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Compile Data Set for Download or QSAR

Found 34 hits with Last Name = 'alabaster' and Initial = 'va'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226814
PNG
(CHEMBL6424)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H29N5O3/c1-31-20-14-18-19(15-21(20)32-2)27-24(28-22(18)25)29-12-9-17(10-13-29)23(30)26-11-8-16-6-4-3-5-7-16/h3-7,14-15,17H,8-13H2,1-2H3,(H,26,30)(H2,25,27,28)
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0.100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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0.190n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226844
PNG
(CHEMBL415288)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C24H29N5O3/c1-28(15-16-7-5-4-6-8-16)23(30)17-9-11-29(12-10-17)24-26-19-14-21(32-3)20(31-2)13-18(19)22(25)27-24/h4-8,13-14,17H,9-12,15H2,1-3H3,(H2,25,26,27)
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0.200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226846
PNG
(CHEMBL6474)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H27N5O3/c1-30-19-12-17-18(13-20(19)31-2)26-23(27-21(17)24)28-10-8-16(9-11-28)22(29)25-14-15-6-4-3-5-7-15/h3-7,12-13,16H,8-11,14H2,1-2H3,(H,25,29)(H2,24,26,27)
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0.220n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226812
PNG
(CHEMBL266317)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCOc1ccccc1
Show InChI InChI=1S/C24H29N5O4/c1-31-20-14-18-19(15-21(20)32-2)27-24(28-22(18)25)29-11-8-16(9-12-29)23(30)26-10-13-33-17-6-4-3-5-7-17/h3-7,14-16H,8-13H2,1-2H3,(H,26,30)(H2,25,27,28)
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0.420n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226847
PNG
(CHEMBL6380)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C22H25N5O3/c1-29-18-12-16-17(13-19(18)30-2)25-22(26-20(16)23)27-10-8-14(9-11-27)21(28)24-15-6-4-3-5-7-15/h3-7,12-14H,8-11H2,1-2H3,(H,24,28)(H2,23,25,26)
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0.470n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226839
PNG
(CHEMBL267457)
Show SMILES CCCCNC(=O)CCC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C22H33N5O3/c1-4-5-10-24-20(28)7-6-15-8-11-27(12-9-15)22-25-17-14-19(30-3)18(29-2)13-16(17)21(23)26-22/h13-15H,4-12H2,1-3H3,(H,24,28)(H2,23,25,26)
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0.470n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226848
PNG
(CHEMBL6598)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NC1CCCC1
Show InChI InChI=1S/C21H29N5O3/c1-28-17-11-15-16(12-18(17)29-2)24-21(25-19(15)22)26-9-7-13(8-10-26)20(27)23-14-5-3-4-6-14/h11-14H,3-10H2,1-2H3,(H,23,27)(H2,22,24,25)
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0.630n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226813
PNG
(CHEMBL6766)
Show SMILES CCCNC(=O)CC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C20H29N5O3/c1-4-7-22-18(26)10-13-5-8-25(9-6-13)20-23-15-12-17(28-3)16(27-2)11-14(15)19(21)24-20/h11-13H,4-10H2,1-3H3,(H,22,26)(H2,21,23,24)
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0.650n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226853
PNG
(CHEMBL6556)
Show SMILES CCCCNC(=O)C1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C20H29N5O3/c1-4-5-8-22-19(26)13-6-9-25(10-7-13)20-23-15-12-17(28-3)16(27-2)11-14(15)18(21)24-20/h11-13H,4-10H2,1-3H3,(H,22,26)(H2,21,23,24)
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0.670n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226842
PNG
(CHEMBL6481)
Show SMILES CCCCNC(=O)COC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C21H31N5O4/c1-4-5-8-23-19(27)13-30-14-6-9-26(10-7-14)21-24-16-12-18(29-3)17(28-2)11-15(16)20(22)25-21/h11-12,14H,4-10,13H2,1-3H3,(H,23,27)(H2,22,24,25)
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0.790n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226838
PNG
(CHEMBL6447)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCC1CC1
