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Compile Data Set for Download or QSAR

Found 30 hits with Last Name = 'aktas' and Initial = 'bh'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018903
PNG
(CHEMBL3287126)
Show SMILES COc1cc2CCc3sc(N\N=C(/Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC
Show InChI InChI=1S/C22H20N4O6S/c1-31-17-10-12-7-8-19-20(14(12)11-18(17)32-2)23-22(33-19)25-24-15(21(27)28)9-13-5-3-4-6-16(13)26(29)30/h3-6,10-11H,7-9H2,1-2H3,(H,23,25)(H,27,28)/b24-15+
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n/an/a 1.05E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018904
PNG
(CHEMBL3287130)
Show SMILES COc1cc2OCc3sc(N\N=C(/Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC
Show InChI InChI=1S/C21H18N4O7S/c1-30-16-8-12-15(9-17(16)31-2)32-10-18-19(12)22-21(33-18)24-23-13(20(26)27)7-11-5-3-4-6-14(11)25(28)29/h3-6,8-9H,7,10H2,1-2H3,(H,22,24)(H,26,27)/b23-13+
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n/an/a 1.05E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018906
PNG
(CHEMBL3287117)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CSc3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O4S2/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12-
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n/an/a 1.15E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018902
PNG
(CHEMBL3287115)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CSc3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O4S2/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13-
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n/an/a 1.40E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018907
PNG
(CHEMBL3287111)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(COc3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12-
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n/an/a 1.55E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018908
PNG
(CHEMBL3287114)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CSc3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O4S2/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+
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n/an/a 1.55E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018926
PNG
(CHEMBL3287128)
Show SMILES COc1ccc2-c3nc(N\N=C(/Cc4ccccc4[N+]([O-])=O)C(O)=O)sc3COc2c1OC
Show InChI InChI=1S/C21H18N4O7S/c1-30-15-8-7-12-17-16(10-32-18(12)19(15)31-2)33-21(22-17)24-23-13(20(26)27)9-11-5-3-4-6-14(11)25(28)29/h3-8H,9-10H2,1-2H3,(H,22,24)(H,26,27)/b23-13+
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n/an/a 1.65E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018909
PNG
(CHEMBL3287112)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(COc3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+
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n/an/a 1.85E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018910
PNG
(CHEMBL3287106)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CCc3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C20H14Cl2N4O4S/c21-13-7-10-5-6-17-18(12(10)9-14(13)22)23-20(31-17)25-24-15(19(27)28)8-11-3-1-2-4-16(11)26(29)30/h1-4,7,9H,5-6,8H2,(H,23,25)(H,27,28)/b24-15+
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n/an/a 2.15E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018911
PNG
(CHEMBL3287110)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(COc3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+
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n/an/a 2.50E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018913
PNG
(CHEMBL3287113)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(COc3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13-
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n/an/a 2.70E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018916
PNG
(CHEMBL3287116)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CSc3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O4S2/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+
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n/an/a 2.80E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018917
PNG
(CHEMBL3287119)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(C[S+]([O-])c3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S2/c20-11-6-10-16(7-12(11)21)32(30)8-15-17(10)22-19(31-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13-
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n/an/a 3.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018920
PNG
(CHEMBL3287118)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(C[S+]([O-])c3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S2/c20-11-6-10-16(7-12(11)21)32(30)8-15-17(10)22-19(31-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+
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n/an/a 3.05E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018918
PNG
(CHEMBL3287108)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CCc3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C20H14Cl2N4O4S/c21-13-7-5-12-11(17(13)22)6-8-16-18(12)23-20(31-16)25-24-14(19(27)28)9-10-3-1-2-4-15(10)26(29)30/h1-5,7H,6,8-9H2,(H,23,25)(H,27,28)/b24-14+
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n/an/a 3.20E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018921
PNG
(CHEMBL3287121)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(C[S+]([O-])c3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S2/c20-11-6-5-10-16-14(8-32(30)17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12-
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n/an/a 3.25E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018927
PNG
(CHEMBL3287107)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CCc3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C20H14Cl2N4O4S/c21-13-7-10-5-6-17-18(12(10)9-14(13)22)23-20(31-17)25-24-15(19(27)28)8-11-3-1-2-4-16(11)26(29)30/h1-4,7,9H,5-6,8H2,(H,23,25)(H,27,28)/b24-15-
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n/an/a 3.40E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018935
PNG
(CHEMBL3287123)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CS(=O)(=O)c3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O6S2/c20-11-6-5-10-16-14(8-33(30,31)17(10)15(11)21)32-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12-
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n/an/a 3.90E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018936
PNG
(CHEMBL3287122)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CS(=O)(=O)c3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O6S2/c20-11-6-5-10-16-14(8-33(30,31)17(10)15(11)21)32-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+
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n/an/a 4.05E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018919
PNG
(CHEMBL254578)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14-
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n/an/a 4.35E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018922
PNG
(CHEMBL3287109)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CCc3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C20H14Cl2N4O4S/c21-13-7-5-12-11(17(13)22)6-8-16-18(12)23-20(31-16)25-24-14(19(27)28)9-10-3-1-2-4-15(10)26(29)30/h1-5,7H,6,8-9H2,(H,23,25)(H,27,28)/b24-14-
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n/an/a 4.35E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018923
PNG
(CHEMBL3287127)
Show SMILES COc1cc2CCc3sc(N\N=C(\Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC
Show InChI InChI=1S/C22H20N4O6S/c1-31-17-10-12-7-8-19-20(14(12)11-18(17)32-2)23-22(33-19)25-24-15(21(27)28)9-13-5-3-4-6-16(13)26(29)30/h3-6,10-11H,7-9H2,1-2H3,(H,23,25)(H,27,28)/b24-15-
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n/an/a 4.50E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018937
PNG
(CHEMBL3287120)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(C[S+]([O-])c3c(Cl)c(Cl)ccc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O5S2/c20-11-6-5-10-16-14(8-32(30)17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+
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n/an/a 4.85E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018924
PNG
(CHEMBL3287124)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CS(=O)(=O)c3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O6S2/c20-11-6-10-16(7-12(11)21)33(30,31)8-15-17(10)22-19(32-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+
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n/an/a 4.90E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018925
PNG
(CHEMBL3287125)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CS(=O)(=O)c3cc(Cl)c(Cl)cc-23)s1
Show InChI InChI=1S/C19H12Cl2N4O6S2/c20-11-6-10-16(7-12(11)21)33(30,31)8-15-17(10)22-19(32-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13-
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n/an/a 4.90E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018928
PNG
(CHEMBL3287131)
Show SMILES COc1cc2OCc3sc(N\N=C(\Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC
Show InChI InChI=1S/C21H18N4O7S/c1-30-16-8-12-15(9-17(16)31-2)32-10-18-19(12)22-21(33-18)24-23-13(20(26)27)7-11-5-3-4-6-14(11)25(28)29/h3-6,8-9H,7,10H2,1-2H3,(H,22,24)(H,26,27)/b23-13-
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n/an/a 5.15E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018934
PNG
(CHEMBL3287129)
Show SMILES COc1ccc2-c3nc(N\N=C(\Cc4ccccc4[N+]([O-])=O)C(O)=O)sc3COc2c1OC
Show InChI InChI=1S/C21H18N4O7S/c1-30-15-8-7-12-17-16(10-32-18(12)19(15)31-2)33-21(22-17)24-23-13(20(26)27)9-11-5-3-4-6-14(11)25(28)29/h3-8H,9-10H2,1-2H3,(H,22,24)(H,26,27)/b23-13-
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n/an/a 5.55E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Displacement of N-alpha-fluorescein tagged eIF4G-derived peptide from GST-DN26-eIF4E (unknown origin) by fluorescence polarization assay


