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Compile Data Set for Download or QSAR

Found 1981 hits with Last Name = 'andresen' and Initial = 'bm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM301997
PNG
(US9598405, 1.5 | US9598405, 1.6)
Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1
Show InChI InChI=1S/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)/t14-,22-/m1/s1
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n/an/a 0.0710n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302002
PNG
(US9598405, 2.1)
Show SMILES Cc1cc(Nc2cc(ccn2)-c2c[nH]nn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O
Show InChI InChI=1S/C23H23N7O3S/c1-13-8-16(18-12-25-22(34-18)23(33)5-2-14(3-6-23)21(31)32)27-20(9-13)28-19-10-15(4-7-24-19)17-11-26-30-29-17/h4,7-12,14,33H,2-3,5-6H2,1H3,(H,31,32)(H,24,27,28)(H,26,29,30)
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n/an/a 0.0720n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302016
PNG
(US9598405, 3.1)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@]1(O)CC[C@@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t15-,23-/m0/s1
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n/an/a 0.0730n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374600
PNG
(2-{3-[3-amino-7-(1-methyl-1H-pyrazol-4-yl)-1H-inda...)
Show SMILES Cn1cc(cn1)-c1cc(cc2c(N)n[nH]c12)-c1cccc(c1CO)-n1ncc2cc(cc(F)c2c1=O)C(C)(C)C
Show InChI InChI=1S/C30H28FN7O2/c1-30(2,3)19-8-17-12-34-38(29(40)26(17)24(31)11-19)25-7-5-6-20(23(25)15-39)16-9-21(18-13-33-37(4)14-18)27-22(10-16)28(32)36-35-27/h5-14,39H,15H2,1-4H3,(H3,32,35,36)
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n/an/a 0.0730n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302034
PNG
(BDBM302035 | US9598405, 4.1)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2(CCCCC2)C1C(O)=O
Show InChI InChI=1/C25H25F3N4O3S/c1-14-9-16(31-19(10-14)32-18-11-15(5-8-29-18)25(26,27)28)17-12-30-22(36-17)24(35)13-23(20(24)21(33)34)6-3-2-4-7-23/h5,8-12,20,35H,2-4,6-7,13H2,1H3,(H,33,34)(H,29,31,32)
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n/an/a 0.0860n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302018
PNG
(US9598405, 3.3 | US9598405, 3.7)
Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(ccn2)C(F)(F)F)n1
Show InChI InChI=1S/C23H23F3N4O3S/c1-21(2)12-22(33,8-6-14(21)19(31)32)20-28-11-16(34-20)15-4-3-5-17(29-15)30-18-10-13(7-9-27-18)23(24,25)26/h3-5,7,9-11,14,33H,6,8,12H2,1-2H3,(H,31,32)(H,27,29,30)/t14-,22-/m1/s1
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n/an/a 0.0920n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374617
PNG
(US10246457, Example 26)
Show SMILES COCCn1cc(cn1)-c1cc(cc2c(N)n[nH]c12)-c1cccc(c1CO)-n1ncc2cc(cc(F)c2c1=O)C(C)(C)C
Show InChI InChI=1S/C32H32FN7O3/c1-32(2,3)21-10-19-14-36-40(31(42)28(19)26(33)13-21)27-7-5-6-22(25(27)17-41)18-11-23(29-24(12-18)30(34)38-37-29)20-15-35-39(16-20)8-9-43-4/h5-7,10-16,41H,8-9,17H2,1-4H3,(H3,34,37,38)
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n/an/a 0.0960n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302028
PNG
(US9598405, 3.13)
Show SMILES Cc1cc(Nc2cc(C)c(Cl)cn2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C24H27ClN4O3S/c1-13-7-17(28-20(8-13)29-19-9-14(2)16(25)10-26-19)18-11-27-22(33-18)24(32)6-5-15(21(30)31)23(3,4)12-24/h7-11,15,32H,5-6,12H2,1-4H3,(H,30,31)(H,26,28,29)/t15-,24-/m1/s1
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n/an/a 0.0970n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM301993
