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Compile Data Set for Download or QSAR

Found 42 hits with Last Name = 'akué-gédu' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326438
PNG
(9-trifluoromethyl-1,10-dihydropyrrolo[2,3-a]carbaz...)
Show SMILES FC(F)(F)c1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C16H9F3N2O/c17-16(18,19)12-3-1-2-10-11-5-4-9-8(7-22)6-20-14(9)15(11)21-13(10)12/h1-7,20-21H
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n/an/a 6n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326436
PNG
(6-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1cccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c12
Show InChI InChI=1S/C15H9BrN2O/c16-11-2-1-3-12-13(11)10-5-4-9-8(7-19)6-17-14(9)15(10)18-12/h1-7,17-18H
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n/an/a 6.80n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim1 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365178
PNG
(CHEMBL1950228)
Show SMILES O=Cc1cn2CCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C19H16N2O/c22-12-13-11-20-9-3-4-10-21-17-6-2-1-5-15(17)16-8-7-14(13)18(20)19(16)21/h1-2,5-8,11-12H,3-4,9-10H2
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n/an/a 8n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299249
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H
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Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299249
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H
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n/an/a 10n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326436
PNG
(6-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1cccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c12
Show InChI InChI=1S/C15H9BrN2O/c16-11-2-1-3-12-13(11)10-5-4-9-8(7-19)6-17-14(9)15(10)18-12/h1-7,17-18H
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n/an/a 12.4n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365178
PNG
(CHEMBL1950228)
Show SMILES O=Cc1cn2CCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C19H16N2O/c22-12-13-11-20-9-3-4-10-21-17-6-2-1-5-15(17)16-8-7-14(13)18(20)19(16)21/h1-2,5-8,11-12H,3-4,9-10H2
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n/an/a 13n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326438
PNG
(9-trifluoromethyl-1,10-dihydropyrrolo[2,3-a]carbaz...)
Show SMILES FC(F)(F)c1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C16H9F3N2O/c17-16(18,19)12-3-1-2-10-11-5-4-9-8(7-22)6-20-14(9)15(11)21-13(10)12/h1-7,20-21H
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n/an/a 18n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim1 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326441
PNG
(9-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C15H9BrN2O/c16-12-3-1-2-10-11-5-4-9-8(7-19)6-17-14(9)15(11)18-13(10)12/h1-7,17-18H
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n/an/a 24n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326439
PNG
(CHEMBL1243128 | Methyl 3-formyl-1,10-dihydropyrrol...)
Show SMILES COC(=O)c1cccc2c3ccc4c(C=O)c[nH]c4c3[nH]c12
Show InChI InChI=1S/C17H12N2O3/c1-22-17(21)13-4-2-3-11-12-6-5-10-9(8-20)7-18-15(10)16(12)19-14(11)13/h2-8,18-19H,1H3
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Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim1 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326441
PNG
(9-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C15H9BrN2O/c16-12-3-1-2-10-11-5-4-9-8(7-19)6-17-14(9)15(11)18-13(10)12/h1-7,17-18H
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n/an/a 31n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim1 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326439
PNG
(CHEMBL1243128 | Methyl 3-formyl-1,10-dihydropyrrol...)
Show SMILES COC(=O)c1cccc2c3ccc4c(C=O)c[nH]c4c3[nH]c12
Show InChI InChI=1S/C17H12N2O3/c1-22-17(21)13-4-2-3-11-12-6-5-10-9(8-20)7-18-15(10)16(12)19-14(11)13/h2-8,18-19H,1H3
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Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299245
PNG
(7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1ccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c2c1
Show InChI InChI=1S/C15H9BrN2O/c16-9-1-4-13-12(5-9)11-3-2-10-8(7-19)6-17-14(10)15(11)18-13/h1-7,17-18H
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n/an/a 40n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385115
PNG
(CHEMBL2036116)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3n(CCCCC#N)c21
Show InChI InChI=1S/C20H17N3O/c21-10-4-1-5-11-23-18-7-3-2-6-16(18)17-9-8-15-14(13-24)12-22-19(15)20(17)23/h2-3,6-9,12-13,22H,1,4-5,11H2
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n/an/a 41n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3 using RSRHSSYPAGT as substrate after 30 mins


Bioorg Med Chem Lett 22: 3807-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.098
BindingDB Entry DOI: 10.7270/Q2HX1DQB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385115
PNG
(CHEMBL2036116)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3n(CCCCC#N)c21
Show InChI InChI=1S/C20H17N3O/c21-10-4-1-5-11-23-18-7-3-2-6-16(18)17-9-8-15-14(13-24)12-22-19(15)20(17)23/h2-3,6-9,12-13,22H,1,4-5,11H2
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Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-1 using RSRHSSYPAGT as substrate after 30 mins


