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Compile Data Set for Download or QSAR

Found 334 hits with Last Name = 'ancellin' and Initial = 'n'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266064
PNG
(CHEMBL4104310)
Show SMILES OC(=O)CCn1c2cc(Cl)c(OCc3ccccn3)cc2oc1=O
Show InChI InChI=1S/C16H13ClN2O5/c17-11-7-12-14(24-16(22)19(12)6-4-15(20)21)8-13(11)23-9-10-3-1-2-5-18-10/h1-3,5,7-8H,4,6,9H2,(H,20,21)
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1n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Rattus norvegicus)
BDBM50266003
PNG
(CHEMBL4091152)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1
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45n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266003
PNG
(CHEMBL4091152)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1
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50n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Competitive inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate ...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266041
PNG
(CHEMBL4070212)
Show SMILES C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O5/c1-10(12-4-2-3-6-19-12)24-14-9-15-13(8-11(14)18)20(17(23)25-15)7-5-16(21)22/h2-4,6,8-10H,5,7H2,1H3,(H,21,22)/t10-/m1/s1
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100n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50131810
PNG
(CHEMBL3634602)
Show SMILES C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1cccnn1
Show InChI InChI=1S/C16H14ClN3O5/c1-9(11-3-2-5-18-19-11)24-13-8-14-12(7-10(13)17)20(16(23)25-14)6-4-15(21)22/h2-3,5,7-9H,4,6H2,1H3,(H,21,22)/t9-/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266097
PNG
(CHEMBL4062730)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccc(C)cn1
Show InChI InChI=1S/C18H17ClN2O4.C4H11NO3/c1-10-3-4-14(20-9-10)11(2)24-17-8-16-12(7-13(17)19)15(21-25-16)5-6-18(22)23;5-4(1-6,2-7)3-8/h3-4,7-9,11H,5-6H2,1-2H3,(H,22,23);6-8H,1-3,5H2/t11-;/m1./s1
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n/an/a 1.60n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266065
PNG
(CHEMBL4084414)
Show SMILES C[C@@H](Oc1cc2sc(=O)n(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O4S/c1-10(12-4-2-3-6-19-12)24-14-9-15-13(8-11(14)18)20(17(23)25-15)7-5-16(21)22/h2-4,6,8-10H,5,7H2,1H3,(H,21,22)/t10-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266002
PNG
(CHEMBL4081917)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccc(C)nn1
Show InChI InChI=1S/C17H16ClN3O4/c1-9-3-4-13(20-19-9)10(2)24-16-8-15-11(7-12(16)18)14(21-25-15)5-6-17(22)23/h3-4,7-8,10H,5-6H2,1-2H3,(H,22,23)/t10-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266033
PNG
(CHEMBL4070050)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O5.C4H11NO3/c1-10(12-4-2-3-6-19-12)24-14-9-15-13(8-11(14)18)20(17(23)25-15)7-5-16(21)22;5-4(1-6,2-7)3-8/h2-4,6,8-10H,5,7H2,1H3,(H,21,22);6-8H,1-3,5H2/t10-;/m1./s1
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n/an/a 2.5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266116
PNG
(CHEMBL4077245)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccc(F)cn1
Show InChI InChI=1S/C17H14ClFN2O5.C4H11NO3/c1-9(12-3-2-10(19)8-20-12)25-14-7-15-13(6-11(14)18)21(17(24)26-15)5-4-16(22)23;5-4(1-6,2-7)3-8/h2-3,6-9H,4-5H2,1H3,(H,22,23);6-8H,1-3,5H2/t9-;/m1./s1
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n/an/a 2.5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50043280
PNG
(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
Show InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
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n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of AT1 receptor