PNG
(BDBM301994 | US9598405, 1.1)
Show SMILES Cc1cc(Nc2cc(ccn2)C2CC2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C26H30N4O3S/c1-15-10-19(29-22(11-15)30-21-12-17(7-9-27-21)16-4-5-16)20-13-28-24(34-20)26(33)8-6-18(23(31)32)25(2,3)14-26/h7,9-13,16,18,33H,4-6,8,14H2,1-3H3,(H,31,32)(H,27,29,30)/t18-,26-/m1/s1
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n/an/a 0.103n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302029
PNG
(US9598405, 3.14)
Show SMILES COc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1
Show InChI InChI=1S/C24H28N4O4S/c1-14-9-17(27-20(10-14)28-19-11-15(32-4)6-8-25-19)18-12-26-22(33-18)24(31)7-5-16(21(29)30)23(2,3)13-24/h6,8-12,16,31H,5,7,13H2,1-4H3,(H,29,30)(H,25,27,28)/t16-,24-/m1/s1
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n/an/a 0.104n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374613
PNG
(US10246457, Example 22)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(-c4cc(-c5ccccn5)c5[nH]nc(N)c5c4)c3CO)c2=O)c1
Show InChI InChI=1S/C31H27FN6O2/c1-31(2,3)19-11-18-15-35-38(30(40)27(18)24(32)14-19)26-9-6-7-20(23(26)16-39)17-12-21(25-8-4-5-10-34-25)28-22(13-17)29(33)37-36-28/h4-15,39H,16H2,1-3H3,(H3,33,36,37)
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n/an/a 0.110n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302032
PNG
(US9598405, 3.17)
Show SMILES Cc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1
Show InChI InChI=1S/C24H28N4O3S/c1-14-6-8-25-19(10-14)28-20-11-15(2)9-17(27-20)18-12-26-22(32-18)24(31)7-5-16(21(29)30)23(3,4)13-24/h6,8-12,16,31H,5,7,13H2,1-4H3,(H,29,30)(H,25,27,28)/t16-,24-/m1/s1
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n/an/a 0.113n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302000
PNG
(US9598405, 1.8)
Show SMILES CC1(C)CC(O)(CCC1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1
Show InChI InChI=1/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)
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n/an/a 0.119n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302030
PNG
(US9598405, 3.15)
Show SMILES Cc1cc(Nc2cc(C)c(F)cn2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C24H27FN4O3S/c1-13-7-17(28-20(8-13)29-19-9-14(2)16(25)10-26-19)18-11-27-22(33-18)24(32)6-5-15(21(30)31)23(3,4)12-24/h7-11,15,32H,5-6,12H2,1-4H3,(H,30,31)(H,26,28,29)/t15-,24-/m1/s1
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n/an/a 0.127n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374609
PNG
(US10246457, Example 18)
Show SMILES Cn1cc(cn1)-c1cc(cc2c(N)n[nH]c12)-c1cccc(NC(=O)c2cc3CCCCc3s2)c1CO
Show InChI InChI=1S/C27H26N6O2S/c1-33-13-17(12-29-33)19-9-16(10-20-25(19)31-32-26(20)28)18-6-4-7-22(21(18)14-34)30-27(35)24-11-15-5-2-3-8-23(15)36-24/h4,6-7,9-13,34H,2-3,5,8,14H2,1H3,(H,30,35)(H3,28,31,32)
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n/an/a 0.130n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374592
PNG
(3-amino-5-[3-(6-tert-butyl-8-fluoro-1-oxophthalazi...)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(-c4cc(C(O)=O)c5[nH]nc(N)c5c4)c3CO)c2=O)c1
Show InChI InChI=1S/C27H24FN5O4/c1-27(2,3)15-7-14-11-30-33(25(35)22(14)20(28)10-15)21-6-4-5-16(19(21)12-34)13-8-17-23(31-32-24(17)29)18(9-13)26(36)37/h4-11,34H,12H2,1-3H3,(H,36,37)(H3,29,31,32)
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n/an/a 0.140n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374597
PNG
(2-[3-{3-amino-7-[1-(1-methylethyl)-1H-pyrazol-4-yl...)