Bioorg Med Chem Lett 22: 3807-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.098
BindingDB Entry DOI: 10.7270/Q2HX1DQB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326440
PNG
(9-Ethyl-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES CCc1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C17H14N2O/c1-2-10-4-3-5-13-14-7-6-12-11(9-20)8-18-16(12)17(14)19-15(10)13/h3-9,18-19H,2H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326440
PNG
(9-Ethyl-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES CCc1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C17H14N2O/c1-2-10-4-3-5-13-14-7-6-12-11(9-20)8-18-16(12)17(14)19-15(10)13/h3-9,18-19H,2H2,1H3
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n/an/a 66n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim1 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385117
PNG
(CHEMBL2036118)
Show SMILES CN(C)CCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C21H23N3O/c1-23(2)11-5-6-12-24-19-8-4-3-7-17(19)18-10-9-16-15(14-25)13-22-20(16)21(18)24/h3-4,7-10,13-14,22H,5-6,11-12H2,1-2H3
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n/an/a 75n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-1 using RSRHSSYPAGT as substrate after 30 mins


Bioorg Med Chem Lett 22: 3807-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.098
BindingDB Entry DOI: 10.7270/Q2HX1DQB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385117
PNG
(CHEMBL2036118)
Show SMILES CN(C)CCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C21H23N3O/c1-23(2)11-5-6-12-24-19-8-4-3-7-17(19)18-10-9-16-15(14-25)13-22-20(16)21(18)24/h3-4,7-10,13-14,22H,5-6,11-12H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3 using RSRHSSYPAGT as substrate after 30 mins


Bioorg Med Chem Lett 22: 3807-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.098
BindingDB Entry DOI: 10.7270/Q2HX1DQB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326437
PNG
(8-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1ccc2c(c1)[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C15H9BrN2O/c16-9-1-2-11-12-4-3-10-8(7-19)6-17-14(10)15(12)18-13(11)5-9/h1-7,17-18H
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n/an/a 90n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365179
PNG
(CHEMBL1950229)
Show SMILES [N-]=[N+]=NCCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C19H17N5O/c20-23-22-9-3-4-10-24-17-6-2-1-5-15(17)16-8-7-14-13(12-25)11-21-18(14)19(16)24/h1-2,5-8,11-12,21H,3-4,9-10H2
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Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365179
PNG
(CHEMBL1950229)
Show SMILES [N-]=[N+]=NCCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C19H17N5O/c20-23-22-9-3-4-10-24-17-6-2-1-5-15(17)16-8-7-14-13(12-25)11-21-18(14)19(16)24/h1-2,5-8,11-12,21H,3-4,9-10H2
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n/an/a 108n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50326442
PNG
(8-Methyl-1,10-dihydropyrrolo[2,3-a]carbazole-3-car...)
Show SMILES Cc1ccc2c(c1)[nH]c1c2ccc2c(C=O)c[nH]c12
Show InChI InChI=1S/C16H12N2O/c1-9-2-3-12-13-5-4-11-10(8-19)7-17-15(11)16(13)18-14(12)6-9/h2-8,17-18H,1H3
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n/an/a 117n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299249
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H
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n/an/a 120n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-1


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299249
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H
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n/an/a 120n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim1 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50326436
PNG
(6-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1cccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c12
Show InChI InChI=1S/C15H9BrN2O/c16-11-2-1-3-12-13(11)10-5-4-9-8(7-19)6-17-14(9)15(10)18-12/h1-7,17-18H
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n/an/a 131n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim2 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299247
PNG
(1-(1,10-Dihydropyrrolo[2,3-a]carbazol-3-yl)-2,2,2-...)
Show SMILES FC(F)(F)C(=O)c1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C16H9F3N2O/c17-16(18,19)15(22)11-7-20-13-10(11)6-5-9-8-3-1-2-4-12(8)21-14(9)13/h1-7,20-21H
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n/an/a 170n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299250
PNG
(7-(2,4-Difluorophenyl)-1,10-dihydropyrrolo[2,3-a]c...)
Show SMILES Fc1ccc(c(F)c1)-c1ccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c2c1
Show InChI InChI=1S/C21H12F2N2O/c22-13-2-3-14(18(23)8-13)11-1-6-19-17(7-11)16-5-4-15-12(10-26)9-24-20(15)21(16)25-19/h1-10,24-25H
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n/an/a 200n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385116
PNG
(CHEMBL2036117)
Show SMILES CC(C)(C)OC(=O)NCCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C24H27N3O3/c1-24(2,3)30-23(29)25-12-6-7-13-27-20-9-5-4-8-18(20)19-11-10-17-16(15-28)14-26-21(17)22(19)27/h4-5,8-11,14-15,26H,6-7,12-13H2,1-3H3,(H,25,29)
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n/an/a 200n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3 using RSRHSSYPAGT as substrate after 30 mins