Bioorg Med Chem Lett 20: 1399-404 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.107
BindingDB Entry DOI: 10.7270/Q2T43T5R
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266038
PNG
(CHEMBL4074106)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2cnn(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H16ClN3O3.C4H11NO3/c1-11(14-4-2-3-6-19-14)24-16-8-12-10-20-21(7-5-17(22)23)15(12)9-13(16)18;5-4(1-6,2-7)3-8/h2-4,6,8-11H,5,7H2,1H3,(H,22,23);6-8H,1-3,5H2/t11-;/m1./s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266002
PNG
(CHEMBL4081917)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccc(C)nn1
Show InChI InChI=1S/C17H16ClN3O4/c1-9-3-4-13(20-19-9)10(2)24-16-8-15-11(7-12(16)18)14(21-25-15)5-6-17(22)23/h3-4,7-8,10H,5-6H2,1-2H3,(H,22,23)/t10-/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50237995
PNG
(CHEMBL4096688)
Show SMILES NC(CO)(CO)CO.OC(=O)CCn1c2cc(Cl)c(OC3CC3)cc2oc1=O
Show InChI InChI=1S/C13H12ClNO5/c14-8-5-9-11(6-10(8)19-7-1-2-7)20-13(18)15(9)4-3-12(16)17/h5-7H,1-4H2,(H,16,17)
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266121
PNG
(CHEMBL4099039)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccc(C)cn1
Show InChI InChI=1S/C18H17ClN2O5.C4H11NO3/c1-10-3-4-13(20-9-10)11(2)25-15-8-16-14(7-12(15)19)21(18(24)26-16)6-5-17(22)23;5-4(1-6,2-7)3-8/h3-4,7-9,11H,5-6H2,1-2H3,(H,22,23);6-8H,1-3,5H2/t11-;/m1./s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266001
PNG
(CHEMBL4071379)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccc(Cl)cn1
Show InChI InChI=1S/C17H14Cl2N2O4.C4H11NO3/c1-9(13-3-2-10(18)8-20-13)24-16-7-15-11(6-12(16)19)14(21-25-15)4-5-17(22)23;5-4(1-6,2-7)3-8/h2-3,6-9H,4-5H2,1H3,(H,22,23);6-8H,1-3,5H2/t9-;/m1./s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266034
PNG
(CHEMBL4075380)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ncco1
Show InChI InChI=1S/C15H13ClN2O6.C4H11NO3/c1-8(14-17-3-5-22-14)23-11-7-12-10(6-9(11)16)18(15(21)24-12)4-2-13(19)20;5-4(1-6,2-7)3-8/h3,5-8H,2,4H2,1H3,(H,19,20);6-8H,1-3,5H2/t8-;/m1./s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Pseudomonas fluorescens)
BDBM50266041
PNG
(CHEMBL4070212)
Show SMILES C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O5/c1-10(12-4-2-3-6-19-12)24-14-9-15-13(8-11(14)18)20(17(23)25-15)7-5-16(21)22/h2-4,6,8-10H,5,7H2,1H3,(H,21,22)/t10-/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas fluorescens KMO expressed in Escherichia coli using kynurenine as substrate measured after 1 hr by RapidFire high-throughpu...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266088
PNG
(CHEMBL4086792)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccc(Cl)cn1
Show InChI InChI=1S/C17H14Cl2N2O5.C4H11NO3/c1-9(12-3-2-10(18)8-20-12)25-14-7-15-13(6-11(14)19)21(17(24)26-15)5-4-16(22)23;5-4(1-6,2-7)3-8/h2-3,6-9H,4-5H2,1H3,(H,22,23);6-8H,1-3,5H2/t9-;/m1./s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266003
PNG
(CHEMBL4091152)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50131813
PNG
(CHEMBL3634599)
Show SMILES CC(Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O5/c1-10(12-4-2-3-6-19-12)24-14-9-15-13(8-11(14)18)20(17(23)25-15)7-5-16(21)22/h2-4,6,8-10H,5,7H2,1H3,(H,21,22)
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266015
PNG
(CHEMBL4076924)
Show SMILES NC(CO)(CO)CO.OC(=O)CCn1c2cc(Cl)c(OCc3ccccn3)cc2oc1=O
Show InChI InChI=1S/C16H13ClN2O5/c17-11-7-12-14(24-16(22)19(12)6-4-15(20)21)8-13(11)23-9-10-3-1-2-5-18-10/h1-3,5,7-8H,4,6,9H2,(H,20,21)
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266096
PNG
(CHEMBL4092169)
Show SMILES Cl.C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccc(C)cn1
Show InChI InChI=1S/C18H17ClN2O4.ClH/c1-10-3-4-14(20-9-10)11(2)24-17-8-16-12(7-13(17)19)15(21-25-16)5-6-18(22)23;/h3-4,7-9,11H,5-6H2,1-2H3,(H,22,23);1H/t11-;/m1./s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266040
PNG
(CHEMBL4099913)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccc(F)cn1
Show InChI InChI=1S/C17H14ClFN2O4/c1-9(13-3-2-10(19)8-20-13)24-16-7-15-11(6-12(16)18)14(21-25-15)4-5-17(22)23/h2-3,6-9H,4-5H2,1H3,(H,22,23)/t9-/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266001
PNG
(CHEMBL4071379)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccc(Cl)cn1
Show InChI InChI=1S/C17H14Cl2N2O4.C4H11NO3/c1-9(13-3-2-10(18)8-20-13)24-16-7-15-11(6-12(16)19)14(21-25-15)4-5-17(22)23;5-4(1-6,2-7)3-8/h2-3,6-9H,4-5H2,1H3,(H,22,23);6-8H,1-3,5H2/t9-;/m1./s1
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266069
PNG
(CHEMBL4075695)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1cc(C)ccn1
Show InChI InChI=1S/C18H17ClN2O5.C4H11NO3/c1-10-3-5-20-13(7-10)11(2)25-15-9-16-14(8-12(15)19)21(18(24)26-16)6-4-17(22)23;5-4(1-6,2-7)3-8/h3,5,7-9,11H,4,6H2,1-2H3,(H,22,23);6-8H,1-3,5H2/t11-;/m1./s1
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266087
PNG
(CHEMBL4064339)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2OCC(=O)N(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C18H17ClN2O5.C4H11NO3/c1-11(13-4-2-3-6-20-13)26-15-9-16-14(8-12(15)19)21(7-5-18(23)24)17(22)10-25-16;5-4(1-6,2-7)3-8/h2-4,6,8-9,11H,5,7,10H2,1H3,(H,23,24);6-8H,1-3,5H2/t11-;/m1./s1
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266003
PNG
(CHEMBL4091152)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266067
PNG
(CHEMBL4072423)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1cccc(C)n1
Show InChI InChI=1S/C18H17ClN2O5.C4H11NO3/c1-10-4-3-5-13(20-10)11(2)25-15-9-16-14(8-12(15)19)21(18(24)26-16)7-6-17(22)23;5-4(1-6,2-7)3-8/h3-5,8-9,11H,6-7H2,1-2H3,(H,22,23);6-8H,1-3,5H2/t11-;/m1./s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50237991
PNG
(CHEMBL4071986)
Show SMILES NC(CO)(CO)CO.CCOc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl
Show InChI InChI=1S/C12H12ClNO5/c1-2-18-9-6-10-8(5-7(9)13)14(12(17)19-10)4-3-11(15)16/h5-6H,2-4H2,1H3,(H,15,16)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266035
PNG
(CHEMBL4071903)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ncccn1
Show InChI InChI=1S/C16H14ClN3O5.C4H11NO3/c1-9(15-18-4-2-5-19-15)24-12-8-13-11(7-10(12)17)20(16(23)25-13)6-3-14(21)22;5-4(1-6,2-7)3-8/h2,4-5,7-9H,3,6H2,1H3,(H,21,22);6-8H,1-3,5H2/t9-;/m1./s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266104
PNG
(CHEMBL4085877)
Show SMILES C[C@@H](Oc1cc2ccn(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C18H17ClN2O3/c1-12(15-4-2-3-7-20-15)24-17-10-13-5-8-21(9-6-18(22)23)16(13)11-14(17)19/h2-5,7-8,10-12H,6,9H2,1H3,(H,22,23)/t12-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266036
PNG
(CHEMBL4092205)
Show SMILES OC(=O)CCn1c2cc(Cl)c(Cl)cc2oc1=O
Show InChI InChI=1S/C10H7Cl2NO4/c11-5-3-7-8(4-6(5)12)17-10(16)13(7)2-1-9(14)15/h3-4H,1-2H2,(H,14,15)
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n/an/a 6.30n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266121
PNG
(CHEMBL4099039)
Show SMILES NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccc(C)cn1
Show InChI InChI=1S/C18H17ClN2O5.C4H11NO3/c1-10-3-4-13(20-9-10)11(2)25-15-8-16-14(7-12(15)19)21(18(24)26-16)6-5-17(22)23;5-4(1-6,2-7)3-8/h3-4,7-9,11H,5-6H2,1-2H3,(H,22,23);6-8H,1-3,5H2/t11-;/m1./s1
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n/an/a 6.30n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50306508
PNG
(4'-((2,3-dimethyl-5-(1-phenylpropylcarbamoyl)-1H-i...)
Show SMILES CCC(NC(=O)c1ccc2n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c(C)c(C)c2c1)c1ccccc1
Show InChI InChI=1S/C34H32N2O3/c1-4-31(26-10-6-5-7-11-26)35-33(37)27-18-19-32-30(20-27)22(2)23(3)36(32)21-24-14-16-25(17-15-24)28-12-8-9-13-29(28)34(38)39/h5-20,31H,4,21H2,1-3H3,(H,35,37)(H,38,39)
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n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of radiolabled ((5-{4-[Methyl-pyridin-2yl-amino)-ethoxy]-benzyl}-thiazolidine-2,4-dione) from human PPARgamma ligand binding domain expr...