Show SMILES CC(C)n1cc(cn1)-c1cc(cc2c(N)n[nH]c12)-c1cccc(c1CO)-n1ncc2cc(cc(F)c2c1=O)C(C)(C)C
Show InChI InChI=1S/C32H32FN7O2/c1-17(2)39-15-20(14-35-39)23-10-18(11-24-29(23)37-38-30(24)34)22-7-6-8-27(25(22)16-41)40-31(42)28-19(13-36-40)9-21(12-26(28)33)32(3,4)5/h6-15,17,41H,16H2,1-5H3,(H3,34,37,38)
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n/an/a 0.150n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302013
PNG
(US9598405, 2.12)
Show SMILES Cc1cc(Nc2cc(OC3CCNCC3)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O
Show InChI InChI=1S/C26H31N5O4S/c1-16-12-20(21-15-29-25(36-21)26(34)7-2-17(3-8-26)24(32)33)30-23(13-16)31-22-14-19(6-11-28-22)35-18-4-9-27-10-5-18/h6,11-15,17-18,27,34H,2-5,7-10H2,1H3,(H,32,33)(H,28,30,31)
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n/an/a 0.152n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302017
PNG
(US9598405, 3.2 | US9598405, 3.6)
Show SMILES CC(C)(C)c1ccnc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1
Show InChI InChI=1S/C26H32N4O3S/c1-24(2,3)16-10-12-27-21(13-16)30-20-8-6-7-18(29-20)19-14-28-23(34-19)26(33)11-9-17(22(31)32)25(4,5)15-26/h6-8,10,12-14,17,33H,9,11,15H2,1-5H3,(H,31,32)(H,27,29,30)/t17-,26-/m1/s1
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n/an/a 0.158n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374602
PNG
(3-amino-5-[3-(6-tert-butyl-8-fluoro-1-oxophthalazi...)
Show SMILES CNC(=O)c1cc(cc2c(N)n[nH]c12)-c1cccc(c1CO)-n1ncc2cc(cc(F)c2c1=O)C(C)(C)C
Show InChI InChI=1S/C28H27FN6O3/c1-28(2,3)16-8-15-12-32-35(27(38)23(15)21(29)11-16)22-7-5-6-17(20(22)13-36)14-9-18-24(33-34-25(18)30)19(10-14)26(37)31-4/h5-12,36H,13H2,1-4H3,(H,31,37)(H3,30,33,34)
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n/an/a 0.160n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302033
PNG
(US9598405, 3.18)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t15-,23-/m1/s1
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n/an/a 0.160n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374608
PNG
(2-[3-{3-amino-7-[1(1-methylethyl)-1H-pyrazol-3-yl]...)
Show SMILES CC(C)n1ccc(n1)-c1cc(cc2c(N)n[nH]c12)-c1cccc(c1CO)-n1ncc2cc(cc(F)c2c1=O)C(C)(C)C
Show InChI InChI=1S/C32H32FN7O2/c1-17(2)39-10-9-26(38-39)22-12-18(13-23-29(22)36-37-30(23)34)21-7-6-8-27(24(21)16-41)40-31(42)28-19(15-35-40)11-20(14-25(28)33)32(3,4)5/h6-15,17,41H,16H2,1-5H3,(H3,34,36,37)
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n/an/a 0.160n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374594
PNG
(3-amino-5-[3-(6-tert-butyl-8-fluoro-1-oxophthalazi...)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(-c4cc(C(N)=O)c5[nH]nc(N)c5c4)c3CO)c2=O)c1
Show InChI InChI=1S/C27H25FN6O3/c1-27(2,3)15-7-14-11-31-34(26(37)22(14)20(28)10-15)21-6-4-5-16(19(21)12-35)13-8-17-23(32-33-24(17)29)18(9-13)25(30)36/h4-11,35H,12H2,1-3H3,(H2,30,36)(H3,29,32,33)
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n/an/a 0.160n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302042
PNG
(US9598405, 5.1)
Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(C)c(F)cn2)n1
Show InChI InChI=1S/C23H25FN4O3S/c1-12-6-17(27-20(7-12)28-19-8-13(2)16(24)10-25-19)18-11-26-22(32-18)23(31)5-4-15(21(29)30)14(3)9-23/h6-8,10-11,14-15,31H,4-5,9H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,15+,23-/m1/s1
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n/an/a 0.161n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM301996
PNG
(US9598405, 1.4)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCC(C(O)=O)C(C)(C)C1
Show InChI InChI=1/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)
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n/an/a 0.164n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374614
PNG
(US10246457, Example 23)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(-c4cc(-c5cnn(CC(O)=O)c5)c5[nH]nc(N)c5c4)c3CO)c2=O)c1
Show InChI InChI=1S/C31H28FN7O4/c1-31(2,3)19-7-17-11-35-39(30(43)27(17)24(32)10-19)25-6-4-5-20(23(25)15-40)16-8-21(28-22(9-16)29(33)37-36-28)18-12-34-38(13-18)14-26(41)42/h4-13,40H,14-15H2,1-3H3,(H,41,42)(H3,33,36,37)
