21(39-26)17-36(2)29(38)32-20-5-7-24(30)25(31)15-20/h3-8,13,15H,9-12,14,16-17H2,1-2H3,(H,32,38)(H,33,34)
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n/an/a 28n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188736
PNG
(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-1-...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H30F4N6OS/c1-38-7-9-40(10-8-38)16-18-3-5-24-19(11-18)12-25-27(24)36-37-28(25)26-6-4-23(42-26)17-39(2)29(41)35-22-14-20(30(32,33)34)13-21(31)15-22/h3-6,11,13-15H,7-10,12,16-17H2,1-2H3,(H,35,41)(H,36,37)
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n/an/a 33n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188748
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(c4)C(F)(F)F)s3)c2)CC1
Show InChI InChI=1S/C29H29F3N6OS/c1-37-9-11-38(12-10-37)17-18-5-7-23-19(13-18)14-24-26(23)35-36-27(24)25-8-6-22(40-25)16-33-28(39)34-21-4-2-3-20(15-21)29(30,31)32/h2-8,13,15H,9-12,14,16-17H2,1H3,(H,35,36)(H2,33,34,39)
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n/an/a 34n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188733
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-4-12-38(32(39)33-25-7-5-6-22(2)17-25)21-26-9-11-29(40-26)31-28-19-24-18-23(8-10-27(24)30(28)34-35-31)20-37-15-13-36(3)14-16-37/h5-11,17-18H,4,12-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
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n/an/a 35n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188752
PNG
(3-(4-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188769
PNG
(3-(3,4-dichlorophenyl)-1-methyl-1-((5-(7-((4-methy...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H30Cl2N6OS/c1-35-9-11-37(12-10-35)16-18-3-4-19-14-23-27(22(19)13-18)33-34-28(23)26-8-6-21(39-26)17-36(2)29(38)32-20-5-7-24(30)25(31)15-20/h3-8,13,15H,9-12,14,16-17H2,1-2H3,(H,32,38)(H,33,34)
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n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188754
PNG
(3-(4-bromophenyl)-1-methyl-1-((5-(7-((4-methylpipe...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C29H31BrN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188735
PNG
(1-(3,5-dichlorophenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(Cl)cc(Cl)c4)s3)c2)CC1
Show InChI InChI=1S/C28H28Cl2N6OS/c1-35-6-8-36(9-7-35)16-17-2-4-23-18(10-17)11-24-26(23)33-34-27(24)25-5-3-22(38-25)15-31-28(37)32-21-13-19(29)12-20(30)14-21/h2-5,10,12-14H,6-9,11,15-16H2,1H3,(H,33,34)(H2,31,32,37)
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n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188732
PNG
(1-cyclopropyl-1-((5-(6-((4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CN(C4CC4)C(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C32H36N6OS/c1-21-4-3-5-24(16-21)33-32(39)38(25-7-8-25)20-26-9-11-29(40-26)31-28-18-23-17-22(6-10-27(23)30(28)34-35-31)19-37-14-12-36(2)13-15-37/h3-6,9-11,16-17,25H,7-8,12-15,18-20H2,1-2H3,(H,33,39)(H,34,35)
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n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188753
PNG
(3-(3-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-10-12-36(13-11-34)17-19-6-7-20-15-25-27(24(20)14-19)32-33-28(25)26-9-8-23(38-26)18-35(2)29(37)31-22-5-3-4-21(30)16-22/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 38n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188751
PNG
((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydro...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(COC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H31N5O2S/c1-19-4-3-5-22(14-19)30-29(35)36-18-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)31-32-28)17-34-12-10-33(2)11-13-34/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,30,35)(H,31,32)
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n/an/a 42n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50210283
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-9-10-27(38-24)29-26-17-22-8-7-21(16-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
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n/an/a 44n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188756
PNG
(1-ethyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-...)