J Med Chem 57: 5094-111 (2014)


Article DOI: 10.1021/jm401733v
BindingDB Entry DOI: 10.7270/Q2251KR7
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018919
PNG
(CHEMBL254578)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14-
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n/an/an/a 8.74E+6n/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...


Eur J Med Chem 77: 361-77 (2014)


Article DOI: 10.1016/j.ejmech.2014.03.034
BindingDB Entry DOI: 10.7270/Q2Z89F19
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50044268
PNG
(CHEMBL3310215)
Show SMILES Nc1ccc(C\C(=N\Nc2nc(cs2)-c2ccc(Cl)c(Cl)c2)C(O)=O)cc1[N+]([O-])=O
Show InChI InChI=1S/C18H13Cl2N5O4S/c19-11-3-2-10(7-12(11)20)15-8-30-18(22-15)24-23-14(17(26)27)5-9-1-4-13(21)16(6-9)25(28)29/h1-4,6-8H,5,21H2,(H,22,24)(H,26,27)/b23-14-
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n/an/an/a 5.01E+6n/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...


Eur J Med Chem 77: 361-77 (2014)


Article DOI: 10.1016/j.ejmech.2014.03.034
BindingDB Entry DOI: 10.7270/Q2Z89F19
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50044269
PNG
(CHEMBL3310347)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H14N4O5S/c23-13-7-5-11(6-8-13)15-10-28-18(19-15)21-20-14(17(24)25)9-12-3-1-2-4-16(12)22(26)27/h1-8,10,23H,9H2,(H,19,21)(H,24,25)/b20-14-
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n/an/an/a 3.66E+7n/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...


Eur J Med Chem 77: 361-77 (2014)


Article DOI: 10.1016/j.ejmech.2014.03.034
BindingDB Entry DOI: 10.7270/Q2Z89F19
More data for this
Ligand-Target Pair