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n/an/a 0.180n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374616
PNG
(US10246457, Example 25)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(c3CO)-c3cc(-c4cnn(c4)C4CCOCC4)c4[nH]nc(N)c4c3)c2=O)c1
Show InChI InChI=1S/C34H34FN7O3/c1-34(2,3)22-11-20-15-38-42(33(44)30(20)28(35)14-22)29-6-4-5-24(27(29)18-43)19-12-25(31-26(13-19)32(36)40-39-31)21-16-37-41(17-21)23-7-9-45-10-8-23/h4-6,11-17,23,43H,7-10,18H2,1-3H3,(H3,36,39,40)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302026
PNG
(US9598405, 3.11)
Show SMILES Cc1cc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)ncc1Cl
Show InChI InChI=1S/C23H25ClN4O3S/c1-13-9-19(25-10-15(13)24)28-18-6-4-5-16(27-18)17-11-26-21(32-17)23(31)8-7-14(20(29)30)22(2,3)12-23/h4-6,9-11,14,31H,7-8,12H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,23-/m1/s1
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n/an/a 0.208n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302036
PNG
(BDBM302037 | US9598405, 4.3)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2CCC(C1)C2C(O)=O
Show InChI InChI=1/C24H23F3N4O3S/c1-12-6-16(30-19(7-12)31-18-8-15(4-5-28-18)24(25,26)27)17-11-29-22(35-17)23(34)9-13-2-3-14(10-23)20(13)21(32)33/h4-8,11,13-14,20,34H,2-3,9-10H2,1H3,(H,32,33)(H,28,30,31)
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n/an/a 0.228n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374615
PNG
(US10246457, Example 24)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(-c4cc(-c5cnn(c5)C(C)(C)C(O)=O)c5[nH]nc(N)c5c4)c3CO)c2=O)c1
Show InChI InChI=1S/C33H32FN7O4/c1-32(2,3)20-9-18-13-37-41(30(43)27(18)25(34)12-20)26-8-6-7-21(24(26)16-42)17-10-22(28-23(11-17)29(35)39-38-28)19-14-36-40(15-19)33(4,5)31(44)45/h6-15,42H,16H2,1-5H3,(H,44,45)(H3,35,38,39)
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n/an/a 0.280n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302006
PNG
(US9598405, 2.5)
Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2cn(C)nn2)n1
Show InChI InChI=1S/C26H29N7O3S/c1-4-36-24(34)17-5-8-26(35,9-6-17)25-28-14-21(37-25)19-11-16(2)12-23(29-19)30-22-13-18(7-10-27-22)20-15-33(3)32-31-20/h7,10-15,17,35H,4-6,8-9H2,1-3H3,(H,27,29,30)
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n/an/a 0.316n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302014
PNG
(US9598405, 2.13)
Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2c[nH]nn2)n1
Show InChI InChI=1S/C25H27N7O3S/c1-3-35-23(33)16-4-7-25(34,8-5-16)24-27-14-20(36-24)18-10-15(2)11-22(29-18)30-21-12-17(6-9-26-21)19-13-28-32-31-19/h6,9-14,16,34H,3-5,7-8H2,1-2H3,(H,26,29,30)(H,28,31,32)
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n/an/a 0.333n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM302039
PNG
(US9598405, 4.6)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O
Show InChI InChI=1S/C22H21F3N4O3S/c1-12-8-15(28-18(9-12)29-17-10-14(4-7-26-17)22(23,24)25)16-11-27-20(33-16)21(32)5-2-13(3-6-21)19(30)31/h4,7-11,13,32H,2-3,5-6H2,1H3,(H,30,31)(H,26,28,29)
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n/an/a 0.392n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9598405 (2017)


Article DOI: 10.1021/jm050756e
BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374618
PNG
(US10246457, Example 27)
Show SMILES Cc1nn(C)cc1-c1cc(cc2c(N)n[nH]c12)-c1cccc(c1CO)-n1ncc2cc(cc(F)c2c1=O)C(C)(C)C
Show InChI InChI=1S/C31H30FN7O2/c1-16-23(14-38(5)37-16)21-10-17(11-22-28(21)35-36-29(22)33)20-7-6-8-26(24(20)15-40)39-30(41)27-18(13-34-39)9-19(12-25(27)32)31(2,3)4/h6-14,40H,15H2,1-5H3,(H3,33,35,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374610
PNG
(US10246457, Example 19)
Show SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(-c4cc(-c5ccccc5)c5[nH]nc(N)c5c4)c3CO)c2=O)c1
Show InChI InChI=1S/C32H28FN5O2/c1-32(2,3)21-12-20-16-35-38(31(40)28(20)26(33)15-21)27-11-7-10-22(25(27)17-39)19-13-23(18-8-5-4-6-9-18)29-24(14-19)30(34)37-36-29/h4-16,39H,17H2,1-3H3,(H3,34,36,37)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM374607
PNG
(3-amino-5-[3-(6-tert-butyl-8-fluoro-1-oxo-3,4-dihy...)