Bioorg Med Chem Lett 22: 3807-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.098
BindingDB Entry DOI: 10.7270/Q2HX1DQB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299248
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carboxamide ...)
Show SMILES NC(=O)c1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H11N3O/c16-15(19)11-7-17-13-10(11)6-5-9-8-3-1-2-4-12(8)18-14(9)13/h1-7,17-18H,(H2,16,19)
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n/an/a 210n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365180
PNG
(CHEMBL1950230)
Show SMILES OCc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C22H21N5O2/c28-13-15-11-23-21-17(15)7-8-19-18-5-1-2-6-20(18)27(22(19)21)10-4-3-9-26-12-16(14-29)24-25-26/h1-2,5-8,11-13,23,29H,3-4,9-10,14H2
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n/an/a 235n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365180
PNG
(CHEMBL1950230)
Show SMILES OCc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C22H21N5O2/c28-13-15-11-23-21-17(15)7-8-19-18-5-1-2-6-20(18)27(22(19)21)10-4-3-9-26-12-16(14-29)24-25-26/h1-2,5-8,11-13,23,29H,3-4,9-10,14H2
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n/an/a 315n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365181
PNG
(CHEMBL1950358)
Show SMILES C[N+](C)(CCO)Cc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C26H30N6O2/c1-32(2,13-14-33)17-20-16-30(29-28-20)11-5-6-12-31-24-8-4-3-7-22(24)23-10-9-21-19(18-34)15-27-25(21)26(23)31/h3-4,7-10,15-16,18,33H,5-6,11-14,17H2,1-2H3/p+1
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n/an/a 327n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50365178
PNG
(CHEMBL1950228)
Show SMILES O=Cc1cn2CCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C19H16N2O/c22-12-13-11-20-9-3-4-10-21-17-6-2-1-5-15(17)16-8-7-14(13)18(20)19(16)21/h1-2,5-8,11-12H,3-4,9-10H2
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n/an/a 350n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PIM2 expressed in Escherichia coli using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299246
PNG
(7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole | CHEM...)
Show SMILES Brc1ccc2[nH]c3c(ccc4cc[nH]c34)c2c1
Show InChI InChI=1S/C14H9BrN2/c15-9-2-4-12-11(7-9)10-3-1-8-5-6-16-13(8)14(10)17-12/h1-7,16-17H
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n/an/a 440n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-3


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385116
PNG
(CHEMBL2036117)
Show SMILES CC(C)(C)OC(=O)NCCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C24H27N3O3/c1-24(2,3)30-23(29)25-12-6-7-13-27-20-9-5-4-8-18(20)19-11-10-17-16(15-28)14-26-21(17)22(19)27/h4-5,8-11,14-15,26H,6-7,12-13H2,1-3H3,(H,25,29)
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n/an/a 470n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-1 using RSRHSSYPAGT as substrate after 30 mins


Bioorg Med Chem Lett 22: 3807-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.098
BindingDB Entry DOI: 10.7270/Q2HX1DQB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50365181
PNG
(CHEMBL1950358)
Show SMILES C[N+](C)(CCO)Cc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C26H30N6O2/c1-32(2,13-14-33)17-20-16-30(29-28-20)11-5-6-12-31-24-8-4-3-7-22(24)23-10-9-21-19(18-34)15-27-25(21)26(23)31/h3-4,7-10,15-16,18,33H,5-6,11-14,17H2,1-2H3/p+1
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n/an/a 490n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins


Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50299249
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H
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n/an/a 510n/an/an/an/an/an/a



Clermont Université

Curated by ChEMBL


Assay Description
Inhibition of human GST fused Pim2 expressed in Escherichia coli after 30 mins


Bioorg Med Chem 18: 6865-73 (2010)


Article DOI: 10.1016/j.bmc.2010.07.036
BindingDB Entry DOI: 10.7270/Q2PK0GBZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50299249
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...)
Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H
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n/an/a 510n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-2


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299245
PNG
(7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carb...)
Show SMILES Brc1ccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c2c1
Show InChI InChI=1S/C15H9BrN2O/c16-9-1-4-13-12(5-9)11-3-2-10-8(7-19)6-17-14(10)15(11)18-13/h1-7,17-18H
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n/an/a 570n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-1


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299250
PNG
(7-(2,4-Difluorophenyl)-1,10-dihydropyrrolo[2,3-a]c...)
Show SMILES Fc1ccc(c(F)c1)-c1ccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c2c1
Show InChI InChI=1S/C21H12F2N2O/c22-13-2-3-14(18(23)8-13)11-1-6-19-17(7-11)16-5-4-15-12(10-26)9-24-20(15)21(16)25-19/h1-10,24-25H
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n/an/a 660n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-1


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50299248
PNG
(1,10-Dihydropyrrolo[2,3-a]carbazole-3-carboxamide ...)
Show SMILES NC(=O)c1c[nH]c2c1ccc1c3ccccc3[nH]c21
Show InChI InChI=1S/C15H11N3O/c16-15(19)11-7-17-13-10(11)6-5-9-8-3-1-2-4-12(8)18-14(9)13/h1-7,17-18H,(H2,16,19)
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n/an/a 780n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of Pim-1


J Med Chem 52: 6369-81 (2009)


Article DOI: 10.1021/jm901018f
BindingDB Entry DOI: 10.7270/Q23F4PPS
More data for this
Ligand-Target Pair