Show InChI InChI=1S/C20H27N5O3/c1-27-16-9-14-15(10-17(16)28-2)23-20(24-18(14)21)25-7-5-13(6-8-25)19(26)22-11-12-3-4-12/h9-10,12-13H,3-8,11H2,1-2H3,(H,22,26)(H2,21,23,24)
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0.900n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226852
PNG
(CHEMBL267164)
Show SMILES COCCNC(=O)C1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C19H27N5O4/c1-26-9-6-21-18(25)12-4-7-24(8-5-12)19-22-14-11-16(28-3)15(27-2)10-13(14)17(20)23-19/h10-12H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
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1.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226854
PNG
(CHEMBL267705)
Show SMILES CCN(CC)C(=O)C1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C20H29N5O3/c1-5-24(6-2)19(26)13-7-9-25(10-8-13)20-22-15-12-17(28-4)16(27-3)11-14(15)18(21)23-20/h11-13H,5-10H2,1-4H3,(H2,21,22,23)
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1.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226855
PNG
(CHEMBL6610)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C20H27N5O4/c1-27-16-11-14-15(12-17(16)28-2)22-20(23-18(14)21)25-5-3-13(4-6-25)19(26)24-7-9-29-10-8-24/h11-13H,3-10H2,1-2H3,(H2,21,22,23)
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1.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226845
PNG
(CHEMBL269537)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC(=O)NCC2CC2)CC1
Show InChI InChI=1S/C21H29N5O3/c1-28-17-10-15-16(11-18(17)29-2)24-21(25-20(15)22)26-7-5-13(6-8-26)9-19(27)23-12-14-3-4-14/h10-11,13-14H,3-9,12H2,1-2H3,(H,23,27)(H2,22,24,25)
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1.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226840
PNG
(CHEMBL6789)
Show SMILES CCCCNC(=O)CC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C21H31N5O3/c1-4-5-8-23-19(27)11-14-6-9-26(10-7-14)21-24-16-13-18(29-3)17(28-2)12-15(16)20(22)25-21/h12-14H,4-11H2,1-3H3,(H,23,27)(H2,22,24,25)
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1.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226841
PNG
(CHEMBL266927)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(N)=O
Show InChI InChI=1S/C16H21N5O3/c1-23-12-7-10-11(8-13(12)24-2)19-16(20-14(10)17)21-5-3-9(4-6-21)15(18)22/h7-9H,3-6H2,1-2H3,(H2,18,22)(H2,17,19,20)
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1.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226843
PNG
(CHEMBL268627)
Show SMILES CCNC(=O)C1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C18H25N5O3/c1-4-20-17(24)11-5-7-23(8-6-11)18-21-13-10-15(26-3)14(25-2)9-12(13)16(19)22-18/h9-11H,4-8H2,1-3H3,(H,20,24)(H2,19,21,22)
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1.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226850
PNG
(CHEMBL6431)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCO
Show InChI InChI=1S/C18H25N5O4/c1-26-14-9-12-13(10-15(14)27-2)21-18(22-16(12)19)23-6-3-11(4-7-23)17(25)20-5-8-24/h9-11,24H,3-8H2,1-2H3,(H,20,25)(H2,19,21,22)
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1.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226849
PNG
(CHEMBL266279)
Show SMILES CCCCNC(=O)C1CCCN(C1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C20H29N5O3/c1-4-5-8-22-19(26)13-7-6-9-25(12-13)20-23-15-11-17(28-3)16(27-2)10-14(15)18(21)24-20/h10-11,13H,4-9,12H2,1-3H3,(H,22,26)(H2,21,23,24)
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8.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226845
PNG
(CHEMBL269537)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC(=O)NCC2CC2)CC1
Show InChI InChI=1S/C21H29N5O3/c1-28-17-10-15-16(11-18(17)29-2)24-21(25-20(15)22)26-7-5-13(6-8-26)9-19(27)23-12-14-3-4-14/h10-11,13-14H,3-9,12H2,1-2H3,(H,23,27)(H2,22,24,25)
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53n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226840
PNG
(CHEMBL6789)
Show SMILES CCCCNC(=O)CC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C21H31N5O3/c1-4-5-8-23-19(27)11-14-6-9-26(10-7-14)21-24-16-13-18(29-3)17(28-2)12-15(16)20(22)25-21/h12-14H,4-11H2,1-3H3,(H,23,27)(H2,22,24,25)