Show SMILES CC(C)(C)c1cc(F)c2C(=O)N(CCc2c1)c1cccc(-c2cc(C(N)=O)c3[nH]nc(N)c3c2)c1CO
Show InChI InChI=1S/C28H28FN5O3/c1-28(2,3)16-9-14-7-8-34(27(37)23(14)21(29)12-16)22-6-4-5-17(20(22)13-35)15-10-18-24(32-33-25(18)30)19(11-15)26(31)36/h4-6,9-12,35H,7-8,13H2,1-3H3,(H2,31,36)(H3,30,32,33)
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n/an/a 0.490n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...


US Patent US10246457 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127939
PNG
(US8796310, 1)
Show SMILES Cc1cc(Nc2cc(OC(C)(C)C)ccn2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1/C29H30N4O4S/c1-17-12-22(32-25(13-17)33-24-15-20(9-11-30-24)37-28(2,3)4)23-16-31-27(38-23)29(36)10-5-6-18-14-19(26(34)35)7-8-21(18)29/h7-9,11-16,36H,5-6,10H2,1-4H3,(H,34,35)(H,30,32,33)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM128011
PNG
(US8796310, 29C)
Show SMILES CCCOc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@@]2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1S/C28H28N4O4S/c1-3-11-36-20-8-10-29-24(15-20)32-25-13-17(2)12-22(31-25)23-16-30-27(37-23)28(35)9-4-5-18-14-19(26(33)34)6-7-21(18)28/h6-8,10,12-16,35H,3-5,9,11H2,1-2H3,(H,33,34)(H,29,31,32)/t28-/m1/s1
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM128013
PNG
(US8796310, 1A)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1/C26H22F2N4O3S/c1-14-9-19(31-22(10-14)32-21-12-16(23(27)28)6-8-29-21)20-13-30-25(36-20)26(35)7-2-3-15-11-17(24(33)34)4-5-18(15)26/h4-6,8-13,23,35H,2-3,7H2,1H3,(H,33,34)(H,29,31,32)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127940
PNG
(US8796310, 1C)
Show SMILES Cc1cc(Nc2cc(ccn2)N2CCN(CCN)CC2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1/C31H35N7O3S/c1-20-15-25(26-19-34-30(42-26)31(41)7-2-3-21-17-22(29(39)40)4-5-24(21)31)35-28(16-20)36-27-18-23(6-9-33-27)38-13-11-37(10-8-32)12-14-38/h4-6,9,15-19,41H,2-3,7-8,10-14,32H2,1H3,(H,39,40)(H,33,35,36)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127941
PNG
(US8796310, 1D)
Show SMILES Cc1cc(Nc2cc(ccn2)N2CCNCC2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1/C29H30N6O3S/c1-18-13-23(33-26(14-18)34-25-16-21(6-8-31-25)35-11-9-30-10-12-35)24-17-32-28(39-24)29(38)7-2-3-19-15-20(27(36)37)4-5-22(19)29/h4-6,8,13-17,30,38H,2-3,7,9-12H2,1H3,(H,36,37)(H,31,33,34)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127942
PNG
(US8796310, 1E)
Show SMILES Cc1cnn(c1)-c1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1/C29H26N6O3S/c1-17-10-23(33-26(11-17)34-25-13-21(7-9-30-25)35-16-18(2)14-32-35)24-15-31-28(39-24)29(38)8-3-4-19-12-20(27(36)37)5-6-22(19)29/h5-7,9-16,38H,3-4,8H2,1-2H3,(H,36,37)(H,30,33,34)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127943
PNG
(US8796310, 1F)