Bioorg Med Chem Lett 20: 1399-404 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.107
BindingDB Entry DOI: 10.7270/Q2T43T5R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50237994
PNG
(CHEMBL4082723)
Show SMILES NC(CO)(CO)CO.CCc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl
Show InChI InChI=1S/C12H12ClNO4/c1-2-7-5-10-9(6-8(7)13)14(12(17)18-10)4-3-11(15)16/h5-6H,2-4H2,1H3,(H,15,16)
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266003
PNG
(CHEMBL4091152)
Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccccn1
Show InChI InChI=1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of KMO in human primary hepatocytes using kynurenine as substrate measured after overnight incubation by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266005
PNG
(CHEMBL4079327)
Show SMILES NC(CO)(CO)CO.OC(=O)CCn1c2cc(Cl)c(OCC3CC3)cc2oc1=O
Show InChI InChI=1S/C14H14ClNO5/c15-9-5-10-12(6-11(9)20-7-8-1-2-8)21-14(19)16(10)4-3-13(17)18/h5-6,8H,1-4,7H2,(H,17,18)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Branched-chain-amino-acid aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM50118668
PNG
(CHEMBL3617086)
Show SMILES CCCCc1cc(=O)n2nc(NCc3c(F)cc(Br)cc3F)c(C#N)c2[nH]1
Show InChI InChI=1S/C18H16BrF2N5O/c1-2-3-4-11-7-16(27)26-18(24-11)12(8-22)17(25-26)23-9-13-14(20)5-10(19)6-15(13)21/h5-7,24H,2-4,9H2,1H3,(H,23,25)
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...