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54n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226813
PNG
(CHEMBL6766)
Show SMILES CCCNC(=O)CC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C20H29N5O3/c1-4-7-22-18(26)10-13-5-8-25(9-6-13)20-23-15-12-17(28-3)16(27-2)11-14(15)19(21)24-20/h11-13H,4-10H2,1-3H3,(H,22,26)(H2,21,23,24)
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55n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226812
PNG
(CHEMBL266317)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCOc1ccccc1
Show InChI InChI=1S/C24H29N5O4/c1-31-20-14-18-19(15-21(20)32-2)27-24(28-22(18)25)29-11-8-16(9-12-29)23(30)26-10-13-33-17-6-4-3-5-7-17/h3-7,14-16H,8-13H2,1-2H3,(H,26,30)(H2,25,27,28)
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56n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226841
PNG
(CHEMBL266927)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(N)=O
Show InChI InChI=1S/C16H21N5O3/c1-23-12-7-10-11(8-13(12)24-2)19-16(20-14(10)17)21-5-3-9(4-6-21)15(18)22/h7-9H,3-6H2,1-2H3,(H2,18,22)(H2,17,19,20)
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56n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226842
PNG
(CHEMBL6481)
Show SMILES CCCCNC(=O)COC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C21H31N5O4/c1-4-5-8-23-19(27)13-30-14-6-9-26(10-7-14)21-24-16-12-18(29-3)17(28-2)11-15(16)20(22)25-21/h11-12,14H,4-10,13H2,1-3H3,(H,23,27)(H2,22,24,25)
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61n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226814
PNG
(CHEMBL6424)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H29N5O3/c1-31-20-14-18-19(15-21(20)32-2)27-24(28-22(18)25)29-12-9-17(10-13-29)23(30)26-11-8-16-6-4-3-5-7-16/h3-7,14-15,17H,8-13H2,1-2H3,(H,26,30)(H2,25,27,28)
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62n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226853
PNG
(CHEMBL6556)
Show SMILES CCCCNC(=O)C1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C20H29N5O3/c1-4-5-8-22-19(26)13-6-9-25(10-7-13)20-23-15-12-17(28-3)16(27-2)11-14(15)18(21)24-20/h11-13H,4-10H2,1-3H3,(H,22,26)(H2,21,23,24)
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63n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226839
PNG
(CHEMBL267457)
Show SMILES CCCCNC(=O)CCC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C22H33N5O3/c1-4-5-10-24-20(28)7-6-15-8-11-27(12-9-15)22-25-17-14-19(30-3)18(29-2)13-16(17)21(23)26-22/h13-15H,4-12H2,1-3H3,(H,24,28)(H2,23,25,26)
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65n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226844
PNG
(CHEMBL415288)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C24H29N5O3/c1-28(15-16-7-5-4-6-8-16)23(30)17-9-11-29(12-10-17)24-26-19-14-21(32-3)20(31-2)13-18(19)22(25)27-24/h4-8,13-14,17H,9-12,15H2,1-3H3,(H2,25,26,27)
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68n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226846
PNG
(CHEMBL6474)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H27N5O3/c1-30-19-12-17-18(13-20(19)31-2)26-23(27-21(17)24)28-10-8-16(9-11-28)22(29)25-14-15-6-4-3-5-7-15/h3-7,12-13,16H,8-11,14H2,1-2H3,(H,25,29)(H2,24,26,27)
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71n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226851
PNG
(CHEMBL6831)
Show SMILES CCN(CC)C(=O)C1CCCN(C1)c1nc(N)c2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C20H29N5O3/c1-5-24(6-2)19(26)13-8-7-9-25(12-13)20-22-15-11-17(28-4)16(27-3)10-14(15)18(21)23-20/h10-11,13H,5-9,12H2,1-4H3,(H2,21,22,23)
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117n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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4.83E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M


J Med Chem 30: 999-1003 (1987)


Article DOI: 10.1021/jm00389a007
More data for this
Ligand-Target Pair