Show SMILES Cc1cc(Nc2cc(ccn2)-n2cccn2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1/C28H24N6O3S/c1-17-12-22(32-25(13-17)33-24-15-20(7-10-29-24)34-11-3-9-31-34)23-16-30-27(38-23)28(37)8-2-4-18-14-19(26(35)36)5-6-21(18)28/h3,5-7,9-16,37H,2,4,8H2,1H3,(H,35,36)(H,29,32,33)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM128015
PNG
(US8796310, 1H)
Show SMILES Cc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1/C26H24N4O3S/c1-15-7-9-27-22(11-15)30-23-12-16(2)10-20(29-23)21-14-28-25(34-21)26(33)8-3-4-17-13-18(24(31)32)5-6-19(17)26/h5-7,9-14,33H,3-4,8H2,1-2H3,(H,31,32)(H,27,29,30)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127946
PNG
(US8796310, 1J)
Show SMILES Cc1ccn(n1)-c1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1/C29H26N6O3S/c1-17-12-23(32-26(13-17)33-25-15-21(7-10-30-25)35-11-8-18(2)34-35)24-16-31-28(39-24)29(38)9-3-4-19-14-20(27(36)37)5-6-22(19)29/h5-8,10-16,38H,3-4,9H2,1-2H3,(H,36,37)(H,30,32,33)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM127947
PNG
(US8796310, 1K)
Show SMILES Cc1cc(Nc2cc(ccn2)C2CCC2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1/C29H28N4O3S/c1-17-12-23(32-26(13-17)33-25-15-19(9-11-30-25)18-4-2-5-18)24-16-31-28(37-24)29(36)10-3-6-20-14-21(27(34)35)7-8-22(20)29/h7-9,11-16,18,36H,2-6,10H2,1H3,(H,34,35)(H,30,32,33)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM128016
PNG
(US8796310, 1M)
Show SMILES CCCc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1/C28H28N4O3S/c1-3-5-18-9-11-29-24(14-18)32-25-13-17(2)12-22(31-25)23-16-30-27(36-23)28(35)10-4-6-19-15-20(26(33)34)7-8-21(19)28/h7-9,11-16,35H,3-6,10H2,1-2H3,(H,33,34)(H,29,31,32)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM128017
PNG
(US8796310, 1N)
Show SMILES CCOc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1/C27H26N4O4S/c1-3-35-19-8-10-28-23(14-19)31-24-12-16(2)11-21(30-24)22-15-29-26(36-22)27(34)9-4-5-17-13-18(25(32)33)6-7-20(17)27/h6-8,10-15,34H,3-5,9H2,1-2H3,(H,32,33)(H,28,30,31)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM128018
PNG
(US8796310, 1P)
Show SMILES CCc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1/C27H26N4O3S/c1-3-17-8-10-28-23(13-17)31-24-12-16(2)11-21(30-24)22-15-29-26(35-22)27(34)9-4-5-18-14-19(25(32)33)6-7-20(18)27/h6-8,10-15,34H,3-5,9H2,1-2H3,(H,32,33)(H,28,30,31)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM128019
PNG
(US8796310, 1R)
Show SMILES CC(C)Oc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1
Show InChI InChI=1/C28H28N4O4S/c1-16(2)36-20-8-10-29-24(14-20)32-25-12-17(3)11-22(31-25)23-15-30-27(37-23)28(35)9-4-5-18-13-19(26(33)34)6-7-21(18)28/h6-8,10-16,35H,4-5,9H2,1-3H3,(H,33,34)(H,29,31,32)
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n/an/a<0.5n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...


US Patent US8796310 (2014)


BindingDB Entry DOI: 10.7270/Q29W0D61
More data for this
Ligand-Target Pair
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