J Med Chem 58: 7140-63 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00313
BindingDB Entry DOI: 10.7270/Q2T43VWK
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50306513
PNG
(4'-((2-methyl-3-(methylthio)-5-(1-phenylpropylcarb...)
Show SMILES CCC(NC(=O)c1ccc2n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c(C)c(SC)c2c1)c1ccccc1
Show InChI InChI=1S/C34H32N2O3S/c1-4-30(25-10-6-5-7-11-25)35-33(37)26-18-19-31-29(20-26)32(40-3)22(2)36(31)21-23-14-16-24(17-15-23)27-12-8-9-13-28(27)34(38)39/h5-20,30H,4,21H2,1-3H3,(H,35,37)(H,38,39)
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n/an/a 12n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of radiolabled ((5-{4-[Methyl-pyridin-2yl-amino)-ethoxy]-benzyl}-thiazolidine-2,4-dione) from human PPARgamma ligand binding domain expr...


Bioorg Med Chem Lett 20: 1399-404 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.107
BindingDB Entry DOI: 10.7270/Q2T43T5R
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50131814
PNG
(CHEMBL3634598)
Show SMILES Cc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl
Show InChI InChI=1S/C11H10ClNO4/c1-6-4-9-8(5-7(6)12)13(11(16)17-9)3-2-10(14)15/h4-5H,2-3H2,1H3,(H,14,15)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Branched-chain-amino-acid aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM50118637
PNG
(CHEMBL3617084)
Show SMILES CCCCc1cc(=O)n2nc(N[C@H](C)c3ccc(Br)cc3F)c(C#N)c2[nH]1
Show InChI InChI=1S/C19H19BrFN5O/c1-3-4-5-13-9-17(27)26-19(24-13)15(10-22)18(25-26)23-11(2)14-7-6-12(20)8-16(14)21/h6-9,11,24H,3-5H2,1-2H3,(H,23,25)/t11-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...


J Med Chem 58: 7140-63 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00313
BindingDB Entry DOI: 10.7270/Q2T43VWK
More data for this
Ligand-Target Pair
Branched-chain-amino-acid aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM50118669
PNG
(CHEMBL3617083)
Show SMILES CCCCc1cc(=O)n2nc(NCc3ccc(Br)cc3F)c(C#N)c2[nH]1
Show InChI InChI=1S/C18H17BrFN5O/c1-2-3-4-13-8-16(26)25-18(23-13)14(9-21)17(24-25)22-10-11-5-6-12(19)7-15(11)20/h5-8,23H,2-4,10H2,1H3,(H,22,24)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...