Show SMILES CCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C31H36N6OS/c1-4-37(31(38)32-24-7-5-6-21(2)16-24)20-25-9-11-28(39-25)30-27-18-23-17-22(8-10-26(23)29(27)33-34-30)19-36-14-12-35(3)13-15-36/h5-11,16-17H,4,12-15,18-20H2,1-3H3,(H,32,38)(H,33,34)
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n/an/a 45n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188757
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5cccc(C)c5)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-8-9-26(37-23)28-25-16-21-7-6-20(15-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50210283
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-9-10-27(38-24)29-26-17-22-8-7-21(16-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
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n/an/a 51n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188727
PNG
(1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O2S/c1-37-10-12-39(13-11-37)17-19-6-8-24-20(14-19)15-25-27(24)35-36-28(25)26-9-7-23(42-26)18-38(2)29(40)34-21-4-3-5-22(16-21)41-30(31,32)33/h3-9,14,16H,10-13,15,17-18H2,1-2H3,(H,34,40)(H,35,36)
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n/an/a 56n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188764
PNG
(3-(4-fluorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C29H31FN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 59n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188733
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-4-12-38(32(39)33-25-7-5-6-22(2)17-25)21-26-9-11-29(40-26)31-28-19-24-18-23(8-10-27(24)30(28)34-35-31)20-37-15-13-36(3)14-16-37/h5-11,17-18H,4,12-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
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n/an/a 59n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188739
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
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n/an/a 61n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188737
PNG
(1-(3,5-dimethylphenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(C)cc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C30H34N6OS/c1-19-12-20(2)14-23(13-19)32-30(37)31-17-24-5-7-27(38-24)29-26-16-22-15-21(4-6-25(22)28(26)33-34-29)18-36-10-8-35(3)9-11-36/h4-7,12-15H,8-11,16-18H2,1-3H3,(H,33,34)(H2,31,32,37)
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n/an/a 63n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188752
PNG
(3-(4-chlorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 64n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188757
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5cccc(C)c5)s4)-c3c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-8-9-26(37-23)28-25-16-21-7-6-20(15-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
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n/an/a 69n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188733
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CCCN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1cc(CN3CCN(C)CC3)ccc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C32H38N6OS/c1-4-12-38(32(39)33-25-7-5-6-22(2)17-25)21-26-9-11-29(40-26)31-28-19-24-18-23(8-10-27(24)30(28)34-35-31)20-37-15-13-36(3)14-16-37/h5-11,17-18H,4,12-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
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n/an/a 75n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50188735
PNG
(1-(3,5-dichlorophenyl)-3-((5-(6-((4-methylpiperazi...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cc(Cl)cc(Cl)c4)s3)c2)CC1
Show InChI InChI=1S/C28H28Cl2N6OS/c1-35-6-8-36(9-7-35)16-17-2-4-23-18(10-17)11-24-26(23)33-34-27(24)25-5-3-22(38-25)15-31-28(37)32-21-13-19(29)12-20(30)14-21/h2-5,10,12-14H,6-9,11,15-16H2,1H3,(H,33,34)(H2,31,32,37)
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n/an/a 79n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50188764
PNG
(3-(4-fluorophenyl)-1-methyl-1-((5-(7-((4-methylpip...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C29H31FN6OS/c1-34-11-13-36(14-12-34)17-19-3-4-20-16-25-27(24(20)15-19)32-33-28(25)26-10-9-23(38-26)18-35(2)29(37)31-22-7-5-21(30)6-8-22/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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n/an/a 83n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT1 at 1mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188739
PNG
(1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(C)c4)s3)c2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-19-4-3-5-22(14-19)31-29(36)30-17-23-7-9-26(37-23)28-25-16-21-15-20(6-8-24(21)27(25)32-33-28)18-35-12-10-34(2)11-13-35/h3-9,14-15H,10-13,16-18H2,1-2H3,(H,32,33)(H2,30,31,36)
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n/an/a 86n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50210283
PNG
(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Show SMILES CN(Cc1ccc(s1)-c1[nH]nc-2c1Cc1ccc(CN3CCN(C)CC3)cc-21)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H34N6OS/c1-20-5-4-6-23(15-20)31-30(37)35(3)19-24-9-10-27(38-24)29-26-17-22-8-7-21(16-25(22)28(26)32-33-29)18-36-13-11-34(2)12-14-36/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,31,37)(H,32,33)
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n/an/a 96n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50188728
PNG
(1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihy...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccc(CNC(=O)Nc5ccccc5)s4)-c3c2)CC1
Show InChI InChI=1S/C28H30N6OS/c1-33-11-13-34(14-12-33)18-19-7-8-20-16-24-26(23(20)15-19)31-32-27(24)25-10-9-22(36-25)17-29-28(35)30-21-5-3-2-4-6-21/h2-10,15H,11-14,16-18H2,1H3,(H,31,32)(H2,29,30,35)
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n/an/a 101n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of cKit at 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 16: 4266-71 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.066
BindingDB Entry DOI: 10.7270/Q2NP242Q
More data for this
Ligand-Target Pair
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