J Med Chem 58: 7140-63 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00313
BindingDB Entry DOI: 10.7270/Q2T43VWK
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50266004
PNG
(CHEMBL4063199)
Show SMILES NC(CO)(CO)CO.CC(C)Cc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl
Show InChI InChI=1S/C14H16ClNO4/c1-8(2)5-9-6-12-11(7-10(9)15)16(14(19)20-12)4-3-13(17)18/h6-8H,3-5H2,1-2H3,(H,17,18)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Kynurenine 3-monooxygenase


(Homo sapiens (Human))
BDBM50237992
PNG
(CHEMBL4061355)
Show SMILES COc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl
Show InChI InChI=1S/C11H10ClNO5/c1-17-8-5-9-7(4-6(8)12)13(11(16)18-9)3-2-10(14)15/h4-5H,2-3H2,1H3,(H,14,15)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...


J Med Chem 60: 3383-3404 (2017)


BindingDB Entry DOI: 10.7270/Q26112SB
More data for this
Ligand-Target Pair
Branched-chain-amino-acid aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM50118665
PNG
(CHEMBL3617085)
Show SMILES CCCCc1cc(=O)n2nc(NCc3c(F)cc(Cl)cc3F)c(C#N)c2[nH]1
Show InChI InChI=1S/C18H16ClF2N5O/c1-2-3-4-11-7-16(27)26-18(24-11)12(8-22)17(25-26)23-9-13-14(20)5-10(19)6-15(13)21/h5-7,24H,2-4,9H2,1H3,(H,23,25)
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...


J Med Chem 58: 7140-63 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00313
BindingDB Entry DOI: 10.7270/Q2T43VWK
More data for this
Ligand-Target Pair
Branched-chain-amino-acid aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM50118672
PNG
(CHEMBL3617082)
Show SMILES CCCCc1cc(=O)n2nc(NCc3ccc(Cl)cc3F)c(C#N)c2[nH]1
Show InChI InChI=1S/C18H17ClFN5O/c1-2-3-4-13-8-16(26)25-18(23-13)14(9-21)17(24-25)22-10-11-5-6-12(19)7-15(11)20/h5-8,23H,2-4,10H2,1H3,(H,22,24)
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...


J Med Chem 58: 7140-63 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00313
BindingDB Entry DOI: 10.7270/Q2T43VWK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50306516
PNG
(4'-((2-methyl-5-(1-phenylpropylcarbamoyl)-1H-indol...)
Show SMILES CCC(NC(=O)c1ccc2n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c(C)cc2c1)c1ccccc1
Show InChI InChI=1S/C33H30N2O3/c1-3-30(25-9-5-4-6-10-25)34-32(36)26-17-18-31-27(20-26)19-22(2)35(31)21-23-13-15-24(16-14-23)28-11-7-8-12-29(28)33(37)38/h4-20,30H,3,21H2,1-2H3,(H,34,36)(H,37,38)
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n/an/a 18n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of radiolabled ((5-{4-[Methyl-pyridin-2yl-amino)-ethoxy]-benzyl}-thiazolidine-2,4-dione) from human PPARgamma ligand binding domain expr...


Bioorg Med Chem Lett 20: 1399-404 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.107
BindingDB Entry DOI: 10.7270/Q2T43T5R
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50306514
PNG
(4'-((2,3-dimethyl-5-(3-phenylpropylcarbamoyl)-1H-i...)
Show SMILES Cc1c(C)c2cc(ccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C34H32N2O3/c1-23-24(2)36(22-26-14-16-27(17-15-26)29-12-6-7-13-30(29)34(38)39)32-19-18-28(21-31(23)32)33(37)35-20-8-11-25-9-4-3-5-10-25/h3-7,9-10,12-19,21H,8,11,20,22H2,1-2H3,(H,35,37)(H,38,39)
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n/an/a 18n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of radiolabled ((5-{4-[Methyl-pyridin-2yl-amino)-ethoxy]-benzyl}-thiazolidine-2,4-dione) from human PPARgamma ligand binding domain expr...


Bioorg Med Chem Lett 20: 1399-404 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.107
BindingDB Entry DOI: 10.7270/Q2T43T5R
More data for this
Ligand-Target Pair
Branched-chain-amino-acid aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM50118524
PNG
(CHEMBL3617080)
Show SMILES CCCc1cc(=O)n2nc(N[C@H](C)c3ccc(Br)cc3F)c(C#N)c2[nH]1
Show InChI InChI=1S/C18H17BrFN5O/c1-3-4-12-8-16(26)25-18(23-12)14(9-21)17(24-25)22-10(2)13-6-5-11(19)7-15(13)20/h5-8,10,23H,3-4H2,1-2H3,(H,22,24)/t10-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...


J Med Chem 58: 7140-63 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00313
BindingDB Entry DOI: 10.7270/Q2T43VWK
More data for this
Ligand-Target Pair
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